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2020

Annexin A1 accounts for an anti-inflammatory binding target of sesamin metabolites

Kabe, Y., Takemoto, D., Kanai, A., Hirai, M., Ono, Y., Akazawa, S., Horikawa, M., Kitagawa, Y., Handa, H., Rogi, T., Shibata, H. & Suematsu, M., 2020 Dec 1, In : npj Science of Food. 4, 1, 4.

Research output: Contribution to journalArticle

Open Access

Comparative Glycomic Analysis of Exosome Subpopulations Derived from Pancreatic Cancer Cell Lines

Matsuda, A., Kuno, A., Yoshida, M., Wagatsuma, T., Sato, T., Miyagishi, M., Zhao, J., Suematsu, M., Kabe, Y. & Narimatsu, H., 2020 Jun 5, In : Journal of Proteome Research. 19, 6, p. 2516-2524 9 p.

Research output: Contribution to journalArticle

Discovery of Pancreatic Ductal Adenocarcinoma-Related Aberrant Glycosylations: A Multilateral Approach of Lectin Microarray-Based Tissue Glycomic Profiling With Public Transcriptomic Datasets

Wagatsuma, T., Nagai-Okatani, C., Matsuda, A., Masugi, Y., Imaoka, M., Yamazaki, K., Sakamoto, M. & Kuno, A., 2020 Mar 13, In : Frontiers in Oncology. 10, 338.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Identification and local manipulation of bone marrow vasculature during intravital imaging

Morikawa, T., Tamaki, S., Fujita, S., Suematsu, M. & Takubo, K., 2020 Dec 1, In : Scientific reports. 10, 1, 6422.

Research output: Contribution to journalArticle

Open Access

Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction

Horii, Y., Nakaya, M., Ohara, H., Nishihara, H., Watari, K., Nagasaka, A., Nakaya, T., Sugiura, Y., Okuno, T., Koga, T., Tanaka, A., Yokomizo, T. & Kurose, H., 2020 Jun 1, In : FASEB Journal. 34, 6, p. 8749-8763 15 p.

Research output: Contribution to journalArticle

Open Access

Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

Takahashi, S. S., Sou, Y. S., Saito, T., Kuma, A., Yabe, T., Sugiura, Y., Lee, H. C., Suematsu, M., Yokomizo, T., Koike, M., Terai, S., Mizushima, N., Waguri, S. & Komatsu, M., 2020, In : Life Science Alliance. 3, 1, e201900513.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Quantitative MALDI-MS/MS assay for serum cortisol through charged derivatization

Nakamura, M., Moritsuna, M., Yuda, K., Fujimura, S., Sugiura, Y., Shimma, S., Nishimoto, K., Nishikawa, T., Suematsu, M., Ogawa, S. & Higashi, T., 2020 Jan 30, In : Journal of Pharmaceutical and Biomedical Analysis. 178, 112912.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes)

Sakae, Y., Oikawa, A., Sugiura, Y., Mita, M., Nakamura, S., Nishimura, T., Suematsu, M. & Tanaka, M., 2020 Apr, In : Biology Open. 9, 4, bio050054.

Research output: Contribution to journalArticle

Open Access
2019

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. & 8 others, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 Jan 31, In : Nature. 565, 7741, p. 600-605 6 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

A thin layer of sucrose octasulfate protects the oesophageal mucosal epithelium in reflux oesophagitis

Hayakawa, T., Kawasaki, S., Hirayama, Y., Tsutsui, T., Sugiyama, E., Adachi, K., Kon, R., Suematsu, M. & Sugiura, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 3559.

Research output: Contribution to journalArticle

Open Access

Autophagy regulates lipid metabolism through selective turnover of NCoR1

Saito, T., Kuma, A., Sugiura, Y., Ichimura, Y., Obata, M., Kitamura, H., Okuda, S., Lee, H. C., Ikeda, K., Kanegae, Y., Saito, I., Auwerx, J., Motohashi, H., Suematsu, M., Soga, T., Yokomizo, T., Waguri, S., Mizushima, N. & Komatsu, M., 2019 Dec 1, In : Nature communications. 10, 1, 1567.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Dendropanax morbiferus leaf extract facilitates oligodendrocyte development

Kim, J. Y., Yoon, J. Y., Sugiura, Y., Lee, S. K., Park, J. D., Song, G. J. & Yang, H. J., 2019 Jun 1, In : Royal Society Open Science. 6, 6, 190266.

Research output: Contribution to journalArticle

Open Access

Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging

Sugiyama, E., Guerrini, M. M., Honda, K., Hattori, Y., Abe, M., Källback, P., Andrén, P. E., Tanaka, K. F., Setou, M., Fagarasan, S., Suematsu, M. & Sugiura, Y., 2019 Oct 25, In : iScience. 20, p. 359-372 14 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 2019 Jul 2, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Fatty acid β-oxidation-dependent and -independent responses and tumor aggressiveness acquired under mild hypoxia

Wakui, M., Kawai, K., Mizushima, T., Nishime, C., Serizawa, A., Suemizu, H., Asakura, K., Yamauchi, Y., Hayashida, T., Suematsu, M. & Murata, M., 2019 Jan, In : Anticancer research. 39, 1, p. 191-200 10 p.

Research output: Contribution to journalArticle

Hydrogen sulfide bypasses the rate-limiting oxygen activation of heme oxygenase

Matsui, T., Sugiyama, R., Sakanashi, K., Tamura, Y., Iida, M., Nambu, Y., Higuchi, T., Suematsu, M. & Ikeda-Saito, M., 2019 Oct 26, In : Journal of Biological Chemistry. 293, 43, p. 16931-16939 9 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Identification of a binding protein for sesamin and characterization of its roles in plant growth

Tera, M., Koyama, T., Murata, J., Furukawa, A., Mori, S., Azuma, T., Watanabe, T., Hori, K., Okazawa, A., Kabe, Y., Suematsu, M., Satake, H., Ono, E. & Horikawa, M., 2019 Dec 1, In : Scientific reports. 9, 1, 8631.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. & 37 others, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 Aug 1, In : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Increased cytotoxicity of herpes simplex virus thymidine kinase expression in human induced pluripotent stem cells

Iwasawa, C., Tamura, R., Sugiura, Y., Suzuki, S., Kuzumaki, N., Narita, M., Suematsu, M., Nakamura, M., Yoshida, K., Toda, M., Okano, H. & Miyoshi, H., 2019 Feb 2, In : International Journal of Molecular Sciences. 20, 4, 810.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Lectin microarray analyses reveal host cell-specific glycan profiles of the hemagglutinins of influenza A viruses

Hiono, T., Matsuda, A., Wagatsuma, T., Okamatsu, M., Sakoda, Y. & Kuno, A., 2019 Jan 15, In : Virology. 527, p. 132-140 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Mechanical allodynia induced by optogenetic sensory nerve excitation activates dopamine signaling and metabolism in medial nucleus accumbens

Sugiyama, E., Kondo, T., Kuzumaki, N., Honda, K., Yamanaka, A., Narita, M., Suematsu, M. & Sugiura, Y., 2019 Oct, In : Neurochemistry International. 129, 104494.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Neutrophil-activating Protein Polymorphism of Helicobacter pylori Determines the Host Risk of Dyspepsia

Matsuzaki, J., Tsugawa, H., Kashiwazaki, Y., Mori, H., Yamamoto, Y., Kameyama, H., Masaoka, T., Kanai, T. & Suzuki, H., 2019, In : CMGH. 8, 2, p. 295-297.e6

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Small molecules assisting eggshell calcium dissolution for embryonic bone formation

Ito, T., Kato, S., Kubo, A., Suematsu, M., Nakata, M. & Saikawa, Y., 2019 Jan 1, (Accepted/In press) In : Tetrahedron. 130854.

Research output: Contribution to journalArticle

Tandem Mass Spectrometry Imaging Reveals Distinct Accumulation Patterns of Steroid Structural Isomers in Human Adrenal Glands

Takeo, E., Sugiura, Y., Uemura, T., Nishimoto, K., Yasuda, M., Sugiyama, E., Ohtsuki, S., Higashi, T., Nishikawa, T., Suematsu, M., Fukusaki, E. & Shimma, S., 2019 Jul 16, In : Analytical chemistry. 91, 14, p. 8918-8925 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides

Fujii, K., Kubo, A., Miyashita, K., Sato, M., Hagiwara, A., Inoue, H., Ryuzaki, M., Tamaki, M., Hishiki, T., Hayakawa, N., Kabe, Y., Itoh, H. & Suematsu, M., 2019 Nov 14, In : JCI Insight. 4, 22, e124816.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Aldosterone and 18-oxocortisol coaccumulation in aldosterone-producing lesions

Sugiura, Y., Takeo, E., Shimma, S., Yokota, M., Higashi, T., Seki, T., Mizuno, Y., Oya, M., Kosaka, T., Omura, M., Nishikawa, T., Suematsu, M. & Nishimoto, K., 2018 Dec, In : Hypertension. 72, 6, p. 1345-1354 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

A method for determination of aldosterone in adrenal tributary venous serum by derivatization using Girard P reagent isotopologues followed by LC/ESI-MS/MS

Higashi, T., Akaishi, M., Yokota, M., Suzuki, T., Ogawa, S., Sugiura, Y., Nishikawa, T., Nishimoto, K. & Suematsu, M., 2018 Aug 15, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1092, p. 106-113 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor–Initiating Stem Cell–Like Cells Resistant to mTORC1 Inhibition

Wu, R., Murali, R., Kabe, Y., French, S. W., Chiang, Y. M., Liu, S., Sher, L., Wang, C. C., Louie, S. & Tsukamoto, H., 2018 Nov 1, In : Hepatology. 68, 5, p. 1726-1740 15 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Biochemical, metabolomic, and genetic analyses of dephospho coenzyme a kinase involved in coenzyme a biosynthesis in the human enteric parasite entamoeba histolytica

Nurkanto, A., Jeelani, G., Yamamoto, T., Hishiki, T., Naito, Y., Suematsu, M., Hashimoto, T. & Nozaki, T., 2018 Nov 30, In : Frontiers in Microbiology. 9, NOV, 2902.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Brief exposure of skin to near-infrared laser modulates mast cell function and augments the immune response

Kimizuka, Y., Katagiri, W., Locascio, J. J., Shigeta, A., Sasaki, Y., Shibata, M., Morse, K., Sirbulescu, R. F., Miyatake, M., Reeves, P., Suematsu, M., Gelfand, J., Brauns, T., Poznansky, M. C., Tsukada, K. & Kashiwagi, S., 2018 Dec 15, In : Journal of Immunology. 201, 12, p. 3587-3603 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy

Tsugawa, H., Mori, H., Matsuzaki, J., Sato, A., Saito, Y., Imoto, M., Suematsu, M. & Suzuki, H., 2018 Jan 1, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target

Nurkanto, A., Jeelani, G., Yamamoto, T., Naito, Y., Hishiki, T., Mori, M., Suematsu, M., Shiomi, K., Hashimoto, T. & Nozaki, T., 2018 Apr, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Cholesterol sulfate is a DOCK2 inhibitor that mediates tissue-specific immune evasion in the eye

Sakurai, T., Uruno, T., Sugiura, Y., Tatsuguchi, T., Yamamura, K., Ushijima, M., Hattori, Y., Kukimoto-Niino, M., Mishima-Tsumagari, C., Watanabe, M., Suematsu, M. & Fuku, Y., 2018 Jul 31, In : Science Signaling. 11, 541, eaao4874.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese

Okada, Y., Momozawa, Y., Sakaue, S., Kanai, M., Ishigaki, K., Akiyama, M., Kishikawa, T., Arai, Y., Sasaki, T., Kosaki, K., Suematsu, M., Matsuda, K., Yamamoto, K., Kubo, M., Hirose, N. & Kamatani, Y., 2018 Dec 1, In : Nature communications. 9, 1, 1631.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Development of a highly sensitive device for counting the number of disease-specific exosomes in human sera

Kabe, Y., Suematsu, M., Sakamoto, S., Hirai, M., Koike, I., Hishiki, T., Matsuda, A., Hasegawa, Y., Tsujita, K., Ono, M., Minegishi, N., Hozawa, A., Murakami, Y., Kubo, M., Itonaga, M. & Handa, H., 2018 Oct, In : Clinical Chemistry. 64, 10, p. 1463-1473 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Extracellular N-acetylaspartylglutamate released in the nucleus accumbens modulates the pain sensation: Analysis using a microdialysis/mass spectrometry integrated system

Watanabe, M., Sugiura, Y., Sugiyama, E., Narita, M., Navratilova, E., Kondo, T., Uchiyama, N., Yamanaka, A., Kuzumaki, N., Porreca, F. & Narita, M., 2018 Jan 1, In : Molecular Pain. 14

Research output: Contribution to journalArticle

8 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 Nov 1, In : Anticancer Research. 38, 11, p. 6163-6170 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure

Umbarawan, Y., Syamsunarno, M. R. A. A., Koitabashi, N., Obinata, H., Yamaguchi, A., Hanaoka, H., Hishiki, T., Hayakawa, N., Sano, M., Sunaga, H., Matsui, H., Tsushima, Y., Suematsu, M., Kurabayashi, M. & Iso, T., 2018 Dec 1, In : Scientific reports. 8, 1, 12035.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Neuroprotective Role of Astroglia in Parkinson Disease by Reducing Oxidative Stress Through Dopamine-Induced Activation of Pentose-Phosphate Pathway

Mashima, K., Takahashi, S., Minami, K., Izawa, Y., Abe, T., Tsukada, N., Hishiki, T., Suematsu, M., Kajimura, M. & Suzuki, N., 2018 May 1, In : ASN Neuro. 10

Research output: Contribution to journalArticle

8 Citations (Scopus)

Optogenetic astrocyte activation evokes BOLD fMRI response with oxygen consumption without neuronal activity modulation

Takata, N., Sugiura, Y., Yoshida, K., Koizumi, M., Hiroshi, N., Honda, K., Yano, R., Komaki, Y., Matsui, K., Suematsu, M., Mimura, M., Okano, H. & Tanaka, K. F., 2018 Sep, In : Glia. 66, 9, p. 2013-2023 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. & 12 others, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., 2018 Mar 12, In : Cancer Cell. 33, 3, p. 355-367.e7

Research output: Contribution to journalArticle

33 Citations (Scopus)

Plant hormone cytokinins control cell cycle progression and plastid replication in apicomplexan parasites

Andrabi, S. B. A., Tahara, M., Matsubara, R., Toyama, T., Aonuma, H., Sakakibara, H., Suematsu, M., Tanabe, K., Nozaki, T. & Nagamune, K., 2018 Feb, In : Parasitology International. 67, 1, p. 47-58 12 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)
2 Citations (Scopus)

Sodium-glucose cotransporter 2 inhibition normalizes glucose metabolism and suppresses oxidative stress in the kidneys of diabetic mice

Tanaka, S., Sugiura, Y., Saito, H., Sugahara, M., Higashijima, Y., Yamaguchi, J., Inagi, R., Suematsu, M., Nangaku, M. & Tanaka, T., 2018 Nov 1, In : Kidney International. 94, 5, p. 912-925 14 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Survey on patients with undiagnosed diseases in Japan: Potential patient numbers benefiting from Japan's initiative on rare and undiagnosed diseases (IRUD)

Adachi, T., Imanishi, N., Ogawa, Y., Furusawa, Y., Izumida, Y., Izumi, Y. & Suematsu, M., 2018 Nov 20, In : Orphanet journal of rare diseases. 13, 1, 208.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

糖鎖プロファイリングによる疾患特異的マーカーの開発

Translated title of the contribution: Development of a disease-specific glycol-biomarker with glycan profilingMatsuda, A., 2018 Jan 1, In : Seikagaku. 90, 4, p. 482-485 4 p.

Research output: Contribution to journalArticle

2017

Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos

Oka, M., Hashimoto, K., Yamaguchi, Y., Saitoh, S. I., Sugiura, Y., Motoi, Y., Honda, K., Kikko, Y., Ohata, S., Suematsu, M., Miura, M., Miyake, K., Katada, T. & Kontani, K., 2017 Jan 1, In : Journal of Cell Science. 130, 20, p. 3568-3577 10 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Assessment of tumor characteristics based on glycoform analysis of membrane-tethered MUC1

Matsuda, A., Higashi, M., Nakagawa, T., Yokoyama, S., Kuno, A., Yonezawa, S. & Narimatsu, H., 2017 Sep 1, In : Laboratory Investigation. 97, 9, p. 1103-1113 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)