School of Medicine

Research Output 1973 2020

2019

Activation of extracellular signal-regulated kinase is associated with hepatocellular carcinoma with aggressive phenotypes

Minagawa, T., Yamazaki, K., Masugi, Y., Tsujikawa, H., Ojima, H., Hibi, T., Abe, Y., Yagi, H., Kitago, M., Shinoda, M., Itano, O., Kitagawa, Y. & Sakamoto, M., 2019 Jan 1, (Accepted/In press) In : Hepatology Research.

Research output: Contribution to journalArticle

Extracellular Signal-Regulated MAP Kinases
Hepatocellular Carcinoma
Phenotype
Hepatocyte Growth Factor
Survival

Activities of daily living among elderly persons with severe aortic stenosis

Fukui, S., Kawakami, M., Otaka, Y., Ishikawa, A., Yashima, F., Hayashida, K., Muraoka, K. & Liu, M., 2019 Jan 1, In : Disability and Rehabilitation.

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Activities of Daily Living
Cerebrovascular Disorders
Heart Failure
Nutritional Status
1 Citation (Scopus)

Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons

Ibata, K., Kono, M., Narumi, S., Motohashi, J., Kakegawa, W., Kohda, K. & Yuzaki, M., 2019 Jun 19, In : Neuron. 102, 6, p. 1184-1198.e10

Research output: Contribution to journalArticle

Lysosomes
Cathepsin B
Axons
Synapses
Exocytosis

Actual practice of standard treatment for pulmonary nontuberculous mycobacteriosis in Japan

Morimoto, K., Izumi, K., Ato, M., Hasegawa, N. & Mitarai, S., 2019 Oct 1, In : Respiratory Medicine. 158, p. 67-69 3 p.

Research output: Contribution to journalArticle

Japan
Lung
Macrolides
Therapeutics
Lung Diseases
7 Citations (Scopus)

Acute and long-term effects of electroconvulsive therapy on human dentate gyrus

Takamiya, A., Plitman, E., Chung, J. K., Chakravarty, M., Graff-Guerrero, A., Mimura, M. & Kishimoto, T., 2019 Jan 1, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Electroconvulsive Therapy
Dentate Gyrus
splenotritin
Antidepressive Agents
Hippocampus
2 Citations (Scopus)

Acute Interstitial Nephritis With Karyomegalic Epithelial Cells After Nivolumab Treatment—Two Case Reports

Ryuzaki, M., Tokuyama, H., Uchiyama, K., Nakaya, H., Hasegawa, K., Miyashita, K., Konishi, K., Hashiguchi, A., Wakino, S. & Itoh, H., 2019 Jun 1, In : Clinical Medicine Insights: Case Reports. 12

Research output: Contribution to journalArticle

Open Access
Interstitial Nephritis
Epithelial Cells
Kidney
Therapeutics
Immunosuppressive Agents

Acute odontogenic infection combined with crowned dens syndrome: A case report

Soma, T., Asoda, S., Kimura, M., Munakata, K., Miyashita, H., Nakagawa, T. & Kawana, H., 2019 May 13, In : Journal of Medical Case Reports. 13, 1, 143.

Research output: Contribution to journalArticle

Open Access
Chondrocalcinosis
C-Reactive Protein
Cheek
Leukocyte Count
Odontoid Process

Acute Paraparesis Due to Protrusion of a Disc Following Lateral Interbody Fusion for Degenerative Kyphoscoliosis: A Case Report

Ruchirawan, S., Fujita, N., Yagi, M., Tsuji, O., Okada, E., Nagoshi, N., Ishii, K., Nakamura, M., Matsumoto, M. & Watanabe, K., 2019 Jan 1, In : JBJS case connector. 9, 1, p. e8

Research output: Contribution to journalArticle

Paraparesis
Spinal Canal
Decompression
Ilium
Spinal Stenosis

Addition of canagliflozin to insulin improves glycaemic control and reduces insulin dose in patients with type 2 diabetes mellitus: A randomized controlled trial

Torimoto, K., Okada, Y., Goshima, Y., Tokutsu, A., Sato, Y. & Tanaka, Y., 2019 Jan 1, In : Diabetes, Obesity and Metabolism.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Randomized Controlled Trials
Insulin
Blood Glucose
Hypoglycemia
74 Citations (Scopus)

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. & 8 others, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 Jan 31, In : Nature. 565, 7741, p. 600-605 6 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Listeriosis
Histocompatibility
Microbiota

Adenovirus type 5 community-Acquired pneumonia in an immunocompetent patient

Masaki, K., Asakura, T., Sakurai, K. & Ohkusu, K., 2019 Apr 1, In : BMJ case reports. 12, 4, e228914.

Research output: Contribution to journalComment/debate

Open Access
Pulmonary Medicine
Bronchitis
Adenoviridae
Communicable Diseases
Pneumonia

Adherence to the guidelines and the pathological diagnosis of high-risk gastrointestinal stromal tumors in the real world

The members of the STAR ReGISTry Study Group, 2019 Jan 1, In : Gastric Cancer.

Research output: Contribution to journalArticle

Open Access
Guideline Adherence
Gastrointestinal Stromal Tumors
Pathology
Neoplasms
Registries
3 Citations (Scopus)

Adipokines and aging: Findings from centenarians and the very old

Arai, Y., Kamide, K. & Hirose, N., 2019 Jan 1, In : Frontiers in Endocrinology. 10, MAR, 142.

Research output: Contribution to journalReview article

Open Access
Adipokines
Insulin Resistance
Adiponectin
Homeostasis
Obesity

Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke

Monai, H., Wang, X., Yahagi, K., Lou, N., Mestre, H., Xu, Q., Abe, Y., Yasui, M., Iwai, Y., Nedergaard, M. & Hirase, H., 2019 May 28, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 11010-11019 10 p.

Research output: Contribution to journalArticle

Adrenergic Receptors
Stroke
Aquaporin 4
Aquaporins
Adrenergic Antagonists

Adult-onset Still's disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse

Takakuwa, Y., Hanaoka, H., Kiyokawa, T., Iida, H., Ishimori, K., Uekusa, T., Yamada, H. & Kawahata, K., 2019 Nov 1, In : Clinical and experimental rheumatology. 37, 6, p. 23-27 5 p.

Research output: Contribution to journalArticle

Adult-Onset Still's Disease
Hemophagocytic Lymphohistiocytosis
Interstitial Lung Diseases
Phenotype
Recurrence

Advances in hematopoietic stem cell transplantation in the Asia-Pacific region: the second report from APBMT 2005–2015

Registry Committee of the Asia-Pacific Blood and Marrow Transplantation Group (APBMT), 2019 Jan 1, In : Bone Marrow Transplantation.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
China
Hemoglobinopathies
Vietnam
Pakistan
1 Citation (Scopus)
Indigo Carmine
Ulcerative Colitis
Pulmonary Hypertension
Intussusception
Liver Diseases

A Familial Case of a Whole Germline CDC73 Deletion Discordant for Primary Hyperparathyroidism

Hatabu, N., Katori, N., Sato, T., Maeda, N., Suzuki, E., Komiyama, O., Tsutsui, H., Nagao, T., Nakauchi-Takahashi, H., Matsunaga, T., Ishii, T., Hasegawa, T. & Yamazawa, K., 2019 Jan 1, In : Hormone Research in Paediatrics.

Research output: Contribution to journalArticle

Primary Hyperparathyroidism
Genes
Hypophosphatemia
Parathyroid Neoplasms
Parathyroidectomy
Open Access
Germ-Line Mutation
Brain Neoplasms
Lung Neoplasms
Prostatic Neoplasms
Neoplasm Metastasis

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver

Nakamura, A., Zhu, Q., Yokoyama, Y., Kitamura, N., Uchida, S., Kumadaki, K., Tsubota, K. & Watanabe, M., 2019 Jan 1, In : Foods. 8, 11, 546.

Research output: Contribution to journalArticle

Open Access
Agaricus subrufescens
Agaricus
Fatty Liver
alcoholism
Anti-Inflammatory Agents

Age group differences in association between IADL decline and depressive symptoms in community-dwelling elderly

Kiyoshige, E., Kabayama, M., Gondo, Y., Masui, Y., Inagaki, H., Ogawa, M., Nakagawa, T., Yasumoto, S., Akasaka, H., Sugimoto, K., Ikebe, K., Arai, Y., Ishizaki, T., Rakugi, H. & Kamide, K., 2019 Nov 13, In : BMC Geriatrics. 19, 1, 309.

Research output: Contribution to journalArticle

Open Access
Independent Living
Activities of Daily Living
Age Groups
Depression
Odds Ratio

Age-Related Conjunctival P2Y2 Receptor Alterations in the Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Dry Eye Model Mice

Dogru, M., Shinzawa, M., Kojima, T., Shimizu, T. & Tsubota, K., 2019 Nov 1, In : Eye & contact lens. 45, 6, p. 405-409 5 p.

Research output: Contribution to journalArticle

Purinergic P2Y2 Receptors
Tears
Staining and Labeling
Fluorescein
Messenger RNA
1 Citation (Scopus)

A high BNP level predicts an improvement in exercise tolerance after a successful catheter ablation of persistent atrial fibrillation

Katsumata, Y., Tamura, Y., Kimura, T., Kosaka, S., Sadahiro, T., Nishiyama, T., Aizawa, Y., Azuma, K., Fukuda, K. & Takatsuki, S., 2019 Jan 1, (Accepted/In press) In : Journal of Cardiovascular Electrophysiology.

Research output: Contribution to journalArticle

Exercise Tolerance
Catheter Ablation
Atrial Fibrillation
Heart Failure
Brain Natriuretic Peptide
6 Citations (Scopus)

A high-throughput neurohistological pipeline for brain-wide mesoscale connectivity mapping of the common marmoset

Lin, M. K., Takahashi, Y. S., Huo, B. X., Hanada, M., Nagashima, J., Hata, J., Tolpygo, A. S., Ram, K., Lee, B. C., Miller, M. I., Rosa, M. G., Sasaki, E., Iriki, A., Okano, H. & Mitra, P., 2019 Feb 5, In : eLife. 8

Research output: Contribution to journalArticle

Open Access
Callithrix
Brain
Pipelines
Throughput
Atlases
1 Citation (Scopus)

A Human Induced Pluripotent Stem Cell-Derived Tissue Model of a Cerebral Tract Connecting Two Cortical Regions

Kirihara, T., Luo, Z., Chow, S. Y. A., Misawa, R., Kawada, J., Shibata, S., Khoyratee, F., Vollette, C. A., Volz, V., Levi, T., Fujii, T. & Ikeuchi, Y., 2019 Apr 26, In : iScience. 14, p. 301-311 11 p.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Axons
Neurons
Brain
Stem Cells
6 Citations (Scopus)

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles

Zhang, J. Z., Termglinchan, V., Shao, N. Y., Itzhaki, I., Liu, C., Ma, N., Tian, L., Wang, V. Y., Chang, A. C. Y., Guo, H., Kitani, T., Wu, H., Lam, C. K., Kodo, K., Sayed, N., Blau, H. M. & Wu, J. C., 2019 May 2, In : Cell stem cell. 24, 5, p. 802-811.e5

Research output: Contribution to journalArticle

Pharmaceutical Preparations
In Vitro Techniques
3 Citations (Scopus)

Airway M Cells arise in the lower airway due to RANKL signaling and reside in the bronchiolar epithelium associated with iBALT in murine models of respiratory disease

Kimura, S., Mutoh, M., Hisamoto, M., Saito, H., Takahashi, S., Asakura, T., Ishii, M., Nakamura, Y., Iida, J., Hase, K. & Iwanaga, T., 2019 Jan 1, In : Frontiers in Immunology. 10, JUN, 1323.

Research output: Contribution to journalArticle

Open Access
Lymphoid Tissue
Bronchi
Epithelium
Respiratory System
Glycoproteins

A Japanese nationwide survey on the cryopreservation of embryos, oocytes and ovarian tissue for cancer patients

Sanada, Y., Harada, M., Kunitomi, C., Kanatani, M., Izumi, G., Hirata, T., Fujii, T., Suzuki, N., Morishige, K. I., Aoki, D., Irahara, M., Tsugawa, K., Tanimoto, M., Nishiyama, H., Hosoi, H., Sugiyama, K., Kawai, A. & Osuga, Y., 2019 Oct 1, In : Journal of Obstetrics and Gynaecology Research. 45, 10, p. 2021-2028 8 p.

Research output: Contribution to journalArticle

Cryopreservation
Ovarian Neoplasms
Oocytes
Embryonic Structures
Neoplasms

Allergic bronchopulmonary aspergillosis in succession to chronic eosinophilic pneumonia

Mochimaru, T., Fukunaga, K., Ueda, S., Kuroda, A., Watanabe, R., Chubachi, S. & Betsuyaku, T., 2019 Jul 1, In : Allergology International. 68, 3, p. 370-371 2 p.

Research output: Contribution to journalLetter

Open Access
Allergic Bronchopulmonary Aspergillosis
Carrington syndrome

Allogeneic hematopoietic cell transplantation in patients with untreated acute myeloid leukemia: a KSGCT multicenter retrospective analysis

on behalf of the Kanto Study Group for Cell Therapy (KSGCT), 2019 Jan 1, (Accepted/In press) In : Bone Marrow Transplantation.

Research output: Contribution to journalLetter

Cell Transplantation
Acute Myeloid Leukemia
Aplastic Anemia
Hematopoietic Stem Cell Transplantation
Cyclophosphamide
Prospective Studies
Transplants
2 Citations (Scopus)

Alopecia areata multiplex following autologous dermal micrograft injection for treatment of androgenetic alopecia

Toshima, S., Kurihara, Y., Wang, E. H. C., Nomura, H., Hayashi, Y., Christiano, A. M., Amagai, M. & Umegaki-Arao, N., 2019 Jan 1, In : Journal of the European Academy of Dermatology and Venereology.

Research output: Contribution to journalLetter

Alopecia Areata
Alopecia
Skin
Injections
Therapeutics

Alopecia in Cronkhite–Canada syndrome: Is it truly telogen effluvium?

Horikawa, H., Hirai, I., Umegaki, N., Amagai, M. & Saito, M., 2019 Jan 1, In : Australasian Journal of Dermatology.

Research output: Contribution to journalLetter

Intestinal Polyposis
Alopecia
Anastomotic Leak
Esophagectomy
Apgar Score
Survival
Esophageal Neoplasms

Alteration in AMPA receptor subunit expression and receptor binding among patients with addictive disorders: A systematic review of human postmortem studies

Ueno, F., Suzuki, T., Nakajima, S., Matsushita, S., Mimura, M., Miyazaki, T., Takahashi, T. & Uchida, H., 2019 Jan 1, In : Neuropsychopharmacology Reports.

Research output: Contribution to journalReview article

Open Access
AMPA Receptors
Amygdala
Hippocampus
Putamen
Heroin

Alteration of Musashi1 Intra-cellular Distribution During Regeneration Following Gentamicin-Induced Hair Cell Loss in the Guinea Pig Crista Ampullaris

Kinoshita, M., Fujimoto, C., Iwasaki, S., Kashio, A., Kikkawa, Y. S., Kondo, K., Okano, H. & Yamasoba, T., 2019 Oct 25, In : Frontiers in Cellular Neuroscience. 13, 481.

Research output: Contribution to journalArticle

Open Access
Semicircular Ducts
Alopecia
Gentamicins
Regeneration
Guinea Pigs

Altered functional connectivity associated with time discounting in chronic pain

Wakaizumi, K., Jabakhanji, R., Ihara, N., Kosugi, S., Terasawa, Y., Morisaki, H., Ogaki, M. & Baliki, M. N., 2019 Dec 1, In : Scientific reports. 9, 1, 8154.

Research output: Contribution to journalArticle

Open Access
Chronic Pain
Healthy Volunteers
Prefrontal Cortex
Pain
Brain

Altered perception might be a symptom of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis

Funayama, M., Mizushima, J., Takata, T., Koreki, A. & Mimura, M., 2019 Jan 1, (Accepted/In press) In : Neurocase.

Research output: Contribution to journalArticle

Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Psychiatry
Psychotic Disorders
Time Perception
Confusion

Alternative to steroid therapy for myasthenia gravis and myositis occurring as immune-related adverse events

Kamada, S., Hanazono, A., Sanpei, Y., Inoue, T., Suzuki, S., Sugawara, M. & Iijima, K., 2019 Jan 1, In : Clinical and Experimental Neuroimmunology.

Research output: Contribution to journalComment/debate

Myositis
Myasthenia Gravis
Anti-Idiotypic Antibodies
Steroids
Therapeutics

Alveolar cleft closure using a triangular flap with an M-shaped incision

Sakamoto, Y., Miyamoto, J. & Kishi, K., 2019 Dec 1, In : Journal of plastic, reconstructive & aesthetic surgery : JPRAS. 72, 12, p. e3-e4

Research output: Contribution to journalLetter

4 Citations (Scopus)

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Kim, Y. H., Choi, J., Yang, M. J., Hong, S. P., Lee, C. K., Kubota, Y., Lim, D. S. & Koh, G. Y., 2019 Dec 1, In : Nature communications. 10, 1, 838.

Research output: Contribution to journalArticle

angiogenesis
Cell Polarity
Mitochondria
Endothelial cells
Reactive Oxygen Species
1 Citation (Scopus)

A multiethnic meta-analysis defined the association of rs12946942 with severe adolescent idiopathic scoliosis

Japan Scoliosis Clinical Research Group (JSCRG), 2019 May 1, In : Journal of Human Genetics. 64, 5, p. 493-498 6 p.

Research output: Contribution to journalArticle

Scoliosis
Meta-Analysis
Genome-Wide Association Study
Adolescent Development
Computer Simulation
6 Citations (Scopus)

A multimodal (FACILE) classification for optical diagnosis of inflammatory bowel disease associated neoplasia

Iacucci, M., McQuaid, K., Gui, X. S., Iwao, Y., Lethebe, B. C., Lowerison, M., Matsumoto, T., Shivaji, U. N., Smith, S. C. L., Subramanian, V., Uraoka, T., Sanduleanu, S., Ghosh, S. & Kiesslich, R., 2019 Jan 1, In : Endoscopy. 51, 2, p. 133-141 9 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Logistic Models
Neoplasms
Inflammation
Colitis
1 Citation (Scopus)

Analysis of DLL3 and ASCL1 in Surgically Resected Small Cell Lung Cancer (HOT1702)

on behalf of Hokkaido Lung Cancer Clinical Study Group, 2019 Jan 1, In : Oncologist.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
delta protein
Neuroendocrine Cells
Antibodies

Analysis of skeletal-muscle condition after excessive loading of the lower legs by sequential magnetic resonance imaging

Hata, J., Endo, K., Tsuji, O., Arakawa, S., Sato, M., Yagi, K., Fujiyoshi, K., Okano, H. & Nakamura, M., 2019 Jan 1, In : Journal of Orthopaedic Science.

Research output: Contribution to journalArticle

Leg
Skeletal Muscle
Magnetic Resonance Imaging
Exercise
Anisotropy

Analysis of systemic lupus erythematosus-related interstitial pneumonia: a retrospective multicentre study

Enomoto, N., Egashira, R., Tabata, K., Hashisako, M., Kitani, M., Waseda, Y., Ishizuka, T., Watanabe, S., Kasahara, K., Izumi, S., Shiraki, A., Miyamoto, A., Kishi, K., Kishaba, T., Sugimoto, C., Inoue, Y., Kataoka, K., Kondoh, Y., Tsuchiya, Y., Baba, T. & 4 others, Sugiura, H., Tanaka, T., Sumikawa, H. & Suda, T., 2019 Dec 1, In : Scientific reports. 9, 1, 7355.

Research output: Contribution to journalArticle

Open Access
Interstitial Lung Diseases
Systemic Lupus Erythematosus
Multicenter Studies
Retrospective Studies
Tomography

Analysis of Temporobasal Vein with Short Subdural Segment for Anterior Transpetrosal Approach

Tamura, R., Toda, M., Morimoto, Y., Sato, M., Akiyama, T. & Yoshida, K., 2019 Jan 1, (Accepted/In press) In : World neurosurgery.

Research output: Contribution to journalArticle

Veins
Transverse Sinuses
Sigmoid Colon
Temporal Lobe
Phlebography

Analysis of the association between the severity of ocular and systemic pain

Yamanishi, R., Uchino, M., Kawashima, M., Dogru, M., Matsuguma, S. & Tsubota, K., 2019 Jan 1, In : Ocular Surface.

Research output: Contribution to journalArticle

Eye Pain
Eye Diseases
Pain Measurement
Visual Analog Scale
Quality of Life

Analysis of the relapse patterns and risk factors of endometrial cancer following postoperative adjuvant chemotherapy in a phase III randomized clinical trial

Nomura, H., Aoki, D., Susumu, N., Mizuno, M., Nakai, H., Arai, M., Nishio, S., Tokunaga, H., Nakanishi, T., Watanabe, Y., Yaegashi, N., Yokoyama, Y. & Takehara, K., 2019 Jan 1, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Phase III Clinical Trials
Adjuvant Chemotherapy
Endometrial Neoplasms
Randomized Controlled Trials
Recurrence
3 Citations (Scopus)

Analysis of various tracts of mastoid air cells related to CSF leak after the anterior transpetrosal approach

Tamura, R., Tomio, R., Mohammad, F., Toda, M. & Yoshida, K., 2019 Feb 1, In : Journal of neurosurgery. 130, 2, p. 360-367 8 p.

Research output: Contribution to journalArticle

Mastoid
Temporal Bone
Air
Eustachian Tube
Middle Ear