Research Output 1978 2019

2019

Abl family tyrosine kinases govern IgG extravasation in the skin in a murine pemphigus model

Ono, S., Egawa, G., Nomura, T., Kitoh, A., Dainichi, T., Otsuka, A., Nakajima, S., Amagai, M., Matsumoto, F., Yamamoto, M., Kubota, Y., Takai, T., Honda, T. & Kabashima, K., 2019 Dec 1, In : Nature communications. 10, 1, 4432.

Research output: Contribution to journalArticle

Open Access
Pemphigus
tyrosine
Protein-Tyrosine Kinases
blood cells
Skin
2 Citations (Scopus)

A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis

Kim, Y. H., Choi, J., Yang, M. J., Hong, S. P., Lee, C. K., Kubota, Y., Lim, D. S. & Koh, G. Y., 2019 Dec 1, In : Nature communications. 10, 1, 838.

Research output: Contribution to journalArticle

angiogenesis
Cell Polarity
Mitochondria
Endothelial cells
Reactive Oxygen Species

Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex

Shin, M., Kitazawa, A., Yoshinaga, S., Hayashi, K., Hirata, Y., Dehay, C., Kubo, K. & Nakajima, K., 2019 Jan 1, In : Journal of Comparative Neurology.

Research output: Contribution to journalArticle

Neocortex
Neurons
Interneurons
Primates
Occipital Lobe
1 Citation (Scopus)

Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing cerebral cortex

Inoue, S., Hayashi, K., Fujita, K., Tagawa, K., Okazawa, H., Kubo, K. & Nakajima, K., 2019 Jan 23, In : Journal of Neuroscience. 39, 4, p. 678-691 14 p.

Research output: Contribution to journalArticle

Cadherins
Cerebral Cortex
Neurons
Actin Cytoskeleton
Time-Lapse Imaging

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

Zahra, F. T., Sajib, M. S., Ichiyama, Y., Akwii, R. G., Tullar, P. E., Cobos, C., Minchew, S. A., Doçi, C. L., Zheng, Y., Kubota, Y., Gutkind, J. S. & Mikelis, C. M., 2019 Dec 1, In : Scientific reports. 9, 1, 11666.

Research output: Contribution to journalArticle

Open Access
GTP Phosphohydrolases
Embryonic Development
rho GTP-Binding Proteins
Cell Movement
Physiologic Neovascularization

Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina

Niimi, K., Adachi, Y., Ishikawa, H., Yamaguchi, W., Kubota, Y., Inagaki, S. & Furuyama, T., 2019 Dec 3, In : Biochemical and Biophysical Research Communications. 520, 2, p. 304-310 7 p.

Research output: Contribution to journalArticle

Thrombospondin 1
Pericytes
Endothelial cells
Retina
Endothelial Cells
Ureter
Hysterectomy
Ligaments
Connective Tissue
Anatomy

Optical characteristics of human skin with hyperpigmentation caused by fluorinated pyrimidine anticancer agent

Kono, T., Imanishi, N., Nozawa, K., Takashima, A., Maheswari, R. U., Gonome, H. & Yamada, J., 2019 Aug 1, In : Biomedical Optics Express. 10, 8, p. 3747-3759 13 p., 366571.

Research output: Contribution to journalArticle

Hyperpigmentation
pyrimidines
Antineoplastic Agents
Skin
scattering coefficients
3 Citations (Scopus)

p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia

Yokoyama, M., Shimizu, I., Nagasawa, A., Yoshida, Y., Katsuumi, G., Wakasugi, T., Hayashi, Y., Ikegami, R., Suda, M., Ota, Y., Okada, S., Fruttiger, M., Kobayashi, Y., Tsuchida, M., Kubota, Y. & Minamino, T., 2019 Apr 1, In : Journal of Molecular and Cellular Cardiology. 129, p. 105-117 13 p.

Research output: Contribution to journalArticle

Vasodilation
Hyperglycemia
Ischemia
Endothelium
Endothelial Cells

Role of the Immune System in the Development of the Central Nervous System

Morimoto, K. & Nakajima, K., 2019 Sep 3, In : Frontiers in Neuroscience. 13, 916.

Research output: Contribution to journalReview article

Open Access
Immune System
Central Nervous System
Brain
Lymphatic Vessels
Toll-Like Receptors
3 Citations (Scopus)

TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity

Naito, H., Iba, T., Wakabayashi, T., Tai-Nagara, I., Suehiro, J. I., Jia, W., Eino, D., Sakimoto, S., Muramatsu, F., Kidoya, H., Sakurai, H., Satoh, T., Akira, S., Kubota, Y. & Takakura, N., 2019 Jan 28, In : Developmental Cell. 48, 2, p. 151-166.e7

Research output: Contribution to journalArticle

Endothelial cells
Blood Vessels
Endothelial Cells
Apoptosis
Myeloid Cells

Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration

Kim, J., Park, J. R., Choi, J., Park, I., Hwang, Y., Bae, H., Kim, Y., Choi, W. J., Yang, J. M., Han, S., Chung, T. Y., Kim, P., Kubota, Y., Augustin, H. G., Oh, W. Y. & Koh, G. Y., 2019 Feb 13, In : Science Advances. 5, 2, eaau6732.

Research output: Contribution to journalArticle

degeneration
regeneration
activation
antibodies
angiogenesis

Timing and shaping mechanisms of neural development

Kageyama, R. & Nakajima, K., 2019 Jan 1, In : Neuroscience Research. 138, p. 1-2 2 p.

Research output: Contribution to journalEditorial

2018
Hypoglossal Nerve
Arteriovenous Fistula
Hypoglossal Nerve Diseases
Veins
Digital Subtraction Angiography
3 Citations (Scopus)

Anatomic basis for flap thinning

Park, S. O., Chang, H. & Imanishi, N., 2018 Jul 1, In : Archives of Plastic Surgery. 45, 4, p. 298-303 6 p.

Research output: Contribution to journalArticle

Perforator Flap
Epigastric Arteries
Thigh
Blood Vessels
Anatomy
5 Citations (Scopus)

Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction

Lee, S. J., Lee, C. K., Kang, S., Park, I., Kim, Y. H., Kim, S. K., Hong, S. P., Bae, H., He, Y., Kubota, Y. & Koh, G. Y., 2018 Nov 1, In : The Journal of clinical investigation. 128, 11, p. 5018-5033 16 p.

Research output: Contribution to journalArticle

Angiopoietin-2
Myocardial Infarction
Inflammation
Myocardial Ischemia
Macrophages
6 Citations (Scopus)

ApoER2 Controls not only neuronal migration in the intermediate zone but also termination of migration in the developing cerebral cortex

Hirota, Y., Kubo, K., Fujino, T., Yamamoto, T. T. & Nakajima, K., 2018 Jan 1, In : Cerebral Cortex. 28, 1, p. 223-235 13 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Neurons
Neocortex
Brain
Integrins
3 Citations (Scopus)

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells

Si, S., Nakajima-Takagi, Y., Iga, T., Tsuji, M., Hou, L., Oshima, M., Koide, S., Saraya, A., Yamazaki, S., Takubo, K., Kubota, Y., Minamino, T. & Iwama, A., 2018 Jul 1, In : Experimental Hematology. 63, p. 41-51.e1

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Endothelial Cells
Bone Marrow
Blood Vessels
Inflammation
3 Citations (Scopus)

Placebo effects in adult and adolescent patients with schizophrenia: combined analysis of nine RCTs

Kubo, K., Fleischhacker, W. W., Suzuki, T., Yasui-Furukori, N., Mimura, M. & Uchida, H., 2018 Jan 1, (Accepted/In press) In : Acta Psychiatrica Scandinavica.

Research output: Contribution to journalArticle

Placebo Effect
Schizophrenia
Placebos
Antipsychotic Agents
Logistic Models

Virtual Blood Vessels in Complex Background Using Stereo X-Ray Images

Chen, Q., Bise, R., Gu, L., Zheng, Y., Sato, I., Hwang, J. N., Aiso, S. & Imanishi, N., 2018 Jan 19, Proceedings - 2017 IEEE International Conference on Computer Vision Workshops, ICCVW 2017. Institute of Electrical and Electronics Engineers Inc., Vol. 2018-January. p. 99-106 8 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Blood vessels
Augmented reality
X rays
Affine transforms
Oils and fats
2017

A crossroad of neuronal diversity to build circuitry

Yoshinaga, S. & Nakajima, K., 2017 Apr 28, In : Science. 356, 6336, p. 376-377 2 p.

Research output: Contribution to journalArticle

cells and cell components
Nerve Net
genetic analysis
rodent
brain
Mandibular Reconstruction
Fibula
Jugular Veins
Arteries
Blood Vessels

Anatomical Study of Perfusion of a Periosteal Flap with a Lateral Pedicle

Kim, B., Inoue, Y., Imanishi, N., Chang, H., Shimizu, Y., Okumoto, T. & Kishi, K., 2017 Sep 1, In : Plastic and Reconstructive Surgery - Global Open. 5, 9, e1476.

Research output: Contribution to journalArticle

Temporal Arteries
Perfusion
Temporal Muscle
Surgical Flaps
Skull Base
5 Citations (Scopus)

Association of impaired neuronal migration with cognitive deficits in extremely preterm infants

Kubo, K., Deguchi, K., Nagai, T., Ito, Y., Yoshida, K., Endo, T., Benner, S., Shan, W., Kitazawa, A., Aramaki, M., Ishii, K., Shin, M., Matsunaga, Y., Hayashi, K., Kakeyama, M., Tohyama, C., Tanaka, K., Tanaka, K., Takashima, S., Nakayama, M. & 7 others, Itoh, M., Hirata, Y., Antalffy, B., Armstrong, D. D., Yamada, K., Inoue, K. & Nakajima, K., 2017 May 18, In : JCI insight. 2, 10

Research output: Contribution to journalArticle

Open Access
Extremely Premature Infants
Brain Injuries
Neocortex
Neurons
Uterine Artery
14 Citations (Scopus)

CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

Okuno, H., Mihara, F. R., Ota, S., Fukuda, K., Kurosawa, K., Akamatsu, W., Sanosaka, T., Kohyama, J., Hayashi, K., Nakajima, K., Takahashi, T., Wysocka, J., Kosaki, K. & Okano, H., 2017 Nov 28, In : eLife. 6, e21114.

Research output: Contribution to journalArticle

CHARGE Syndrome
Induced Pluripotent Stem Cells
Neural Crest
Stem cells
Mutation
12 Citations (Scopus)
Cerebral Cortex
Neurons
Neocortex
Periventricular Nodular Heterotopia
Lissencephaly
5 Citations (Scopus)

Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma

Shiihashi, G., Ito, D., Arai, I., Kobayashi, Y., Hayashi, K., Otsuka, S., Nakajima, K., Yuzaki, M., Itohara, S. & Suzuki, N., 2017, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Sarcoma
Homeostasis
Messenger RNA
Brain
3 Citations (Scopus)

Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction

Kurotsu, S., Osakabe, R., Isomi, M., Tamura, F., Sadahiro, T., Muraoka, N., Kojima, H., Haginiwa, S., Tani, H., Nara, K., Kubota, Y., Ema, M., Fukuda, K., Suzuki, T. & Ieda, M., 2017 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Endothelial cells
Blood Vessels
Myocardial Infarction
Coronary Vessels
Vascular Endothelial Growth Factor A
1 Citation (Scopus)
Drainage
Veins
Iliac Vein
Blood Vessels
Arteries

Enhanced expression of Pafah1b1 causes over-migration of cerebral cortical neurons into the marginal zone

Katayama, K. I., Hayashi, K., Inoue, S., Sakaguchi, K. & Nakajima, K., 2017 Aug 23, (Accepted/In press) In : Brain Structure and Function. p. 1-9 9 p.

Research output: Contribution to journalArticle

Neurons
Lissencephaly
Electroporation
Brain
Nervous System Diseases
8 Citations (Scopus)

Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse

Kimura, E., Kubo, K., Endo, T., Nakajima, K., Kakeyama, M. & Tohyama, C., 2017, In : Journal of Toxicological Sciences. 42, 1, p. 25-30 6 p.

Research output: Contribution to journalLetter

Hippocampal CA1 Region
Aryl Hydrocarbon Receptors
Chemical activation
Dioxins
Xenobiotics

External jugular veno-accompanying artery adipofascial flap: A novel and convenient flap for head and neck reconstruction

Park, S. O., Ahn, K. C., Hong, K. Y., Chang, H. & Imanishi, N., 2017 Nov 1, In : Head and Neck. 39, 11, p. 2249-2255 7 p.

Research output: Contribution to journalArticle

Neck
Arteries
Head
Jugular Veins
Reconstructive Surgical Procedures
12 Citations (Scopus)

Heterogeneity of D-serine distribution in the human central nervous system

Suzuki, M., Imanishi, N., Mita, M., Hamase, K., Aiso, S. & Sasabe, J., 2017 May 1, In : ASN Neuro. 9, 3

Research output: Contribution to journalArticle

Serine
Central Nervous System
Cerebrum
4 alpha-glucanotransferase
Neurophysiology
12 Citations (Scopus)

Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma

Kim, J., Park, D. Y., Bae, H., Park, D. Y., Kim, D., Lee, C. K., Song, S., Chung, T. Y., Lim, D. H., Kubota, Y., Hong, Y. K., He, Y., Augustin, H. G., Oliver, G. & Koh, G. Y., 2017 Oct 2, In : Journal of Clinical Investigation. 127, 10, p. 3877-3896 20 p.

Research output: Contribution to journalArticle

Angiopoietins
Aqueous Humor
Glaucoma
Transcytosis
Intraocular Pressure
3 Citations (Scopus)

Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse

Kimura, E., Kubo, K., Endo, T., Ling, W., Nakajima, K., Kakeyama, M. & Tohyama, C., 2017 Aug 1, In : PLoS One. 12, 8, e0183497.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Pyramidal Cells
Neurons
hydrocarbons
neurons
4 Citations (Scopus)

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling

Tai-Nagara, I., Yoshikawa, Y., Numata, N., Ando, T., Okabe, K., Sugiura, Y., Ieda, M., Takakura, N., Nakagawa, O., Zhou, B., Okabayashi, K., Suematsu, M., Kitagawa, Y., Bastmeyer, M., Sato, K., Klein, R., Navankasattusas, S., Li, D. Y., Yamagishi, S. & Kubota, Y., 2017, In : Development (Cambridge). 144, 13, p. 2392-2401 10 p.

Research output: Contribution to journalArticle

Inner Ear
Fibronectins
Leucine
Endothelial Cells
Proteins
48 Citations (Scopus)

Plastic roles of pericytes in the blood-retinal barrier

Park, D. Y., Lee, J., Kim, J., Kim, K., Hong, S., Han, S., Kubota, Y., Augustin, H. G., Ding, L., Kim, J. W., Kim, H., He, Y., Adams, R. H. & Koh, G. Y., 2017 May 16, In : Nature Communications. 8, 15296.

Research output: Contribution to journalArticle

Blood-Retinal Barrier
Pericytes
Plastics
blood
Blood
12 Citations (Scopus)

Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development

Matsunaga, Y., Noda, M., Murakawa, H., Hayashi, K., Nagasaka, A., Inoue, S., Miyata, T., Miura, T., Kubo, K. & Nakajima, K., 2017 Feb 21, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 8, p. 2048-2053 6 p.

Research output: Contribution to journalArticle

Cadherins
Neurons
Ependymoglial Cells
Adhesiveness
Neocortex
8 Citations (Scopus)

Semi-supervised learning for biomedical image segmentation via forest oriented super pixels(voxels)

Gu, L., Zheng, Y., Bise, R., Sato, I., Imanishi, N. & Aiso, S., 2017, Medical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings. Springer Verlag, Vol. 10433 LNCS. p. 702-710 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10433 LNCS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Semi-supervised Learning
Supervised learning
Voxel
Image segmentation
Image Segmentation
1 Citation (Scopus)

Subtype Specification of Cerebral Cortical Neurons in Their Immature Stages

Oishi, K. & Nakajima, K., 2017 Nov 28, (Accepted/In press) In : Neurochemical Research. p. 1-7 7 p.

Research output: Contribution to journalArticle

Neurons
Specifications
Cues
Plasticity
Axons
3 Citations (Scopus)

The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination

Hayashi, K., Furuya, A., Sakamaki, Y., Akagi, T., Shinoda, Y., Sadakata, T., Hashikawa, T., Shimizu, K., Minami, H., Sano, Y., Nakayama, M. & Furuichi, T., 2017 Mar 1, In : PLoS One. 12, 3, e0173175.

Research output: Contribution to journalArticle

Knockout Mice
granules
Brain
Animals
brain
4 Citations (Scopus)

Three-dimensional innate mobility of the human foot bones under axial loading using biplane X-ray fluoroscopy

Ito, K., Hosoda, K., Shimizu, M., Ikemoto, S., Nagura, T., Seki, H., Kitashiro, M., Imanishi, N., Aiso, S., Jinzaki, M. & Ogihara, N., 2017 Oct 18, In : Royal Society Open Science. 4, 10, 171086.

Research output: Contribution to journalArticle

Foot Bones
Fluoroscopy
Weight-Bearing
Foot
X-Rays

Three-dimensional measurement of the human cadaver foot bone kinematics under axial loading condition using biplane X-ray fluoroscopy

Ito, K., Hosoda, K., Shimizu, M., Ikemoto, S., Nagura, T., Seki, H., Kitashiro, M., Jinzaki, M., Imanishi, N., Aiso, S. & Ogihara, N., 2017 Jun 30, In : Footwear Science. 9, p. S148-S150

Research output: Contribution to journalArticle

30 Citations (Scopus)

Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature

Yamazaki, T., Nalbandian, A., Uchida, Y., Li, W., Arnold, T. D., Kubota, Y., Yamamoto, S., Ema, M. & Mukouyama, Y. S., 2017 Mar 21, In : Cell Reports. 18, 12, p. 2991-3004 14 p.

Research output: Contribution to journalArticle

Pericytes
Transforming Growth Factors
Skin
Tissue
Myeloid Progenitor Cells
3 Citations (Scopus)

Transplanted mesenchymal stem cells are effective for skin regeneration in acute cutaneous wounds of pigs

Ochiai, H., Kishi, K., Kubota, Y., Oka, A., Hirata, E., Yabuki, H., Iso, Y., Suzuki, H. & Umezawa, A., 2017 Dec 1, In : Regenerative Therapy. 7, p. 8-16 9 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Regeneration
Skin
Swine
7 Citations (Scopus)

VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis

Jang, J. Y., Choi, S. Y., Park, I., Park, D. Y., Choe, K., Kim, P., Kim, Y. K., Lee, B. J., Hirashima, M., Kubota, Y., Park, J. W., Cheng, S. Y., Nagy, A., Park, Y. J., Alitalo, K., Shong, M. & Koh, G. Y., 2017 Jun 1, In : EMBO Molecular Medicine. 9, 6, p. 750-769 20 p.

Research output: Contribution to journalArticle

Thyroid Gland
Thyrotropin
Vascular Endothelial Growth Factor A
Blood Vessels
Maintenance
1 Citation (Scopus)

Venous anastomosis for prevention of venous congestion in distally based flaps

Ihara, J., Imanishi, N. & Kishi, K., 2017 Jan 1, In : Plastic and Reconstructive Surgery - Global Open. 5, 12, e1585.

Research output: Contribution to journalArticle

Hyperemia
Veins
Leg
Necrosis
Extremities
52 Citations (Scopus)

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation

Kim, J., Kim, Y. H., Kim, J., Park, D. Y., Bae, H., Lee, D. H., Kim, K. H., Hong, S. P., Jang, S. P., Kubota, Y., Kwon, Y. G., Lim, D. S. & Koh, G. Y., 2017 Sep 1, In : Journal of Clinical Investigation. 127, 9, p. 3441-3461 21 p.

Research output: Contribution to journalArticle

Blood Vessels
Endothelial Cells
Pseudopodia
Cell Proliferation
Pathologic Neovascularization
2016
2 Citations (Scopus)

Abnormal D-serine metabolism in amyotrophic lateral sclerosis

Sasabe, J. & Aiso, S., 2016 Jan 1, D-Amino Acids: Physiology, Metabolism, and Application. Springer Japan, p. 137-149 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Amyotrophic Lateral Sclerosis
Metabolism
Serine
D-Amino-Acid Oxidase
Motor Neurons
15 Citations (Scopus)

ADP ribosylation factor 6 regulates neuronal migration in the developing cerebral cortex through FIP3/arfophilin-1-dependent endosomal trafficking of N-cadherin

Hara, Y., Fukaya, M., Hayashi, K., Kawauchi, T., Nakajima, K. & Sakagami, H., 2016, In : eNeuro. 3, 4, e0148-16.2016.

Research output: Contribution to journalArticle

Cadherins
Cerebral Cortex
Proteins
Neurons
Membrane Transport Proteins