Departments of Basic Medical Sciences

Research Output 1978 2020

2019

Prediction of Prognosis of Intermediate-Stage HCC Patients: Validation of the Tumor Marker Score in a Nationwide Database in Japan

The Liver Cancer Study Group Of Japan, 2019 Jan 1, In : Liver Cancer.

Research output: Contribution to journalArticle

Open Access
Tumor Biomarkers
Hepatocellular Carcinoma
Japan
Databases
alpha-Fetoproteins

Predictive factors for liver volume and function recovery after resection using three-dimensional analysis

Nakano, Y., Itano, O., Shinoda, M., Kitago, M., Yagi, H., Abe, Y., Takeuchi, A., Takemura, Y. & Kitagawa, Y., 2019 Jan 1, (Accepted/In press) In : HPB.

Research output: Contribution to journalArticle

Recovery of Function
Liver
Hepatectomy
Collagen Type IV
Platelet Count

Pregnancy and neonatal outcomes of small follicle–derived blastocyst transfer in modified natural cycle in vitro fertilization

Teramoto, S., Osada, H., Sato, Y. & Shozu, M., 2019 Jan 1, In : Fertility and Sterility.

Research output: Contribution to journalArticle

Open Access
Embryo Transfer
Live Birth
Fertilization in Vitro
Pregnancy Outcome
Incidence

Prevalence, clinical profiles, and prognosis of POEMS syndrome in Japanese nationwide survey

Suichi, T., Misawa, S., Beppu, M., Takahashi, S., Sekiguchi, Y., Shibuya, K., Amino, H., Tsuneyama, A., Suzuki, Y. I., Nakamura, K., Sato, Y. & Kuwabara, S., 2019 Sep 3, In : Neurology. 93, 10, p. e975-e983

Research output: Contribution to journalArticle

POEMS Syndrome
Stem Cell Transplantation
Adrenal Cortex Hormones
Thalidomide
Skin
Open Access
Life Style
Odds Ratio
Environment and Public Health
Logistic Models
Breakfast

Primary Peritoneal Low-grade Serous Carcinoma in a Patient with Lynch Syndrome: A Case Report

Makiuchi, S., Yoshida, H., Ishikawa, M., Kojima, N., Kanai, Y. & Kato, T., 2019 Jan 1, (Accepted/In press) In : International Journal of Gynecological Pathology.

Research output: Contribution to journalArticle

Hereditary Nonpolyposis Colorectal Neoplasms
Carcinoma
Neoplasms
Germ-Line Mutation
Endometrial Neoplasms

Procedure- and Hospital-Level Variation of Deep Sternal Wound Infection From All-Japan Registry

Hirahara, N., Miyata, H., Motomura, N., Kohsaka, S., Nishimura, T. & Takamoto, S., 2019 Jan 1, (Accepted/In press) In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

Wound Infection
Registries
Japan
Mortality
Confidence Intervals

Prosthetic aortic valve endocarditis

Ko, S., Uno, S. & Kohsaka, S., 2019 Jan 1, In : Internal Medicine. 58, 21, 1 p.

Research output: Contribution to journalComment/debate

Open Access
Enterobacter cloacae
Endocarditis
Aortic Valve

Pseudomyogenic hemangioendothelioma of bone treated with denosumab: A case report

Otani, S., Nakayama, T. R., Sekita, T., Hirozane, T., Asano, N., Nishimoto, K., Sasaki, A., Okita, H., Morioka, H., Nakamura, M. & Matsumoto, M., 2019 Sep 3, In : BMC Cancer. 19, 1, 872.

Research output: Contribution to journalArticle

Open Access
Hemangioendothelioma
Bone and Bones
Bones of Lower Extremity
Osteosclerosis
Pain
6 Citations (Scopus)

Randomized phase II trial comparing site-specific treatment based on gene expression profiling with carboplatin and paclitaxel for patients with cancer of unknown primary site

Hayashi, H., Kurata, T., Takiguchi, Y., Arai, M., Takeda, K., Akiyoshi, K., Matsumoto, K., Onoe, T., Mukai, H., Matsubara, N., Minami, H., Toyoda, M., Onozawa, Y., Ono, A., Fujita, Y., Sakai, K., Koh, Y., Takeuchi, A., Ohashi, Y., Nishio, K. & 1 others, Nakagawa, K., 2019 Jan 1, In : Journal of Clinical Oncology. 37, 7, p. 570-579 10 p.

Research output: Contribution to journalArticle

Carboplatin
Gene Expression Profiling
Paclitaxel
Neoplasms
Therapeutics

Recovery of FRI-5 carbapenemase at a Japanese hospital where FRI-4 carbapenemase was discovered

Uwamino, Y., Kubota, H., Sasaki, T., Kosaka, A., Furuhashi, M., Uno, S., Kudoh, J., Murata, M. & Hasegawa, N., 2019 Nov 1, In : The Journal of antimicrobial chemotherapy. 74, 11, p. 3390-3492 103 p.

Research output: Contribution to journalArticle

carbapenemase
4 Citations (Scopus)

Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations

Iwasawa, C., Kuzumaki, N., Suda, Y., Kagawa, R., Oka, Y., Hattori, N., Okano, H. & Narita, M., 2019 Jan 18, In : Molecular Brain. 12, 1, 5.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Interneurons
Somatostatin
Parkinson Disease
GABAergic Neurons

Relation of koniocellular layers of dorsal lateral geniculate to inferior pulvinar nuclei in common marmosets

Huo, B. X., Zeater, N., Lin, M. K., Takahashi, Y. S., Hanada, M., Nagashima, J., Lee, B. C., Hata, J., Zaheer, A., Grünert, U., Miller, M. I., Rosa, M. G. P., Okano, H., Martin, P. R. & Mitra, P. P., 2019 Jan 1, (Accepted/In press) In : European Journal of Neuroscience.

Research output: Contribution to journalArticle

Pulvinar
Geniculate Bodies
Callithrix
Calbindins
Visual Cortex
Dietary Fiber
Cardiovascular Diseases
Carbohydrates
Mortality
Starch
1 Citation (Scopus)

Requirements for multivalent Yb body assembly in transposon silencing in Drosophila

Hirakata, S., Ishizu, H., Fujita, A., Tomoe, Y. & Siomi, M. C., 2019 Jan 1, In : EMBO Reports. e47708.

Research output: Contribution to journalArticle

RNA Helicases
Drosophila
RNA
Liquids

Response Evaluation Criteria in Cancer of the Liver version 5 (RECICL 2019 revised version)

Kudo, M., Ikeda, M., Ueshima, K., Sakamoto, M., Shiina, S., Tateishi, R., Hasegawa, K., Furuse, J., Miyayama, S., Murakami, T., Yamashita, T. & Kokudo, N., 2019 Jan 1, (Accepted/In press) In : Hepatology Research.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatocellular Carcinoma
Japan
Therapeutics
Clinical Trials
3 Citations (Scopus)

Risk score system for late aortic events in patients with uncomplicated type B aortic dissection

Matsushita, A., Tabata, M., Mihara, W., Shimamoto, T., Komiya, T., Takanashi, S., Tobaru, T., Nakao, T., Nakamura, S. & Sato, Y., 2019 Jan 1, In : Journal of Thoracic and Cardiovascular Surgery.

Research output: Contribution to journalArticle

Open Access
Dissection
ROC Curve
Proportional Hazards Models
Ulcer
Incidence
4 Citations (Scopus)

Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system

Yoshimatsu, S., Okahara, J., Sone, T., Takeda, Y., Nakamura, M., Sasaki, E., Kishi, N., Shiozawa, S. & Okano, H., 2019 Dec 1, In : Scientific Reports. 9, 1, 1528.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Callithrix
Embryonic Stem Cells
Embryonic Structures
Homologous Recombination
3 Citations (Scopus)

Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

Muraoka, N., Nara, K., Tamura, F., Kojima, H., Yamakawa, H., Sadahiro, T., Miyamoto, K., Isomi, M., Haginiwa, S., Tani, H., Kurotsu, S., Osakabe, R., Torii, S., Shimizu, S., Okano, H., Sugimoto, Y., Fukuda, K. & Ieda, M., 2019 Dec 1, In : Nature communications. 10, 1, 674.

Research output: Contribution to journalArticle

Receptors, Prostaglandin E, EP4 Subtype
prostaglandins
fibroblasts
Cyclooxygenase 2
Fibroblasts
1 Citation (Scopus)

Role of Postmastectomy Radiotherapy After Neoadjuvant Chemotherapy in Breast Cancer Patients: A Study from the Japanese Breast Cancer Registry

Miyashita, M., Niikura, N., Kumamaru, H., Miyata, H., Iwamoto, T., Kawai, M., Anan, K., Hayashi, N., Aogi, K., Ishida, T., Masuoka, H., Iijima, K., Masuda, S., Tsugawa, K., Kinoshita, T., Tsuda, H., Nakamura, S. & Tokuda, Y., 2019 Jan 1, In : Annals of Surgical Oncology.

Research output: Contribution to journalArticle

Registries
Radiotherapy
Breast Neoplasms
Drug Therapy
Survival

Role of the Immune System in the Development of the Central Nervous System

Morimoto, K. & Nakajima, K., 2019 Sep 3, In : Frontiers in Neuroscience. 13, 916.

Research output: Contribution to journalReview article

Open Access
Immune System
Central Nervous System
Brain
Lymphatic Vessels
Toll-Like Receptors

Ropinirole Hydrochloride, a Candidate Drug for ALS Treatment

Takahashi, S., Morimoto, S. & Okano, H., 2019 Sep 1, In : Brain and nerve = Shinkei kenkyu no shinpo. 71, 9, p. 943-952 10 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Induced Pluripotent Stem Cells
Pharmaceutical Preparations
Motor Neurons
RNA-Binding Protein FUS

Ropinirole Hydrochloride for ALS

Takahashi, S., Morimoto, S., Fukushima, K., Nakahara, J. & Okano, H., 2019 Nov 1, In : Brain and nerve = Shinkei kenkyu no shinpo. 71, 11, p. 1279-1288 10 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Motor Neurons
Pharmaceutical Preparations
Placebos
Clinical Trials
Open Access
Clinical Trials, Phase I
Amyotrophic Lateral Sclerosis
Labels
Placebos
Stem cells

Seasonal changes in indoor airborne fungal concentration in a hematology ward

Mori, T., Kikuchi, T., Kato, J., Koda, Y., Sakurai, M., Kikumi, O., Inose, R., Murata, M., Hasegawa, N., Nakayama, H., Yamazaki, R. & Okamoto, S., 2019 Jan 1, (Accepted/In press) In : Journal of Infection and Chemotherapy.

Research output: Contribution to journalArticle

Mycoses
Hematology
Air
Japan
Air Filters

Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study

JPHC Study Group, 2019 Dec 1, In : The American journal of clinical nutrition. 110, 6, p. 1449-1455 7 p.

Research output: Contribution to journalArticle

Seaweed
Japan
Cardiovascular Diseases
Public Health
Myocardial Ischemia

Semi-supervised deep learning of brain tissue segmentation

Ito, R., Nakae, K., Hata, J., Okano, H. & Ishii, S., 2019 Aug 1, In : Neural Networks. 116, p. 25-34 10 p.

Research output: Contribution to journalArticle

Brain
Tissue
Atlases
Image segmentation
Anatomists

Serum d-serine accumulation after proximal renal tubular damage involves neutral amino acid transporter Asc-1

Suzuki, M., Gonda, Y., Yamada, M., Vandebroek, A. A., Mita, M., Hamase, K., Yasui, M. & Sasabe, J., 2019 Dec 1, In : Scientific reports. 9, 1, 16705.

Research output: Contribution to journalArticle

Open Access
Neutral Amino Acid Transport Systems
Serine
Kidney
Serum
Cisplatin
Mycobacterium avium Complex
Lung Diseases
Observational Studies
Soil
Water
2 Citations (Scopus)

Significant association between joint ultrasonographic parameters and synovial inflammatory factors in rheumatoid arthritis

Kondo, Y., Suzuki, K., Inoue, Y., Sakata, K., Takahashi, C., Takeshita, M., Kassai, Y., Miyazaki, T., Morita, R., Niki, Y., Kaneko, Y., Yasuoka, H., Yamaoka, K., Yoshimura, A. & Takeuchi, T., 2019 Oct 1, In : Arthritis Research and Therapy. 21, 1, 14.

Research output: Contribution to journalArticle

Ultrasonography
Rheumatoid Arthritis
Joints
Synovitis
Synovial Membrane

Sitafloxacin-containing regimen for the treatment of refractory mycobacterium avium complex lung disease

Asakura, T., Suzuki, S., Fukano, H., Okamori, S., Kusumoto, T., Uwamino, Y., Ogawa, T., So, M., Uno, S., Namkoong, H., Yoshida, M., Kamata, H., Ishii, M., Nishimura, T., Hoshino, Y. & Hasegawa, N., 2019 Apr 1, In : Open Forum Infectious Diseases. 6, 4, ofz108.

Research output: Contribution to journalArticle

Open Access
Mycobacterium avium Complex
Lung Diseases
Sputum
Therapeutics
Macrolides

Sleep stage detection using only heart rate

Mitsukura, Y., Fukunaga, K., Yasui, M. & Mimura, M., 2019 Jan 1, In : Health Informatics Journal.

Research output: Contribution to journalArticle

Sleep Stages
Sleep
Heart Rate
Polysomnography
Sleep Deprivation

"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu, E., Ogawa, Y., Yazu, H., Aketa, N., Yang, F., Yamane, M., Sato, Y., Kawakami, Y. & Tsubota, K., 2019 May 1, In : PloS one. 14, 5, e0215130.

Research output: Contribution to journalArticle

eye diseases
Eye Diseases
disease models
Tears
cameras

Socioeconomic and lifestyle factors associated with depressive tendencies in general Japanese men and women: NIPPON DATA2010

Suzuki, H., Kadota, A., Okuda, N., Hayakawa, T., Nishi, N., Nakamura, Y., Arima, H., Miyagawa, N., Satoh, A., Miyamatsu, N., Yanagita, M., Yatsuya, H., Yamagata, Z., Ohkubo, T., Okamura, T., Ueshima, H., Okayama, A. & Miura, K., 2019 May 28, In : Environmental Health and Preventive Medicine. 24, 1, 37.

Research output: Contribution to journalArticle

Open Access
Life Style
Odds Ratio
Depression
Confidence Intervals
Psychiatry

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

Iida, M., Sahashi, K., Kondo, N., Nakatsuji, H., Tohnai, G., Tsutsumi, Y., Noda, S., Murakami, A., Onodera, K., Okada, Y., Nakatochi, M., Tsukagoshi Okabe, Y., Shimizu, S., Mizuno, M., Adachi, H., Okano, H., Sobue, G. & Katsuno, M., 2019 Sep 19, In : Nature communications. 10, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Atrophic Muscular Disorders
atrophy
degeneration
Androgen Receptors
mice

Steatotic and nonsteatotic scirrhous hepatocellular carcinomas reveal distinct clinicopathological features

Hatano, M., Ojima, H., Masugi, Y., Tsujikawa, H., Hiraoka, N., Kanai, Y., Shimada, K., Shinoda, M. & Sakamoto, M., 2019 Apr 1, In : Human Pathology. 86, p. 222-232 11 p.

Research output: Contribution to journalArticle

Scirrhous Adenocarcinoma
Hepatocellular Carcinoma
Catenins
Neoplasms
Stem Cells

Stereotactic radiosurgery in elderly patients with brain metastases: comparison with non-elderly patients using database of a multi-institutional prospective observational study (JLGK0901-Elderly)

Higuchi, Y., Yamamoto, M., Serizawa, T., Sato, Y., Shuto, T., Akabane, A., Jokura, H., Yomo, S., Nagano, O., Kawagishi, J., Yamanaka, K. & Aoyama, H., 2019 Jan 1, In : Journal of Neuro-Oncology.

Research output: Contribution to journalArticle

Radiosurgery
Observational Studies
Databases
Prospective Studies
Neoplasm Metastasis
3 Citations (Scopus)

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

Naito, H., Iba, T., Wakabayashi, T., Tai-Nagara, I., Suehiro, J. I., Jia, W., Eino, D., Sakimoto, S., Muramatsu, F., Kidoya, H., Sakurai, H., Satoh, T., Akira, S., Kubota, Y. & Takakura, N., 2019 Jan 28, In : Developmental Cell. 48, 2, p. 151-166.e7

Research output: Contribution to journalArticle

Endothelial cells
Blood Vessels
Endothelial Cells
Apoptosis
Myeloid Cells

Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands

Takeo, E., Sugiura, Y., Uemura, T., Nishimoto, K., Yasuda, M., Sugiyama, E., Ohtsuki, S., Higashi, T., Nishikawa, T., Suematsu, M., Fukusaki, E. & Shimma, S., 2019 Jan 1, In : Analytical chemistry.

Research output: Contribution to journalArticle

Aldosterone
Isomers
Mass spectrometry
Steroids
Imaging techniques

Tau isoform expression and phosphorylation in marmoset brains

Sharma, G., Huo, A., Kimura, T., Shiozawa, S., Kobayashi, R., Sahara, N., Ishibashi, M., Ishigaki, S., Saito, T., Ando, K., Murayama, S., Hasegawa, M., Sobue, G., Okano, H. & Hisanaga, S. I., 2019 Jan 1, In : Journal of Biological Chemistry. 294, 30, p. 11433-11444 12 p.

Research output: Contribution to journalArticle

Open Access
Callithrix
Phosphorylation
Brain
Protein Isoforms
Neurodegenerative diseases

Taxane-based combinations as adjuvant chemotherapy for node-positive ER-positive breast cancer based on 2004–2009 data from the Breast Cancer Registry of the Japanese Breast Cancer Society

Hojo, T., Masuda, N., Iwamoto, T., Niikura, N., Anan, K., Aogi, K., Ohnishi, T., Yamauchi, C., Yoshida, M., Kinoshita, T., Masuoka, H., Sagara, Y., Sakatani, T., Kojima, Y., Tsuda, H., Kumamaru, H., Miyata, H. & Nakamura, S., 2019 Jan 1, In : Breast Cancer.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Estrogen Receptors
Registries
Breast Neoplasms
Anthracyclines

Template Activating Factor-I α Regulates Retroviral Silencing during Reprogramming

Bui, P. L., Nishimura, K., Seminario Mondejar, G., Kumar, A., Aizawa, S., Murano, K., Nagata, K., Hayashi, Y., Fukuda, A., Onuma, Y., Ito, Y., Nakanishi, M. & Hisatake, K., 2019 Nov 12, In : Cell Reports. 29, 7, p. 1909-1922.e5

Research output: Contribution to journalArticle

Open Access
Endogenous Retroviruses
Histone Acetyltransferases
Sendai virus
Induced Pluripotent Stem Cells
Proviruses

The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury

Hoshino, Y., Nishide, K., Nagoshi, N., Shibata, S., Moritoki, N., Kojima, K., Tsuji, O., Matsumoto, M., Kohyama, J., Nakamura, M. & Okano, H., 2019 Dec 1, In : Scientific reports. 9, 1, 9844.

Research output: Contribution to journalArticle

Open Access
Dependovirus
Spinal Cord Injuries
Venus
Tropism
Genes

The association of home and accurately measured office blood pressure with coronary artery calcification among general Japanese men

Satoh, A., Arima, H., Hozawa, A., Ohkubo, T., Hisamatsu, T., Kadowaki, S., Kadota, A., Fujiyoshi, A., Miyagawa, N., Zaid, M., Torii, S., Okamura, T., Sekikawa, A., Miura, K. & Ueshima, H., 2019 Aug 1, In : Journal of hypertension. 37, 8, p. 1676-1681 6 p.

Research output: Contribution to journalArticle

Coronary Vessels
Blood Pressure
Confidence Intervals
Odds Ratio
Population
2 Citations (Scopus)

The effect of body weight in infants undergoing ventricular septal defect closure: A report from the Nationwide Japanese Congenital Surgical Database

Inohara, T., Ichihara, N., Kosaka, S., Miyata, H., Hirata, Y., Murakami, A., Shimizu, H. & Aeba, R., 2019 Mar 1, In : Journal of Thoracic and Cardiovascular Surgery. 157, 3, p. 1132-1141.e7

Research output: Contribution to journalArticle

Ventricular Heart Septal Defects
Body Weight
Databases
Morbidity
Mortality

The impact of EGFR-TKI use on clinical outcomes of lung adenocarcinoma patients with brain metastases after Gamma Knife radiosurgery: a propensity score-matched analysis based on extended JLGK0901 dataset (JLGK0901-EGFR-TKI)

Yomo, S., Serizawa, T., Yamamoto, M., Higuchi, Y., Sato, Y., Shuto, T., Akabane, A., Jokura, H., Kawagishi, J. & Aoyama, H., 2019 Oct 1, In : Journal of Neuro-Oncology. 145, 1, p. 151-157 7 p.

Research output: Contribution to journalArticle

Propensity Score
Radiosurgery
Epidermal Growth Factor Receptor
Protein-Tyrosine Kinases
Neoplasm Metastasis
5 Citations (Scopus)

The impact of sex on risk of cardiovascular disease and all-cause mortality in adults with or without diabetes mellitus: A comparison between the U.S. and Japan

Liu, L., Miura, K., Kadota, A., Fujiyoshi, A., Gracely, E. J., Xue, F., Liu, Z., Takashima, N., Miyagawa, N., Ohkubo, T., Arima, H., Okayama, A., Okamura, T. & Ueshima, H., 2019 Jan 1, In : Journal of Diabetes and its Complications.

Research output: Contribution to journalArticle

Diabetes Mellitus
Japan
Cardiovascular Diseases
Mortality
Heart Diseases

The Liver-Stage Plasmodium Infection Is a Critical Checkpoint for Development of Experimental Cerebral Malaria

Sato, Y., Ries, S., Stenzel, W., Fillatreau, S. & Matuschewski, K., 2019 Nov 1, In : Frontiers in Immunology. 10, 2554.

Research output: Contribution to journalArticle

Open Access
Cerebral Malaria
Malaria
Liver
Infection
Sporozoites
1 Citation (Scopus)

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

Kim, J., Park, J. R., Choi, J., Park, I., Hwang, Y., Bae, H., Kim, Y., Choi, W. J., Yang, J. M., Han, S., Chung, T. Y., Kim, P., Kubota, Y., Augustin, H. G., Oh, W. Y. & Koh, G. Y., 2019 Feb 13, In : Science Advances. 5, 2, eaau6732.

Research output: Contribution to journalArticle

degeneration
regeneration
activation
antibodies
angiogenesis