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2005

Carbon monoxide as a guardian against hepatobiliary dysfunction

Suematsu, M., Tsukada, K., Tajima, T., Yamamoto, T., Ochiai, D., Watanabe, H., Yoshimura, Y. & Goda, N., 2005 Nov 1, In : Alcoholism: Clinical and Experimental Research. 29, 11 SUPPL., p. 134S-139S

Research output: Contribution to journalArticle

6 Citations (Scopus)

Detection of potentially novel bacterial components of the human skin microbiota using culture-independent molecular profiling

Dekio, I., Hayashi, H., Sakamoto, M., Kitahara, M., Nishikawa, T., Suematsu, M. & Benno, Y., 2005 Dec 1, In : Journal of Medical Microbiology. 54, 12, p. 1231-1238 8 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Expression and function of cGMP-dependent protein kinase type I during medaka fish embryogenesis

Yamamoto, T. & Suzuki, N., 2005 Apr 29, In : Journal of Biological Chemistry. 280, 17, p. 16979-16986 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Hydrogen sulfide as an endogenous modulator of biliary bicarbonate excretion in the rat liver

Fujii, K., Sakuragawa, T., Kashiba, M., Sugiura, Y., Kondo, M., Maruyama, K., Goda, N., Nimura, Y. & Suematsu, M., 2005 May 1, In : Antioxidants and Redox Signaling. 7, 5-6, p. 788-794 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Invasive phenotype and apoptosis induction of Plesiomonas shigelloides P-1 strain to Caco-2 cells

Tsugawa, H., Ono, T., Murakami, H. & Okawa, Y., 2005 Dec 12, In : Journal of Applied Microbiology. 99, 6, p. 1435-1443 9 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes

Kabe, Y., Yamada, J., Uga, H., Yamaguchi, Y., Wada, T. & Handa, H., 2005 Jan 1, In : Molecular and cellular biology. 25, 1, p. 512-522 11 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: Identification of α-ketoglutarate decarboxylase

Tian, J., Bryk, R., Itoh, M., Suematsu, M. & Nathan, C., 2005 Jul 26, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 30, p. 10670-10675 6 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)
2004

Physiological capacity of the reticuloendothelial system for the degradation of hemoglobin vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusions for 14 days

Sakai, H., Masada, Y., Horinouchi, H., Ikeda, E., Sou, K., Takeoka, S., Suematsu, M., Takaori, M., Kobayashi, K. & Tsuchida, E., 2004 Dec 1, In : Journal of Pharmacology and Experimental Therapeutics. 311, 3, p. 874-884 11 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Pioglitazone Prevents Alcohol-Induced Fatty Liver in Rats Through Upregulation of c-Met

Tomita, K., Azuma, T., Kitamura, N., Nishida, J., Tamiya, G., Oka, A., Inokuchi, S., Nishimura, T., Suematsu, M. & Ishii, H., 2004 Mar, In : Gastroenterology. 126, 3, p. 873-885 13 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

Role of Thromboxane Derived from COX-1 and -2 in Hepatic Microcirculatory Dysfunction during endotoxemia in Mice

Katagiri, H., Ito, Y., Ishii, K. I., Hayashi, I., Suematsu, M., Yamashina, S., Murata, T., Narumiya, S., Kakita, A. & Majima, M., 2004 Jan 1, In : Hepatology. 39, 1, p. 139-150 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2003

Bilirubin Production and Hemeoxygenase-1 Expression in Ischemia-Reperfused Rat Liver in vivo

Kobayashi, T., Sato, Y., Yamamoto, S., Takeishi, T., Hirano, K. I., Watanabe, T., Kurosaki, I., Shirai, Y., Naito, M., Suematsu, M. & Hatakeyama, K., 2003 Dec 1, In : Japanese Pharmacology and Therapeutics. 31, SUPPL. 1, p. S109-S117+S131

Research output: Contribution to journalArticle

Bilirubin rinse: A simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning

Kato, Y., Shimazu, M., Kondo, M., Uchida, K., Kumamoto, Y., Wakabayashi, G., Kitajima, M. & Suematsu, M., 2003 Aug 1, In : Hepatology. 38, 2, p. 364-373 10 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Expression of heme oxygenase-1 in rat ontogeny

Watanabe, T., Hasegawa, G., Yamamoto, T., Hatakeyama, K., Suematsu, M. & Naito, M., 2003 May 1, In : Archives of Histology and Cytology. 66, 2, p. 155-162 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Human serum albumin incorporating synthetic heme: Red blood cell substitute without hypertension by nitric oxide scavenging

Tsuchida, E., Komatsu, T., Matsukawa, Y., Nakagawa, A., Sakai, H., Kobayashi, K. & Suematsu, M., 2003 Feb 1, In : Journal of Biomedical Materials Research - Part A. 64, 2, p. 257-261 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Identification of outer mitochondrial membrane cytochrome b5 as a modulator for androgen synthesis in Leydig cells

Ogishima, T., Kinoshita, J. Y., Mitani, F., Suematsu, M. & Ito, A., 2003 Jun 6, In : Journal of Biological Chemistry. 278, 23, p. 21204-21211 8 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Kinetic and Spectroscopic Characterization of a Hydroperoxy Compound in the Reaction of Native Myoglobin with Hydrogen Peroxide

Egawa, T., Yoshioka, S., Takahashi, S., Hori, H., Nagano, S., Shimada, H., Ishimori, K., Morishima, I., Suematsu, M. & Ishimura, Y., 2003 Oct 24, In : Journal of Biological Chemistry. 278, 43, p. 41597-41606 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction

Murai, M., Yoneyama, H., Ezaki, T., Suematsu, M., Terashima, Y., Harada, A., Hamada, H., Asakura, H., Ishikawa, H. & Matsushima, K., 2003 Feb 1, In : Nature Immunology. 4, 2, p. 154-160 7 p.

Research output: Contribution to journalArticle

215 Citations (Scopus)
2002

Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicity

Hori, R., Kashiba, M., Toma, T., Yachie, A., Goda, N., Makino, N., Soejima, A., Nagasawa, T., Nakabayashi, K. & Suematsu, M., 2002 Mar 22, In : Journal of Biological Chemistry. 277, 12, p. 10712-10718 7 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress

Ozawa, N., Goda, N., Makino, N., Yamaguchi, T., Yoshimura, Y. & Suematsu, M., 2002 Jan 1, In : Journal of Clinical Investigation. 109, 4, p. 457-467 11 p.

Research output: Contribution to journalArticle

Open Access
87 Citations (Scopus)

The protective role of Kupffer cells in the ischemia-reperfused rat liver

Kobayashi, T., Hirano, K. I., Yamamoto, T., Hasegawa, G., Hatakeyama, K., Suematsu, M. & Naito, M., 2002 Aug, In : Archives of Histology and Cytology. 65, 3, p. 251-261 11 p.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)
2001

Activated platelets and endothelial cell interaction with neutrophils under flow conditions

Mine, S., Fujisaki, T., Suematsu, M. & Tanaka, Y., 2001 Jan 1, In : Internal Medicine. 40, 11, p. 1085-1092 8 p.

Research output: Contribution to journalArticle

Open Access
35 Citations (Scopus)

Altered expression of heme oxygenase-1 in the livers of patients with portal hypertensive diseases

Makino, N., Suematsu, M., Sugiura, Y., Morikawa, H., Shiomi, S., Goda, N., Sano, T., Nimura, Y., Sugimachi, K. & Ishimura, Y., 2001 Jan 1, In : Hepatology. 33, 1, p. 32-42 11 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

An ELISA assay for heme oxygenase (HO-1)

Kitchin, K. T., Anderson, W. L. & Suematsu, M., 2001 Jan 1, In : Journal of Immunological Methods. 247, 1-2, p. 153-161 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver

Kyokane, T., Norimizu, S., Taniai, H., Yamaguchi, T., Takeoka, S., Tsuchida, E., Naito, M., Nimura, Y., Ishimura, Y. & Suematsu, M., 2001 Jan 1, In : Gastroenterology. 120, 5, p. 1227-1240 14 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Endothelin B receptor-mediated protection against anoxia-reoxygenation injury in perfused rat liver: Nitric oxide-dependent and-independent mechanisms

Taniai, H., Suematsu, M., Susuki, T., Norimizu, S., Hori, R., Ishimura, Y. & Nimura, Y., 2001 Jan 1, In : Hepatology. 33, 4, p. 894-901 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Increased expression of heme oxygenase-1 and bilirubin accumulation in foam cells of rabbit atherosclerotic lesions

Nakayama, M., Takahashi, K., Komaru, T., Fukuchi, M., Shioiri, H., Sato, K. I., Kitamuro, T., Shirato, K., Yamaguchi, T., Suematsu, M. & Shibahara, S., 2001 Jan 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 21, 8, p. 1373-1377 5 p.

Research output: Contribution to journalArticle

Open Access
60 Citations (Scopus)

Kupffer cell-mediated recruitment of rat dendritic cells to the liver: Roles of N-acetylgalactosamine-specific sugar receptors

Uwatoku, R., Suematsu, M., Ezaki, T., Saiki, T., Tsuiji, M., Irimura, T., Kawada, N., Suganuma, T., Naito, M. & Matsuno, K., 2001 Jan 1, In : Gastroenterology. 121, 6, p. 1460-1472 13 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Organic phosphates as a new class of soluble guanylate cyclase inhibitors

Suzuki, T., Suematsu, M. & Makino, R., 2001 Oct 19, In : FEBS Letters. 507, 1, p. 49-53 5 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Role of heme oxygenase-1 and kupffer cells in the production of bilirubin in the rat liver

Hirano, K. I., Kobayashi, T., Watanabe, T., Yamamoto, T., Hasegawa, G., Hatakeyama, K., Suematsu, M. & Naito, M., 2001 Jan 1, In : Archives of Histology and Cytology. 64, 2, p. 169-178 10 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice

Imai, T., Morita, T., Shindo, T., Nagai, R., Yazaki, Y., Kurihara, H., Suematsu, M. & Katayama, S., 2001 Jul 6, In : Circulation research. 89, 1, p. 55-62 8 p.

Research output: Contribution to journalArticle

Open Access
95 Citations (Scopus)
2000

Increased sensitivity to the C-X-C chemokine CINC/gro in a model of chronic inflammation

Johnston, B., Burns, A. R., Suematsu, M., Watanabe, K., Issekutz, T. B. & Kubes, P., 2000 Jan 1, In : Microcirculation. 7, 2, p. 109-118 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Protective roles of endogenous carbon monoxide in neointimal development elicited by arterial injury

Togane, Y., Morita, T., Suematsu, M., Ishimura, Y., Yamazaki, J. I. & Katayama, S., 2000 Feb 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 278, 2 47-2, p. H623-H632

Research output: Contribution to journalArticle

112 Citations (Scopus)

Stage-specific expression of mucosal addressin cell adhesion molecule-1 during embryogenesis in rats

Iizuka, T., Tanaka, T., Suematsu, M., Miura, S., Watanabe, T., Koike, R., Ishimura, Y., Ishii, H., Miyasaka, N. & Miyasaka, M., 2000 Mar 1, In : Journal of Immunology. 164, 5, p. 2463-2471 9 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)
1999

Carbon monoxide overproduced by heme oxygenase-1 causes a reduction of vascular resistance in perfused rat liver

Wakabayashi, Y., Takamiya, R., Mizuki, A., Kyokane, T., Goda, N., Yamaguchi, T., Takeoka, S., Tsuchida, E., Suematsu, M. & Ishimura, Y., 1999 Nov 1, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 5 40-5, p. G1088-G1096

Research output: Contribution to journalArticle

62 Citations (Scopus)

Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1

Johnston, B., Burns, A. R., Suematsu, M., Issekutz, T. B., Woodman, R. C. & Kubes, P., 1999 May, In : Journal of Clinical Investigation. 103, 9, p. 1269-1276 8 p.

Research output: Contribution to journalArticle

Open Access
155 Citations (Scopus)

Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: Role of bilirubin generated by the enzyme

Hayashi, S., Takamiya, R., Yamaguchi, T., Matsumoto, K., Tojo, S. J., Tamatani, T., Kitajima, M., Makino, N., Ishimura, Y. & Suematsu, M., 1999 Oct 15, In : Circulation research. 85, 8, p. 663-671 9 p.

Research output: Contribution to journalArticle

Open Access
315 Citations (Scopus)

Kupffer cell-independent acute hepatocellular oxidative stress and decreased bile formation in post-cold-ischemic rat liver

Kumamoto, Y., Suematsu, M., Shimazu, M., Kato, Y., Sano, T., Makino, N., Hirano, K. I., Naito, M., Wakabayashi, G. O., Ishimura, Y. & Kitajima, M., 1999 Jan 1, In : Hepatology. 30, 6, p. 1454-1463 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Nitric oxide inhibits microvascular protein leakage induced by leukocyte adhesion-independent and adhesion-dependent inflammatory mediators

Johnston, B., Gaboury, J. P., Suematsu, M. & Kubes, P., 1999 Jan 1, In : Microcirculation. 6, 2, p. 153-162 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Recent advances in the vascular pathophysiology of heme oxygenase-carbon monoxide system

Suematsu, M., Makino, N. & Ishimura, Y., 1999 Dec 1, In : Pathophysiology. 6, 3, p. 143-148 6 p.

Research output: Contribution to journalArticle

1998

Carbon monoxide as a regulator of bile canalicular contractility in cultured rat hepatocytes

Shinoda, Y., Suematsu, M., Wakabayashi, Y., Suzuki, T., Goda, N., Saito, S., Yamaguchi, T. & Ishimura, Y., 1998 Aug 17, In : Hepatology. 28, 2, p. 286-295 10 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

CINC/gro and MCP-1 induce CD18-dependent neutrophil migration from inflamed venules in vivo

Johnston, B., Burns, A. R., Suematsu, M., Issekutz, T. B. & Kubes, P., 1998 Mar 20, In : FASEB Journal. 12, 5, p. A646

Research output: Contribution to journalArticle

CO overproduction is responcible for heme oxygenase 1-mediated microvascular hyporeactivity in perfused rat liver

Wakabayashi, Y., Takamiya, R., Mizuki, A., Suematsu, M. & Ishimura, Y., 1998 Mar 20, In : FASEB Journal. 12, 5, p. A1001

Research output: Contribution to journalArticle

Discontinuous total parenteral nutrition prevents postischemic mitochondrial dysfunction in rat liver

Morikawa, N., Suematsu, M., Kyokane, T., Goda, N., Kumamoto, Y., Okitsu, T., Ishimura, Y. & Kitajima, M., 1998 Nov 10, In : Hepatology. 28, 5, p. 1289-1299 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation

Goda, N., Suzuki, K., Naito, M., Takeoka, S., Tsuchida, E., Ishimura, Y., Tamatani, T. & Suematsu, M., 1998 Feb 1, In : Journal of Clinical Investigation. 101, 3, p. 604-612 9 p.

Research output: Contribution to journalArticle

Open Access
240 Citations (Scopus)

Distribution of heme oxygenase isoforms in rat liver characterized by novel monoclonal antibodies

Goda, N., Naito, M., Tamatani, T., Ishimura, Y. & Suematsu, M., 1998 Mar 20, In : FASEB Journal. 12, 5, p. A1001

Research output: Contribution to journalArticle

Modulation of P-selectin dependent leukocyte-endothelial cell interactions by inducible heme oxygenase in rat post-capillary venules in vivo

Takamiya, R., Hayashi, S., Goda, N., Wakabayashi, Y., Kitajima, M., Tamatani, T., Tojo, S., Ishimura, Y. & Suematsu, M., 1998 Mar 20, In : FASEB Journal. 12, 5, p. A806

Research output: Contribution to journalArticle

Nitric oxide modulates T-lymphocyte migration in Peyer's patches and villous submucosa of rat small intestine

Hokari, R., Miura, S., Fujimori, H., Tsuzuki, Y., Shigematsu, T., Higuchi, H., Kimura, H., Kurose, I., Serizawa, H., Suematsu, M., Yagita, H., Granger, D. N. & Ishii, H., 1998 Jan 1, In : Gastroenterology. 115, 3, p. 618-627 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Nitric oxide suppression reversibly attenuates mitochondrial dysfunction and cholestasis in endotoxemic rat liver

Shiomi, M., Wakabayashi, Y., Sano, T., Shinoda, Y., Nimura, Y., Ishimura, Y. & Suematsu, M., 1998 Jan 29, In : Hepatology. 27, 1, p. 108-115 8 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)
1997

Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy

Iigo, Y., Suematsu, M., Higashida, T., Oheda, J. I., Matsumoto, K., Wakabayashi, Y., Ishimura, Y., Miyasaka, M. & Takashi, T., 1997, In : American Journal of Physiology - Heart and Circulatory Physiology. 42, 1

Research output: Contribution to journalArticle

Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy

Iigo, Y., Suematsu, M., Higashida, T., Oheda, J. I., Matsumoto, K., Wakabayashi, Y., Ishimura, Y., Miyasaka, M. & Takashi, T., 1997 Jul 1, In : American Journal of Physiology - Heart and Circulatory Physiology. 273, 1 42-1, p. H138-H147

Research output: Contribution to journalArticle

66 Citations (Scopus)