Research Output

2020

Accelerated Versus Standard Corneal Cross-Linking for Progressive Keratoconus: A Meta-Analysis of Randomized Controlled Trials

Kobashi, H. & Tsubota, K., 2020 Feb 1, In : Cornea. 39, 2, p. 172-180 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Advances in the diagnosis and treatment of dry eye

Kojima, T., Dogru, M., Kawashima, M., Nakamura, S. & Tsubota, K., 2020 Jan 1, (Accepted/In press) In : Progress in Retinal and Eye Research. 100842.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Age is a determining factor of dry eye-related signs and symptoms

Ayaki, M., Negishi, K., Kawashima, M., Uchino, M., Kaido, M. & Tsubota, K., 2020, In : Diagnostics. 10, 4, 193.

Research output: Contribution to journalArticle

Open Access

A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice

Yokoyama, Y., Nakamura, T. J., Yoshimoto, K., Ijyuin, H., Tachikawa, N., Oda, H., Shiraishi, R., Shinohara, K., Kumadaki, K., Honda, S., Nakamura, A., Kitamura, N., Tsubota, K. & Watanabe, M., 2020 May, In : PloS one. 15, 5, e0233386.

Research output: Contribution to journalArticle

Open Access

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society

Members of The Asia Dry Eye Society, 2020 Jan 1, In : Eye & contact lens. 46, p. S2-S13

Research output: Contribution to journalReview article

3 Citations (Scopus)

A review on the epidemiology of myopia in school children worldwide

Grzybowski, A., Kanclerz, P., Tsubota, K., Lanca, C. & Saw, S. M., 2020 Jan 14, In : BMC ophthalmology. 20, 1, 27.

Research output: Contribution to journalReview article

Open Access
2 Citations (Scopus)

Association between dry eye and depressive symptoms: Large-scale crowdsourced research using the DryEyeRhythm iPhone application

Inomata, T., Iwagami, M., Nakamura, M., Shiang, T., Fujimoto, K., Okumura, Y., Iwata, N., Fujio, K., Hiratsuka, Y., Hori, S., Tsubota, K., Dana, R. & Murakami, A., 2020 Apr, In : Ocular Surface. 18, 2, p. 312-319 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
Open Access
Open Access

Baseline factors predicting the need for corneal crosslinking in patients with keratoconus

Kato, N., Negishi, K., Sakai, C. & Tsubota, K., 2020 Apr, In : PloS one. 15, 4, e0231439.

Research output: Contribution to journalArticle

Open Access

Binocular superior visual field areas associated with driving self-regulation in patients with primary open-angle glaucoma

Yamasaki, T., Yuki, K., Awano-Tanabe, S., Ono, T., Murata, H., Tsubota, K. & Asaoka, R., 2020, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Capsaicin-induced pain sensitivity in short tear break-up time dry eye

Kaido, M., Inoue, S., Kawashima, M., Ishida, R., Nakamura, S. & Tsubota, K., 2020 Oct, In : Ocular Surface. 18, 4, p. 620-626 7 p.

Research output: Contribution to journalArticle

Changes in Distribution of Dry Eye Diagnostic Status among Visual Display Terminal Workers According to the Revised Criteria of the Asia Dry Eye Society

Yamanishi, R., Uchino, M., Uchino, Y., Kawashima, M., Dogru, M., Yokoi, N. & Tsubota, K., 2020 May 1, In : Cornea. 39, 5, p. 578-583 6 p.

Research output: Contribution to journalArticle

Characteristics and Risk Factors Associated with Diagnosed and Undiagnosed Symptomatic Dry Eye Using a Smartphone Application

Inomata, T., Iwagami, M., Nakamura, M., Shiang, T., Yoshimura, Y., Fujimoto, K., Okumura, Y., Eguchi, A., Iwata, N., Miura, M., Hori, S., Hiratsuka, Y., Uchino, M., Tsubota, K., Dana, R. & Murakami, A., 2020 Jan, In : JAMA Ophthalmology. 138, 1, p. 58-68 11 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Clinical and genetic characteristics of 10 Japanese patients with PROM1-associated retinal disorder: A report of the phenotype spectrum and a literature review in the Japanese population

Fujinami, K., Oishi, A., Yang, L., Arno, G., Pontikos, N., Yoshitake, K., Fujinami-Yokokawa, Y., Liu, X., Hayashi, T., Katagiri, S., Mizobuchi, K., Mizota, A., Shinoda, K., Nakamura, N., Kurihara, T., Tsubota, K., Miyake, Y., Iwata, T., Tsujikawa, A. & Tsunoda, K., 2020, (Accepted/In press) In : American Journal of Medical Genetics, Part C: Seminars in Medical Genetics.

Research output: Contribution to journalArticle

Open Access

Clinical and genetic characteristics of 15 affected patients from 12 Japanese families with GUCY2D-associated retinal disorder

Liu, X., Fujinami, K., Kuniyoshi, K., Kondo, M., Ueno, S., Hayashi, T., Mochizuki, K., Kameya, S., Yang, L., Fujinami-Yokokawa, Y., Arno, G., Pontikos, N., Sakuramoto, H., Kominami, T., Terasaki, H., Katagiri, S., Mizobuchi, K., Nakamura, N., Yoshitake, K., Miyake, Y. & 6 others, Li, S., Kurihara, T., Tsubota, K., Iwata, T., Tsunoda, K. & Consortium, J. E. G., 2020 May, In : Translational Vision Science and Technology. 9, 6, 2.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
Open Access
2 Citations (Scopus)

Clinical and genetic characteristics of Stargardt disease in a large Western China cohort: Report 1

Liu, X., Meng, X., Yang, L., Long, Y., Fujinami-Yokokawa, Y., Ren, J., Kurihara, T., Tsubota, K., Tsunoda, K., Fujinami, K. & Li, S., 2020, (Accepted/In press) In : American Journal of Medical Genetics, Part C: Seminars in Medical Genetics.

Research output: Contribution to journalArticle

Open Access
Open Access

Conjunctival Epithelial Ingrowth After Penetrating Keratoplasty

Hata-Mizuno, M., Ingaki, E., Mitamura, H., Uchino, Y., Tsubota, K. & Shimmura, S., 2020 Sep 1, In : Cornea. 39, 9, p. 1181-1183 3 p.

Research output: Contribution to journalArticle

Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease

Shimizu, E., Aketa, N., Yazu, H., Uchino, M., Kamoi, M., Sato, Y., Tsubota, K. & Ogawa, Y., 2020 Jan, In : Ocular Surface. 18, 1, p. 98-107 10 p.

Research output: Contribution to journalArticle

Corneal in vivo laser-scanning confocal microscopy findings in dry eye patients with sjögren's syndrome

Matsumoto, Y., Ibrahim, O. M. A., Kojima, T., Dogru, M., Shimazaki, J. & Tsubota, K., 2020 Jul, In : Diagnostics. 10, 7, 497.

Research output: Contribution to journalArticle

Open Access

Correlation between macular pigment optical density and neural thickness and volume of the retina

Nagai, N., Asato, T., Minami, S., Suzuki, M., Shinoda, H., Kurihara, T., Sonobe, H., Watanabe, K., Uchida, A., Ban, N., Tsubota, K. & Ozawa, Y., 2020 Apr, In : Nutrients. 12, 4, p. 1-10 10 p., 888.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Dietary saturated fatty acid intake and early age-related macular degeneration in a Japanese population

Sasaki, M., Harada, S., Tsubota, K., Yasukawa, T., Takebayashi, T., Nishiwaki, Y. & Kawasaki, R., 2020 Mar, In : Investigative Ophthalmology and Visual Science. 61, 3, 23.

Research output: Contribution to journalArticle

Open Access

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., Okano, H., Nabeshima, Y. I., Imai, S. I., Yasui, M., Tsubota, K. & Itoh, H., 2020, In : Endocrine journal. 67, 2, p. 153-160 8 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Eosinophils promote corneal wound healing via the 12/15-lipoxygenase pathway

Ogawa, M., Ishihara, T., Isobe, Y., Kato, T., Kuba, K., Imai, Y., Uchino, Y., Tsubota, K. & Arita, M., 2020 Sep 1, In : FASEB Journal. 34, 9, p. 12492-12501 10 p.

Research output: Contribution to journalArticle

Open Access

Estimation of the minimum effective dose of dietary supplement crocetin for prevention of myopia progression in mice

Mori, K., Kurihara, T., Jiang, X., Ikeda, S. I., Yotsukura, E., Torii, H. & Tsubota, K., 2020, In : Nutrients. 12, 1, 180.

Research output: Contribution to journalArticle

Open Access

Evaluation of fear of falling in patients with primary open-angle glaucoma and the importance of inferior visual field damage

Yuki, K., Asaoka, R., Ono, T., Awano-Tanabe, S., Murata, H. & Tsubota, K., 2020 Mar, In : Investigative Ophthalmology and Visual Science. 61, 3, 52.

Research output: Contribution to journalArticle

Open Access

Five-year Outcomes of Corneal Cross-Linking for Keratoconus: Comparison between Conventional and Accelerated Procedures

Kato, N., Negishi, K., Sakai, C., Toda, I., Ide, T., Torii, H. & Tsubota, K., 2020 Jan 1, In : Cornea. 39, 1, p. e1-e2

Research output: Contribution to journalLetter

Open Access
2 Citations (Scopus)

Hypoxia-inducible factor inhibitors derived from marine products suppress a murine model of neovascular retinopathy

Shoda, C., Miwa, Y., Nimura, K., Okamoto, K., Yamagami, S., Tsubota, K. & Kurihara, T., 2020 Apr, In : Nutrients. 12, 4, 1055.

Research output: Contribution to journalArticle

Open Access

Identification of Lacrimal Gland Postganglionic Innervation and Its Regulation of Tear Secretion

Jin, K., Imada, T., Hisamura, R., Ito, M., Toriumi, H., Tanaka, K. F., Nakamura, S. & Tsubota, K., 2020 May, In : American Journal of Pathology. 190, 5, p. 1068-1079 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization

Ibuki, M., Shoda, C., Miwa, Y., Ishida, A., Tsubota, K. & Kurihara, T., 2020 Feb 28, In : Frontiers in Pharmacology. 11, 174.

Research output: Contribution to journalArticle

Open Access

Long-term outcomes of cultivated cell sheet transplantation for treating total limbal stem cell deficiency: Long-term outcomes of cultivated cell sheet transplantation

Shimazaki, J., Satake, Y., Higa, K., Yamaguchi, T., Noma, H. & Tsubota, K., 2020 Oct, In : Ocular Surface. 18, 4, p. 663-671 9 p.

Research output: Contribution to journalArticle

Loss of concentration may occur by blink inhibition in DED simulation models

Mitsukura, Y., Negishi, K., Ayaki, M., Santo, M., Kawashima, M. & Tsubota, K., 2020 May, In : Life. 10, 5, 61.

Research output: Contribution to journalArticle

Open Access

Low-carbohydrate-diet scores and the risk of primary open-angle glaucoma: data from three US cohorts

Hanyuda, A., Rosner, B. A., Wiggs, J. L., Willett, W. C., Tsubota, K., Pasquale, L. R. & Kang, J. H., 2020 Aug 1, In : Eye (Basingstoke). 34, 8, p. 1465-1475 11 p.

Research output: Contribution to journalArticle

Machine-learning approach to predict on-road driving ability in healthy older people

Yamamoto, Y., Hirano, J., Yoshitake, H., Negishi, K., Mimura, M., Shino, M. & Yamagata, B., 2020 Sep 1, In : Psychiatry and Clinical Neurosciences. 74, 9, p. 488-495 8 p.

Research output: Contribution to journalArticle

N-3 fatty acid and its metabolite 18-HEPE ameliorate retinal neuronal cell dysfunction by enhancing Müller BDNF in diabetic retinopathy

Suzumura, A., Kaneko, H., Funahashi, Y., Takayama, K., Nagaya, M., Ito, S., Okuno, T., Hirakata, T., Nonobe, N., Kataoka, K., Shimizu, H., Namba, R., Yamada, K., Ye, F., Ozawa, Y., Yokomizo, T. & Terasaki, H., 2020 Apr 1, In : Diabetes. 69, 4, p. 724-735 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator

Kawashima, H., Ozawa, Y., Toda, E., Homma, K., Osada, H., Narimatsu, T., Nagai, N. & Tsubota, K., 2020 Apr 1, In : FASEB Journal. 34, 4, p. 5016-5026 11 p.

Research output: Contribution to journalArticle

Open Access

Ocular and systemic effects of antioxidative supplement use in young and healthy adults: Real-world cross-sectional data

Minami, S., Nagai, N., Suzuki, M., Uchida, A., Shinoda, H., Tsubota, K. & Ozawa, Y., 2020 Jun, In : Antioxidants. 9, 6, 487.

Research output: Contribution to journalArticle

Open Access

Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice

Yamaguchi, T., Higa, K., Yagi-Yaguchi, Y., Ueda, K., Noma, H., Shibata, S., Nagai, T., Tomida, D., Yasu-Mimura, R., Ibrahim, O., Matoba, R., Tsubota, K., Hamrah, P., Yamada, J., Kanekura, K. & Shimazaki, J., 2020 May, In : Science Advances. 6, 20, eaaz5195.

Research output: Contribution to journalArticle

Open Access

Persistently worsened tear break-up time and keratitis in unilateral pseudophakic eyes after a longpostoperative period

Hanyuda, A., Negishi, K., Tsubota, K. & Ayaki, M., 2020 Apr 1, In : Biomedicines. 8, 4, 77.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease: JPHC-NEXT study

JPHC-NEXT Study Group, 2020 Jan, In : Ocular Surface. 18, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy

Suzuki, M., Nagai, N., Minami, S., Kurihara, T., Kamoshita, M., Sonobe, H., Watanabe, K., Shinoda, H., Tsubota, K. & Ozawa, Y., 2020 Jan 1, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 258, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Open Access

Quantitative Assessment of the Retina Using OCT and Associations with Cognitive Function

Ito, Y., Sasaki, M., Takahashi, H., Nozaki, S., Matsuguma, S., Motomura, K., Ui, R., Shikimoto, R., Kawasaki, R., Yuki, K., Sawada, N., Mimura, M., Tsubota, K. & Tsugane, S., 2020 Jan, In : Ophthalmology. 127, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Ratio of Axial Length to Corneal Radius in Japanese Patients and Accuracy of Intraocular Lens Power Calculation Based on Biometric Data

Omoto, M. K., Torii, H., Hayashi, K., Ayaki, M., Tsubota, K. & Negishi, K., 2020 Jan 1, (Accepted/In press) In : American Journal of Ophthalmology.

Research output: Contribution to journalArticle

Open Access

Real frontier in clinical applications of regenerative medicine

Tsubota, K., 2020 Mar 26, In : Inflammation and Regeneration. 40, 1, 3.

Research output: Contribution to journalEditorial

Open Access

Relationship between Indoor Daytime Light Exposure and Circadian Phase Response under Laboratory Free-Living Conditions

Yoshimura, M., Kitamura, S., Eto, N., Hida, A., Katsunuma, R., Ayabe, N., Motomura, Y., Nishiwaki, Y., Negishi, K., Tsubota, K. & Mishima, K., 2020, (Accepted/In press) In : Biological Rhythm Research.

Research output: Contribution to journalArticle

Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study

Uchida, A., Sasaki, M., Motomura, K., Yuki, K., Kurihara, T., Tomita, Y., Ozawa, Y., Yamagishi, K., Kawasaki, R., Hanyuda, A., Sawada, N., Tsubota, K., Tsugane, S. & Iso, H., 2020 Dec 1, In : Scientific reports. 10, 1, 779.

Research output: Contribution to journalArticle

Open Access

Relationship between visual function and cognitive function in the elderly: A crosssectional observational study

Kaido, M., Fukui, M., Kawashima, M., Negishi, K. & Tsubota, K., 2020 May, In : PloS one. 15, 5, e0233381.

Research output: Contribution to journalArticle

Open Access