Departments of Basic Medical Sciences

Research Output 1978 2020

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2019

In Vitro Conversion of Activated T Cells into Stem Cell Memory-Like T Cells

Kondo, T., Imura, Y., Ando, M., Chikuma, S. & Yoshimura, A., 2019 Jan 1, Methods in Molecular Biology. Humana Press Inc., p. 41-51 11 p. (Methods in Molecular Biology; vol. 2048).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stem Cells
T-Lymphocytes
Neoplasm Antigens
Cell- and Tissue-Based Therapy
Coculture Techniques
2018
1 Citation (Scopus)

Assessment of mitophagy in iPS cell-derived neurons

Ishikawa, K. I., Yamaguchi, A., Okano, H. & Akamatsu, W., 2018 Jan 1, Methods in Molecular Biology. Humana Press Inc., p. 59-67 9 p. (Methods in Molecular Biology; vol. 1759).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mitochondrial Degradation
Induced Pluripotent Stem Cells
Neurons
Mitochondria
Homeostasis
3 Citations (Scopus)

Isolation of cancer stem cells by side population method

Shimoda, M., Ota, M. & Okada, Y., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1692. p. 49-59 11 p. (Methods in Molecular Biology; vol. 1692).

Research output: Chapter in Book/Report/Conference proceedingChapter

Side-Population Cells
Neoplastic Stem Cells
ATP-Binding Cassette Transporters
Population
Flow Cytometry

Profiling open chromatin structure in the ovarian somatic cells using ATAC-seq

Murano, K., Iwasaki, Y. & Siomi, H., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1680. p. 165-177 13 p. (Methods in Molecular Biology; vol. 1680).

Research output: Chapter in Book/Report/Conference proceedingChapter

Transposases
Chromatin
DNA Transposable Elements
Deoxyribonucleases
Heterochromatin
2017
12 Citations (Scopus)

CTLA-4, an essential immune-checkpoint for T-Cell activation

Chikuma, S., 2017 Jan 1, Current Topics in Microbiology and Immunology. Springer Verlag, Vol. 410. p. 99-126 28 p. (Current Topics in Microbiology and Immunology; vol. 410).

Research output: Chapter in Book/Report/Conference proceedingChapter

T-Lymphocytes
Antigen-Presenting Cells
CD86 Antigens
Immunological Synapses
Antibodies, Monoclonal, Humanized
1 Citation (Scopus)

Identification of mouse piRNA pathway components using anti-MIWI2 antibodies

Hirano, T., Hasuwa, H. & Siomi, H., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1463. p. 205-216 12 p. (Methods in Molecular Biology; vol. 1463).

Research output: Chapter in Book/Report/Conference proceedingChapter

Epigenomics
Small Interfering RNA
Anti-Idiotypic Antibodies
RNA
Biological Phenomena
1 Citation (Scopus)

Neuroscience research using non-human primate models and genome editing

Kishi, N. & Okano, H., 2017, Research and Perspectives in Neurosciences. 9783319601915 ed. Springer Verlag, p. 73-81 9 p. (Research and Perspectives in Neurosciences; no. 9783319601915).

Research output: Chapter in Book/Report/Conference proceedingChapter

Callithrix
Neurosciences
Primates
Research
Germ Cells
2016
2 Citations (Scopus)

Abnormal D-serine metabolism in amyotrophic lateral sclerosis

Sasabe, J. & Aiso, S., 2016 Jan 1, D-Amino Acids: Physiology, Metabolism, and Application. Springer Japan, p. 137-149 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyotrophic Lateral Sclerosis
Metabolism
Serine
D-Amino-Acid Oxidase
Motor Neurons

Air pollution and health in Japan

Takebayashi, T., 2016 Apr 6, Hazardous Air Pollutants: Case Studies from Asia. CRC Press, p. 65-75 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Air Pollution
air pollution
Japan
atmospheric pollution
Health

Autophagy

Tsugawa, H. & Suzuki, H., 2016 Jan 1, Helicobacter Pylori. Springer Japan, p. 67-71 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Autophagy
Cytotoxins
Helicobacter pylori
Stomach Neoplasms
Low Density Lipoprotein Receptor-Related Protein-1
14 Citations (Scopus)

In vitro Th differentiation protocol

Sekiya, T. & Yoshimura, A., 2016, Methods in Molecular Biology. Humana Press Inc., Vol. 1344. p. 183-191 9 p. (Methods in Molecular Biology; vol. 1344).

Research output: Chapter in Book/Report/Conference proceedingChapter

Regulatory T-Lymphocytes
T-Lymphocytes
Th17 Cells
Th2 Cells
Th1 Cells

Long-term depression at parallel fiber-Purkinje cell synapses

Kohda, K., Kakegawa, W. & Yuzaki, M., 2016 Jan 1, Essentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students. Springer International Publishing, p. 329-334 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

fiber cells
Purkinje Cells
endocytosis
dendritic cells
synapse

Physiological functions of D-serine mediated through δ2 glutamate receptors in the cerebellum

Kakegawa, W. & Yuzaki, M., 2016 Jan 1, D-Amino Acids: Physiology, Metabolism, and Application. Springer Japan, p. 65-80 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ionotropic Glutamate Receptors
Glutamate Receptors
Cerebellum
Serine
Neuronal Plasticity
2015
1 Citation (Scopus)

Immuno-electron microscopy and electron microscopic in situ hybridization for visualizing pirna biogenesis bodies in Drosophila ovaries

Shibata, S., Murota, Y., Nishimoto, Y., Yoshimura, M., Nagai, T., Okano, H. & Siomi, M. C., 2015 Aug 31, Drosophila Oogenesis: Methods and Protocols. Springer New York, p. 163-178 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunoelectron Microscopy
somatic cells
Gold
in situ hybridization
gold
2014

[Indium lung disease].

Nakano, M. & Omae, K., 2014, Nihon rinsho. Japanese journal of clinical medicine. 2 ed. Vol. 72. p. 317-322 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Indium
Lung Diseases
Japan
Pulmonary Alveolar Proteinosis
Interstitial Lung Diseases

[Series: Clinical study from Japan and its reflections; LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men].

Okamura, T., Sekikawa, A., Sawamura, T. & Ueshima, H., 2014, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 1 ed. Vol. 103. p. 173-180 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Application of microRNA in the treatment and diagnosis of cervical cancer

Banno, K., Iida, M., Yanokura, M., Kisu, I., Nakamura, K., Adachi, M., Iwata, T., Tanaka, K. & Aoki, D., 2014 Feb 1, MicroRNA Targeted Cancer Therapy. Springer International Publishing, p. 129-137 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

MicroRNAs
Uterine Cervical Neoplasms
Neoplasms
Carcinogenesis
Small Untranslated RNA

Direct Induction of Neural Stem Cells from Somatic Cells

Akamatsu, W. & Okano, H., 2014 Nov 13, Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition. Elsevier Inc., p. 103-106 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Induced Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Spinal Cord Injuries
Fibroblasts

Novel therapeutic agents for treatment of endometrial cancer

Banno, K., Iida, M., Farghaly, S. A., Umene, K., Kisu, I. & Aoki, D., 2014 Oct 1, Endometrial Cancer: Current Epidemiology, Detection and Management. Nova Science Publishers, Inc., p. 321-337 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endometrial Neoplasms
Sirolimus
dienogest
Neoplasms
Therapeutics

RNAi and overexpression of genes in ovarian somatic cells

Saito, K., 2014, Methods in Molecular Biology. Vol. 1093. p. 25-33 9 p. (Methods in Molecular Biology; vol. 1093).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA Interference
Germ Cells
Drosophila
Genes
Cell Line
5 Citations (Scopus)

RNAi and overexpression of genes in ovarian somatic cells

Saito, K., 2014, Methods in Molecular Biology. Humana Press Inc., Vol. 1093. p. 25-33 9 p. (Methods in Molecular Biology; vol. 1093).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA Interference
Germ Cells
Drosophila
Genes
Cell Line
1 Citation (Scopus)

The Potential of Using Induced Pluripotent Stem Cells in Skin Diseases

Ota, S., Veraitch, O., Okano, H., Ohyama, M. & Kawakami, Y., 2014 Nov 10, Cell and Molecular Biology and Imaging of Stem Cells. Wiley Blackwell, p. 223-245 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Induced Pluripotent Stem Cells
Stem cells
Skin Diseases
Skin
Neoplastic Stem Cells

Water Biology in Human Body

Yasui, M., 2014 Jul 25, Comprehensive Biomedical Physics. Elsevier, Vol. 10. p. 83-89 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

human body
biology
water
water balance
secretions
2013

ADAM28

Mochizuki, S. & Okada, Y., 2013, Handbook of Proteolytic Enzymes. Elsevier Ltd, Vol. 1. p. 1136-1139 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Assessment of injured spinal cord using diffusion tensor tractography

Fujiyoshi, K., Konomi, T., Tsuji, O., Yamada, M., Hikishima, K., Momoshima, S., Okano, H., Toyama, Y. & Nakamura, M., 2013 Nov 1, Neuroprotection and Regeneration of the Spinal Cord. Springer Japan, Vol. 9784431545026. p. 345-365 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Diffusion Tensor Imaging
Spinal Cord
Spinal Cord Injuries
Magnetic Resonance Imaging
Callithrix

Biochemistry and Metabolism of Toxoplasma gondii. Carbohydrates, Lipids and Nucleotides.

Coppens, I., Asai, T. & Tomavo, S., 2013 Sep, Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition. Elsevier Ltd., p. 257-295 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Toxoplasma
Biochemistry
Nucleotides
Carbohydrates
Apicomplexa
5 Citations (Scopus)

Cell Polarity and Initiation of Migration

Sekine, K., Tabata, H. & Nakajima, K., 2013, Cellular Migration and Formation of Neuronal Connections. Elsevier Inc., p. 231-244 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell Polarity
11 Citations (Scopus)

Generation of human melanocytes from induced pluripotent stem cells

Ota, S., Imaizumi, Y., Akamatsu, W., Okano, H. & Kawakami, Y., 2013, Methods in Molecular Biology. Vol. 989. p. 193-215 23 p. (Methods in Molecular Biology; vol. 989).

Research output: Chapter in Book/Report/Conference proceedingChapter

Induced Pluripotent Stem Cells
Melanocytes
Stem Cells
Hair Follicle
Human Development
1 Citation (Scopus)

In vivo tracing of neural tracts in tiptoe-walking yoshimura mice by diffusion tensor tractography

Takano, M., Komaki, Y., Hikishima, K., Konomi, T., Fujiyoshi, K., Tsuji, O., Okano, H., Toyama, Y. & Nakamura, M., 2013 Nov 1, Neuroprotection and Regeneration of the Spinal Cord. Springer Japan, Vol. 9784431545026. p. 107-117 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Diffusion Tensor Imaging
Walking
Ossification of Posterior Longitudinal Ligament
Spinal Cord Compression
Spinal Cord

Purification of dFMR1-containing complexes using tandem affinity purification

Miyoshi, K., Ogino, A., Siomi, M. C. & Siomi, H., 2013, Methods in Molecular Biology. Vol. 1010. p. 111-121 11 p. (Methods in Molecular Biology; vol. 1010).

Research output: Chapter in Book/Report/Conference proceedingChapter

Fragile X Syndrome
RNA Interference
Drosophila
Proteins
RNA
2 Citations (Scopus)

Recombinant human hepatocyte growth factor promotes functional recovery after spinal cord injury

Kitamura, K., Iwanami, A., Fujiyoshi, K., Yamane, J. I., Hikishima, K., Funakoshi, H., Nakamura, T., Aoki, M., Toyama, Y., Okano, H. & Nakamura, M., 2013 Nov 1, Neuroprotection and Regeneration of the Spinal Cord. Springer Japan, Vol. 9784431545026. p. 147-167 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hepatocyte Growth Factor
Spinal Cord Injuries
Therapeutic Uses
Primates
Callithrix

Regenerative medicine for spinal cord injury utilizing iPS cells

Tsuji, O., Nori, S., Kobayashi, Y., Fujiyoshi, K., Okano, H., Toyama, Y. & Nakamura, M., 2013 Nov 1, Neuroprotection and Regeneration of the Spinal Cord. Springer Japan, Vol. 9784431545026. p. 229-245 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Induced Pluripotent Stem Cells
Regenerative Medicine
Spinal Cord Injuries
Stem Cells
Neural Stem Cells
1 Citation (Scopus)

Regulatory mechanisms underlying the neurogenesis-to-gliogenesis switch by neural stem cells

Shimazaki, T., 2013 Jan 1, Cortical Development: Neural Diversity and Neocortical Organization. Springer Japan, p. 63-88 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Stem Cells
Neurogenesis
Adult Stem Cells
Central Nervous System
Neuroglia
2012

Atherosclerosis: Risk factors, prevention and treatment

Nakajima, K. & Fujita, M. Q., 2012 Mar, Atherosclerosis: Risk Factors, Prevention and Treatment. Nova Science Publishers, Inc., p. 41-70 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Atherosclerosis

Characterisation of neural crest-derived stem cells in different tissues

Nagoshi, N. & Okano, H., 2012 Jan 1, Neural Crest Stem Cells: Breakthroughs and Applications. World Scientific Publishing Co., p. 87-107 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neural Crest
Stem cells
Stem Cells
Tissue
Cranes
7 Citations (Scopus)

Derivation of induced pluripotent stem cells by retroviral gene transduction in mammalian species

Imamura, M., Okuno, H., Tomioka, I., Kawamura, Y., Lin, Z. Y. C., Nakajima, R., Akamatsu, W., Okano, H. J., Matsuzaki, Y., Sasaki, E. & Okano, H., 2012, Methods in Molecular Biology. Vol. 925. p. 21-48 28 p. (Methods in Molecular Biology; vol. 925).

Research output: Chapter in Book/Report/Conference proceedingChapter

Induced Pluripotent Stem Cells
Callithrix
Pluripotent Stem Cells
Genes
Genomic Imprinting

Generation of neural cells from pluripotent stem cells

Shimazaki, T. & Okano, H., 2012 Jan 1, Nuclear Reprogramming and Stem Cells. Humana Press Inc., p. 127-140 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Induced Pluripotent Stem Cells
Pluripotent Stem Cells
Stem cells
Preclinical Drug Evaluations
Inborn Genetic Diseases
2 Citations (Scopus)

Japan’s long-term care regulations focused on structure – rationale and future prospects

Ikegami, N., Ishibashi, T. & Amano, T., 2012 Jan 1, Regulating Long-Term Care Quality: An International Comparison. Cambridge University Press, p. 121-144 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Long-term care
Rationale
Japan
Government
Lobbies
1 Citation (Scopus)

Nanoparticle-assisted laser desorption/ionization (nano- PALDI)-based imaging mass spectrometry (IMS) and its application to brain sciences

Hameed, S., Sugiura, Y., Kimura, Y., Shrivas, K. K. & Setou, M., 2012 Jan 1, Nanomedicine and the Nervous System. CRC Press, p. 97-118 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanoparticles
Ionization
Mass spectrometry
Desorption
Brain
25 Citations (Scopus)

Notch signaling and the developing inner ear

Murata, J., Ikeda, K. & Okano, H., 2012, Advances in Experimental Medicine and Biology. Vol. 727. p. 161-173 13 p. (Advances in Experimental Medicine and Biology; vol. 727).

Research output: Chapter in Book/Report/Conference proceedingChapter

Inner Ear
Delamination
Ligands
Mammals
Gene expression

Pharmaceutical implications of curcumin in the development of drugs for cf pharmacotherapy: Combined effects with genistein

Sohma, Y., Yu, Y. C., Miki, H., Nakamura, Y., Hanyuda, A., Lin, H. Y., Yasui, M., Bompadre, S. & Hwang, T. C., 2012 Feb, Curcumin: Biosynthesis, Medicinal Uses and Health Benefits. Nova Science Publishers, Inc., p. 223-234 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cystic Fibrosis Transmembrane Conductance Regulator
Curcumin
curcumin
Genistein
cystic fibrosis
2 Citations (Scopus)

Structure, function and formation of glycans in Drosophila

Yamamoto-Hino, M., Okano, H., Kanie, O. & Goto, S., 2012 Feb, Glycans: Biochemistry, Characterization and Applications. Nova Science Publishers, Inc., p. 165-188 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Drosophila
Polysaccharides
Glycosylation
Cytology
Mammals
2011
1 Citation (Scopus)

Roles of stress-inducible carbon monoxide in the regulation of liver function

Suematsu, M., Kajimura, M. & Kabe, Y., 2011 Feb 1, Gas Biology Research in Clinical Practice. S. Karger AG, p. 1-5 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carbon Monoxide
Liver
Heme Oxygenase (Decyclizing)
Heme
Cystathionine
2010

Affinity magnetic beads for chemical biology and medicine

Iizumi, Y., Kabe, Y., Hatakeyama, M., Sakamoto, S. & Handa, H., 2010 Jan 1, Colloids in Biotechnology. CRC Press, p. 197-208 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Medicine
Chemical compounds
Purification
Proteins
Nanoparticles

Carbon monoxide-dependent regulation of microvascular function: One gas regulates another

Suematsu, M., Kajimura, M. & Kabe, Y., 2010 Dec 21, Free Radical Biology in Digestive Diseases. S. Karger AG, Vol. 29. p. 79-84 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Carbon Monoxide
carbon monoxide
Gases
Gasotransmitters
gases

Carbon monoxide-dependent regulation of microvascular function: One gas regulates another

Suematsu, M., Kajimura, M. & Kabe, Y., 2010 Dec, Frontiers of Gastrointestinal Research. Vol. 29. p. 79-84 6 p. (Frontiers of Gastrointestinal Research; vol. 29).

Research output: Chapter in Book/Report/Conference proceedingChapter

Carbon Monoxide
Gases
Gasotransmitters
Cystathionine
Hemeproteins
1 Citation (Scopus)

Free radicals in helicobacter pylori infection

Suzuki, H., Nishizawa, T., Tsugawa, H. & Hibi, T., 2010 Dec, Frontiers of Gastrointestinal Research. Vol. 29. p. 111-120 10 p. (Frontiers of Gastrointestinal Research; vol. 29).

Research output: Chapter in Book/Report/Conference proceedingChapter

Helicobacter Infections
Helicobacter pylori
Free Radicals
Gastric Mucosa
Stomach

Free radicals in Helicobacter pylori infection

Suzuki, H., Nishizawa, T., Tsugawa, H. & Hibi, T., 2010 Dec 21, Free Radical Biology in Digestive Diseases. S. Karger AG, Vol. 29. p. 111-120 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Helicobacter Infections
infectious diseases
Helicobacter pylori
free radicals
Free Radicals
2009
2 Citations (Scopus)

Comprehensive long-term care in Japan and Germany: Policy learning and cross-national comparison

Campbell, J. C. & Ikegami, N., 2009, Comparative Studies and the Politics of Modern Medical Care. Yale University Press, p. 265-287 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Long-Term Care
Germany
Japan
Learning
learning
1 Citation (Scopus)

In utero electroporation: Assay system for migration of cerebral cortical neurons

Tabata, H. & Nakajima, K., 2009, Electroporation and Sonoporation in Developmental Biology. Springer Japan, p. 143-152 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurons
Assays
On-off control systems
Plasmids
Genes