Departments of Basic Medical Sciences

Research Output 1978 2020

2019
2 Citations (Scopus)

Endothelial-mesenchymal transition drives expression of CD44 variant and xCT in pulmonary hypertension

Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., Shimoda, M., Chiba, T., Masuko, T., Hakamata, Y., Kobayashi, E., Saya, H., Fukuda, K. & Sano, M., 2019 Jan 1, In : American journal of respiratory cell and molecular biology. 61, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

Sulfasalazine
Pulmonary Hypertension
Glutathione
Antioxidants
Chemotherapy

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

Zahra, F. T., Sajib, M. S., Ichiyama, Y., Akwii, R. G., Tullar, P. E., Cobos, C., Minchew, S. A., Doçi, C. L., Zheng, Y., Kubota, Y., Gutkind, J. S. & Mikelis, C. M., 2019 Dec 1, In : Scientific reports. 9, 1, 11666.

Research output: Contribution to journalArticle

Open Access
GTP Phosphohydrolases
Embryonic Development
rho GTP-Binding Proteins
Cell Movement
Physiologic Neovascularization

Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina

Niimi, K., Adachi, Y., Ishikawa, H., Yamaguchi, W., Kubota, Y., Inagaki, S. & Furuyama, T., 2019 Dec 3, In : Biochemical and Biophysical Research Communications. 520, 2, p. 304-310 7 p.

Research output: Contribution to journalArticle

Pericytes
Retina
Endothelium
Thrombospondin 1
Endothelial cells

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 2019 Jul 2, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Stem cells
Maintenance
Fatty Acids
Cell culture
2 Citations (Scopus)

Essential roles of Windei and nuclear monoubiquitination of Eggless/SETDB1 in transposon silencing

Osumi, K., Sato, K., Murano, K., Siomi, H. & Siomi, M. C., 2019 Jan 1, (Accepted/In press) In : EMBO Reports. e48296.

Research output: Contribution to journalArticle

Small Interfering RNA
Genes
Nuclear Localization Signals
Cell Nucleus Active Transport
Gene Silencing
1 Citation (Scopus)

Establishment of induced pluripotent stem cells from common marmoset fibroblasts by RNA-based reprogramming

Nakajima, M., Yoshimatsu, S., Sato, T., Nakamura, M., Okahara, J., Sasaki, E., Shiozawa, S. & Okano, H., 2019 Jan 1, In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Callithrix
Fibroblasts
Stem cells
RNA
5 Citations (Scopus)

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

Saito, Y., Muramatsu, T., Kanai, Y., Ojima, H., Sukeda, A., Hiraoka, N., Arai, E., Sugiyama, Y., Matsuzaki, J., Uchida, R., Yoshikawa, N., Furukawa, R. & Saito, H., 2019 Apr 23, In : Cell Reports. 27, 4, p. 1265-1276.e4

Research output: Contribution to journalArticle

Open Access
Organoids
Preclinical Drug Evaluations
Biliary Tract
Screening
Biomarkers

Establishment of permutation for cancer risk estimation in the urothelium based on genome-wide DNA methylation analysis

Tsumura, K., Arai, E., Tian, Y., Shibuya, A., Nishihara, H., Yotani, T., Yamada, Y., Takahashi, Y., Maeshima, A. M., Fujimoto, H., Nakagawa, T., Kume, H., Homma, Y., Yoshida, T. & Kanai, Y., 2019 Nov 25, In : Carcinogenesis. 40, 11, p. 1308-1319 12 p.

Research output: Contribution to journalArticle

Urothelium
DNA Methylation
Genome
Neoplasms
Carcinoma
1 Citation (Scopus)

Estimating the concentration of therapeutic range using disease-specific iPS cells: Low-dose rapamycin therapy for Pendred syndrome

Hosoya, M., Saeki, T., Saegusa, C., Matsunaga, T., Okano, H., Fujioka, M. & Ogawa, K., 2019 Jun 1, In : Regenerative Therapy. 10, p. 54-63 10 p.

Research output: Contribution to journalArticle

Audition
Sirolimus
Cell death
Cells
Stem cells

Evaluating the efficacy of small molecules for neural differentiation of common marmoset ESCs and iPSCs

Yoshimatsu, S., Nakamura, M., Nakajima, M., Nemoto, A., Sato, T., Sasaki, E., Shiozawa, S. & Okano, H., 2019 Jan 1, (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Callithrix
Embryonic Stem Cells
Pluripotent Stem Cells
Neurosciences

Evaluation for optimal dosing of vancomycin in patients with different physical types

Hashimoto, M., Iketani, O., Ichinose, N., Enoki, Y., Taguchi, K., Uno, S., Uwamino, Y., Hasegawa, N. & Matsumoto, K., 2019 Jan 1, In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Vancomycin
Body Mass Index
Obesity
Body Weight

Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex

Arai, Y., Cwetsch, A. W., Coppola, E., Cipriani, S., Nishihara, H., Kanki, H., Saillour, Y., Freret-Hodara, B., Dutriaux, A., Okada, N., Okano, H., Dehay, C., Nardelli, J., Gressens, P., Shimogori, T., D'Onofrio, G. & Pierani, A., 2019 Oct 15, In : Cell Reports. 29, 3, p. 645-658.e5

Research output: Contribution to journalArticle

Open Access
Cerebral Cortex
Primates
Neurons
Brain
Genes
1 Citation (Scopus)

Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology

Ide, M., Ohnishi, T., Toyoshima, M., Balan, S., Maekawa, M., Shimamoto-Mitsuyama, C., Iwayama, Y., Ohba, H., Watanabe, A., Ishii, T., Shibuya, N., Kimura, Y., Hisano, Y., Murata, Y., Hara, T., Morikawa, M., Hashimoto, K., Nozaki, Y., Toyota, T., Wada, Y. & 17 others, Tanaka, Y., Kato, T., Nishi, A., Fujisawa, S., Okano, H., Itokawa, M., Hirokawa, N., Kunii, Y., Kakita, A., Yabe, H., Iwamoto, K., Meno, K., Katagiri, T., Dean, B., Uchida, K., Kimura, H. & Yoshikawa, T., 2019 Jan 1, (Accepted/In press) In : EMBO Molecular Medicine. e10695.

Research output: Contribution to journalArticle

Open Access
Hydrogen Sulfide
Schizophrenia
Sulfides
Inbred C3H Mouse
Energy Metabolism
3 Citations (Scopus)

Explaining the decline in coronary heart disease mortality rates in Japan: Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012

Ogata, S., Nishimura, K., Guzman-Castillo, M., Sumita, Y., Nakai, M., Nakao, Y. M., Nishi, N., Noguchi, T., Sekikawa, A., Saito, Y., Watanabe, T., Kobayashi, Y., Okamura, T., Ogawa, H., Yasuda, S., Miyamoto, Y., Capewell, S. & O'Flaherty, M., 2019 Jan 1, In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Open Access
Coronary Disease
Japan
Mortality
Blood Pressure
Body Mass Index

Exposure to loud noise and risk of vestibular schwannoma: Results from the interphone international case‒control study

INTERPHONE Study Group, 2019 Jan 1, In : Scandinavian Journal of Work, Environment and Health. 45, 2, p. 183-193 11 p.

Research output: Contribution to journalArticle

Open Access
Acoustic Neuroma
Noise
Odds Ratio
Confidence Intervals
Leisure Activities

Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis

Kobayashi, J., Hasegawa, T., Sugeno, N., Yoshida, S., Akiyama, T., Fujimori, K., Hatakeyama, H., Miki, Y., Tomiyama, A., Kawata, Y., Fukuda, M., Kawahata, I., Yamakuni, T., Ezura, M., Kikuchi, A., Baba, T., Takeda, A., Kanzaki, M., Wakabayashi, K., Okano, H. & 1 others, Aoki, M., 2019 Sep 1, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 10240-10256 17 p.

Research output: Contribution to journalArticle

Synucleins
Dopamine Plasma Membrane Transport Proteins
Endocytosis
Neurons
Parkinson Disease
1 Citation (Scopus)

First Database Comparison Between the United States and Japan: Coronary Artery Bypass Grafting

Nawata, K., D'Agostino, R. S., Habib, R. H., Kumamaru, H., Hirahara, N., Miyata, H., Motomura, N., Takamoto, S., Shahian, D. M. & Grover, F. L., 2019 Jan 1, (Accepted/In press) In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

Coronary Artery Bypass
Japan
Databases
Thorax
Transplants

First report of hepatobiliary Mycobacterium avium infection developing obstructive jaundice in a patient with neutralizing anti–interferon-gamma autoantibodies

Namkoong, H., Asakura, T., Ishii, M., Yoda, S., Masaki, K., Sakagami, T., Iwasaki, E., Yamagishi, Y., Kanai, T., Betsuyaku, T. & Hasegawa, N., 2019 Jan 1, In : New Microbes and New Infections. 27, p. 4-6 3 p.

Research output: Contribution to journalArticle

Mycobacterium avium
Mycobacterium Infections
Obstructive Jaundice
Autoantibodies
Jaundice

Generation of a human iPS cell line (CGMH.SLC26A4919-2) from a Pendred syndrome patient carrying SLC26A4 c.919-2A>G splice-site mutation

Cheng, Y. F., Chan, Y. H., Hu, C. J., Lu, Y. C., Saeki, T., Hosoya, M., Saegusa, C., Fujioka, M., Okano, H., Weng, S. M., Hsu, C. J., Chang, K. H. & Wu, C. C., 2019 Oct 1, In : Stem Cell Research. 40, 101524.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Cell Line
Mutation
Genes
Germ Layers
1 Citation (Scopus)
Conjugate Vaccines
Haemophilus influenzae
Otitis Media
Microbial Drug Resistance
Japan
3 Citations (Scopus)

Genome-wide DNA methylation profile of early-onset endometrial cancer: Its correlation with genetic aberrations and comparison with late-onset endometrial cancer

Makabe, T., Arai, E., Hirano, T., Ito, N., Fukamachi, Y., Takahashi, Y., Hirasawa, A., Yamagami, W., Susumu, N., Aoki, D. & Kanai, Y., 2019 Jul 4, In : Carcinogenesis. 40, 5, p. 611-623 13 p.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Endometrial Neoplasms
Genome
Genes
Neoplasms

Growth-promoting effects of the hydrogen-sulfide compounds produced by Desulfovibrio desulfuricans subsp. desulfuricans cocultured with Escherichia coli (DH5α) on the growth of Entamoeba and Endolimax species isolates from swine

Yoshida, N., Kobayashi, S., Suzuki, J., Azuma, Y., Kobayashi-Ogata, N., Kartikasari, D. P., Yanagawa, Y. & Iwata, S., 2019 Jan 1, In : BioScience Trends. 13, 5, p. 402-410 9 p.

Research output: Contribution to journalArticle

Open Access
Endolimax
Desulfovibrio desulfuricans
Entamoeba
Hydrogen Sulfide
Amoeba
17 Citations (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Cho, H., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Jan 1, (Accepted/In press) In : Nature Microbiology.

Research output: Contribution to journalArticle

Th17 Cells
Sclerosing Cholangitis
Liver Diseases
Microbiota
Bacterial Translocation
3 Citations (Scopus)

Having few remaining teeth is associated with a low nutrient intake and low serum albumin levels in middle-aged and older Japanese individuals: Findings from the NIPPON DATA2010

Nakamura, M., Ojima, T., Nagahata, T., Kondo, I., Ninomiya, T., Yoshita, K., Arai, Y., Ohkubo, T., Murakami, K., Nishi, N., Murakami, Y., Takashima, N., Okuda, N., Kadota, A., Miyagawa, N., Kondo, K., Okamura, T., Ueshima, H., Okayama, A. & Miura, K., 2019 Jan 5, In : Environmental Health and Preventive Medicine. 24, 1, 1.

Research output: Contribution to journalArticle

Serum Albumin
Tooth
Food
Social Class
Oral Health
1 Citation (Scopus)

Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: The KOBE study

Kubo, S., Nishida, Y., Kubota, Y., Higashiyama, A., Sugiyama, D., Hirata, T., Miyamatsu, N., Tanabe, A., Hirata, A., Tatsumi, Y., Kadota, A., Kuwabara, K., Nishikawa, T., Miyamoto, Y. & Okamura, T., 2019 Apr 2, In : BMC Nephrology. 20, 1, 117.

Research output: Contribution to journalArticle

Open Access
Cystatin C
Uric Acid
Glomerular Filtration Rate
Chronic Renal Insufficiency
Kidney

How I do it: Endoscopic diagnosis for superficial non-ampullary duodenal epithelial tumors

Nakayama, A., Kato, M., Takatori, Y., Shimoda, M., Mizutani, M., Tsutsumi, K., Kiguchi, Y., Akimoto, T., Sasaki, M., Mutaguchi, M., Takabayashi, K., Maehata, T., Ochiai, Y., Kanai, T. & Yahagi, N., 2019 Jan 1, (Accepted/In press) In : Digestive Endoscopy.

Research output: Contribution to journalArticle

Neoplasms
Odds Ratio
Endoscopy
Observational Studies
Multivariate Analysis

Hyaluronan synthesis supports glutamate transporter activity

Hayashi, M. K., Nishioka, T., Shimizu, H., Takahashi, K., Kakegawa, W., Mikami, T., Hirayama, Y., Koizumi, S., Yoshida, S., Yuzaki, M., Tammi, M., Sekino, Y., Kaibuchi, K., Shigemoto-Mogami, Y., Yasui, M. & Sato, K., 2019 Jan 1, In : Journal of Neurochemistry.

Research output: Contribution to journalArticle

Amino Acid Transport System X-AG
Hyaluronic Acid
Hyaluronoglucosaminidase
Glutamic Acid
Neurology
1 Citation (Scopus)

Identification of a binding protein for sesamin and characterization of its roles in plant growth

Tera, M., Koyama, T., Murata, J., Furukawa, A., Mori, S., Azuma, T., Watanabe, T., Hori, K., Okazawa, A., Kabe, Y., Suematsu, M., Satake, H., Ono, E. & Horikawa, M., 2019 Dec 1, In : Scientific reports. 9, 1, 8631.

Research output: Contribution to journalArticle

Open Access
Carrier Proteins
Growth
Sesamum
sesamin
Lignans
3 Citations (Scopus)

IL-10 produced by macrophages regulates epithelial integrity in the small intestine

Morhardt, T. L., Hayashi, A., Ochi, T., Quirós, M., Kitamoto, S., Nagao-Kitamoto, H., Kuffa, P., Atarashi, K., Honda, K., Kao, J. Y., Nusrat, A. & Kamada, N., 2019 Dec 1, In : Scientific Reports. 9, 1, 1223.

Research output: Contribution to journalArticle

Interleukin-10
Small Intestine
Macrophages
Anti-Inflammatory Agents
Microbiota
2 Citations (Scopus)

Immunohistochemistry for aldosterone synthase CYP11B2 and matrix-assisted laser desorption ionization imaging mass spectrometry for in-situ aldosterone detection

Zhang, Z., Sugiura, Y., Mune, T., Nishiyama, M., Terada, Y., Mukai, K. & Nishimoto, K., 2019 Mar 1, In : Current Opinion in Nephrology and Hypertension. 28, 2, p. 105-112 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Aldosterone
Immunohistochemistry
Hyperaldosteronism
6 Citations (Scopus)

Impact of Advanced Age on Survival in Patients Undergoing Resection of Hepatocellular Carcinoma: Report of a Japanese Nationwide Survey

Liver Cancer Study Group of Japan, 2019 Apr 1, In : Annals of surgery. 269, 4, p. 692-699 8 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Survival
Liver
Cause of Death
Age Groups

Impact of care coordination on oral anticoagulant therapy among patients with atrial fibrillation in routine clinical practice in Japan: A prospective, observational study

Ono, F., Akiyama, S., Suzuki, A., Ikeda, Y., Takahashi, A., Matsuoka, H., Sasaki, M., Okamura, T. & Yoshihara, N., 2019 Oct 24, In : BMC Cardiovascular Disorders. 19, 1, 235.

Research output: Contribution to journalArticle

Open Access
Anticoagulants
Atrial Fibrillation
Observational Studies
Japan
Prospective Studies

Impact of hypertension on hospitalizations for cardiovascular diseases in a worksite population: An epidemiologic study using claims data for workers

Fukushima, A., Khabtheni, W., Guelfucci, F., Onishi, Y., Sugiyama, D., Okamura, T. & Toumi, M., 2019 Feb 12, In : American Journal of Hypertension. 32, 3, p. 298-307 10 p.

Research output: Contribution to journalArticle

Workplace
Epidemiologic Studies
Hospitalization
Cardiovascular Diseases
Blood Pressure
1 Citation (Scopus)

Impact of nutrition in the treatment of congenital diaphragmatic hernia

Terui, K., Usui, N., Tazuke, Y., Nagata, K., Ito, M., Okuyama, H., Hayakawa, M., Taguchi, T., Sato, Y. & Yoshida, H., 2019 May 1, In : Pediatrics International. 61, 5, p. 482-488 7 p.

Research output: Contribution to journalArticle

Parenteral Nutrition
Small Intestine
Weight Gain
Enteral Nutrition
Therapeutics

Impact of Stent Graft Design on External Iliac Artery Limb Occlusion Rates After Endovascular Aneurysm Repair: Post-hoc Analysis of a Japanese Multicentre Database

Shintani, T., Obara, H., Matsubara, K., Hayashi, K., Hayashi, M., Ono, S., Shimogawara, T., Shibutani, S., Watada, S., Sekimoto, Y., Uchida, N., Asami, A., Fujii, T., Harada, H., Fujimura, N., Sato, Y. & Kitagawa, Y., 2019 Jan 1, (Accepted/In press) In : European Journal of Vascular and Endovascular Surgery.

Research output: Contribution to journalArticle

Iliac Artery
Stents
Aneurysm
Extremities
Databases
4 Citations (Scopus)

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. & 37 others, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 Aug 1, In : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Glioblastoma
Carcinogenesis
Transfer RNA
Guanine Nucleotides
2 Citations (Scopus)

Increased cytotoxicity of herpes simplex virus thymidine kinase expression in human induced pluripotent stem cells

Iwasawa, C., Tamura, R., Sugiura, Y., Suzuki, S., Kuzumaki, N., Narita, M., Suematsu, M., Nakamura, M., Yoshida, K., Toda, M., Okano, H. & Miyoshi, H., 2019 Feb 2, In : International Journal of Molecular Sciences. 20, 4, 810.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
thymidine
Thymidine Kinase
stem cells
Human Herpesvirus 1
1 Citation (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M., Tada, N., Okano, H. & Akamatsu, W., 2019 Feb 12, In : Stem Cell Reports. 12, 2, p. 305-318 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Pluripotent Stem Cells
Fibroblast Growth Factor 4
Stem Cells
11 Citations (Scopus)

Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid

Morita, H., Kubo, T., Rückert, B., Ravindran, A., Soyka, M. B., Rinaldi, A. O., Sugita, K., Wawrzyniak, M., Wawrzyniak, P., Motomura, K., Tamari, M., Orimo, K., Okada, N., Arae, K., Saito, K., Altunbulakli, C., Castro-Giner, F., Tan, G., Neumann, A., Sudo, K. & 9 others, O'Mahony, L., Honda, K., Nakae, S., Saito, H., Mjösberg, J., Nilsson, G., Matsumoto, K., Akdis, M. & Akdis, C. A., 2019 Jan 1, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Tretinoin
Lymphocytes
Interleukin-10
Nose
Nasal Polyps

Influence of foot position on the measurement of first metatarsal axial rotation using the first metatarsal axial radiographs

Sadamasu, A., Yamaguchi, S., Kimura, S., Ono, Y., Sato, Y., Akagi, R., Sasho, T. & Ohtori, S., 2019 Jan 1, (Accepted/In press) In : Journal of Orthopaedic Science.

Research output: Contribution to journalArticle

Metatarsal Bones
Pronation
Foot
Hallux Valgus
Supination
1 Citation (Scopus)

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 Jul 1, In : Cancer science. 110, 7, p. 2156-2165 10 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-13
Carcinogenesis
Obesity
Colorectal Neoplasms
Cytokines
Cellular Structures
Cadherins
Ulcerative Colitis
Colitis
Signet Ring Cell Carcinoma
1 Citation (Scopus)

In Utero Amniotic Fluid Stem Cell Therapy Protects Against Myelomeningocele via Spinal Cord Coverage and Hepatocyte Growth Factor Secretion

Abe, Y., Ochiai, D., Masuda, H., Sato, Y., Otani, T., Fukutake, M., Ikenoue, S., Miyakoshi, K., Okano, H. & Tanaka, M., 2019 Jan 1, (Accepted/In press) In : Stem Cells Translational Medicine.

Research output: Contribution to journalArticle

Open Access
Meningomyelocele
Hepatocyte Growth Factor
Amniotic Fluid
Cell- and Tissue-Based Therapy
Spinal Cord

In Vitro Conversion of Activated T Cells into Stem Cell Memory-Like T Cells

Kondo, T., Imura, Y., Ando, M., Chikuma, S. & Yoshimura, A., 2019 Jan 1, Methods in Molecular Biology. Humana Press Inc., p. 41-51 11 p. (Methods in Molecular Biology; vol. 2048).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stem Cells
T-Lymphocytes
Neoplasm Antigens
Cell- and Tissue-Based Therapy
Coculture Techniques

In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019 Sep 1, In : eNeuro. 6, 5

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Bipolar Disorder
Schizophrenia
Neurons
Psychiatry
1 Citation (Scopus)

In vivoTwo-photon imaging of anesthesia-specific alterations in microglial surveillance and photodamage-directed motility in mouse cortex

Sun, W., Suzuki, K., Toptunov, D., Stoyanov, S., Yuzaki, M., Khiroug, L. & Dityatev, A., 2019 Jan 1, In : Frontiers in Neuroscience. 13, MAY, 421.

Research output: Contribution to journalArticle

Open Access
Isoflurane
Photons
Ketamine
Anesthesia
Brain-Computer Interfaces
1 Citation (Scopus)

Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling

Kase, Y., Otsu, K., Shimazaki, T. & Okano, H., 2019 Jun 11, In : Stem cell reports. 12, 6, p. 1313-1328 16 p.

Research output: Contribution to journalArticle

Open Access
Neurogenesis
Stem Cells
Modulation
Neural Stem Cells
Brain
Platelet-Derived Growth Factor beta Receptor
Myofibroma
Genetic Databases
Arachnoid Cysts
Induced Pluripotent Stem Cells

Large-area fluorescence and electron microscopic correlative imaging with multibeam scanning electron microscopy

Shibata, S., Iseda, T., Mitsuhashi, T., Oka, A., Shindo, T., Moritoki, N., Nagai, T., Otsubo, S., Inoue, T., Sasaki, E., Akazawa, C., Takahashi, T., Schalek, R., Lichtman, J. W. & Okano, H., 2019 Apr 24, In : Frontiers in Neural Circuits. 13, 29.

Research output: Contribution to journalArticle

Open Access
Electron Scanning Microscopy
Electron Microscopy
Fluorescence
Electrons
Light
Human Herpesvirus 3
Acute Liver Failure
Hematopoietic Stem Cell Transplantation
Virus Diseases
Herpes Zoster