Research Output

2020

Advances in the diagnosis and treatment of dry eye

Kojima, T., Dogru, M., Kawashima, M., Nakamura, S. & Tsubota, K., 2020 Jan 1, (Accepted/In press) In : Progress in Retinal and Eye Research. 100842.

Research output: Contribution to journalReview article

Open Access

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society

Members of The Asia Dry Eye Society, 2020 Jan 1, In : Eye & contact lens. 46, p. S2-S13

Research output: Contribution to journalArticle

A review on the epidemiology of myopia in school children worldwide

Grzybowski, A., Kanclerz, P., Tsubota, K., Lanca, C. & Saw, S. M., 2020 Jan 14, In : BMC ophthalmology. 20, 1, 1 p.

Research output: Contribution to journalReview article

Open Access

Estimation of the minimum effective dose of dietary supplement crocetin for prevention of myopia progression in mice

Mori, K., Kurihara, T., Jiang, X., Ikeda, S. I., Yotsukura, E., Torii, H. & Tsubota, K., 2020 Jan 1, In : Nutrients. 12, 1, 180.

Research output: Contribution to journalArticle

Open Access

Five-year Outcomes of Corneal Cross-Linking for Keratoconus: Comparison Between Conventional and Accelerated Procedures

Kato, N., Negishi, K., Sakai, C., Toda, I., Ide, T., Torii, H. & Tsubota, K., 2020 Jan 1, In : Cornea. 39, 1, p. e1

Research output: Contribution to journalArticle

Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study

Uchida, A., Sasaki, M., Motomura, K., Yuki, K., Kurihara, T., Tomita, Y., Ozawa, Y., Yamagishi, K., Kawasaki, R., Hanyuda, A., Sawada, N., Tsubota, K., Tsugane, S. & Iso, H., 2020 Dec 1, In : Scientific reports. 10, 1, 779.

Research output: Contribution to journalArticle

Open Access

Tear Film Dynamics of Soft Contact Lens-Induced Dry Eye

Kaido, M., Kawashima, M., Ishida, R. & Tsubota, K., 2020 Jan 1, (Accepted/In press) In : Current Eye Research.

Research output: Contribution to journalArticle

The effects of 3% diquafosol sodium eye drops on tear function and the ocular surface of Cu, Zn-superoxide dismutase-1 (SOD1) knockout mice treated with antiglaucoma eye medications

Yagi-Yaguchi, Y., Kojima, T., Higa, K., Dogru, M., Ibrahim, O. M. A., Shimizu, T., Tsubota, K. & Shimazaki, J., 2020 Jan 1, In : Diagnostics. 10, 1, 20.

Research output: Contribution to journalArticle

Open Access
2019

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver

Nakamura, A., Zhu, Q., Yokoyama, Y., Kitamura, N., Uchida, S., Kumadaki, K., Tsubota, K. & Watanabe, M., 2019 Jan 1, In : Foods. 8, 11, 546.

Research output: Contribution to journalArticle

Open Access

Age-Related Conjunctival P2Y2 Receptor Alterations in the Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Dry Eye Model Mice

Dogru, M., Shinzawa, M., Kojima, T., Shimizu, T. & Tsubota, K., 2019 Nov 1, In : Eye & contact lens. 45, 6, p. 405-409 5 p.

Research output: Contribution to journalArticle

Analysis of the association between the severity of ocular and systemic pain

Yamanishi, R., Uchino, M., Kawashima, M., Dogru, M., Matsuguma, S. & Tsubota, K., 2019 Jan 1, In : Ocular Surface.

Research output: Contribution to journalArticle

A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion

Kunimi, H., Miwa, Y., Inoue, H., Tsubota, K. & Kurihara, T., 2019 Jun 28, In : International journal of molecular sciences. 20, 13

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
Open Access
1 Citation (Scopus)

Association between retinal nerve fiber layer thickness and eye fatigue

Ayaki, M., Kuze, M., Kondo, M., Tsubota, K. & Negishi, K., 2019 Jan 1, In : BioMed Research International. 2019, 3014567.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Changes in Murine Subbasal Corneal Nerves After Scopolamine-Induced Dry Eye Stress Exposure

Simsek, C., Kojima, T., Nagata, T., Dogru, M. & Tsubota, K., 2019 Feb 1, In : Investigative ophthalmology & visual science. 60, 2, p. 615-623 9 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Characteristics and Risk Factors Associated with Diagnosed and Undiagnosed Symptomatic Dry Eye Using a Smartphone Application

Inomata, T., Iwagami, M., Nakamura, M., Shiang, T., Yoshimura, Y., Fujimoto, K., Okumura, Y., Eguchi, A., Iwata, N., Miura, M., Hori, S., Hiratsuka, Y., Uchino, M., Tsubota, K., Dana, R. & Murakami, A., 2019 Jan 1, (Accepted/In press) In : JAMA Ophthalmology.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Choosing Core Outcomes for Use in Clinical Trials in Ophthalmology: Perspectives from Three Ophthalmology Outcomes Working Groups

Ophthalmology Outcomes Working Groups, 2019 Jan 1, In : Ophthalmology. 126, 1, p. 6-9 4 p.

Research output: Contribution to journalEditorial

Open Access
3 Citations (Scopus)

Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake Disease): East Asia Occult Macular Dystrophy Studies Report Number 1

Fujinami, K., Yang, L., Joo, K., Tsunoda, K., Kameya, S., Hanazono, G., Fujinami-Yokokawa, Y., Arno, G., Kondo, M., Nakamura, N., Kurihara, T., Tsubota, K., Zou, X., Li, H., Park, K. H., Iwata, T., Miyake, Y., Woo, S. J. & Sui, R., 2019 Jan 1, In : Ophthalmology.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cluster of differentiation 30 expression in lacrimal gland and conjunctival tissues in patients with Sjögren's syndrome: Case series

Ogawa, A., Ogawa, Y., Mukai, S., Shimizu, E., Kuwana, M., Kawakami, Y. & Tsubota, K., 2019 Jul 1, In : Medicine. 98, 29, p. e16390

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Commensal microflora in human conjunctiva; characteristics of microflora in the patients with chronic ocular graft-versus-host disease

Shimizu, E., Ogawa, Y., Saijo, Y., Yamane, M., Uchino, M., Kamoi, M., Fukui, M., Yang, F., He, J., Mukai, S. & Tsubota, K., 2019 Jan 1, In : Ocular Surface.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease

Shimizu, E., Aketa, N., Yazu, H., Uchino, M., Kamoi, M., Sato, Y., Tsubota, K. & Ogawa, Y., 2019 Jan 1, (Accepted/In press) In : Ocular Surface.

Research output: Contribution to journalArticle

Corneal Higher-Order Aberrations in Eyes with Corneal Scar after Traumatic Perforation

Shimizu, E., Yamaguchi, T., Tsubota, K. & Shimazaki, J., 2019 Mar 1, In : Eye and Contact Lens. 45, 2, p. 124-131 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Corneal higher-order aberrations in Stevens-Johnson syndrome and toxic epidermal necrolysis

Ibrahim, O. M. A., Yagi-Yaguchi, Y., Noma, H., Tsubota, K., Shimazaki, J. & Yamaguchi, T., 2019 Jan 1, In : Ocular Surface.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Corneal Sensory Experience via Transient Receptor Potential Vanilloid 1 Accelerates the Maturation of Neonatal Tearing

Jin, K., Imada, T., Nakamura, S., Izuta, Y., Oonishi, E., Shibuya, M., Sakaguchi, H., Tanabe, H., Ito, M., Katanosaka, K. & Tsubota, K., 2019 Sep 1, In : American Journal of Pathology. 189, 9, p. 1699-1710 12 p.

Research output: Contribution to journalArticle

Corrigendum to “TFOS DEWS II pathophysiology report” (The Ocular Surface (2017) 15(3) (438–510), (S1542012417301349), (10.1016/j.jtos.2017.05.011))

Bron, A. J., de Paiva, C. S., Chauhan, S. K., Bonini, S., Gabison, E. E., Jain, S., Knop, E., Markoulli, M., Ogawa, Y., Perez, V., Uchino, Y., Yokoi, N., Zoukhri, D. & Sullivan, D. A., 2019 Oct, In : Ocular Surface. 17, 4, 1 p.

Research output: Contribution to journalComment/debate

Current Prevalence of Myopia and Association of Myopia with Environmental Factors among Schoolchildren in Japan

Yotsukura, E., Torii, H., Inokuchi, M., Tokumura, M., Uchino, M., Nakamura, K., Hyodo, M., Mori, K., Jiang, X., Ikeda, S. I., Kondo, S., Negishi, K., Kurihara, T. & Tsubota, K., 2019 Jan 1, (Accepted/In press) In : JAMA Ophthalmology.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy

Suzuki, N., Yamaguchi, T., Shibata, S., Nagai, T., Noma, H., Tsubota, K. & Shimazaki, J., 2019 Feb 1, In : American Journal of Ophthalmology. 198, p. 174-180 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Dietary spirulina supplementation protects visual function from photostress by suppressing retinal neurodegeneration in mice

Okamoto, T., Kawashima, H., Osada, H., Toda, E., Homma, K., Nagai, N., Imai, Y., Tsubota, K. & Ozawa, Y., 2019 Nov, In : Translational Vision Science and Technology. 8, 6, 20.

Research output: Contribution to journalArticle

Open Access

Diurnal variation of human tear meniscus volume measured with tear strip meniscometry self-examination

Ayaki, M., Tachi, N., Hashimoto, Y., Kawashima, M., Tsubota, K. & Negishi, K., 2019 Apr 1, In : PloS one. 14, 4, e0215922.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy

Nagai, N., Suzuki, M., Minami, S., Kurihara, T., Kamoshita, M., Sonobe, H., Watanabe, K., Uchida, A., Shinoda, H., Tsubota, K. & Ozawa, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 11389.

Research output: Contribution to journalArticle

Open Access
Open Access

Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy

Minami, S., Shinoda, H., Shigeno, Y., Nagai, N., Kurihara, T., Watanabe, K., Sonobe, H., Takagi, H., Tsubota, K. & Ozawa, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 19056.

Research output: Contribution to journalArticle

Open Access

Effect of eyelid hygiene detergent on obstructive meibomian gland dysfunction

Tanabe, H., Kaido, M., Kawashima, M., Ishida, R., Ayaki, M. & Tsubota, K., 2019 Jan 1, In : Journal of Oleo Science. 68, 1, p. 67-78 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effect of midazolam, medetomidine, and butorphanol tartrate combination anesthetic on electroretinograms of mice

Miwa, Y., Tsubota, K. & Kurihara, T., 2019 Jan 1, In : Molecular vision. 25, p. 645-653 9 p.

Research output: Contribution to journalArticle

Effects of hyperoxia on the refraction in murine neonatal and adult models

Mori, K., Kurihara, T., Jiang, X., Ikeda, S. I., Ishida, A., Torii, H. & Tsubota, K., 2019 Dec 1, In : International journal of molecular sciences. 20, 23, 6014.

Research output: Contribution to journalArticle

Open Access

Efficacy of Plate Expression of Meibum on Tear Function and Ocular Surface Findings in Meibomian Gland Disease

Aketa, N., Shinzawa, M., Kawashima, M., Dogru, M., Okamoto, S., Tsubota, K. & Shimazaki, J., 2019 Jan 1, In : Eye & contact lens. 45, 1, p. 19-22 4 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Enriched environment alleviates stress-induced dry-eye through the BDNF axis

Sano, K., Kawashima, M., Imada, T., Suzuki, T., Nakamura, S., Mimura, M., Tanaka, K. & Tsubota, K., 2019 Dec 1, In : Scientific reports. 9, 1, 3422.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Evaluation of AAV-DJ vector for retinal gene therapy

Katada, Y., Kobayashi, K., Tsubota, K. & Kurihara, T., 2019 Jan 1, In : PeerJ. 2019, 1, e6317.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency

and The International Limbal Stem Cell Deficiency Working Group, 2019 Mar 1, In : Cornea. 38, 3, p. 364-375 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model

Kunimi, H., Miwa, Y., Katada, Y., Tsubota, K. & Kurihara, T., 2019 Jan 1, In : PeerJ. 2019, 10, e7849.

Research output: Contribution to journalArticle

Open Access

Hydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals

Kawashima, M., Tsuno, S., Matsumoto, M. & Tsubota, K., 2019 Oct, In : Ocular Surface. 17, 4, p. 714-721 8 p.

Research output: Contribution to journalArticle

IMI – Clinical myopia control trials and instrumentation report

Wolffsohn, J. S., Kollbaum, P. S., Berntsen, D. A., Atchison, D. A., Benavente, A., Bradley, A., Buckhurst, H., Collins, M., Fujikado, T., Hiraoka, T., Hirota, M., Jones, D., Logan, N. S., Lundström, L., Torii, H., Read, S. A. & Naidoo, K., 2019 Feb 1, In : Investigative Ophthalmology and Visual Science. 60, p. M132-M160

Research output: Contribution to journalArticle

Open Access
11 Citations (Scopus)

Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells

Fujii, S., Yoshida, S., Inagaki, E., Hatou, S., Tsubota, K., Takahashi, M., Shimmura, S. & Sugita, S., 2019 Jan 1, In : Stem Cells and Development. 28, 1, p. 28-43 16 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Impact of Corneal Higher-Order Aberrations on Visual Acuity After Deep Anterior Lamellar Keratoplasty in Treating Keratoconus

Suzuki, N., Yamaguchi, T., Tomida, D., Tsubota, K. & Shimazaki, J., 2019 Jul 1, In : Eye & contact lens. 45, 4, p. 238-245 8 p.

Research output: Contribution to journalArticle

Inducement and Evaluation of a Murine Model of Experimental Myopia

Jiang, X., Kurihara, T., Ikeda, S. I., Kunimi, H., Mori, K., Torii, H. & Tsubota, K., 2019 Jan 22, In : Journal of visualized experiments : JoVE. 143

Research output: Contribution to journalArticle

Kinetic visual acuity is correlated with functional visual acuity at higher speeds

Iehisa, I., Negishi, K., Ayaki, M. & Tsubota, K., 2019 Nov 1, In : BMJ Open Ophthalmology. 4, 1, 000383.

Research output: Contribution to journalArticle

Open Access

Lack of social support and social trust as potential risk factors for dry eye disease: JPHC-NEXT study

for the JPHC-NEXT Study Group, 2019 Apr 1, In : Ocular Surface. 17, 2, p. 278-284 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Latanoprost could exacerbate the progression of presbyopia

Ayaki, M., Tsuneyoshi, Y., Yuki, K., Tsubota, K. & Negishi, K., 2019 Jan 1, In : PLoS One. 14, 1, e0211631.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Melon GliSODin® prevents diet-induced NASH onset by reducing fat synthesis and improving liver function

Nakamura, A., Kitamura, N., Yokoyama, Y., Uchida, S., Kumadaki, K., Tsubota, K. & Watanabe, M., 2019 Aug 1, In : Nutrients. 11, 8, 1779.

Research output: Contribution to journalArticle

Open Access