Departments of Basic Medical Sciences

Research Output 1978 2020

Article
1 Citation (Scopus)

[Descriptive epidemiology of inflammatory bowel disease in Japan].

Takebayashi, T., 2012 Feb, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 1, p. 39-43 5 p.

Research output: Contribution to journalArticle

Preschool Children
Inflammatory Bowel Diseases
Japan
Epidemiology
13 Citations (Scopus)

[Destruction of the articular cartilage in osteoarthritis].

Okubo, M. & Okada, Y., 2013 Dec, In : Clinical calcium. 23, 12, p. 1705-1713 9 p.

Research output: Contribution to journalArticle

Articular Cartilage
Osteoarthritis
Extracellular Matrix
Thrombospondins
Disintegrins
1 Citation (Scopus)

[Effect of cardiovascular risk factors on individual and population medical expenditures: a 10-year cohort study of 4,535 National Health Insurance beneficiaries in Shiga].

Okamura, T., Nakamura, K., Hayakawa, T., Kanda, H., Miura, K., Okayama, A. & Ueshima, H., 2012 Jan, In : Nihon eiseigaku zasshi. Japanese journal of hygiene. 67, 1, p. 38-43 6 p.

Research output: Contribution to journalArticle

National Health Programs
Insurance Benefits
Health Expenditures
Cohort Studies
Population
1 Citation (Scopus)
Environmental Exposure
Heavy Metals
Toxicology
Cardiovascular Diseases
Carbon Disulfide

[Future prospect of regenerative medicine into cure of genetic diseases].

Okuno, H. & Kosaki, K., 2010 Aug, In : Nippon rinsho. Japanese journal of clinical medicine. 68 Suppl 8, p. 71-75 5 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Inborn Genetic Diseases
Regenerative Medicine
Tissue Engineering
Embryonic Stem Cells
1 Citation (Scopus)

[Peroxiredoxin triggers post-ischemic inflammation].

Yoshimura, A., Ito, M., Kondo, T. & Shichita, T., 2013 Mar, In : Seikagaku. The Journal of Japanese Biochemical Society. 85, 3, p. 179-186 8 p.

Research output: Contribution to journalArticle

Peroxiredoxins
Brain Ischemia
Oxidative Stress
Antioxidants
Stroke
3 Citations (Scopus)

[Post-ischemic innate immunity and its application for novel therapeutic strategy targeting brain inflammation].

Ito, M., Kondo, T., Shichita, T. & Yoshimura, A., 2013 Jul, In : Nihon rinsho. Japanese journal of clinical medicine. 71, 7, p. 1291-1301 11 p.

Research output: Contribution to journalArticle

Interleukin-23
Interleukin-17
Encephalitis
Innate Immunity
Brain Ischemia

[Smoking is an important risk factor for cardiovascular disease in Japan].

Okamura, T. & Morimoto, A., 2011 Sep, In : Nihon rinsho. Japanese journal of clinical medicine. 69 Suppl 7, p. 599-603 5 p.

Research output: Contribution to journalArticle

Japan
Cardiovascular Diseases
Smoking
3 Citations (Scopus)

[Suppression of leptin and insulin signaling by SOCS3].

Yoshimura, A., 2011 Jan, In : Nihon rinsho. Japanese journal of clinical medicine. 69 Suppl 1, p. 782-789 8 p.

Research output: Contribution to journalArticle

Suppressor of Cytokine Signaling Proteins
Leptin
Signal Transduction
Insulin

[Validity of serum surfactant protein D measurements in a cross-sectional study].

Nakano, M., Tanaka, A., Hirata, M. & Omae, K., 2011 Apr, In : Rinsho byori. The Japanese journal of clinical pathology. 59, 4, p. 337-344 8 p.

Research output: Contribution to journalArticle

Pulmonary Surfactant-Associated Protein D
Blood Proteins
Cross-Sectional Studies
Indium
Immunoenzyme Techniques
1 Citation (Scopus)

[Work environment measurements of nanoparticles in the nanoparticle-handling-process using portable type particle sizer spectrometers].

Iwasawa, S., Tanaka, S., Miyauchi, H., Minozoe, A., Nakaza, M. & Takebayashi, T., 2013 Dec 12, In : Sangyō eiseigaku zasshi = Journal of occupational health. 55, 6, p. 269-272 4 p.

Research output: Contribution to journalArticle

Occupational Air Pollutants
Particle spectrometers
Nanotechnology
Nanostructures
Occupational Exposure
261 Citations (Scopus)

1,25-Dihydroxyvitamin D 3 ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A

Joshi, S., Pantalena, L. C., Liu, X. K., Gaffen, S. L., Liu, H., Rohowsky-Kochan, C., Ichiyama, K., Yoshimura, A., Steinman, L., Christakos, S. & Youssef, S., 2011 Sep, In : Molecular and Cellular Biology. 31, 17, p. 3653-3669 17 p.

Research output: Contribution to journalArticle

Interleukin-17
Autoimmunity
Calcitriol Receptors
T-Lymphocytes
Vitamin D
13 Citations (Scopus)
amino acids
Amino Acids
Fluctuations
Water
water
38 Citations (Scopus)

1′-acetoxychavicol acetate is a novel nuclear factor κB inhibitor with significant activity against multiple myeloma in vitro and in vivo

Ito, K., Nakazato, T., Xian, M. J., Yamada, T., Hozumi, N., Murakami, A., Ohigashi, H., Ikeda, Y. & Kizaki, M., 2005 May 15, In : Cancer Research. 65, 10, p. 4417-4424 8 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Apoptosis
1'-acetoxychavicol acetate
In Vitro Techniques
Cytosol
28 Citations (Scopus)

3′-Untranslated region of doublecortin mRNA is a binding target of the Musashi1 RNA-binding protein

Horisawa, K., Imai, T., Okano, H. & Yanagawa, H., 2009 Jul 21, In : FEBS Letters. 583, 14, p. 2429-2434 6 p.

Research output: Contribution to journalArticle

RNA-Binding Proteins
3' Untranslated Regions
Messenger RNA
Neural Stem Cells
Stem cells
25 Citations (Scopus)

50 years of pursuing a healthy society in Japan

Reich, M. R., Ikegami, N., Shibuya, K. & Takemi, K., 2011 Sep 17, In : The Lancet. 378, 9796, p. 1051-1053 3 p.

Research output: Contribution to journalArticle

Universal Coverage
National Health Programs
Population Dynamics
Politics
Health Policy
47 Citations (Scopus)

5-Aza-2′-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis

Nam, J. S., Ino, Y., Kanai, Y., Sakamoto, M. & Hirohashi, S., 2004, In : Clinical and Experimental Metastasis. 21, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

decitabine
Cadherins
Neoplasm Metastasis
Neoplasms
Severe Combined Immunodeficiency
7 Citations (Scopus)

A 13-week toxicity study of bismuth in rats by intratracheal intermittent administration

Sano, Y., Satoh, H., Chiba, M., Shinohara, A., Okamoto, M., Serizawa, K., Nakashima, H. & Omae, K., 2005 May, In : Journal of Occupational Health. 47, 3, p. 242-248 7 p.

Research output: Contribution to journalArticle

Bismuth
Toxicity
Rats
Inhalation
Poisons
8 Citations (Scopus)

A 27-year-old woman with Alström syndrome who had liver cirrhosis.

Awazu, M., Tanaka, T., Yamazaki, K., Kato, S., Higuchi, M. & Matsuo, N., 1995 Jun, In : Keio Journal of Medicine. 44, 2, p. 67-73 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A 38-year-old man with pulmonary hypertension, who had undergone atrial septal closure 26 years previously

Satoh, T., Yagi, T., Kato, S., Azuma, K., Kataoka, M., Takahashi, T., Sato, A. & Okita, H., 2003 Dec, In : Keio Journal of Medicine. 52, 4, p. 250-262 13 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Heart Failure
Pulmonary Artery
Eisenmenger Complex
Skiing

A 59-year-old man with an abnormal shadow in the right lung.

Kobayashi, K., Kohda, E., Sakamoto, M., Hosoda, Y., Iino, K., Kikuchi, H., Iri, H. & Nakayama, M., 1991 Sep, In : Keio Journal of Medicine. 40, 3, p. 160-166 7 p.

Research output: Contribution to journalArticle

Lung Neoplasms
Lung
21 Citations (Scopus)

ABCB1 is predominantly expressed in human fetal neural stem/progenitor cells at an early development stage

Yamamoto, A., Shofuda, T., Islam, M. O., Nakamura, Y., Yamasaki, M., Okano, H. & Kanemura, Y., 2009 Sep, In : Journal of Neuroscience Research. 87, 12, p. 2615-2623 9 p.

Research output: Contribution to journalArticle

Fetal Stem Cells
Neural Stem Cells
Stem Cells
Nestin
Gene Expression

Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons

Akiyama, T., Suzuki, N., Ishikawa, M., Fujimori, K., Sone, T., Kawada, J., Funayama, R., Fujishima, F., Mitsuzawa, S., Ikeda, K., Ono, H., Shijo, T., Osana, S., Shirota, M., Nakagawa, T., Kitajima, Y., Nishiyama, A., Izumi, R., Morimoto, S., Okada, Y. & 11 others, Kamei, T., Nishida, M., Nogami, M., Kaneda, S., Ikeuchi, Y., Mitsuhashi, H., Nakayama, K., Fujii, T., Warita, H., Okano, H. & Aoki, M., 2019 Jul 1, In : EBioMedicine. 45, p. 362-378 17 p.

Research output: Contribution to journalArticle

Open Access
Amyotrophic Lateral Sclerosis
Motor Neurons
Sarcoma
Neurons
Axons
14 Citations (Scopus)
Amyotrophic Lateral Sclerosis
Glycine
Serine
Amino acids
Glutamic Acid
3 Citations (Scopus)

Aberrant Gene Expression and Sexually Incompatible Genomic Imprinting in Oocytes Derived from XY Mouse Embryonic Stem Cells In Vitro

Nitta, M., Imamura, M., Inoue, Y., Kunitomo, Y., Lin, Z. Y. C., Ogawa, T., Yogo, K., Ishida-Kitagawa, N., Fukunaga, N., Okano, H., Sato, E., Takeya, T. & Miyoshi, J., 2013 Mar 5, In : PLoS One. 8, 3, e58555.

Research output: Contribution to journalArticle

Genomic Imprinting
genomic imprinting
embryonic stem cells
Embryonic Stem Cells
Stem cells
9 Citations (Scopus)

Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations

Nakaya, M., Hamano, S., Kawasumi, M., Yoshida, H., Yoshimura, A. & Kobayashi, T., 2011, In : International Immunology. 23, 3, p. 195-202 8 p.

Research output: Contribution to journalArticle

Leishmania major
Interleukin-4
T-Lymphocytes
Cytokines
Infection
97 Citations (Scopus)

Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death

Nishiyama, J., Miura, E., Mizushima, N., Watanabe, M. & Yuzaki, M., 2007 Nov, In : Autophagy. 3, 6, p. 591-596 6 p.

Research output: Contribution to journalArticle

Null Lymphocytes
Purkinje Cells
Autophagy
Axons
Membranes
12 Citations (Scopus)

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Venken, K., Seeuws, S., Zabeau, L., Jacques, P., Decruy, T., Coudenys, J., Verheugen, E., Windels, F., Catteeuw, D., Drennan, M., Van Calenbergh, S., Lambrecht, B. N., Yoshimura, A., Tavernier, J. & Elewaut, D., 2014 Jan, In : Journal of Hepatology. 60, 1, p. 175-182 8 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
Leptin
Adipocytes
Hepatitis
Leptin Receptors

Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

Ono, S., Egawa, G., Nomura, T., Kitoh, A., Dainichi, T., Otsuka, A., Nakajima, S., Amagai, M., Matsumoto, F., Yamamoto, M., Kubota, Y., Takai, T., Honda, T. & Kabashima, K., 2019 Dec 1, In : Nature communications. 10, 1, 4432.

Research output: Contribution to journalArticle

Open Access
Pemphigus
tyrosine
Protein-Tyrosine Kinases
blood cells
Skin
77 Citations (Scopus)

Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis

Nakahara, J., Kanekura, K., Nawa, M., Aiso, S. & Suzuki, N., 2009 Jan 5, In : Journal of Clinical Investigation. 119, 1, p. 169-181 13 p.

Research output: Contribution to journalArticle

Contactins
Cell Nucleus Active Transport
Oligodendroglia
Multiple Sclerosis
Axons
4 Citations (Scopus)
Restorative Proctocolectomy
Immunogenetics
Mucosal Immunity
Ulcerative Colitis
Inflammatory Bowel Diseases
122 Citations (Scopus)

Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset callithrix jacchus

Kelava, I., Reillo, I., Murayama, A. Y., Kalinka, A. T., Stenzel, D., Tomancak, P., Matsuzaki, F., Lebrand, C., Sasaki, E., Schwamborn, J. C., Okano, H., Huttner, W. B. & Borrell, V., 2012 Feb, In : Cerebral Cortex. 22, 2, p. 469-481 13 p.

Research output: Contribution to journalArticle

Callithrix
Lateral Ventricles
Neocortex
Neuroglia
Primates

Academic Press: Introduction

Okano, H., 2003 Jun, In : Seminars in Cell and Developmental Biology. 14, 3, p. 159 1 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells

Sakaguchi, M., Shingo, T., Shimazaki, T., Okano, H. J., Shiwa, M., Ishibashi, S., Oguro, H., Ninomiya, M., Kadoya, T., Horie, H., Shibuya, A., Mizusawa, H., Poirier, F., Nakauchi, H., Sawamoto, K. & Okano, H., 2006 May 2, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 18, p. 7112-7117 6 p.

Research output: Contribution to journalArticle

Galectin 1
Adult Stem Cells
Neural Stem Cells
Lateral Ventricles
Intraventricular Infusions
114 Citations (Scopus)

A case-control study of calciphylaxis in Japanese end-stage renal disease patients

Hayashi, M., Takamatsu, I., Kanno, Y., Yoshida, T., Abe, T. & Sato, Y., 2012 Apr, In : Nephrology Dialysis Transplantation. 27, 4, p. 1580-1584 5 p.

Research output: Contribution to journalArticle

Calciphylaxis
Chronic Kidney Failure
Case-Control Studies
Renal Dialysis
Warfarin
16 Citations (Scopus)

A case for the adoption of pharmacoeconomic guidelines in Japan

Ikeda, S., Ikegami, N., Oliver, A. J. & Ikeda, M., 1996, In : PharmacoEconomics. 10, 6, p. 546-551 6 p.

Research output: Contribution to journalArticle

Pharmaceutical Economics
Japan
Guidelines
Pharmaceutical Preparations
Decision Support Techniques

A case of Acanthamoeba keratitis in a water polo player

Tamura, T., Yamada, M., Mashima, Y., Kobayashi, S. & Takeuchi, T., 1998 Sep, In : Folia Ophthalmologica Japonica. 49, 9, p. 780-782 3 p.

Research output: Contribution to journalArticle

Acanthamoeba Keratitis
Hydrophilic Contact Lens
Water
Eye Pain
Acanthamoeba

A case of acute bacterial endocarditis with severe anterior uveitis

Andou, Y., Suzuki, S. & Okano, H., 1988, In : Folia Ophthalmologica Japonica. 39, 12, p. 2168-2173 6 p.

Research output: Contribution to journalArticle

Anterior Uveitis
Bacterial Endocarditis
1 Citation (Scopus)
Hematoma, Subdural, Acute
Chondrosarcoma
Skull
Hemorrhage
Neoplasm Metastasis

A Case of Aggressive Recurrent Intracranial Subdural Hematoma Associated with Angiosarcoma Originating from the Skull

Kanazawa, T., Miwa, T., Akiyama, T., Ohara, K., Kosugi, K., Nishimoto, M. & Yoshida, K., 2019 Jun 1, In : World neurosurgery. 126, p. 120-123 4 p.

Research output: Contribution to journalArticle

Intracranial Subdural Hematoma
Subdural Hematoma
Hemangiosarcoma
Skull
Meningeal Arteries
1 Citation (Scopus)

A case of an infant suffered from a fatal scald injury - Validity and limitations of postmortem CT imaging

Iino, M., Nakajima, Y., Ueno, M., Mikami, K. & Fujita, M. Q., 2014 Nov 1, In : Legal Medicine. 16, 6, p. 367-372 6 p.

Research output: Contribution to journalArticle

Accidents
Tomography
Autopsy
Wounds and Injuries
Confidentiality
1 Citation (Scopus)

A case of aortoduodenal fistula occurring after surgery and radiation for pancreatic cancer

Kitajima, M., Takahashi, S., Ueda, M., Hoshimoto, S., Koizumi, J., Matsumoto, K., Suzuki, H., Takeda, A., Kutsuki, S., Okita, H. & Hata, J. I., 2000 Mar, In : Keio Journal of Medicine. 49, 1, p. 35-44 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Celiac Artery
Fistula
Pathologic Constriction
Superior Mesenteric Artery
11 Citations (Scopus)

A case of atypical POEMS syndrome without polyneuropathy

Morizane, R., Sasamura, H., Minakuchi, H., Takae, Y., Kikuchi, H., Yoshiya, N., Hashiguchi, A., Konishi, K., Okamoto, S. & Itoh, H., 2008 May, In : European Journal of Haematology. 80, 5, p. 452-455 4 p.

Research output: Contribution to journalArticle

POEMS Syndrome
Polyneuropathies
Terminology
Hematologic Diseases
Neural Conduction
9 Citations (Scopus)

A case of beef tapeworm (Taenia saginata) infection observed by using video capsule endoscopy and radiography (with videos)

Hosoe, N., Imaeda, H., Okamoto, S., Bessho, R., Saito, R., Ida, Y., Kobayashi, S., Kanai, T., Hibi, T. & Ogata, H., 2011 Sep, In : Gastrointestinal Endoscopy. 74, 3, p. 690-691 2 p.

Research output: Contribution to journalArticle

Parasitic Intestinal Diseases
Taenia saginata
Taeniasis
Capsule Endoscopy
Radiography
4 Citations (Scopus)

A case of diabetic glomerulosclerosis without concurrent diabetes mellitus

Jo, Y., Ichihara, A., Eguchi, T., Kurihara, I., Hashiguchi, A., Konishi, K., Hayashi, M. & Saruta, T., 2002, In : Japanese Journal of Nephrology. 44, 7, p. 552-557 6 p.

Research output: Contribution to journalArticle

Diabetic Nephropathies
Diabetes Mellitus
Renal Hypertension
Glucose Intolerance
Nephrotic Syndrome

A case of eosinophilic enteritis-usefulness of electron microscopy in differential diagnosis-

Houzawa, S., Kurokawa, T., Inoue, N., Sekizuka, E., Aiso, S. & Hosoda, Y., 1993, In : Gastroenterological Endoscopy. 35, 5, p. 1015 1 p.

Research output: Contribution to journalArticle

Eosinophils
Electron Microscopy
Differential Diagnosis
Biopsy
Mucous Membrane
12 Citations (Scopus)

A case of generalized Hailey-Hailey disease with fatal liver injury

Amagai, M., Kobayashi, M., Wakabayashi, K., Hakuno, M., Hashiguchi, A., Nishikawa, T. & Hata, J. I., 2001 Jun, In : Keio Journal of Medicine. 50, 2, p. 109-116 8 p.

Research output: Contribution to journalArticle

Benign Familial Pemphigus
Skin
Liver
Wounds and Injuries
Liver Diseases

A case of glioblastoma resected immediately after administering bevacizumab: consideration on histopathological findings and safety of surgery

Tokuda, Y., Tamura, R., Ohara, K., Yoshida, K. & Sasaki, H., 2017 Apr 1, In : Brain Tumor Pathology. 34, 2, p. 98-102 5 p.

Research output: Contribution to journalArticle

Glioblastoma
Safety
temozolomide
Neoplasms
Thrombosis
6 Citations (Scopus)

A case of IgA-related enteropathy complicated with gastrointestinal bleeding and progressive IgA nephropathy: A possible variant Henoch-Schönlein purpura?

Nakamura, S., Hisamatsu, T., Kikuchi, J., Adachi, M., Yamagishi, Y., Imaeda, H., Hosoe, N., Naganuma, M., Ebinuma, H., Okamoto, S., Kanai, T., Ogata, H., Hanaoka, H., Furuya, Y., Kawano, Y., Bokuda, K., Sasamura, H., Uchida, H., Endo, T., Hashiguchi, A. & 3 others, Kameyama, K., Mukai, M. & Hibi, T., 2010, In : Internal Medicine. 49, 16, p. 1755-1761 7 p.

Research output: Contribution to journalArticle

Schoenlein-Henoch Purpura
Immunoglobulin A
Hemorrhage
Small Intestine
Skin
8 Citations (Scopus)

A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission

Sakamaki, Y., Hayashi, M., Wakino, S., Fukuda, S., Konishi, K., Hashiguchi, A., Hayashi, K. & Itoh, H., 2011, In : Internal Medicine. 50, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

Membranous Glomerulonephritis
Biliary Liver Cirrhosis
Cyclosporine
Proteinuria
Liver Diseases