Department of Biochemistry

2020

Quantitative MALDI-MS/MS assay for serum cortisol through charged derivatization

Nakamura, M., Moritsuna, M., Yuda, K., Fujimura, S., Sugiura, Y., Shimma, S., Nishimoto, K., Nishikawa, T., Suematsu, M., Ogawa, S. & Higashi, T., 2020 Jan 30, In : Journal of Pharmaceutical and Biomedical Analysis. 178, 112912.

Research output: Contribution to journal › Article

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry

Hydrocortisone

Assays

Serum

Electrospray ionization

2019

70 Citations (Scopus)

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. & 8 others, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 Jan 31, In : Nature. 565, 7741, p. 600-605 6 p.

Research output: Contribution to journal › Article

Immunity

T-Lymphocytes

Listeriosis

Histocompatibility

Microbiota

3 Citations (Scopus)

Application of high-performance magnetic nanobeads to biological sensing devices

Kabe, Y., Sakamoto, S., Hatakeyama, M., Yamaguchi, Y., Suematsu, M., Itonaga, M. & Handa, H., 2019 Jan 1, (Accepted/In press) In : Analytical and Bioanalytical Chemistry.

Research output: Contribution to journal › Article

Exosomes

Equipment and Supplies

Technology

Immunoassay

Drug Receptors

A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

Hayakawa, T., Kawasaki, S., Hirayama, Y., Tsutsui, T., Sugiyama, E., Adachi, K., Kon, R., Suematsu, M. & Sugiura, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 3559.

Research output: Contribution to journal › Article

Open Access

Peptic Esophagitis

Sucralfate

Epithelium

Gastric Juice

Pepsin A

12 Citations (Scopus)

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H. C., Ikeda, K., Kanegae, Y., Saito, I., Auwerx, J., Motohashi, H., Suematsu, M., Soga, T., Yokomizo, T., Waguri, S., Mizushima, N. & Komatsu, M., 2019 Dec 1, In : Nature communications. 10, 1, 1567.

Research output: Contribution to journal › Article

Open Access

Nuclear Receptor Co-Repressor 1

lipid metabolism

Peroxisome Proliferator-Activated Receptors

Autophagy

Lipid Metabolism

1 Citation (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journal › Article

Open Access

Helicobacter

Neoplastic Stem Cells

Catenins

Protein Splicing

Histones

Dendropanax morbiferus leaf extract facilitates oligodendrocyte development

Kim, J. Y., Yoon, J. Y., Sugiura, Y., Lee, S. K., Park, J. D., Song, G. J. & Yang, H. J., 2019 Jun 1, In : Royal Society Open Science. 6, 6, 190266.

Research output: Contribution to journal › Article

Open Access

Oligodendroglia

Cell Culture Techniques

Multiple Sclerosis

Anti-Inflammatory Agents

Up-Regulation

Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging

Sugiyama, E., Guerrini, M. M., Honda, K., Hattori, Y., Abe, M., Källback, P., Andrén, P. E., Tanaka, K. F., Setou, M., Fagarasan, S., Suematsu, M. & Sugiura, Y., 2019 Oct 25, In : iScience. 20, p. 359-372 14 p.

Research output: Contribution to journal › Article

Open Access

Mass Spectrometry

Serotonin

Midline Thalamic Nuclei

Brain

Norepinephrine

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 2019 Jul 2, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journal › Article

Open Access

Hematopoietic Stem Cells

Stem cells

Maintenance

Fatty Acids

Cell culture

1 Citation (Scopus)

Identification of a binding protein for sesamin and characterization of its roles in plant growth

Tera, M., Koyama, T., Murata, J., Furukawa, A., Mori, S., Azuma, T., Watanabe, T., Hori, K., Okazawa, A., Kabe, Y., Suematsu, M., Satake, H., Ono, E. & Horikawa, M., 2019 Dec 1, In : Scientific reports. 9, 1, 8631.

Research output: Contribution to journal › Article

Open Access

Carrier Proteins

Growth

Sesamum

sesamin

Lignans

2 Citations (Scopus)

Immunohistochemistry for aldosterone synthase CYP11B2 and matrix-assisted laser desorption ionization imaging mass spectrometry for in-situ aldosterone detection

Zhang, Z., Sugiura, Y., Mune, T., Nishiyama, M., Terada, Y., Mukai, K. & Nishimoto, K., 2019 Mar 1, In : Current Opinion in Nephrology and Hypertension. 28, 2, p. 105-112 8 p.

Research output: Contribution to journal › Article

Cytochrome P-450 CYP11B2

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry

Aldosterone

Immunohistochemistry

Hyperaldosteronism

4 Citations (Scopus)

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. & 37 others, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 Aug 1, In : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

Research output: Contribution to journal › Article

IMP Dehydrogenase

Glioblastoma

Carcinogenesis

Transfer RNA

Guanine Nucleotides

2 Citations (Scopus)

Increased cytotoxicity of herpes simplex virus thymidine kinase expression in human induced pluripotent stem cells

Iwasawa, C., Tamura, R., Sugiura, Y., Suzuki, S., Kuzumaki, N., Narita, M., Suematsu, M., Nakamura, M., Yoshida, K., Toda, M., Okano, H. & Miyoshi, H., 2019 Feb 2, In : International Journal of Molecular Sciences. 20, 4, 810.

Research output: Contribution to journal › Article

Open Access

Induced Pluripotent Stem Cells

thymidine

Thymidine Kinase

stem cells

Human Herpesvirus 1

Lectin microarray analyses reveal host cell-specific glycan profiles of the hemagglutinins of influenza A viruses

Hiono, T., Matsuda, A., Wagatsuma, T., Okamatsu, M., Sakoda, Y. & Kuno, A., 2019 Jan 15, In : Virology. 527, p. 132-140 9 p.

Research output: Contribution to journal › Article

Influenza A virus

Hemagglutinins

Microarray Analysis

Lectins

Polysaccharides

1 Citation (Scopus)

Mechanical allodynia induced by optogenetic sensory nerve excitation activates dopamine signaling and metabolism in medial nucleus accumbens

Sugiyama, E., Kondo, T., Kuzumaki, N., Honda, K., Yamanaka, A., Narita, M., Suematsu, M. & Sugiura, Y., 2019 Oct 1, In : Neurochemistry International. 129, 104494.

Research output: Contribution to journal › Article

Open Access

Optogenetics

Hyperalgesia

Nucleus Accumbens

Dopamine

Pain

Neutrophil-activating Protein Polymorphism of Helicobacter pylori Determines the Host Risk of Dyspepsia

Matsuzaki, J., Tsugawa, H., Kashiwazaki, Y., Mori, H., Yamamoto, Y., Kameyama, H., Masaoka, T., Kanai, T. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 2, p. 295-297.e6

Research output: Contribution to journal › Article

Open Access

Dyspepsia

Helicobacter pylori neutrophil-activating protein A

Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands

Takeo, E., Sugiura, Y., Uemura, T., Nishimoto, K., Yasuda, M., Sugiyama, E., Ohtsuki, S., Higashi, T., Nishikawa, T., Suematsu, M., Fukusaki, E. & Shimma, S., 2019 Jan 1, In : Analytical chemistry.

Research output: Contribution to journal › Article

Aldosterone

Isomers

Mass spectrometry

Steroids

Imaging techniques

2018

4 Citations (Scopus)

Aldosterone and 18-Oxocortisol Coaccumulation in Aldosterone-Producing Lesions

Sugiura, Y., Takeo, E., Shimma, S., Yokota, M., Higashi, T., Seki, T., Mizuno, Y., Oya, M., Kosaka, T., Omura, M., Nishikawa, T., Suematsu, M. & Nishimoto, K., 2018 Dec 1, In : Hypertension (Dallas, Tex. : 1979). 72, 6, p. 1345-1354 10 p.

Research output: Contribution to journal › Article

Aldosterone

Hyperaldosteronism

Adenoma

Cytochrome P-450 CYP11B2

18-oxocortisol

4 Citations (Scopus)

A method for determination of aldosterone in adrenal tributary venous serum by derivatization using Girard P reagent isotopologues followed by LC/ESI-MS/MS

Higashi, T., Akaishi, M., Yokota, M., Suzuki, T., Ogawa, S., Sugiura, Y., Nishikawa, T., Nishimoto, K. & Suematsu, M., 2018 Aug 15, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1092, p. 106-113 8 p.

Research output: Contribution to journal › Article

Aldosterone

Serum

Sampling

Hyperaldosteronism

Assays

11 Citations (Scopus)

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor–Initiating Stem Cell–Like Cells Resistant to mTORC1 Inhibition

Wu, R., Murali, R., Kabe, Y., French, S. W., Chiang, Y. M., Liu, S., Sher, L., Wang, C. C., Louie, S. & Tsukamoto, H., 2018 Nov 1, In : Hepatology. 68, 5, p. 1726-1740 15 p.

Research output: Contribution to journal › Article

GTP Phosphohydrolases

Autophagy

Sirolimus

Stem Cells

Liver

2 Citations (Scopus)

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journal › Article

Entamoeba histolytica

Metabolomics

Coenzymes

Molecular Biology

Parasites

3 Citations (Scopus)

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

Tsugawa, H., Mori, H., Matsuzaki, J., Sato, A., Saito, Y., Imoto, M., Suematsu, M. & Suzuki, H., 2018 Jan 1, (Accepted/In press) In : Autophagy.

Research output: Contribution to journal › Article

Lysosomal-Associated Membrane Protein 1

Low Density Lipoprotein Receptor-Related Protein-1

Autophagy

Helicobacter pylori

Actins

2 Citations (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr 1, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journal › Article

Entamoeba histolytica

Coenzyme A

Pharmaceutical Preparations

Enzymes

Amebiasis

4 Citations (Scopus)

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Sugiura, Y., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fuku, Y., 2018 Jul 31, In : Science Signaling. 11, 541, eaao4874.

Research output: Contribution to journal › Article

Immune Evasion

Cytokinesis

Tissue

Guanine Nucleotide Exchange Factors

Proteins

7 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct 1, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journal › Article

Exosomes

Equipment and Supplies

CD147 Antigens

Serum

Flow cytometry

6 Citations (Scopus)

Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system

Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., Uchiyama, N., Yamanaka, A., Kuzumaki, N., Porreca, F. & Narita, M., 2018 Jan 1, In : Molecular Pain. 14

Research output: Contribution to journal › Article

Microdialysis

Nucleus Accumbens

Mass Spectrometry

Pain

Neurotransmitter Agents

20 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journal › Article

Raman Spectrum Analysis

Oxidants

Gold

Raman spectroscopy

tumors

4 Citations (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 Nov 1, In : Anticancer Research. 38, 11, p. 6163-6170 8 p.

Research output: Contribution to journal › Article

Fluorouracil

Stomach Neoplasms

Neoplastic Stem Cells

Antiporters

Drug Therapy

15 Citations (Scopus)

Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation

Takata, N., Sugiura, Y., Yoshida, K., Koizumi, M., Hiroshi, N., Honda, K., Yano, R., Komaki, Y., Matsui, K., Suematsu, M., Mimura, M., Okano, H. & Tanaka, K., 2018 Sep 1, In : GLIA. 66, 9, p. 2013-2023 11 p.

Research output: Contribution to journal › Article

Optogenetics

Oxygen Consumption

Astrocytes

Magnetic Resonance Imaging

Acetylcarnitine

22 Citations (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., 2018 Mar 12, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journal › Article

Small Cell Lung Carcinoma

Growth

Neoplasms

Protein Isoforms

Neuroendocrine Tumors

2 Citations (Scopus)

Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia

Goto, S., Morikawa, T., Kubo, A., Takubo, K., Fukuda, K., Kajimura, M. & Suematsu, M., 2018 Jul 1, In : Journal of Clinical Biochemistry and Nutrition. 63, 1, p. 70-79 10 p.

Research output: Contribution to journal › Article

Brain Ischemia

Brain

Mass Spectrometry

Spectroscopy

Imaging techniques

16 Citations (Scopus)

Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice

Tanaka, S., Sugiura, Y., Saito, H., Sugahara, M., Higashijima, Y., Yamaguchi, J., Inagi, R., Suematsu, M., Nangaku, M. & Tanaka, T., 2018 Nov 1, In : Kidney International. 94, 5, p. 912-925 14 p.

Research output: Contribution to journal › Article

Sodium-Glucose Transport Proteins

Oxidative Stress

Kidney

Glucose

Citric Acid Cycle

糖鎖プロファイリングによる疾患特異的マーカーの開発

Translated title of the contribution: Development of a disease-specific glycol-biomarker with glycan profilingMatsuda, A., 2018 Jan 1, In : Seikagaku. 90, 4, p. 482-485 4 p.

Research output: Contribution to journal › Article

Glycols

Biomarkers

Polysaccharides

2017

6 Citations (Scopus)

Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos

Oka, M., Hashimoto, K., Yamaguchi, Y., Saitoh, S. I., Sugiura, Y., Motoi, Y., Honda, K., Kikko, Y., Ohata, S., Suematsu, M., Miura, M., Miyake, K., Katada, T. & Kontani, K., 2017, In : Journal of Cell Science. 130, 20, p. 3568-3577 10 p.

Research output: Contribution to journal › Article

Yolk Sac

Endoderm

Proteolysis

Embryonic Structures

Mothers

4 Citations (Scopus)

Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying

Fukuhara, S., Masaoka, T., Nishimura, S., Nakamura, M., Matsuzaki, J., Tsugawa, H., Miyoshi, S., Mori, H., Kawase, S., Shibata, S., Okano, H., Kanai, T. & Suzuki, H., 2017 Nov 2, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-11 11 p.

Research output: Contribution to journal › Article

Gastric Emptying

Apolipoproteins E

Neuroglia

Knockout Mice

Glial Fibrillary Acidic Protein

29 Citations (Scopus)

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

Miyajima, M., Zhang, B., Sugiura, Y., Sonomura, K., Guerrini, M. M., Tsutsui, Y., Maruya, M., Vogelzang, A., Chamoto, K., Honda, K., Hikida, T., Ito, S., Qin, H., Sanuki, R., Suzuki, K., Furukawa, T., Ishihama, Y., Matsuda, F., Suematsu, M., Honjo, T. & 1 others, Fagarasan, S., 2017 Nov 16, In : Nature Immunology. 18, 12, p. 1342-1352 11 p.

Research output: Contribution to journal › Article

T-Lymphocytes

Brain

Amino Acids

Programmed Cell Death 1 Receptor

Immune System

5 Citations (Scopus)

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling

Tai-Nagara, I., Yoshikawa, Y., Numata, N., Ando, T., Okabe, K., Sugiura, Y., Ieda, M., Takakura, N., Nakagawa, O., Zhou, B., Okabayashi, K., Suematsu, M., Kitagawa, Y., Bastmeyer, M., Sato, K., Klein, R., Navankasattusas, S., Li, D. Y., Yamagishi, S. & Kubota, Y., 2017, In : Development (Cambridge). 144, 13, p. 2392-2401 10 p.

Research output: Contribution to journal › Article

Inner Ear

Fibronectins

Leucine

Endothelial Cells

Proteins

1 Citation (Scopus)

Quiescence of adult oligodendrocyte precursor cells requires thyroid hormone and hypoxia to activate Runx1 /631/136/532/2443 /631/532/2443 /13 /13/100 /13/106 /38 /38/89 /38/39 /42 /42/44 /96 article

Tokumoto, Y., Tamaki, S., Kabe, Y., Takubo, K. & Suematsu, M., 2017 Dec 1, In : Scientific Reports. 7, 1, 1019.

Research output: Contribution to journal › Article

Oligodendroglia

Thyroid Hormones

Adult Stem Cells

Core Binding Factor Alpha 2 Subunit

Cyclin-Dependent Kinase Inhibitor p15

19 Citations (Scopus)

Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching

Miyazawa, H., Yamaguchi, Y., Sugiura, Y., Honda, K., Kondo, K., Matsuda, F., Yamamoto, T., Suematsu, M. & Miura, M., 2017, In : Journal of Cell Science. 130, 2, p. 63-73 11 p.

Research output: Contribution to journal › Article

Fructose-Bisphosphate Aldolase

Embryonic Structures

Energy Metabolism

Glucose

Lactic Acid

20 Citations (Scopus)

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1

Pati, M. L., Groza, D., Riganti, C., Kopecka, J., Niso, M., Berardi, F., Hager, S., Heffeter, P., Hirai, M., Tsugawa, H., Kabe, Y., Suematsu, M. & Abate, C., 2017 Mar 1, In : Pharmacological Research. 117, p. 67-74 8 p.

Research output: Contribution to journal › Article

Progesterone Receptors

Ligands

Membranes

Proteins

Heme

10 Citations (Scopus)

Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism

Tamura, A., Nishimoto, K., Seki, T., Matsuzawa, Y., Saito, J., Omura, M., Gomez-Sanchez, C. E., Makita, K., Matsui, S., Moriya, N., Inoue, A., Nagata, M., Sasano, H., Nakamura, Y., Yamazaki, Y., Kabe, Y., Mukai, K., Kosaka, T., Oya, M., Suematsu, S. & 1 others, Nishikawa, T., 2017 Feb 5, In : Molecular and Cellular Endocrinology. 441, p. 134-139 6 p.

Research output: Contribution to journal › Article

Hyperaldosteronism

Aldosterone

Cytochrome P-450 CYP11B2

Adrenal Glands

Mutation

27 Citations (Scopus)

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

Lai, K. K. Y., Kweon, S. M., Chi, F., Hwang, E., Kabe, Y., Higashiyama, R., Qin, L., Yan, R., Wu, R. P., Lai, K., Fujii, N., French, S., Xu, J., Wang, J. Y., Murali, R., Mishra, L., Lee, J. S., Ntambi, J. M. & Tsukamoto, H., 2017 May 1, In : Gastroenterology. 152, 6, p. 1477-1491 15 p.

Research output: Contribution to journal › Article

Low Density Lipoprotein Receptor-Related Protein-6

Low Density Lipoprotein Receptor-Related Protein-5

Stearoyl-CoA Desaturase

Liver Cirrhosis

Hepatic Stellate Cells

3 Citations (Scopus)

Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 Aug 1, In : Molecular and Cellular Biology. 37, 16, e00248-17.

Research output: Contribution to journal › Article

Prolyl Hydroxylases

Lactic Acidosis

Metformin

Oxygen

Prolyl-Hydroxylase Inhibitors

3 Citations (Scopus)

Utilizing mass spectrometry imaging to map the thyroid hormones triiodothyronine and thyroxine in Xenopus tropicalis tadpoles

Goto-Inoue, N., Sato, T., Morisasa, M., Kashiwagi, A., Kashiwagi, K., Sugiura, Y., Sugiyama, E., Suematsu, M. & Mori, T., 2017 Dec 15, (Accepted/In press) In : Analytical and Bioanalytical Chemistry. p. 1-8 8 p.

Research output: Contribution to journal › Article

Triiodothyronine

Xenopus

Thyroxine

Thyroid Hormones

Mass spectrometry

2016

4 Citations (Scopus)

Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis

Takeshita, M., Kuno, A., Suzuki, K., Matsuda, A., Shimazaki, H., Nakagawa, T., Otomo, Y., Kabe, Y., Suematsu, M., Narimatsu, H. & Takeuchi, T., 2016 May 21, In : Arthritis Research and Therapy. 18, 1, 112.

Research output: Contribution to journal › Article

Matrix Metalloproteinase 3

Polysaccharides

Rheumatoid Arthritis

Biomarkers

Agrocybe

2 Citations (Scopus)

Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study

Uchida, T., Nishimoto, K., Fukumura, Y., Asahina, M., Goto, H., Kawano, Y., Shimizu, F., Tsujimura, A., Seki, T., Mukai, K., Kabe, Y., Suematsu, M., Gomez-Sanchez, C. E., Yao, T., Horie, S. & Watada, H., 2016 Jul 18, (Accepted/In press) In : Endocrine Pathology. p. 1-9 9 p.

Research output: Contribution to journal › Article

Adrenocortical Carcinoma

Steroid 11-beta-Hydroxylase

Cytochrome P-450 CYP11B2

Hydrocortisone

Aldosterone

20 Citations (Scopus)

Efficacy of 10-day Sitafloxacin-Containing Third-Line Rescue Therapies for Helicobacter pylori Strains Containing the gyrA Mutation

Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Hirata, K., Seino, T., Matsushita, M., Masaoka, T. & Kanai, T., 2016 Aug 1, In : Helicobacter. 21, 4, p. 286-294 9 p.

Research output: Contribution to journal › Article

Helicobacter pylori

Mutation

Esomeprazole

Amoxicillin

Metronidazole

17 Citations (Scopus)

Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility

Takeda, A., Kobayashi, D., Aoi, K., Sasaki, N., Sugiura, Y., Igarashi, H., Tohya, K., Inoue, A., Hata, E., Akahoshi, N., Hayasaka, H., Kikuta, J., Scandella, E., Ludewig, B., Ishii, S., Aoki, J., Suematsu, M., Ishii, M., Takeda, K., Jalkanen, S. & 2 others, Miyasaka, M. & Umemoto, E., 2016 Feb 2, In : eLife. 5, FEBRUARY2016, e10561.

Research output: Contribution to journal › Article

T-cells

Cell Movement

T-Lymphocytes

Lymph Nodes

Myosin Type II

59 Citations (Scopus)

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi, Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. & 1 others, Suematsu, M., 2016 Mar 18, In : Nature Communications. 7, 11030.

Research output: Contribution to journal › Article

Dimerization

dimerization

Heme

cancer

cytochromes

64 Citations (Scopus)

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, D. M. R., Choi, H., Kim, J. W., Asagiri, M., Cowburn, A. S., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N. & 4 others, Johnson, R. S., Manabe, I., Nagai, R. & Komuro, I., 2016 May 18, In : Nature Communications. 7, 11635.

Research output: Contribution to journal › Article

glycolysis

macrophages

Macrophages

Glycolysis

adenosine triphosphate