Research Output 1985 2020

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2020

Quantitative MALDI-MS/MS assay for serum cortisol through charged derivatization

Nakamura, M., Moritsuna, M., Yuda, K., Fujimura, S., Sugiura, Y., Shimma, S., Nishimoto, K., Nishikawa, T., Suematsu, M., Ogawa, S. & Higashi, T., 2020 Jan 30, In : Journal of Pharmaceutical and Biomedical Analysis. 178, 112912.

Research output: Contribution to journalArticle

Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Hydrocortisone
Assays
Serum
Electrospray ionization
2019
52 Citations (Scopus)

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. & 8 others, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 Jan 31, In : Nature. 565, 7741, p. 600-605 6 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Listeriosis
Histocompatibility
Microbiota
3 Citations (Scopus)

Application of high-performance magnetic nanobeads to biological sensing devices

Kabe, Y., Sakamoto, S., Hatakeyama, M., Yamaguchi, Y., Suematsu, M., Itonaga, M. & Handa, H., 2019 Jan 1, (Accepted/In press) In : Analytical and Bioanalytical Chemistry.

Research output: Contribution to journalArticle

Exosomes
Equipment and Supplies
Technology
Immunoassay
Drug Receptors

A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

Hayakawa, T., Kawasaki, S., Hirayama, Y., Tsutsui, T., Sugiyama, E., Adachi, K., Kon, R., Suematsu, M. & Sugiura, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 3559.

Research output: Contribution to journalArticle

Open Access
Peptic Esophagitis
Sucralfate
Epithelium
Gastric Juice
Pepsin A
10 Citations (Scopus)

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H. C., Ikeda, K., Kanegae, Y., Saito, I., Auwerx, J., Motohashi, H., Suematsu, M., Soga, T., Yokomizo, T., Waguri, S., Mizushima, N. & Komatsu, M., 2019 Dec 1, In : Nature communications. 10, 1, 1567.

Research output: Contribution to journalArticle

Open Access
Nuclear Receptor Co-Repressor 1
lipid metabolism
Peroxisome Proliferator-Activated Receptors
Autophagy
Lipid Metabolism
1 Citation (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journalArticle

Open Access
Helicobacter
Neoplastic Stem Cells
Catenins
Protein Splicing
Histones

Dendropanax morbiferus leaf extract facilitates oligodendrocyte development

Kim, J. Y., Yoon, J. Y., Sugiura, Y., Lee, S. K., Park, J. D., Song, G. J. & Yang, H. J., 2019 Jun 1, In : Royal Society Open Science. 6, 6, 190266.

Research output: Contribution to journalArticle

Open Access
Oligodendroglia
Cell Culture Techniques
Multiple Sclerosis
Anti-Inflammatory Agents
Up-Regulation

Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging

Sugiyama, E., Guerrini, M. M., Honda, K., Hattori, Y., Abe, M., Källback, P., Andrén, P. E., Tanaka, K. F., Setou, M., Fagarasan, S., Suematsu, M. & Sugiura, Y., 2019 Oct 25, In : iScience. 20, p. 359-372 14 p.

Research output: Contribution to journalArticle

Open Access
Mass Spectrometry
Serotonin
Midline Thalamic Nuclei
Brain
Norepinephrine

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 2019 Jul 2, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Stem cells
Maintenance
Fatty Acids
Cell culture

Identification of a binding protein for sesamin and characterization of its roles in plant growth

Tera, M., Koyama, T., Murata, J., Furukawa, A., Mori, S., Azuma, T., Watanabe, T., Hori, K., Okazawa, A., Kabe, Y., Suematsu, M., Satake, H., Ono, E. & Horikawa, M., 2019 Dec 1, In : Scientific reports. 9, 1, 8631.

Research output: Contribution to journalArticle

Open Access
Carrier Proteins
Growth
Sesamum
sesamin
Lignans
2 Citations (Scopus)

Immunohistochemistry for aldosterone synthase CYP11B2 and matrix-assisted laser desorption ionization imaging mass spectrometry for in-situ aldosterone detection

Zhang, Z., Sugiura, Y., Mune, T., Nishiyama, M., Terada, Y., Mukai, K. & Nishimoto, K., 2019 Mar 1, In : Current Opinion in Nephrology and Hypertension. 28, 2, p. 105-112 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP11B2
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Aldosterone
Immunohistochemistry
Hyperaldosteronism

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. & 37 others, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 Aug 1, In : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

IMP Dehydrogenase
Glioblastoma
Carcinogenesis
Transfer RNA
Guanine Nucleotides
1 Citation (Scopus)

Increased cytotoxicity of herpes simplex virus thymidine kinase expression in human induced pluripotent stem cells

Iwasawa, C., Tamura, R., Sugiura, Y., Suzuki, S., Kuzumaki, N., Narita, M., Suematsu, M., Nakamura, M., Yoshida, K., Toda, M., Okano, H. & Miyoshi, H., 2019 Feb 2, In : International Journal of Molecular Sciences. 20, 4, 810.

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
thymidine
Thymidine Kinase
stem cells
Human Herpesvirus 1

Lectin microarray analyses reveal host cell-specific glycan profiles of the hemagglutinins of influenza A viruses

Hiono, T., Matsuda, A., Wagatsuma, T., Okamatsu, M., Sakoda, Y. & Kuno, A., 2019 Jan 15, In : Virology. 527, p. 132-140 9 p.

Research output: Contribution to journalArticle

Influenza A virus
Hemagglutinins
Microarray Analysis
Lectins
Polysaccharides
1 Citation (Scopus)

Mechanical allodynia induced by optogenetic sensory nerve excitation activates dopamine signaling and metabolism in medial nucleus accumbens

Sugiyama, E., Kondo, T., Kuzumaki, N., Honda, K., Yamanaka, A., Narita, M., Suematsu, M. & Sugiura, Y., 2019 Oct 1, In : Neurochemistry International. 129, 104494.

Research output: Contribution to journalArticle

Open Access
Optogenetics
Hyperalgesia
Nucleus Accumbens
Dopamine
Pain

Neutrophil-activating Protein Polymorphism of Helicobacter pylori Determines the Host Risk of Dyspepsia

Matsuzaki, J., Tsugawa, H., Kashiwazaki, Y., Mori, H., Yamamoto, Y., Kameyama, H., Masaoka, T., Kanai, T. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 2, p. 295-297.e6

Research output: Contribution to journalArticle

Open Access
Dyspepsia
Helicobacter pylori neutrophil-activating protein A

Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands

Takeo, E., Sugiura, Y., Uemura, T., Nishimoto, K., Yasuda, M., Sugiyama, E., Ohtsuki, S., Higashi, T., Nishikawa, T., Suematsu, M., Fukusaki, E. & Shimma, S., 2019 Jan 1, In : Analytical chemistry.

Research output: Contribution to journalArticle

Aldosterone
Isomers
Mass spectrometry
Steroids
Imaging techniques
2018
4 Citations (Scopus)

Aldosterone and 18-Oxocortisol Coaccumulation in Aldosterone-Producing Lesions

Sugiura, Y., Takeo, E., Shimma, S., Yokota, M., Higashi, T., Seki, T., Mizuno, Y., Oya, M., Kosaka, T., Omura, M., Nishikawa, T., Suematsu, M. & Nishimoto, K., 2018 Dec 1, In : Hypertension (Dallas, Tex. : 1979). 72, 6, p. 1345-1354 10 p.

Research output: Contribution to journalArticle

Aldosterone
Hyperaldosteronism
Adenoma
Cytochrome P-450 CYP11B2
18-oxocortisol
4 Citations (Scopus)

A method for determination of aldosterone in adrenal tributary venous serum by derivatization using Girard P reagent isotopologues followed by LC/ESI-MS/MS

Higashi, T., Akaishi, M., Yokota, M., Suzuki, T., Ogawa, S., Sugiura, Y., Nishikawa, T., Nishimoto, K. & Suematsu, M., 2018 Aug 15, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1092, p. 106-113 8 p.

Research output: Contribution to journalArticle

Aldosterone
Serum
Sampling
Hyperaldosteronism
Assays
9 Citations (Scopus)

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor–Initiating Stem Cell–Like Cells Resistant to mTORC1 Inhibition

Wu, R., Murali, R., Kabe, Y., French, S. W., Chiang, Y. M., Liu, S., Sher, L., Wang, C. C., Louie, S. & Tsukamoto, H., 2018 Nov 1, In : Hepatology. 68, 5, p. 1726-1740 15 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolases
Autophagy
Sirolimus
Stem Cells
Liver
2 Citations (Scopus)

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journalArticle

Entamoeba histolytica
Metabolomics
Coenzymes
Molecular Biology
Parasites
2 Citations (Scopus)

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

Tsugawa, H., Mori, H., Matsuzaki, J., Sato, A., Saito, Y., Imoto, M., Suematsu, M. & Suzuki, H., 2018 Jan 1, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

Lysosomal-Associated Membrane Protein 1
Low Density Lipoprotein Receptor-Related Protein-1
Autophagy
Helicobacter pylori
Actins
2 Citations (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr 1, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

Entamoeba histolytica
Coenzyme A
Pharmaceutical Preparations
Enzymes
Amebiasis
3 Citations (Scopus)

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Sugiura, Y., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fuku, Y., 2018 Jul 31, In : Science Signaling. 11, 541, eaao4874.

Research output: Contribution to journalArticle

Immune Evasion
Cytokinesis
Tissue
Guanine Nucleotide Exchange Factors
Proteins
7 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct 1, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

Exosomes
Equipment and Supplies
CD147 Antigens
Serum
Flow cytometry
6 Citations (Scopus)

Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system

Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., Uchiyama, N., Yamanaka, A., Kuzumaki, N., Porreca, F. & Narita, M., 2018 Jan 1, In : Molecular Pain. 14

Research output: Contribution to journalArticle

Microdialysis
Nucleus Accumbens
Mass Spectrometry
Pain
Neurotransmitter Agents
17 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Oxidants
Gold
Raman spectroscopy
tumors
4 Citations (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 Nov 1, In : Anticancer Research. 38, 11, p. 6163-6170 8 p.

Research output: Contribution to journalArticle

Fluorouracil
Stomach Neoplasms
Neoplastic Stem Cells
Antiporters
Drug Therapy
13 Citations (Scopus)

Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation

Takata, N., Sugiura, Y., Yoshida, K., Koizumi, M., Hiroshi, N., Honda, K., Yano, R., Komaki, Y., Matsui, K., Suematsu, M., Mimura, M., Okano, H. & Tanaka, K., 2018 Sep 1, In : GLIA. 66, 9, p. 2013-2023 11 p.

Research output: Contribution to journalArticle

Optogenetics
Oxygen Consumption
Astrocytes
Magnetic Resonance Imaging
Acetylcarnitine
18 Citations (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., 2018 Mar 12, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Growth
Neoplasms
Protein Isoforms
Neuroendocrine Tumors
2 Citations (Scopus)

Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia

Goto, S., Morikawa, T., Kubo, A., Takubo, K., Fukuda, K., Kajimura, M. & Suematsu, M., 2018 Jul 1, In : Journal of Clinical Biochemistry and Nutrition. 63, 1, p. 70-79 10 p.

Research output: Contribution to journalArticle

Brain Ischemia
Brain
Mass Spectrometry
Spectroscopy
Imaging techniques
12 Citations (Scopus)

Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice

Tanaka, S., Sugiura, Y., Saito, H., Sugahara, M., Higashijima, Y., Yamaguchi, J., Inagi, R., Suematsu, M., Nangaku, M. & Tanaka, T., 2018 Nov 1, In : Kidney International. 94, 5, p. 912-925 14 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transport Proteins
Oxidative Stress
Kidney
Glucose
Citric Acid Cycle

糖鎖プロファイリングによる疾患特異的マーカーの開発

Translated title of the contribution: Development of a disease-specific glycol-biomarker with glycan profilingMatsuda, A., 2018 Jan 1, In : Seikagaku. 90, 4, p. 482-485 4 p.

Research output: Contribution to journalArticle

Glycols
Biomarkers
Polysaccharides
2017
6 Citations (Scopus)

Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos

Oka, M., Hashimoto, K., Yamaguchi, Y., Saitoh, S. I., Sugiura, Y., Motoi, Y., Honda, K., Kikko, Y., Ohata, S., Suematsu, M., Miura, M., Miyake, K., Katada, T. & Kontani, K., 2017, In : Journal of Cell Science. 130, 20, p. 3568-3577 10 p.

Research output: Contribution to journalArticle

Yolk Sac
Endoderm
Proteolysis
Embryonic Structures
Mothers
4 Citations (Scopus)

Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying

Fukuhara, S., Masaoka, T., Nishimura, S., Nakamura, M., Matsuzaki, J., Tsugawa, H., Miyoshi, S., Mori, H., Kawase, S., Shibata, S., Okano, H., Kanai, T. & Suzuki, H., 2017 Nov 2, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-11 11 p.

Research output: Contribution to journalArticle

Gastric Emptying
Apolipoproteins E
Neuroglia
Knockout Mice
Glial Fibrillary Acidic Protein
27 Citations (Scopus)

Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

Miyajima, M., Zhang, B., Sugiura, Y., Sonomura, K., Guerrini, M. M., Tsutsui, Y., Maruya, M., Vogelzang, A., Chamoto, K., Honda, K., Hikida, T., Ito, S., Qin, H., Sanuki, R., Suzuki, K., Furukawa, T., Ishihama, Y., Matsuda, F., Suematsu, M., Honjo, T. & 1 others, Fagarasan, S., 2017 Nov 16, In : Nature Immunology. 18, 12, p. 1342-1352 11 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Brain
Amino Acids
Programmed Cell Death 1 Receptor
Immune System
4 Citations (Scopus)

Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling

Tai-Nagara, I., Yoshikawa, Y., Numata, N., Ando, T., Okabe, K., Sugiura, Y., Ieda, M., Takakura, N., Nakagawa, O., Zhou, B., Okabayashi, K., Suematsu, M., Kitagawa, Y., Bastmeyer, M., Sato, K., Klein, R., Navankasattusas, S., Li, D. Y., Yamagishi, S. & Kubota, Y., 2017, In : Development (Cambridge). 144, 13, p. 2392-2401 10 p.

Research output: Contribution to journalArticle

Inner Ear
Fibronectins
Leucine
Endothelial Cells
Proteins
1 Citation (Scopus)
Oligodendroglia
Thyroid Hormones
Adult Stem Cells
Core Binding Factor Alpha 2 Subunit
Cyclin-Dependent Kinase Inhibitor p15
18 Citations (Scopus)

Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching

Miyazawa, H., Yamaguchi, Y., Sugiura, Y., Honda, K., Kondo, K., Matsuda, F., Yamamoto, T., Suematsu, M. & Miura, M., 2017, In : Journal of Cell Science. 130, 2, p. 63-73 11 p.

Research output: Contribution to journalArticle

Fructose-Bisphosphate Aldolase
Embryonic Structures
Energy Metabolism
Glucose
Lactic Acid
20 Citations (Scopus)

Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1

Pati, M. L., Groza, D., Riganti, C., Kopecka, J., Niso, M., Berardi, F., Hager, S., Heffeter, P., Hirai, M., Tsugawa, H., Kabe, Y., Suematsu, M. & Abate, C., 2017 Mar 1, In : Pharmacological Research. 117, p. 67-74 8 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Ligands
Membranes
Proteins
Heme
9 Citations (Scopus)

Somatic KCNJ5 mutation occurring early in adrenal development may cause a novel form of juvenile primary aldosteronism

Tamura, A., Nishimoto, K., Seki, T., Matsuzawa, Y., Saito, J., Omura, M., Gomez-Sanchez, C. E., Makita, K., Matsui, S., Moriya, N., Inoue, A., Nagata, M., Sasano, H., Nakamura, Y., Yamazaki, Y., Kabe, Y., Mukai, K., Kosaka, T., Oya, M., Suematsu, S. & 1 others, Nishikawa, T., 2017 Feb 5, In : Molecular and Cellular Endocrinology. 441, p. 134-139 6 p.

Research output: Contribution to journalArticle

Hyperaldosteronism
Aldosterone
Cytochrome P-450 CYP11B2
Adrenal Glands
Mutation
26 Citations (Scopus)

Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6

Lai, K. K. Y., Kweon, S. M., Chi, F., Hwang, E., Kabe, Y., Higashiyama, R., Qin, L., Yan, R., Wu, R. P., Lai, K., Fujii, N., French, S., Xu, J., Wang, J. Y., Murali, R., Mishra, L., Lee, J. S., Ntambi, J. M. & Tsukamoto, H., 2017 May 1, In : Gastroenterology. 152, 6, p. 1477-1491 15 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Low Density Lipoprotein Receptor-Related Protein-5
Stearoyl-CoA Desaturase
Liver Cirrhosis
Hepatic Stellate Cells
3 Citations (Scopus)

Targeting oxygen-sensing prolyl hydroxylase for metformin-associated lactic acidosis treatment

Toramaru, T., Suhara, T., Hayakawa, N., Nakamura, T., Kubo, A., Minamishima, S., Yamaguchi, K., Hishiki, T., Morisaki, H., Suematsu, M. & Minamishima, Y. A., 2017 Aug 1, In : Molecular and Cellular Biology. 37, 16, e00248-17.

Research output: Contribution to journalArticle

Prolyl Hydroxylases
Lactic Acidosis
Metformin
Oxygen
Prolyl-Hydroxylase Inhibitors
2 Citations (Scopus)

Utilizing mass spectrometry imaging to map the thyroid hormones triiodothyronine and thyroxine in Xenopus tropicalis tadpoles

Goto-Inoue, N., Sato, T., Morisasa, M., Kashiwagi, A., Kashiwagi, K., Sugiura, Y., Sugiyama, E., Suematsu, M. & Mori, T., 2017 Dec 15, (Accepted/In press) In : Analytical and Bioanalytical Chemistry. p. 1-8 8 p.

Research output: Contribution to journalArticle

Triiodothyronine
Xenopus
Thyroxine
Thyroid Hormones
Mass spectrometry
2016
4 Citations (Scopus)

Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis

Takeshita, M., Kuno, A., Suzuki, K., Matsuda, A., Shimazaki, H., Nakagawa, T., Otomo, Y., Kabe, Y., Suematsu, M., Narimatsu, H. & Takeuchi, T., 2016 May 21, In : Arthritis Research and Therapy. 18, 1, 112.

Research output: Contribution to journalArticle

Matrix Metalloproteinase 3
Polysaccharides
Rheumatoid Arthritis
Biomarkers
Agrocybe
2 Citations (Scopus)

Disorganized Steroidogenesis in Adrenocortical Carcinoma, a Case Study

Uchida, T., Nishimoto, K., Fukumura, Y., Asahina, M., Goto, H., Kawano, Y., Shimizu, F., Tsujimura, A., Seki, T., Mukai, K., Kabe, Y., Suematsu, M., Gomez-Sanchez, C. E., Yao, T., Horie, S. & Watada, H., 2016 Jul 18, (Accepted/In press) In : Endocrine Pathology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Adrenocortical Carcinoma
Steroid 11-beta-Hydroxylase
Cytochrome P-450 CYP11B2
Hydrocortisone
Aldosterone
20 Citations (Scopus)

Efficacy of 10-day Sitafloxacin-Containing Third-Line Rescue Therapies for Helicobacter pylori Strains Containing the gyrA Mutation

Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Hirata, K., Seino, T., Matsushita, M., Masaoka, T. & Kanai, T., 2016 Aug 1, In : Helicobacter. 21, 4, p. 286-294 9 p.

Research output: Contribution to journalArticle

Helicobacter pylori
Mutation
Esomeprazole
Amoxicillin
Metronidazole
17 Citations (Scopus)

Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility

Takeda, A., Kobayashi, D., Aoi, K., Sasaki, N., Sugiura, Y., Igarashi, H., Tohya, K., Inoue, A., Hata, E., Akahoshi, N., Hayasaka, H., Kikuta, J., Scandella, E., Ludewig, B., Ishii, S., Aoki, J., Suematsu, M., Ishii, M., Takeda, K., Jalkanen, S. & 2 others, Miyasaka, M. & Umemoto, E., 2016 Feb 2, In : eLife. 5, FEBRUARY2016, e10561.

Research output: Contribution to journalArticle

T-cells
Cell Movement
T-Lymphocytes
Lymph Nodes
Myosin Type II
55 Citations (Scopus)

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

Kabe, Y., Nakane, T., Koike, I., Yamamoto, T., Sugiura, Y., Harada, E., Sugase, K., Shimamura, T., Ohmura, M., Muraoka, K., Yamamoto, A., Uchida, T., Iwata, S., Yamaguchi, Y., Krayukhina, E., Noda, M., Handa, H., Ishimori, K., Uchiyama, S., Kobayashi, T. & 1 others, Suematsu, M., 2016 Mar 18, In : Nature Communications. 7, 11030.

Research output: Contribution to journalArticle

Dimerization
dimerization
Heme
cancer
cytochromes
57 Citations (Scopus)

HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity

Semba, H., Takeda, N., Isagawa, T., Sugiura, Y., Honda, K., Wake, M., Miyazawa, H., Yamaguchi, Y., Miura, M., Jenkins, D. M. R., Choi, H., Kim, J. W., Asagiri, M., Cowburn, A. S., Abe, H., Soma, K., Koyama, K., Katoh, M., Sayama, K., Goda, N. & 4 others, Johnson, R. S., Manabe, I., Nagai, R. & Komuro, I., 2016 May 18, In : Nature Communications. 7, 11635.

Research output: Contribution to journalArticle

glycolysis
macrophages
Macrophages
Glycolysis
adenosine triphosphate