Departments of Basic Medical Sciences

Research Output

2021

Effect of Asian dust on respiratory symptoms among children with and without asthma, and their sensitivity

Hasunuma, H., Takeuchi, A., Ono, R., Amimoto, Y., Hwang, Y. H., Uno, I., Shimizu, A., Nishiwaki, Y., Hashizume, M., Askew, D. J. & Odajima, H., 2021 Jan 20, In : Science of the Total Environment. 753, 141585.

Research output: Contribution to journalArticle

2020

2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche

Koike, N., Kota, R., Naito, Y., Hayakawa, N., Matsuura, T., Hishiki, T., Onishi, N., Fukada, J., Suematsu, M., Shigematsu, N., Saya, H. & Sampetrean, O., 2020 Dec 1, In : Communications biology. 3, 1, 450.

Research output: Contribution to journalArticle

Open Access

5-Aminosalicylic acid intolerance is associated with a risk of adverse clinical outcomes and dysbiosis in patients with ulcerative colitis

Mizuno, S., Ono, K., Mikami, Y., Naganuma, M., Fukuda, T., Minami, K., Masaoka, T., Terada, S., Yoshida, T., Saigusa, K., Hirahara, N., Miyata, H., Suda, W., Hattori, M. & Kanai, T., 2020 Jan 1, In : Intestinal Research. 18, 1, p. 69-78 10 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas

Tian, Y., Arai, E., Makiuchi, S., Tsuda, N., Kuramoto, J., Ohara, K., Takahashi, Y., Ito, N., Ojima, H., Hiraoka, N., Gotoh, M., Yoshida, T. & Kanai, Y., 2020 Oct 1, In : Journal of Cancer Research and Clinical Oncology. 146, 10, p. 2461-2477 17 p.

Research output: Contribution to journalArticle

Open Access

A case of intrahepatic cholangiocellular carcinoma due to thorotrast deposition, well-controlled by radiofrequency ablation therapy

Taniki, N., Nakamoto, N., Yoshida, A., Chu, P. S., Ikura, A., Yamataka, K., Morikawa, R., Shiba, S., Yamaguchi, A., Usui, S., Ojiro, K., Ebinuma, H., Saito, H., Kubota, N., Masugi, Y., Sakamto, M. & Kanai, T., 2020, In : Acta Hepatologica Japonica. 61, 5, p. 262-269 8 p.

Research output: Contribution to journalArticle

Open Access

A case of pancreatic hamartoma with characteristic radiological findings: radiological-pathological correlation

Toyama, K., Matsusaka, Y., Okuda, S., Miura, E., Kubota, N., Masugi, Y., Kitago, M., Hori, S., Yokose, T., Shinoda, M., Sakamoto, M. & Jinzaki, M., 2020 Jul 1, In : Abdominal Radiology. 45, 7, p. 2244-2248 5 p.

Research output: Contribution to journalArticle

A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling

Shiba-Fukushima, K., Inoshita, T., Sano, O., Iwata, H., Ishikawa, K. I., Okano, H., Akamatsu, W., Imai, Y. & Hattori, N., 2020 May 22, In : iScience. 23, 5, 101048.

Research output: Contribution to journalArticle

Open Access

A Cohort Study of Stereotactic Radiosurgery Results for Patients With 5 to 15 Versus 2 to 4 Brain Metastatic Tumors

Yamamoto, M., Sato, Y., Higuchi, Y., Kasuya, H. & Barfod, B. E., 2020 May 1, In : Advances in Radiation Oncology. 5, 3, p. 358-368 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

A combinational treatment of carotenoids decreases Aβ secretion in human neurons via β-secretase inhibition

Sho, M., Ichiyanagi, N., Imaizumi, K., Ishikawa, M., Morimoto, S., Watanabe, H. & Okano, H., 2020 Sep, In : Neuroscience Research. 158, p. 47-55 9 p.

Research output: Contribution to journalArticle

Activation of extracellular signal-regulated kinase is associated with hepatocellular carcinoma with aggressive phenotypes

Minagawa, T., Yamazaki, K., Masugi, Y., Tsujikawa, H., Ojima, H., Hibi, T., Abe, Y., Yagi, H., Kitago, M., Shinoda, M., Itano, O., Kitagawa, Y. & Sakamoto, M., 2020 Mar 1, In : Hepatology Research. 50, 3, p. 353-364 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Acute onset olfactory/taste disorders are associated with a high viral burden in mild or asymptomatic SARS-CoV-2 infections

for the Keio Donner Project, 2020 Oct, In : International Journal of Infectious Diseases. 99, p. 19-22 4 p.

Research output: Contribution to journalArticle

Open Access

ADAM10 is indispensable for longitudinal bone growth in mice

Mizuno, S., Yoda, M., Kimura, T., Shimoda, M., Akiyama, H., Chiba, K., Nakamura, M. & Horiuchi, K., 2020 May, In : Bone. 134, 115273.

Research output: Contribution to journalArticle

1 Citation (Scopus)

ADAM17 protects against elastase-induced emphysema by suppressing CD62L+ leukocyte infiltration in mice

Suzuki, S., Ishii, M., Asakura, T., Namkoong, H., Okamori, S., Yagi, K., Kamata, H., Kusumoto, T., Kagawa, S., Hegab, A. E., Yoda, M., Horiuchi, K., Hasegawa, N. & Betsuyaku, T., 2020 Jun, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 318, 6, p. L1172-L1182

Research output: Contribution to journalArticle

Adherence to antihypertensive medication and its predictors among non-elderly adults in Japan

Nishimura, S., Kumamaru, H., Shoji, S., Sawano, M., Kohsaka, S. & Miyata, H., 2020 Jul 1, In : Hypertension Research. 43, 7, p. 705-714 10 p.

Research output: Contribution to journalArticle

Analysis of the nucleocytoplasmic shuttling RNA-binding protein HNRNPU using optimized HITS-CLIP method

Yugami, M., Okano, H., Nakanishi, A. & Yano, M., 2020 Apr, In : PloS one. 15, 4, e0231450.

Research output: Contribution to journalArticle

Open Access

A nationwide questionnaire survey of clinic doctors on antimicrobial stewardship in Japan

Gu, Y., Fujitomo, Y., Soeda, H., Nakahama, C., Hasegawa, N., Maesaki, S., Maeda, M., Matsumoto, T., Miyairi, I. & Ohmagari, N., 2020 Feb, In : Journal of Infection and Chemotherapy. 26, 2, p. 149-156 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Anger expression and the risk of cardiovascular disease among urban and rural Japanese residents: The circulatory risk in communities study

CIRCS investigators, 2020 Feb 1, In : Psychosomatic Medicine. 82, 2, p. 215-223 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

An improved de novo genome assembly of the common marmoset genome yields improved contiguity and increased mapping rates of sequence data

Jayakumar, V., Ishii, H., Seki, M., Kumita, W., Inoue, T., Hase, S., Sato, K., Okano, H., Sasaki, E. & Sakakibara, Y., 2020 Apr 2, In : BMC Genomics. 21, 243.

Research output: Contribution to journalArticle

Open Access

Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites

Kabe, Y., Takemoto, D., Kanai, A., Hirai, M., Ono, Y., Akazawa, S., Horikawa, M., Kitagawa, Y., Handa, H., Rogi, T., Shibata, H. & Suematsu, M., 2020 Dec 1, In : npj Science of Food. 4, 1, 4.

Research output: Contribution to journalArticle

Open Access

Annual report of the Japanese Breast Cancer Registry for 2017

Hayashi, N., Kumamaru, H., Isozumi, U., Aogi, K., Asaga, S., Iijima, K., Kadoya, T., Kojima, Y., Kubo, M., Miyashita, M., Miyata, H., Nagahashi, M., Niikura, N., Ogo, E., Tamura, K., Tanakura, K., Yamamoto, Y., Yoshida, M., Imoto, S. & Jinno, H., 2020 Sep 1, In : Breast Cancer. 27, 5, p. 803-809 7 p.

Research output: Contribution to journalArticle

Annual report of the Japanese Breast Cancer Society registry for 2016

Kubo, M., Kumamaru, H., Isozumi, U., Miyashita, M., Nagahashi, M., Kadoya, T., Kojima, Y., Aogi, K., Hayashi, N., Tamura, K., Asaga, S., Niikura, N., Ogo, E., Iijima, K., Tanakura, K., Yoshida, M., Miyata, H., Yamamoto, Y., Imoto, S. & Jinno, H., 2020 Jul 1, In : Breast Cancer. 27, 4, p. 511-518 8 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

A phase I/IIa double blind single institute trial of low dose sirolimus for Pendred syndrome/DFNB4

Fujioka, M., Akiyama, T., Hosoya, M., Kikuchi, K., Fujiki, Y., Saito, Y., Yoshihama, K., Ozawa, H., Tsukada, K., Nishio, S. Y., Usami, S. I., Matsunaga, T., Hasegawa, T., Sato, Y. & Ogawa, K., 2020 May 1, In : Medicine. 99, 19, p. e19763

Research output: Contribution to journalArticle

Open Access

Armitage determines Piwi−piRISC processing from precursor formation and quality control to inter-organelle translocation

Yamashiro, H., Negishi, M., Kinoshita, T., Ishizu, H., Ohtani, H. & Siomi, M. C., 2020 Feb 5, In : EMBO Reports. 21, 2, e48769.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Association between Asian dust exposure and respiratory function in children with bronchial asthma in Nagasaki Prefecture, Japan

Nakamura, T., Nishiwaki, Y., Hashimoto, K., Takeuchi, A., Kitajima, T., Komori, K., Tashiro, K., Hasunuma, H., Ueda, K., Shimizu, A., Odajima, H., Moriuchi, H. & Hashizume, M., 2020 Mar 4, In : Environmental Health and Preventive Medicine. 25, 1, 8.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Association between prehospital transfer distance and surgical mortality in emergency thoracic aortic surgery

Izumisawa, Y., Endo, H., Ichihara, N., Takahashi, A., Nawata, K., Shiraishi, H., Miyata, H. & Motomura, N., 2020, (Accepted/In press) In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Association of blood cadmium levels in pregnant women with infant birth size and small for gestational age infants: The Japan Environment and Children's study

The Japan Environment and Children's Study Group, 2020 Dec, In : Environmental Research. 191, 110007.

Research output: Contribution to journalArticle

Open Access

Association of eHealth literacy with lifestyle behaviors in university students: Questionnaire-based cross-sectional study

Tsukahara, S., Yamaguchi, S., Igarashi, F., Uruma, R., Ikuina, N., Iwakura, K., Koizumi, K. & Sato, Y., 2020 Jun, In : Journal of medical Internet research. 22, 6, e18155.

Research output: Contribution to journalArticle

Open Access

Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy

Hayashi, K., Hishikawa, A., Hashiguchi, A., Azegami, T., Yoshimoto, N., Nakamichi, R., Tokuyama, H. & Itoh, H., 2020 Dec 1, In : Scientific reports. 10, 1, 237.

Research output: Contribution to journalArticle

Open Access

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Hirata, T., Arai, Y., Yuasa, S., Abe, Y., Takayama, M., Sasaki, T., Kunitomi, A., Inagaki, H., Endo, M., Morinaga, J., Yoshimura, K., Adachi, T., Oike, Y., Takebayashi, T., Okano, H. & Hirose, N., 2020 Dec 1, In : Nature communications. 11, 1, 3820.

Research output: Contribution to journalArticle

Open Access

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

Suzuki, K., Elegheert, J., Song, I., Sasakura, H., Senkov, O., Matsuda, K., Kakegawa, W., Clayton, A. J., Chang, V. T., Ferrer-Ferrer, M., Miura, E., Kaushik, R., Ikeno, M., Morioka, Y., Takeuchi, Y., Shimada, T., Otsuka, S., Stoyanov, S., Watanabe, M., Takeuchi, K. & 3 others, Dityatev, A., Radu Aricescu, A. & Yuzaki, M., 2020 Aug 28, In : Science. 369, 6507, eabb4853.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development

Kodo, K., Shibata, S., Miyagawa-Tomita, S., Ong, S. G., Takahashi, H., Kume, T., Okano, H., Matsuoka, R. & Yamagishi, H., 2020 Jan 1, Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension. Springer Singapore, p. 377-379 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Open Access

Author Correction: Microbiota modulate sympathetic neurons via a gut–brain circuit (Nature, (2020), 583, 7816, (441-446), 10.1038/s41586-020-2474-7)

Muller, P. A., Schneeberger, M., Matheis, F., Wang, P., Kerner, Z., Ilanges, A., Pellegrino, K., del Mármol, J., Castro, T. B. R., Furuichi, M., Perkins, M., Han, W., Rao, A., Pickard, A. J., Cross, J. R., Honda, K., de Araujo, I. & Mucida, D., 2020 Sep 3, In : Nature. 585, 7823, p. E2

Research output: Contribution to journalComment/debate

Open Access

Author Correction: Identification of a binding protein for sesamin and characterization of its roles in plant growth (Scientific Reports, (2019), 9, 1, (8631), 10.1038/s41598-019-45003-7)

Tera, M., Koyama, T., Murata, J., Furukawa, A., Mori, S., Azuma, T., Watanabe, T., Hori, K., Okazawa, A., Kabe, Y., Suematsu, M., Satake, H., Ono, E. & Horikawa, M., 2020 Dec 1, In : Scientific reports. 10, 1, 7884.

Research output: Contribution to journalComment/debate

Open Access

Author reply: Early operation and establishment of an endocarditis team

Ko, S., Uno, S. & Kohsaka, S., 2020 Feb 1, In : Internal Medicine. 59, 3, p. 469 1 p.

Research output: Contribution to journalLetter

Open Access

Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

Tsurugizawa, T., Tamada, K., Ono, N., Karakawa, S., Kodama, Y., Debacker, C., Hata, J., Okano, H., Kitamura, A., Zalesky, A. & Takumi, T., 2020 Feb 5, In : Science Advances. 6, 6, eaav4520.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Behavioral and electrophysiological evidence for a neuroprotective role of aquaporin-4 in the 5xFAD transgenic mice model

Abe, Y., Ikegawa, N., Yoshida, K., Muramatsu, K., Hattori, S., Kawai, K., Murakami, M., Tanaka, T., Goda, W., Goto, M., Yamamoto, T., Hashimoto, T., Yamada, K., Shibata, T., Misawa, H., Mimura, M., Tanaka, K. F., Miyakawa, T., Iwatsubo, T., Hata, J. I. & 2 others, Niikura, T. & Yasui, M., 2020 May 12, In : Acta Neuropathologica Communications. 8, 1, 67.

Research output: Contribution to journalArticle

Open Access

Blood metabolite signature of metabolic syndrome implicates alterations in amino acid metabolism: Findings from the baltimore longitudinal study of aging (blsa) and the tsuruoka metabolomics cohort study (TMCS)

Roberts, J. A., Varma, V. R., Huang, C. W., An, Y., Oommen, A., Tanaka, T., Ferrucci, L., Elango, P., Takebayashi, T., Harada, S., Iida, M. & Thambisetty, M., 2020 Feb, In : International journal of molecular sciences. 21, 4, 1249.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Blood metabolite signatures of metabolic syndrome in two cross-cultural older adult cohorts

Mahajan, U. V., Varma, V. R., Huang, C. W., An, Y., Tanaka, T., Ferrucci, L., Takebayashi, T., Harada, S., Iida, M., Legido-Quigley, C. & Thambisetty, M., 2020 Feb 2, In : International journal of molecular sciences. 21, 4, 1324.

Research output: Contribution to journalArticle

Open Access

Body mass index as a tool for optimizing surgical care in coronary artery bypass grafting through understanding risks of specific complications

Nishioka, N., Ichihara, N., Bando, K., Motomura, N., Koyama, N., Miyata, H., Kohsaka, S., Takamoto, S. & Hashimoto, K., 2020 Aug, In : Journal of Thoracic and Cardiovascular Surgery. 160, 2, p. 409-420.e14

Research output: Contribution to journalArticle

2 Citations (Scopus)

Brain transcriptome analysis links deficiencies of stress-responsive proteins to the pathomechanism of Kii ALS/PDC

Morimoto, S., Ishikawa, M., Watanabe, H., Isoda, M., Takao, M., Nakamura, S., Ozawa, F., Hirokawa, Y., Kuzuhara, S., Okano, H. & Kokubo, Y., 2020 May, In : Antioxidants. 9, 5, 423.

Research output: Contribution to journalArticle

Open Access

Breast cancer survival among Japanese individuals and US residents of Japanese and other origins: a comparative registry-based study

Ogiya, R., Niikura, N., Kumamaru, H., Takeuchi, Y., Okamura, T., Kinoshita, T., Aogi, K., Anan, K., Iijima, K., Ishida, T., Iwamoto, T., Kawai, M., Kojima, Y., Sakatani, T., Sagara, Y., Hayashi, N., Masuoka, H., Yoshida, M., Miyata, H., Tsuda, H. & 2 others, Imoto, S. & Jinno, H., 2020, (Accepted/In press) In : Breast Cancer Research and Treatment.

Research output: Contribution to journalArticle

Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways

Kim, H., Kim, D., Kim, J., Lee, H. Y., Park, D., Kang, H., Matsuda, K., Sterky, F. H., Yuzaki, M., Kim, J. Y., Choi, S. Y., Ko, J. & Um, J. W., 2020 Jul 3, In : The Journal of biological chemistry. 295, 27, p. 9244-9262 19 p.

Research output: Contribution to journalArticle

Can Minimally Invasive Esophagectomy Replace Open Esophagectomy for Esophageal Cancer? Latest Analysis of 24,233 Esophagectomies From the Japanese National Clinical Database

Yoshida, N., Yamamoto, H., Baba, H., Miyata, H., Watanabe, M., Toh, Y., Matsubara, H., Kakeji, Y. & Seto, Y., 2020 Jul 1, In : Annals of surgery. 272, 1, p. 118-124 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Can we harness the microbiota to enhance the efficacy of cancer immunotherapy?

Finlay, B. B., Goldszmid, R., Honda, K., Trinchieri, G., Wargo, J. & Zitvogel, L., 2020 Sep 1, In : Nature Reviews Immunology. 20, 9, p. 522-528 7 p.

Research output: Contribution to journalArticle

CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD

Imura, Y., Ando, M., Kondo, T., Ito, M. & Yoshimura, A., 2020 Jun 23, In : JCI Insight. 5, 14, e136185.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells

Kajikawa, K., Imaizumi, K., Shinozaki, M., Shibata, S., Shindo, T., Kitagawa, T., Shibata, R., Kamata, Y., Kojima, K., Nagoshi, N., Matsumoto, M., Nakamura, M. & Okano, H., 2020 Sep 3, In : Molecular brain. 13, 1, p. 120 1 p.

Research output: Contribution to journalArticle

Open Access

Changes in laryngeal airway patency in response to complete reversal of rocuronium-induced paralysis with sugammadex in small children with a supraglottic airway: protective effect of fentanyl?

Ishibashi, K., Kitamura, Y., Kato, S., Sugano, M., Sakaguchi, Y., Sato, Y. & Isono, S., 2020 Jul, In : British Journal of Anaesthesia. 125, 1, p. e158-e160

Research output: Contribution to journalLetter

1 Citation (Scopus)

Characteristics of leiomyosarcoma: Induction of hematogenous metastasis by isolated uterine mesenchymal tumor stem-like cells

Hayashi, T., Sano, K., Ichimura, T., Kanai, Y., Zharhary, D., Aburatani, H., Yaegashi, N. & Konishi, I., 2020, In : Anticancer research. 40, 3, p. 1255-1265 11 p.

Research output: Contribution to journalArticle

Open Access

Characteristics of the Mucosal Surface on Scanning Electron Microscopy in Patients with Remitting Ulcerative Colitis

Nomura, E., Sujino, T., Hosoe, N., Yoshimatsu, Y., Tanemoto, S., Takabayashi, K., Mutaguchi, M., Shimoda, M., Naganuma, M., Ogata, H. & Kanai, T., 2020, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle

Clinical, Endoscopic, and Pathological Characteristics of Immune Checkpoint Inhibitor-Induced Gastroenterocolitis

Hayashi, Y., Hosoe, N., Takabayashi, K., Limpias Kamiya, K. J. L., Tsugaru, K., Shimozaki, K., Hirata, K., Fukuhara, K., Fukuhara, S., Mutaguchi, M., Sujino, T., Sukawa, Y., Hamamoto, Y., Naganuma, M., Takaishi, H., Shimoda, M., Ogata, H. & Kanai, T., 2020, (Accepted/In press) In : Digestive Diseases and Sciences.

Research output: Contribution to journalArticle