Research Output 1978 2019

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2007
49 Citations (Scopus)

The extremely conserved C-terminal region of Reelin is not necessary for secretion but is required for efficient activation of downstream signaling

Nakano, Y., Kohno, T., Hibi, T., Kohno, S., Baba, A., Mikoshiba, K., Nakajima, K. & Hattori, M., 2007 Jul 13, In : Journal of Biological Chemistry. 282, 28, p. 20544-20552 9 p.

Research output: Contribution to journalArticle

Chemical activation
Cell Membrane
Cell membranes
Neurons
Brain
41 Citations (Scopus)

Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal

Kawasaki, A., Torii, K., Yamashita, Y., Nishizawa, K., Kanekura, K., Katada, M., Ito, M., Nishimoto, I., Terashita, K., Aiso, S. & Matsuoka, M., 2007 Dec, In : Cellular Signalling. 19, 12, p. 2498-2506 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Fibroblasts
Skin
Cysteine
Central Nervous System
2006
72 Citations (Scopus)

Angiopoietins and angiopoietin-like proteins in angiogenesis

Morisada, T., Kubota, Y., Urano, T., Suda, T. & Oike, Y., 2006 Mar, In : Endothelium: Journal of Endothelial Cell Research. 13, 2, p. 71-79 9 p.

Research output: Contribution to journalArticle

Angiopoietins
Proteins
Blood Vessels
TIE-2 Receptor
Endothelial Cells
98 Citations (Scopus)

Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization

Nagai, N., Oike, Y., Izumi-Nagai, K., Urano, T., Kubota, Y., Noda, K., Ozawa, Y., Inoue, M., Tsubota, K., Suda, T. & Ishida, S., 2006 Oct, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 10, p. 2252-2259 8 p.

Research output: Contribution to journalArticle

Choroidal Neovascularization
Angiotensin Type 1 Receptor
Inflammation
Peroxisome Proliferator-Activated Receptors
Intercellular Adhesion Molecule-1
131 Citations (Scopus)

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

Kanekura, K., Nishimoto, I., Aiso, S. & Matsuoka, M., 2006 Oct 6, In : Journal of Biological Chemistry. 281, 40, p. 30223-30233 11 p.

Research output: Contribution to journalArticle

R-SNARE Proteins
Unfolded Protein Response
Amyotrophic Lateral Sclerosis
Mutation
Reticulum
32 Citations (Scopus)

Colivelin prolongs survival of an ALS model mouse

Chiba, T., Yamada, M., Sasabe, J., Terashita, K., Aiso, S., Matsuoka, M. & Nishimoto, I., 2006 May 12, In : Biochemical and Biophysical Research Communications. 343, 3, p. 793-798 6 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Peptides
Motor Neuron Disease
Injections
Transgenic Mice
2 Citations (Scopus)

Direct determination of p-hydroxymethamphetamine glucuronide in human urine by high-performance liquid chromatography

Nakajima, R., Morishita, M., Aiso, S. & Yajima, T., 2006 Apr, In : Chemical and Pharmaceutical Bulletin. 54, 4, p. 493-495 3 p.

Research output: Contribution to journalArticle

Glucuronides
High performance liquid chromatography
Metabolites
High Pressure Liquid Chromatography
Urine
14 Citations (Scopus)

Fc receptor-positive cells in remyelinating multiple sclerosis lesions

Nakahara, J. & Aiso, S., 2006 Jun, In : Journal of Neuropathology and Experimental Neurology. 65, 6, p. 582-591 10 p.

Research output: Contribution to journalArticle

Fc Receptors
Oligodendroglia
Multiple Sclerosis
Microglia
Immunoglobulin Subunits
39 Citations (Scopus)

Humanin and colivelin: Neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis

Matsuoka, M., Hashimoto, Y., Aiso, S. & Nishimoto, I., 2006 Jun, In : CNS Drug Reviews. 12, 2, p. 113-122 10 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Alzheimer Disease
Peptides
Amino Acids
Occipital Lobe
18 Citations (Scopus)

Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development

Ajioka, I., Maeda, T. & Nakajima, K., 2006 Jan, In : European Journal of Neuroscience. 23, 2, p. 296-308 13 p.

Research output: Contribution to journalArticle

Neurons
Cell Cycle
Ependymoglial Cells
Double-Stranded DNA Breaks
Cellular Structures
5 Citations (Scopus)

Large-scale correlation of DNA accession numbers to the cDNAs in the FANTOM full-length mouse cDNA clone set

Ajioka, I., Maeda, T. & Nakajima, K., 2006, In : Keio Journal of Medicine. 55, 3, p. 107-110 4 p.

Research output: Contribution to journalArticle

Complementary DNA
Clone Cells
DNA
Amino Acid Sequence
Biological Phenomena

Macroscopic and histological studies of the subcutaneous adipofascial tissue

Imanishi, N., Nakajima, H. & Kishi, K., 2006 Oct, In : Japanese Journal of Plastic and Reconstructive Surgery. 49, 10, p. 1083-1088 6 p.

Research output: Contribution to journalArticle

Subcutaneous Tissue
Cadaver
Adipocytes
Fats
32 Citations (Scopus)

Mouse disabled1 (DAB1) is a nucleocytoplasmic shuttling protein

Honda, T. & Nakajima, K., 2006 Dec 15, In : Journal of Biological Chemistry. 281, 50, p. 38951-38965 15 p.

Research output: Contribution to journalArticle

Brain
Cytoplasm
Proto-Oncogene Proteins c-fyn
Maintenance
Nuclear Export Signals
13 Citations (Scopus)

Mutual dependence of murine fetal cutaneous regeneration and peripheral nerve regeneration

Kishi, K., Ohyama, K., Satoh, H., Kubota, Y., Tanaka, T., Imanishi, N., Nakajima, H., Kawamura, K. & Nakajima, T., 2006 Jan, In : Wound Repair and Regeneration. 14, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

Nerve Regeneration
Peripheral Nerves
Regeneration
Skin
Denervation
7 Citations (Scopus)

Regulation of 5′-promoter activity of the rat growth hormone and growth hormone-releasing hormone receptor genes in the MtT/S and MtT/E cells

Nogami, H., Hiraoka, Y., Inoue, K., Aiso, S. & Hisano, S., 2006 Dec, In : Neuroendocrinology. 84, 1, p. 31-41 11 p.

Research output: Contribution to journalArticle

Growth Hormone
Dexamethasone
Genes
Tretinoin
Hormones
538 Citations (Scopus)

Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum

Yamashita, T., Ninomiya, M., Acosta, P. H., García-Verdugo, J. M., Sunabori, T., Sakaguchi, M., Adachi, K., Kojima, T., Hirota, Y., Kawase, T., Araki, N., Abe, K., Okano, H. & Sawamoto, K., 2006, In : Journal of Neuroscience. 26, 24, p. 6627-6636 10 p.

Research output: Contribution to journalArticle

Lateral Ventricles
Stroke
Neurons
Olfactory Bulb
Corpus Striatum

The reconstruction of the lower eyelid with V-Y advancement flap

Kishi, K., Nakajima, H., Imanishi, N. & Nakajima, T., 2006 Jul, In : Japanese Journal of Plastic and Reconstructive Surgery. 49, 7, p. 749-754 6 p.

Research output: Contribution to journalArticle

Eyelids
Cicatrix
Ectropion
Fascia Lata
Cheek
21 Citations (Scopus)

Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β

Hashimoto, Y., Nawa, M., Chiba, T., Aiso, S., Nishimoto, I. & Matsuoka, M., 2006 May 1, In : Journal of Neuroscience Research. 83, 6, p. 1039-1047 9 p.

Research output: Contribution to journalArticle

Transforming Growth Factors
Amyloid
Cell Death
Neurons
Amyloid Precursor Protein Secretases
2005
75 Citations (Scopus)

A humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice

Tajima, H., Kawasumi, M., Chiba, T., Yamada, M., Yamashita, K., Nawa, M., Kita, Y., Koyama, K., Aiso, S., Matsuoka, M., Niikura, T. & Nishimoto, I., 2005 Mar 1, In : Journal of Neuroscience Research. 79, 5, p. 714-723 10 p.

Research output: Contribution to journalArticle

Amyloid
Amnesia
Alzheimer Disease
Protein-Tyrosine Kinases
Cholinergic Neurons
97 Citations (Scopus)

Angiopoietin-like proteins: Potential new targets for metabolic syndrome therapy

Oike, Y., Akao, M., Kubota, Y. & Suda, T., 2005, In : Trends in Molecular Medicine. 11, 10, p. 473-479 7 p.

Research output: Contribution to journalArticle

Angiopoietins
Homeostasis
Proteins
Insulin Resistance
Hepatocytes
145 Citations (Scopus)

Angiopoietin-related growth factor antagonizes obesity and insulin resistance

Oike, Y., Akao, M., Yasunaga, K., Yamauchi, T., Morisada, T., Ito, Y., Urano, T., Kimura, Y., Kubota, Y., Maekawa, H., Miyamoto, T., Miyata, K., Matsumoto, S. I., Sakai, J., Nakagata, N., Takeya, M., Koseki, H., Ogawa, Y., Kadowaki, T. & Suda, T., 2005 Apr, In : Nature Medicine. 11, 4, p. 400-408 9 p.

Research output: Contribution to journalArticle

Angiopoietins
Insulin Resistance
Intercellular Signaling Peptides and Proteins
Obesity
Insulin
73 Citations (Scopus)

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by alsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

Kanekura, K., Hashimoto, Y., Kita, Y., Sasabe, J., Aiso, S., Nishimoto, I. & Matsuoka, M., 2005 Feb 11, In : Journal of Biological Chemistry. 280, 6, p. 4532-4543 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Cell death
Cell Death
Guanine Nucleotides
Genes
402 Citations (Scopus)

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

Kamiya, A., Kubo, K., Tomoda, T., Takaki, M., Youn, R., Ozeki, Y., Sawamura, N., Park, U., Kudo, C., Okawa, M., Ross, C. A., Hatten, M. E., Nakajima, K. & Sawa, A., 2005 Dec, In : Nature Cell Biology. 7, 12, p. 1067-1078 12 p.

Research output: Contribution to journalArticle

Cerebral Cortex
Schizophrenia
Mutation
Dyneins
Centrosome
29 Citations (Scopus)

Birth-date-dependent segregation of the mouse cerebral cortical neurons in reaggregation cultures

Ajioka, I. & Nakajima, K., 2005 Jul, In : European Journal of Neuroscience. 22, 2, p. 331-342 12 p.

Research output: Contribution to journalArticle

Parturition
Neurons
Ferrets
Carisoprodol
Transplantation
70 Citations (Scopus)

Cooperative interaction of Angiopoietin-like proteins 1 and 2 in vascular development

Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Nagai, N., Koh, G. Y., Watanabe, S. & Suda, T., 2005 Sep 20, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 38, p. 13502-13507 6 p.

Research output: Contribution to journalArticle

Angiopoietins
Phosphatidylinositol 3-Kinase
Blood Vessels
Endothelial Cells
Morpholinos
66 Citations (Scopus)

Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: Characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo

Chiba, T., Yamada, M., Hashimoto, Y., Sato, M., Sasabe, J., Kita, Y., Terashita, K., Aiso, S., Nishimoto, I. & Matsuoka, M., 2005 Nov 2, In : Journal of Neuroscience. 25, 44, p. 10252-10261 10 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Calcium-Calmodulin-Dependent Protein Kinase Type 4
Quinuclidinyl Benzilate
STAT3 Transcription Factor
Peptides
10 Citations (Scopus)

Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity

Obata, Y., Niikura, T., Kanekura, K., Hashimoto, Y., Kawasumi, M., Kita, Y., Aiso, S., Matsuoka, M. & Nishimoto, I., 2005 Sep 1, In : Journal of Neuroscience Research. 81, 5, p. 720-729 10 p.

Research output: Contribution to journalArticle

Polymerization
Amyotrophic Lateral Sclerosis
Motor Neuron Disease
Ubiquitination
Oxidative Stress
25 Citations (Scopus)

Expression profiles of EphA3 at both the RNA and protein level in the developing mammalian forebrain

Kudo, C., Ajioka, I., Hirata, Y. & Nakajima, K., 2005 Jul 4, In : Journal of Comparative Neurology. 487, 3, p. 255-269 15 p.

Research output: Contribution to journalArticle

EphA3 Receptor
Prosencephalon
RNA
Axons
Thalamus
51 Citations (Scopus)

Implanted cannula-mediated repetitive administration of Aβ25-35 into the mouse cerebral ventricle effectively impairs spatial working memory

Yamada, M., Chiba, T., Sasabe, J., Nawa, M., Tajima, H., Niikura, T., Terashita, K., Aiso, S., Kita, Y., Matsuoka, M. & Nishimoto, I., 2005 Nov 7, In : Behavioural Brain Research. 164, 2, p. 139-146 8 p.

Research output: Contribution to journalArticle

Cerebral Ventricles
Short-Term Memory
Alzheimer Disease
Poisons
Choline O-Acetyltransferase
22 Citations (Scopus)

Involvement of CD45 in central nervous system myelination

Nakahara, J., Seiwa, C., Tan-Takeuchi, K., Gotoh, M., Kishihara, K., Ogawa, M., Asou, H. & Aiso, S., 2005 May 6, In : Neuroscience Letters. 379, 2, p. 116-121 6 p.

Research output: Contribution to journalArticle

Oligodendroglia
Central Nervous System
Proto-Oncogene Proteins c-fyn
Myelin Sheath
Protein Tyrosine Phosphatases
80 Citations (Scopus)

Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection

Hashimoto, Y., Suzuki, H., Aiso, S., Niikura, T., Nishimoto, I. & Matsuoka, M., 2005 Oct 28, In : Life Sciences. 77, 24, p. 3092-3104 13 p.

Research output: Contribution to journalArticle

Protein-Tyrosine Kinases
Cell death
G-Protein-Coupled Receptors
GTP-Binding Proteins
Alzheimer Disease
23 Citations (Scopus)

Isolation and expression patterns of genes for three angiopoietin-like proteins, Angptl1, 2 and 6 in zebrafish

Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Watanabe, S. & Suda, T., 2005 Jun, In : Gene Expression Patterns. 5, 5, p. 679-685 7 p.

Research output: Contribution to journalArticle

Angiopoietins
Branchial Region
Notochord
Somites
Yolk Sac
33 Citations (Scopus)

Is the platysma flap musculocutaneous? Angiographic study of the platysma

Imanishi, N., Nakajima, H., Kishi, K., Chang, H. & Aiso, S., 2005 Apr, In : Plastic and Reconstructive Surgery. 115, 4, p. 1018-1024 7 p.

Research output: Contribution to journalArticle

Myocutaneous Flap
Skin
Neck
Subcutaneous Tissue
Gelatin
38 Citations (Scopus)

Membrane-proximal α/β stalk interactions differentially regulate integrin activation

Kamata, T., Handa, M., Sato, Y., Ikeda, Y. & Aiso, S., 2005 Jul 1, In : Journal of Biological Chemistry. 280, 26, p. 24775-24783 9 p.

Research output: Contribution to journalArticle

Integrins
Chemical activation
Ligands
Membranes
Divalent Cations
22 Citations (Scopus)

Neuronal migration in cortical development

Kanatani, S., Tabata, H. & Nakajima, K., 2005 Apr, In : Journal of Child Neurology. 20, 4, p. 274-279 6 p.

Research output: Contribution to journalArticle

Neuroglia
Asymmetric Cell Division
Time-Lapse Imaging
Ependymoglial Cells
Neural Stem Cells
62 Citations (Scopus)

Selective suppression of pathologic, but not physiologic, retinal neovascularization by blocking the angiotensin II type 1 receptor

Nagai, N., Noda, K., Urano, T., Kubota, Y., Shinoda, H., Koto, T., Shinoda, K., Inoue, M., Shiomi, T., Ikeda, E., Tsubota, K., Suda, T., Oike, Y. & Ishida, S., 2005 Mar, In : Investigative Ophthalmology and Visual Science. 46, 3, p. 1078-1084 7 p.

Research output: Contribution to journalArticle

Physiologic Neovascularization
Retinal Neovascularization
Angiotensin Type 1 Receptor
Retinal Vessels
Vascular Endothelial Growth Factor Receptor-1

Skin reconstitution in SCID mice

Kishi, K., Kubota, Y., Katsube, K., Satoh, H., Shimizu, Y., Imanishi, N., Nakajima, H. & Nahajima, T., 2005 Sep, In : Japanese Journal of Plastic and Reconstructive Surgery. 48, 9, p. 979-984 6 p.

Research output: Contribution to journalArticle

SCID Mice
Skin
Cicatrix
Cell Transplantation
Wounds and Injuries
67 Citations (Scopus)

Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor

Nagai, N., Oike, Y., Noda, K., Urano, T., Kubota, Y., Ozawa, Y., Shinoda, H., Koto, T., Shinoda, K., Inoue, M., Tsubota, K., Yamashiro, K., Suda, T. & Ishida, S., 2005, In : Investigative Ophthalmology and Visual Science. 46, 8, p. 2925-2931 7 p.

Research output: Contribution to journalArticle

Angiotensin Type 1 Receptor
Uveitis
Endotoxins
Inflammation
Intercellular Adhesion Molecule-1
9 Citations (Scopus)

Switching of α-catenin from αE-catenin in the cortical ventricular zone to αN-catenin II in the intermediate zone

Ajioka, I. & Nakajima, K., 2005 Nov 7, In : Developmental Brain Research. 160, 1, p. 106-111 6 p.

Research output: Contribution to journalArticle

Catenins
Telencephalon
Cadherins
111 Citations (Scopus)
Interneurons
Prosencephalon
Telencephalon
Hippocampus
Time-Lapse Imaging
10 Citations (Scopus)

The fetal dermal but not loose fascial mesenchymal cells possess regenerative activity of dermal structure

Kishi, K., Katsube, K., Satoh, H., Imanishi, N., Nakajima, H. & Nakajima, T., 2005, In : Cell Transplantation. 14, 9, p. 709-714 6 p.

Research output: Contribution to journalArticle

Skin
Cells
Defects
Fetal Movement
Fascia
3 Citations (Scopus)

The role of pit-1 in the regulation of the rat growth hormone-releasing hormone receptor transcription by glucocorticoids

Nogami, H., Hiraoka, Y., Ogasawara, K., Aiso, S. & Hisano, S., 2005 Dec, In : Journal of Molecular Endocrinology. 35, 3, p. 477-488 12 p.

Research output: Contribution to journalArticle

Glucocorticoids
Transcription Factor Pit-1
Transcriptional Silencer Elements
Response Elements
Genes
2 Citations (Scopus)

The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster

Hirota, Y., Sawamoto, K., Takahashi, K., Ueda, R. & Okano, H., 2005 Feb, In : Development Genes and Evolution. 215, 2, p. 90-96 7 p.

Research output: Contribution to journalArticle

transmembrane proteins
compound eyes
Drosophila melanogaster
eyes
peripheral nervous system
40 Citations (Scopus)

Transforming growth factor β2 is a neuronal death-inducing ligand for amyloid-β precursor protein

Hashimoto, Y., Chiba, T., Yamada, M., Nawa, M., Kanekura, K., Suzuki, H., Terashita, K., Aiso, S., Nishimoto, I. & Matsuoka, M., 2005 Nov, In : Molecular and Cellular Biology. 25, 21, p. 9304-9317 14 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Transforming Growth Factors
Ligands
Alzheimer Disease
Gi-Go GTP-Binding Protein alpha Subunits
2004
22 Citations (Scopus)

Amino- and Carboxyl-Terminal Mutants of Presenilin 1 Cause Neuronal Cell Death Through Distinct Toxic Mechanisms: Study of 27 Different Presenilin 1 Mutants

Hashimoto, Y., Tsukamoto, E., Niikura, T., Yamagishi, Y., Ishizaka, M., Aiso, S., Takashima, A. & Nishimoto, I., 2004 Feb 1, In : Journal of Neuroscience Research. 75, 3, p. 417-428 12 p.

Research output: Contribution to journalArticle

Presenilin-1
Poisons
Alzheimer Disease
Cell Death
NADPH Oxidase
31 Citations (Scopus)
Lubricants
Subcutaneous Tissue
Cadaver
24 Citations (Scopus)

Arterial anatomy of the lower lip

Kawai, K., Imanishi, N., Nakajima, H., Aiso, S., Kakibuchi, M. & Hosokawa, K., 2004, In : Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery. 38, 3, p. 135-139 5 p.

Research output: Contribution to journalArticle

Lip
Anatomy
Arteries
Muscles
Subcutaneous Tissue
38 Citations (Scopus)
GABAergic Neurons
Visual Cortex
Parturition
Neurons
Interneurons
39 Citations (Scopus)

CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis

Inoue, T., Fujishima, S., Ikeda, E., Yoshie, O., Tsukamoto, N., Aiso, S., Aikawa, N., Kubo, A., Matsushima, K. & Yamaguchi, K., 2004 Jul, In : European Respiratory Journal. 24, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Radiation Pneumonitis
Idiopathic Pulmonary Fibrosis
Chemokines
Pulmonary Fibrosis
CCR4 Receptors
41 Citations (Scopus)

Characterization of V642I-AβPP-induced cytotoxicity in primary neurons

Niikura, T., Yamada, M., Chiba, T., Aiso, S., Matsuoka, M. & Nishimoto, I., 2004 Jul 1, In : Journal of Neuroscience Research. 77, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Neurons
Alzheimer Disease
Amyloid
Protein Multimerization