Departments of Basic Medical Sciences

Research Output 1978 2020

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Review article
2019
3 Citations (Scopus)

Are We There Yet? How and When Specific Biotechnologies Will Improve Human Health

O'Day, E., Hosta-Rigau, L., Oyarzún, D. A., Okano, H., de Lorenzo, V., von Kameke, C., Alsafar, H., Cao, C., Chen, G. Q., Ji, W., Roberts, R. J., Ronaghi, M., Yeung, K., Zhang, F. & Lee, S. Y., 2019 Jan 1, In : Biotechnology Journal. 14, 1, 1800195.

Research output: Contribution to journalReview article

Open Access
glimepiride
Biotechnology
Hip
Hip Replacement Arthroplasties
Metformin
1 Citation (Scopus)

Can cognitive leisure activity prevent cognitive decline in older adults? A systematic review of intervention studies

Iizuka, A., Suzuki, H., Ogawa, S., Kobayashi-Cuya, K. E., Kobayashi, M., Takebayashi, T. & Fujiwara, Y., 2019 Jan 1, In : Geriatrics and Gerontology International.

Research output: Contribution to journalReview article

Leisure Activities
Art
Cognition
Reading
Learning

Cell therapy for spinal cord injury using induced pluripotent stem cells

Nagoshi, N., Tsuji, O., Nakamura, M. & Okano, H., 2019 Dec 1, In : Regenerative Therapy. 11, p. 75-80 6 p.

Research output: Contribution to journalReview article

Open Access
Induced Pluripotent Stem Cells
Cell- and Tissue-Based Therapy
Stem cells
Spinal Cord Injuries
Cytology
Thoracic Surgery
Japan
Databases
Prostheses and Implants
Mitral Valve

Current status of cardiovascular surgery in Japan, 2015 and 2016: a report based on the Japan Cardiovascular Surgery Database. 1—congenital heart surgery

Hirata, Y., Hirahara, N., Murakami, A., Motomura, N., Miyata, H. & Takamoto, S., 2019 Sep 5, In : General thoracic and cardiovascular surgery. 67, 9, p. 731-735 5 p.

Research output: Contribution to journalReview article

Thoracic Surgery
Japan
Databases
Mortality
Norwood Procedures
Japan
Thorax
Databases
Thoracic Aorta
Stroke
Coronary Artery Bypass
Japan
Databases
Mammary Arteries
Arteries

Distinctive roles of d-Amino acids in the homochiral world: Chirality of amino acids modulates mammalian physiology and pathology

Sasabe, J. & Suzuki, M., 2019 Jan 1, In : Keio Journal of Medicine. 68, 1, p. 1-16 16 p.

Research output: Contribution to journalReview article

Open Access
Pathology
Serine
Amino Acids
Aspartic Acid
Synaptic Transmission
12 Citations (Scopus)

Mining the microbiota for microbial and metabolite-based immunotherapies

Skelly, A. N., Sato, Y., Kearney, S. & Honda, K., 2019 Jan 1, In : Nature Reviews Immunology.

Research output: Contribution to journalReview article

Microbiota
Immunotherapy
Bacteria
Phenotype
Gastrointestinal Tract

Role of the Immune System in the Development of the Central Nervous System

Morimoto, K. & Nakajima, K., 2019 Sep 3, In : Frontiers in Neuroscience. 13, 916.

Research output: Contribution to journalReview article

Open Access
Immune System
Central Nervous System
Brain
Lymphatic Vessels
Toll-Like Receptors

Update of occupational lung disease

Japan Society for Occupational Health Occupational Lung Disease Study Group, 2019 Jan 1, In : Journal of Occupational Health. 61, 1, p. 10-18 9 p.

Research output: Contribution to journalReview article

Occupational diseases
Pulmonary diseases
Occupational Diseases
Lung Diseases
Occupational Health
2018

Development and Functional Modulation of Regulatory T Cells by Transcription Factors and Epigenetics

Ito, M., Iizuka-Koga, M., Ando, M. & Yoshimura, A., 2018 Nov 1, In : Cornea. 37, p. S42-S49

Research output: Contribution to journalReview article

TCF Transcription Factors
Regulatory T-Lymphocytes
Epigenomics
Transcription Factors
Homeostasis

Exposure Assessment in Japan Environment and Children's Study

Nakayama, S. F., Isobe, T., Iwai-Shimada, M., Kobayashi, Y., Oguri, T. & Takeuchi, A., 2018 Jan 1, In : Nihon eiseigaku zasshi. Japanese journal of hygiene. 73, 2, p. 156-163 8 p.

Research output: Contribution to journalReview article

Japan
Environmental Monitoring
Parturition
Hair
Pharmacokinetics
1 Citation (Scopus)

Function and structural regulation of the carbon monoxide (CO)-responsive membrane protein PGRMC1

Kabe, Y., Handa, H. & Suematsu, M., 2018 Jul 1, In : Journal of Clinical Biochemistry and Nutrition. 63, 1, p. 12-17 6 p.

Research output: Contribution to journalReview article

Progesterone Receptors
Carbon Monoxide
Membrane Proteins
Membranes
Heme
9 Citations (Scopus)

Investigation of brain science and neurological/psychiatric disorders using genetically modified non-human primates

Okano, H. & Kishi, N., 2018 Jun 1, In : Current Opinion in Neurobiology. 50, p. 1-6 6 p.

Research output: Contribution to journalReview article

Nervous System Diseases
Primates
Psychiatry
Rodentia
Brain
6 Citations (Scopus)

Observational Evidence of the Association Between Handgrip Strength, Hand Dexterity, and Cognitive Performance in Community-Dwelling Older Adults: A Systematic Review

Kobayashi-Cuya, K. E., Sakurai, R., Suzuki, H., Ogawa, S., Takebayashi, T. & Fujiwara, Y., 2018 Sep 5, In : Journal of Epidemiology. 28, 9, p. 373-381 9 p.

Research output: Contribution to journalReview article

Independent Living
Hand Strength
Hand
Observational Studies
Longitudinal Studies
1 Citation (Scopus)

Rab family small GTPases-mediated regulation of intracellular logistics in neural development

Shikanai, M., Yuzaki, M. & Kawauchi, T., 2018 Aug 1, In : Histology and Histopathology. 33, 8, p. 765-771 7 p.

Research output: Contribution to journalReview article

Monomeric GTP-Binding Proteins
Proteins
PC12 Cells
Brain
Dendrites
2 Citations (Scopus)

Temporal trends in renal function and birthweight in Japanese adolescent males (1998-2015)

Kanda, T., Takeda, A., Hirose, H., Abe, T., Urai, H., Inokuchi, M., Wakino, S., Tokumura, M., Itoh, H. & Kawabe, H., 2018 Feb 1, In : Nephrology Dialysis Transplantation. 33, 2, p. 304-310 7 p.

Research output: Contribution to journalReview article

Glomerular Filtration Rate
Kidney
Population
Chronic Renal Insufficiency
Proteinuria

The mechanism underlying the resolution of sterile inflammation through scavenger receptor

Shchita, T. & Yoshimura, A., 2018 Jan 1, In : Seikagaku. 90, 1, p. 99-102 4 p.

Research output: Contribution to journalReview article

Scavenger Receptors
9 Citations (Scopus)

The updated network meta-analysis of neoadjuvant therapy for HER2-positive breast cancer

Nakashoji, A., Hayashida, T., Yokoe, T., Maeda, H., Toyota, T., Kikuchi, M., Watanuki, R., Nagayama, A., Seki, T., Takahashi, M., Abe, T. & Kitagawa, Y., 2018 Jan 1, In : Cancer Treatment Reviews. 62, p. 9-17 9 p.

Research output: Contribution to journalReview article

Neoadjuvant Therapy
Breast Neoplasms
Statistical Models
Network Meta-Analysis
human ERBB2 protein
7 Citations (Scopus)

Two Classes of Secreted Synaptic Organizers in the Central Nervous System

Yuzaki, M., 2018 Feb 10, In : Annual Review of Physiology. 80, p. 243-262 20 p.

Research output: Contribution to journalReview article

Central Nervous System
Glypicans
Semaphorins
Thrombospondins
Proteins
2017
2 Citations (Scopus)

Aberrant chromatin remodeling in gynecological cancer (Review)

Okawa, R., Banno, K., Iida, M., Yanokura, M., Takeda, T., Iijima, M., Irie, H. K., Nakamura, K., Adachi, M., Umene, K., Nogami, Y., Masuda, K., Kobayashi, Y., Tominaga, E. & Aoki, D., 2017 Nov 1, In : Oncology Letters. 14, 5, p. 5107-5113 7 p.

Research output: Contribution to journalReview article

Chromatin Assembly and Disassembly
Mutation
Chromatin
Myeloid-Lymphoid Leukemia Protein
Neoplasms
12 Citations (Scopus)
Cerebral Cortex
Neurons
Neocortex
Periventricular Nodular Heterotopia
Lissencephaly
2 Citations (Scopus)

Genome-wide analysis of gynecologic cancer: The cancer genome atlas in ovarian and endometrial cancer (Review)

Iijima, M., Banno, K., Okawa, R., Yanokura, M., Iida, M., Takeda, T., Kunitomi-Irie, H., Adachi, M., Nakamura, K., Umene, K., Nogami, Y., Masuda, K., Tominaga, E. & Aoki, D., 2017 Mar 1, In : Oncology Letters. 13, 3, p. 1063-1070 8 p.

Research output: Contribution to journalReview article

Atlases
Endometrial Neoplasms
Ovarian Neoplasms
Genome
Neoplasms

Identification of a novel CO-sensor protein PGRMCl that contributes to cancer proliferation

Kabe, Y. & Suematsu, M., 2017 Jan 1, In : Seikagaku. 89, 6, p. 889-893 5 p.

Research output: Contribution to journalReview article

Carbon Monoxide
Sensors
Proteins
21 Citations (Scopus)

Immunohistochemistry of aldosterone synthase leads the way to the pathogenesis of primary aldosteronism

Nishimoto, K., Koga, M., Seki, T., Oki, K., Gomez-Sanchez, E. P., Gomez-Sanchez, C. E., Naruse, M., Sakaguchi, T., Morita, S., Kosaka, T., Oya, M., Ogishima, T., Yasuda, M., Suematsu, M., Kabe, Y., Omura, M., Nishikawa, T. & Mukai, K., 2017 Feb 5, In : Molecular and Cellular Endocrinology. 441, p. 124-133 10 p.

Research output: Contribution to journalReview article

Cytochrome P-450 CYP11B2
Hyperaldosteronism
Steroid 11-beta-Hydroxylase
Zona Glomerulosa
Aldosterone
13 Citations (Scopus)

Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications

Iizuka-Koga, M., Nakatsukasa, H., Ito, M., Akanuma, T., Lu, Q. & Yoshimura, A., 2017 Sep 1, In : Journal of Autoimmunity. 83, p. 113-121 9 p.

Research output: Contribution to journalReview article

TCF Transcription Factors
Regulatory T-Lymphocytes
Epigenomics
Transcription Factors
Maintenance
2 Citations (Scopus)
Leukoencephalopathies
Cysts
Rare Diseases
Visual Fields
Cerebellum
6 Citations (Scopus)

New use of microsatellite instability analysis in endometrial cancer (Review)

Kunitomi, H., Banno, K., Yanokura, M., Takeda, T., Iijima, M., Nakamura, K., Iida, M., Adachi, M., Watanabe, K., Matoba, Y., Kobayashi, Y., Tominaga, E. & Aoki, D., 2017, In : Oncology Letters. 14, 3, p. 3297-3301 5 p.

Research output: Contribution to journalReview article

Microsatellite Instability
Endometrial Neoplasms
Pharmaceutical Preparations
Menarche
DNA Mismatch Repair
3 Citations (Scopus)

Optimal plateau pressure for patients with acute respiratory distress syndrome: A protocol for a systematic review and meta-analysis with meta-regression

Yasuda, H., Nishimura, T., Kamo, T., Sanui, M., Nango, E., Abe, T., Takebayashi, T., Lefor, A. K. & Hashimoto, S., 2017 May 1, In : BMJ Open. 7, 5, e015091.

Research output: Contribution to journalReview article

Adult Respiratory Distress Syndrome
Meta-Analysis
Pressure
Ventilator-Induced Lung Injury
Tidal Volume
3 Citations (Scopus)

Placebo effects in the treatment of Noncognitive symptoms of Alzheimer’s disease: Analysis of the CATIE-AD data

Ozawa, C., Roberts, R., Yoshida, K., Suzuki, T., Lebowitz, B., Reeves, S., Howard, R., Abe, T., Mimura, M. & Uchida, H., 2017 Nov 1, In : Journal of Clinical Psychiatry. 78, 9, p. e1204-e1210

Research output: Contribution to journalReview article

Placebo Effect
Antipsychotic Agents
Alzheimer Disease
Placebos
Clinical Trials
25 Citations (Scopus)

Suppressors of cytokine signaling: Potential immune checkpoint molecules for cancer immunotherapy

Chikuma, S., Kanamori, M., Mise-Omata, S. & Yoshimura, A., 2017 Apr 1, In : Cancer Science. 108, 4, p. 574-580 7 p.

Research output: Contribution to journalReview article

Immunotherapy
Suppressor of Cytokine Signaling Proteins
Cytokines
Janus Kinases
T-Lymphocytes
12 Citations (Scopus)

Synapse organization and modulation via C1q family proteins and their receptors in the central nervous system

Matsuda, K., 2017 Mar 1, In : Neuroscience Research. 116, p. 46-53 8 p.

Research output: Contribution to journalReview article

Synapses
Kainic Acid Receptors
Central Nervous System
Organizations
Glutamate Receptors
26 Citations (Scopus)

The C1q complement family of synaptic organizers: not just complementary

Yuzaki, M., 2017 Aug 1, In : Current Opinion in Neurobiology. 45, p. 9-15 7 p.

Research output: Contribution to journalReview article

Complement C1q
Synapses
Purkinje Cells
Maintenance
Kainic Acid Receptors
2 Citations (Scopus)
Regenerative Medicine
Spinal Cord Injuries
Animal Models
Therapeutics
Cell Transplantation
2016
10 Citations (Scopus)

CO-CBS-H2S Axis: From Vascular Mediator to Cancer Regulator

Suematsu, M., Nakamura, T., Tokumoto, Y., Yamamoto, T., Kajimura, M. & Kabe, Y., 2016, In : Microcirculation. 23, 3, p. 183-190 8 p.

Research output: Contribution to journalReview article

Carbon Monoxide
Blood Vessels
Neoplasms
Gasotransmitters
Hemeproteins
9 Citations (Scopus)

Cystathionine β-synthase and PGRMC1 as CO sensors

Kabe, Y., Yamamoto, T., Kajimura, M., Sugiura, Y., Koike, I., Ohmura, M., Nakamura, T., Tokumoto, Y., Tsugawa, H., Handa, H., Kobayashi, T. & Suematsu, M., 2016 Oct 1, In : Free Radical Biology and Medicine. 99, p. 333-344 12 p.

Research output: Contribution to journalReview article

Cystathionine
Progesterone Receptors
Carbon Monoxide
Heme
Membranes
4 Citations (Scopus)

Development of an annually updated Japanese national clinical database for chest surgery in 2014

Endo, S., Ikeda, N., Kondo, T., Nakajima, J., Kondo, H., Yokoi, K., Chida, M., Sato, M., Toyooka, S., Yoshida, K., Okada, Y., Sato, Y., Okumura, M., Masuda, M., Chihara, K. & Miyata, H., 2016 Oct 1, In : General Thoracic and Cardiovascular Surgery. 64, 10, p. 569-576 8 p.

Research output: Contribution to journalReview article

Thorax
Databases
Internet
Certification
Thoracic Surgery
95 Citations (Scopus)

Fecal microbiota transplantation for patients with steroid-resistant acute graft-versus-host disease of the gut

Kakihana, K., Fujioka, Y., Suda, W., Najima, Y., Kuwata, G., Sasajima, S., Mimura, I., Morita, H., Sugiyama, D., Nishikawa, H., Hattori, M., Hino, Y., Ikegawa, S., Yamamoto, K., Toya, T., Doki, N., Koizumi, K., Honda, K. & Ohashi, K., 2016 Oct 20, In : Blood. 128, 16, p. 2083-2088 6 p.

Research output: Contribution to journalReview article

Transplantation (surgical)
Graft vs Host Disease
Grafts
Stem cells
Steroids
65 Citations (Scopus)

Induced Regulatory T Cells: Their Development, Stability, and Applications

Kanamori, M., Nakatsukasa, H., Okada, M., Lu, Q. & Yoshimura, A., 2016 Nov 1, In : Trends in Immunology. 37, 11, p. 803-811 9 p.

Research output: Contribution to journalReview article

Regulatory T-Lymphocytes
Interleukin-2
Immune System
Transcription Factors
T-Lymphocytes
Methylation
Metabolism
Methionine
Arginine
Animals
Histocytochemistry
Molecular Pathology
Liver Neoplasms
Hepatocellular Carcinoma
Neoplasms
1 Citation (Scopus)

Molecular pathology and novel clinical therapy for uterine leiomyosarcoma

Hayashi, T., Kawano, M., Ichimura, T., Ida, K., Ando, H., Zharhary, D., Kanai, Y., Aburatani, H., Tonegawa, S., Shiozawa, T., Yaegashi, N. & Konishi, I., 2016 Oct 1, In : Anticancer Research. 36, 10, p. 4997-5007 11 p.

Research output: Contribution to journalReview article

Leiomyosarcoma
Molecular Pathology
Proteasome Endopeptidase Complex
Janus Kinase 1
STAT1 Transcription Factor
31 Citations (Scopus)

Reelin and neuropsychiatric disorders

Ishii, K., Kubo, K. & Nakajima, K., 2016 Oct 18, In : Frontiers in Cellular Neuroscience. 10, OCT2016, 229.

Research output: Contribution to journalReview article

Psychiatry
Haploinsufficiency
Medical Genetics
Brain
Interneurons

Role of reelin during layer formation in the cerebralneocortex

Nakajima, K., 2016 Aug 1, In : Brain and Nerve. 68, 8, p. 931-937 7 p.

Research output: Contribution to journalReview article

Neurons
Behavior Control
Lateral Ventricles
Neocortex
Cadherins
358 Citations (Scopus)

The microbiota in adaptive immune homeostasis and disease

Honda, K. & Littman, D. R., 2016 Jul 6, In : Nature. 535, 7610, p. 75-84 10 p.

Research output: Contribution to journalReview article

Microbiota
Immune System Diseases
Mucous Membrane
Homeostasis
Dysbiosis
2014
8 Citations (Scopus)

Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) represents a typical wnt/β-catenin pathway-activated hepatocellular carcinoma

Effendi, K., Yamazaki, K., Fukuma, M. & Sakamoto, M., 2014 Apr 16, In : Liver Cancer. 3, 3-4, p. 451-457 7 p.

Research output: Contribution to journalReview article

Catenins
Wnt Signaling Pathway
G-Protein-Coupled Receptors
Leucine
Hepatocellular Carcinoma
1 Citation (Scopus)

Study of infection strategies of Helicobacter pylori and host cell response against CagA oncoprotein

Tsugawa, H., 2014, In : Japanese Journal of Bacteriology. 69, 4, p. 565-575 11 p.

Research output: Contribution to journalReview article

Oncogene Proteins
Helicobacter pylori
2-oxoglutarate synthase
Autophagy
Infection
2013
59 Citations (Scopus)

Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells

Kurebayashi, Y., Nagai, S., Ikejiri, A. & Koyasu, S., 2013 Apr, In : Genes to Cells. 18, 4, p. 247-265 19 p.

Research output: Contribution to journalReview article

Th17 Cells
Hypoxia-Inducible Factor 1
1-Phosphatidylinositol 4-Kinase
Interleukin-17
Helper-Inducer T-Lymphocytes