Departments of Basic Medical Sciences

Research Output 1978 2020

2019
1 Citation (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journalArticle

Open Access
Helicobacter
Neoplastic Stem Cells
Catenins
Protein Splicing
Histones
1 Citation (Scopus)

Can cognitive leisure activity prevent cognitive decline in older adults? A systematic review of intervention studies

Iizuka, A., Suzuki, H., Ogawa, S., Kobayashi-Cuya, K. E., Kobayashi, M., Takebayashi, T. & Fujiwara, Y., 2019 Jan 1, In : Geriatrics and Gerontology International.

Research output: Contribution to journalReview article

Leisure Activities
Art
Cognition
Reading
Learning

Cardiovascular risk assessment chart by dietary factors in Japan: NIPPON DATA80

NIPPON DATA80 Research Group, 2019 Jan 1, In : Circulation Journal. 83, 6, p. 1254-1260 7 p.

Research output: Contribution to journalArticle

Open Access
Japan
Vegetables
Cardiovascular Diseases
Fruit
Salts
Open Access
Carotid Intima-Media Thickness
Epidemiologic Studies
Computer aided design
Atherosclerosis
Japan
1 Citation (Scopus)

Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease

Kuzumaki, N., Suda, Y., Iwasawa, C., Narita, M., Sone, T., Watanabe, M., Maekawa, A., Matsumoto, T., Akamatsu, W., Igarashi, K., Tamura, H., Takeshima, H., Tawfik, V. L., Ushijima, T., Hattori, N., Okano, H. & Narita, M., 2019 Jun 1, In : Brain : a journal of neurology. 142, 6, p. 1675-1689 15 p.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
Dopaminergic Neurons
Parkinson Disease
Induced Pluripotent Stem Cells
Clustered Regularly Interspaced Short Palindromic Repeats

Cell therapy for spinal cord injury using induced pluripotent stem cells

Nagoshi, N., Tsuji, O., Nakamura, M. & Okano, H., 2019 Dec 1, In : Regenerative Therapy. 11, p. 75-80 6 p.

Research output: Contribution to journalReview article

Open Access
Induced Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Stem cells
Spinal Cord Injuries
Cytology

Chagas disease: A report of 17 suspected cases in Japan, 2012-2017

Imai, K., Misawa, K., Osa, M., Tarumoto, N., Sakai, J., Mikita, K., Sayama, Y., Fujikura, Y., Kawana, A., Murakami, T., Maesaki, S., Miura, S. & Maeda, T., 2019 Jun 13, In : Tropical Medicine and Health. 47, 1, 38.

Research output: Contribution to journalArticle

Open Access
Chagas Disease
Japan
Trypanosoma cruzi
Parasitemia
Chagas Cardiomyopathy
1 Citation (Scopus)

Characterization of Intra/Extracellular Water States Probed by Ultrabroadband Multiplex Coherent Anti-Stokes Raman Scattering (CARS) Spectroscopic Imaging

Nuriya, M., Yoneyama, H., Takahashi, K., Leproux, P., Couderc, V., Yasui, M. & Kano, H., 2019 May 2, In : Journal of Physical Chemistry A. 123, 17, p. 3928-3934 7 p.

Research output: Contribution to journalArticle

Raman scattering
Raman spectra
Stretching
Imaging techniques
Water
1 Citation (Scopus)
Pancreatic Neoplasms
T-Lymphocytes
Survival
Neoplasms
Cell Count

Chronic Implantation of Whole-cortical Electrocorticographic Array in the Common Marmoset

Komatsu, M., Kaneko, T., Okano, H. & Ichinohe, N., 2019 Feb 1, In : Journal of visualized experiments : JoVE. 144

Research output: Contribution to journalArticle

Callithrix
Brain
Macaca
Poles
Epidural Space

Circadian patterns of hallucinatory experiences in patients with schizophrenia: Potentials for chrono-pharmacology

Koizumi, T., Suzuki, T., Pillai, N. S., Bies, R. R., Takeuchi, H., Yoshimura, K., Mimura, M. & Uchida, H., 2019 Oct 1, In : Journal of Psychiatric Research. 117, p. 1-6 6 p.

Research output: Contribution to journalArticle

Hallucinations
Schizophrenia
Pharmacology
Dopamine D2 Receptors
olanzapine

Classic-type epithelioid sarcoma arising from the sciatic nerve: A case report

Maeda, K., Asano, N., Kikuta, K., Okita, H., Nakamura, M., Matsumoto, M. & Nakayama, T. R., 2019 Jan 1, (Accepted/In press) In : Journal of Orthopaedic Science.

Research output: Contribution to journalArticle

Sciatic Nerve
Sarcoma
Cavernous Hemangioma
Spinal Cord
Cohort Studies
Retrospective Studies
Gait
1 Citation (Scopus)

Combined Genetic and Chromosomal Characterization of Wilms Tumors Identifies Chromosome 12 Gain as a Potential New Marker Predicting a Favorable Outcome

Haruta, M., Arai, Y., Okita, H., Tanaka, Y., Takimoto, T., Sugino, R. P., Yamada, Y., Kamijo, T., Oue, T., Fukuzawa, M., Koshinaga, T. & Kaneko, Y., 2019 Jan 1, In : Neoplasia (United States). 21, 1, p. 117-131 15 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 12
Wilms Tumor
Neoplasms
Genes
Survival
2 Citations (Scopus)

Comparative principles for next-generation neuroscience

Miller, C. T., Hale, M. E., Okano, H., Okabe, S. & Mitra, P., 2019 Jan 30, In : Frontiers in Behavioral Neuroscience. 13, 12.

Research output: Contribution to journalArticle

Open Access
Neurosciences
Nervous System
Technology
Molecular Biology
History
Inner Ear
Ear
Injections
Photons
Pharmaceutical Preparations
Open Access
Povidone-Iodine
Surgical Wound Infection
Local Anti-Infective Agents
Randomized Controlled Trials
Research Ethics Committees

Comparison of spatial interpolation methods based on exposure assessments of air pollutants: A case study on nuclear substances in Fukushima

Otani, T., Takahashi, K., Takeuchi, A. & Asami, M., 2019 Jan 1, HEALTHINF 2019 - 12th International Conference on Health Informatics, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019. Moucek, R., Fred, A. & Gamboa, H. (eds.). SciTePress, p. 415-421 7 p. (HEALTHINF 2019 - 12th International Conference on Health Informatics, Proceedings; Part of 12th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2019).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Interpolation
Disasters
Accidents
Air
Tsunamis
1 Citation (Scopus)

Comprehensive genetic analysis of cholangiolocellular carcinoma with a coexistent hepatocellular carcinoma-like area and metachronous hepatocellular carcinoma

Kawai-Kitahata, F., Asahina, Y., Kaneko, S., Tsuchiya, J., Sato, A., Miyoshi, M., Tsunoda, T., Inoue-Shinomiya, E., Murakawa, M., Nitta, S., Itsui, Y., Nakagawa, M., Azuma, S., Kakinuma, S., Tanabe, M., Sugawara, E., Takemoto, A., Ojima, H., Sakamoto, M., Muraoka, M. & 4 others, Takano, S., Maekawa, S., Enomoto, N. & Watanabe, M., 2019 Jan 1, (Accepted/In press) In : Hepatology Research.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Carcinoma
Mutation
Phosphotransferases
Laser Capture Microdissection
1 Citation (Scopus)

Contact-free unconstraint respiratory measurements with load cells under the bed in awake healthy volunteers: Breath-by-breath comparison with pneumotachography

Isono, S., Nozaki-Taguchi, N., Hasegawa, M., Kato, S., Todoroki, S., Masuda, S., Iida, N., Nishimura, T., Noto, M. & Sato, Y., 2019 May 1, In : Journal of Applied Physiology. 126, 5, p. 1432-1441 10 p.

Research output: Contribution to journalArticle

Respiratory Rate
Healthy Volunteers
Posture
Respiration
Leg

Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease

Shimizu, E., Aketa, N., Yazu, H., Uchino, M., Kamoi, M., Sato, Y., Tsubota, K. & Ogawa, Y., 2019 Jan 1, (Accepted/In press) In : Ocular Surface.

Research output: Contribution to journalArticle

Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Visual Acuity
Vision Disorders
Optical Coherence Tomography
Optogenetics
Corpus Striatum
Microscopy
Neurons
Diffusion Tensor Imaging
1 Citation (Scopus)
Thoracic Surgery
Japan
Databases
Prostheses and Implants
Mitral Valve

Current status of cardiovascular surgery in Japan, 2015 and 2016: a report based on the Japan Cardiovascular Surgery Database. 1—congenital heart surgery

Hirata, Y., Hirahara, N., Murakami, A., Motomura, N., Miyata, H. & Takamoto, S., 2019 Sep 5, In : General thoracic and cardiovascular surgery. 67, 9, p. 731-735 5 p.

Research output: Contribution to journalReview article

Thoracic Surgery
Japan
Databases
Mortality
Norwood Procedures
1 Citation (Scopus)
Japan
Thorax
Databases
Thoracic Aorta
Stroke
1 Citation (Scopus)
Coronary Artery Bypass
Japan
Databases
Mammary Arteries
Arteries
1 Citation (Scopus)

Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-Sectional Study

Nishikawa, T., Miyamatsu, N., Higashiyama, A., Hojo, M., Nishida, Y., Fukuda, S., Hirata, T., Ichiura, K., Kubota, Y., Kubo, S., Ueba, T., Kadota, A., Sugiyama, D. & Okamura, T., 2019 Jan 1, In : Cerebrovascular Diseases.

Research output: Contribution to journalArticle

Open Access
Cerebral Infarction
Drinking
Habits
Cross-Sectional Studies
Population

Degradation of Extracellular Matrix by Matrix Metalloproteinase 2 Is Essential for the Establishment of the Blood-Brain Barrier in Drosophila

Kanda, H., Shimamura, R., Koizumi-Kitajima, M. & Okano, H., 2019 Jun 28, In : iScience. 16, p. 218-229 12 p.

Research output: Contribution to journalArticle

Open Access
Matrix Metalloproteinase 2
Blood-Brain Barrier
Drosophila
Extracellular Matrix
Epithelial-Mesenchymal Transition

Dendropanax morbiferus leaf extract facilitates oligodendrocyte development

Kim, J. Y., Yoon, J. Y., Sugiura, Y., Lee, S. K., Park, J. D., Song, G. J. & Yang, H. J., 2019 Jun 1, In : Royal Society Open Science. 6, 6, 190266.

Research output: Contribution to journalArticle

Open Access
Oligodendroglia
Cell Culture Techniques
Multiple Sclerosis
Anti-Inflammatory Agents
Up-Regulation

Deregulation of the histone lysine-specific demethylase 1 is involved in human hepatocellular carcinoma

Kim, S., Bolatkan, A., Kaneko, S., Ikawa, N., Asada, K., Komatsu, M., Hayami, S., Ojima, H., Abe, N., Yamaue, H. & Hamamoto, R., 2019 Dec, In : Biomolecules. 9, 12, 810.

Research output: Contribution to journalArticle

Open Access
Histone Demethylases
Deregulation
Liver
Histones
Lysine

Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging

Sugiyama, E., Guerrini, M. M., Honda, K., Hattori, Y., Abe, M., Källback, P., Andrén, P. E., Tanaka, K. F., Setou, M., Fagarasan, S., Suematsu, M. & Sugiura, Y., 2019 Oct 25, In : iScience. 20, p. 359-372 14 p.

Research output: Contribution to journalArticle

Open Access
Mass Spectrometry
Serotonin
Midline Thalamic Nuclei
Brain
Norepinephrine

Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers

Serizawa, T., Isotani, A., Matsumura, T., Nakanishi, K., Nonaka, S., Shibata, S., Ikawa, M. & Okano, H., 2019 Jan 1, In : Development (Cambridge). 146, 21, dev174938.

Research output: Contribution to journalArticle

Open Access
Germ Layers
Embryonic Structures
Neural Stem Cells
Cell Lineage
Embryonic Development
Colitis
Ulcerative Colitis
Neoplasms
Mucous Membrane
Colectomy
2 Citations (Scopus)
Glypicans
Hepatocellular Carcinoma
Staining and Labeling
Neoplasms
Fetal Proteins

Disseminated histoplasmosis from a calcified lung nodule after long-term corticosteroid therapy in an elderly Japanese patient: A case report

Kobayashi, K., Asakura, T., Kawada, I., Hasegawa, H., Chubachi, S., Ohara, K., Kuramoto, J., Sugiura, H., Fujishima, S., Iwata, S., Umeyama, T., Katano, H., Uwamino, Y., Miyazaki, Y., Kamei, K., Hasegawa, N. & Betsuyaku, T., 2019 Apr 1, In : Medicine. 98, 17, p. e15264

Research output: Contribution to journalArticle

Open Access
Histoplasmosis
Adrenal Cortex Hormones
Lung
Fever
meropenem
2 Citations (Scopus)

Distinctive roles of d-Amino acids in the homochiral world: Chirality of amino acids modulates mammalian physiology and pathology

Sasabe, J. & Suzuki, M., 2019 Jan 1, In : Keio Journal of Medicine. 68, 1, p. 1-16 16 p.

Research output: Contribution to journalReview article

Open Access
Pathology
Serine
Amino Acids
Aspartic Acid
Synaptic Transmission

Does Posterior Cervical Decompression Conducted by Junior Surgeons Affect Clinical Outcomes in the Treatment of Cervical Spondylotic Myelopathy? Results From a Multicenter Study

Nagoshi, N., Iwanami, A., Isogai, N., Ishikawa, M., Nojiri, K., Tsuji, T., Daimon, K., Takeuchi, A., Tsuji, O., Okada, E., Fujita, N., Yagi, M., Watanabe, K., Nakamura, M., Matsumoto, M., Ishii, K. & Yamane, J., 2019 Feb 1, In : Global Spine Journal. 9, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

Spinal Cord Diseases
Decompression
Multicenter Studies
Spine
Articular Range of Motion

Draft genome sequence of mycolicibacterium sp. strain ncctsukiji, isolated from blood culture of a patient with malignant lymphoma

Fukano, H., Yoshida, M., Shouji, M., Hatta, S., Maruyama, D., Izutsu, K., Shiotsuka, M., Ogura, Y., Hayashi, T., Hasegawa, N., Iwata, S. & Hoshino, Y., 2019 Jan 1, In : Microbiology Resource Announcements. 8, 14, e01575-18.

Research output: Contribution to journalArticle

Open Access
Multilocus Sequence Typing
Lymphoma
Genome
Blood Culture
2 Citations (Scopus)

Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing cerebral cortex

Inoue, S., Hayashi, K., Fujita, K., Tagawa, K., Okazawa, H., Kubo, K. & Nakajima, K., 2019 Jan 23, In : Journal of Neuroscience. 39, 4, p. 678-691 14 p.

Research output: Contribution to journalArticle

Cadherins
Cerebral Cortex
Neurons
Actin Cytoskeleton
Time-Lapse Imaging

Dual usage of a stage-specific fluorescent reporter system based on a helper-dependent adenoviral vector to visualize osteogenic differentiation

Sone, T., Shin, M., Ouchi, T., Sasanuma, H., Miyamoto, A., Ohte, S., Tsukamoto, S., Nakanishi, M., Okano, H., Katagiri, T. & Mitani, K., 2019 Dec 1, In : Scientific reports. 9, 1, 9705.

Research output: Contribution to journalArticle

Open Access
Osteoblasts
Induced Pluripotent Stem Cells
Osteocalcin
Venus
Bone and Bones
2 Citations (Scopus)

Effectiveness of inactivated influenza vaccine in children by vaccine dose, 2013–18

Shinjo(H), M., Sugaya, N., Furuichi, M., Araki, E., Maeda, N., Isshiki, K., Ohnishi, T., Nakamura, S., Yamada, G., Narabayashi, A., Nishida, M., Taguchi, N., Nakata, Y., Yoshida, M., Tsunematsu, K., Shibata, M., Munenaga, T., Hirano, Y., Ookawara, I., Sekiguchi, S. & 5 others, Kobayashi, Y., Yamaguchi, Y., Yoshida, N., Mitamura, K. & Takahashi, T., 2019 Jul 9, In : Vaccine. 37, 30, p. 4047-4054 8 p.

Research output: Contribution to journalArticle

Inactivated Vaccines
Influenza Vaccines
influenza
Human Influenza
Vaccines

Effect of empagliflozin on endothelial function in patients with type 2 diabetes and cardiovascular disease: Results from the multicenter, randomized, placebo- controlled, double-blind EMBLEM trial

Tanaka, A., Shimabukuro, M., MacHii, N., Teragawa, H., Okada, Y., Shima, K. R., Takamura, T., Taguchi, I., Hisauchi, I., Toyoda, S., Matsuzawa, Y., Tomiyama, H., Yamaoka-Tojo, M., Yoshida, H., Sato, Y., Ikehara, Y., Ueda, S., Higashi, Y. & Node, K., 2019 Oct 1, In : Diabetes care. 42, 10, p. E159-E161

Research output: Contribution to journalLetter

Open Access
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Placebos
empagliflozin

Effect of refrigeration of blood samples in lithium-heparin tubes on QuantiFERON TB Gold Plus test result

Uwamino, Y., Sakai, A., Nishimura, T., Noguchi, M., Uno, S., Fujiwara, H., Mori, M., Wakui, M., Murata, M. & Hasegawa, N., 2019 Jan 1, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Refrigeration
Lithium
Gold
Heparin
Product Labeling
Postoperative Nausea and Vomiting
Scoliosis
Dexamethasone
Randomized Controlled Trials
Placebos

Effects of sulfur dioxide on fractional exhaled nitric oxide concentration in the child residents of Miyakejima Island

Iwasawa, S., Tsuboi, T., Nakano, M., Hirata, A., Yoshioka, N., Suzuki, S., Tanaka, S. & Omae, K., 2019 Jun 1, In : Asian Journal of Atmospheric Environment. 13, 2, p. 145-149 5 p.

Research output: Contribution to journalArticle

nitric oxide
sulfur dioxide
student
volcanic gas
dose-response relationship
Open Access
Mitomycin
Pancreatic Neoplasms
Fluorouracil
Cisplatin
Radiotherapy
1 Citation (Scopus)

Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

Kumita, W., Sato, K., Suzuki, Y., Kurotaki, Y., Harada, T., Zhou, Y., Kishi, N., Sato, K., Aiba, A., Sakakibara, Y., Feng, G., Okano, H. & Sasaki, E., 2019 Dec 1, In : Scientific reports. 9, 1, 12719.

Research output: Contribution to journalArticle

Open Access
Clustered Regularly Interspaced Short Palindromic Repeats
Callithrix
Embryonic Structures
Gene Knockout Techniques
Primates
17 Citations (Scopus)

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

Ladinsky, M. S., Araujo, L. P., Zhang, X., Veltri, J., Galan-Diez, M., Soualhi, S., Lee, C., Irie, K., Pinker, E. Y., Narushima, S., Bandyopadhyay, S., Nagayama, M., Elhenawy, W., Coombes, B. K., Ferraris, R. P., Honda, K., Iliev, I. D., Gao, N., Bjorkman, P. J. & Ivanov, I. I., 2019 Jan 1, In : Science. 363, 6431, eaat4042.

Research output: Contribution to journalArticle

Endocytosis
Homeostasis
Epithelial Cells
Bacteria
T-Lymphocytes
1 Citation (Scopus)

Endoscopic Endonasal Removal of Large Calcified Pituitary Adenoma: Case Report and Review of the Literature

Murase, M., Toda, M., Ohara, K., Ishihara, E. & Yoshida, K., 2019 Mar 1, In : World Neurosurgery. 123, p. 239-243 5 p.

Research output: Contribution to journalArticle

Pituitary Neoplasms
Magnetic Resonance Imaging
Amenorrhea
Gadolinium
Neoplasms