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2020

Accelerated Versus Standard Corneal Cross-Linking for Progressive Keratoconus: A Meta-Analysis of Randomized Controlled Trials

Kobashi, H. & Tsubota, K., 2020 Feb 1, In : Cornea. 39, 2, p. 172-180 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Age is a determining factor of dry eye-related signs and symptoms

Ayaki, M., Negishi, K., Kawashima, M., Uchino, M., Kaido, M. & Tsubota, K., 2020 Jan 1, In : Diagnostics. 10, 4, 193.

Research output: Contribution to journalArticle

Open Access

A high-salt/high fat diet alters circadian locomotor activity and glucocorticoid synthesis in mice

Yokoyama, Y., Nakamura, T. J., Yoshimoto, K., Ijyuin, H., Tachikawa, N., Oda, H., Shiraishi, R., Shinohara, K., Kumadaki, K., Honda, S., Nakamura, A., Kitamura, N., Tsubota, K. & Watanabe, M., 2020 May, In : PloS one. 15, 5, e0233386.

Research output: Contribution to journalArticle

Open Access

A New Perspective on Dry Eye Classification: Proposal by the Asia Dry Eye Society

Members of The Asia Dry Eye Society, 2020 Jan 1, In : Eye & contact lens. 46, p. S2-S13

Research output: Contribution to journalArticle

2 Citations (Scopus)

Association between dry eye and depressive symptoms: Large-scale crowdsourced research using the DryEyeRhythm iPhone application

Inomata, T., Iwagami, M., Nakamura, M., Shiang, T., Fujimoto, K., Okumura, Y., Iwata, N., Fujio, K., Hiratsuka, Y., Hori, S., Tsubota, K., Dana, R. & Murakami, A., 2020 Apr, In : Ocular Surface. 18, 2, p. 312-319 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Baseline factors predicting the need for corneal crosslinking in patients with keratoconus

Kato, N., Negishi, K., Sakai, C. & Tsubota, K., 2020 Apr, In : PloS one. 15, 4, e0231439.

Research output: Contribution to journalArticle

Open Access

Binocular superior visual field areas associated with driving self-regulation in patients with primary open-angle glaucoma

Yamasaki, T., Yuki, K., Awano-Tanabe, S., Ono, T., Murata, H., Tsubota, K. & Asaoka, R., 2020 Jan 1, (Accepted/In press) In : British Journal of Ophthalmology.

Research output: Contribution to journalArticle

Changes in Distribution of Dry Eye Diagnostic Status among Visual Display Terminal Workers According to the Revised Criteria of the Asia Dry Eye Society

Yamanishi, R., Uchino, M., Uchino, Y., Kawashima, M., Dogru, M., Yokoi, N. & Tsubota, K., 2020 May 1, In : Cornea. 39, 5, p. 578-583 6 p.

Research output: Contribution to journalArticle

Characteristics and Risk Factors Associated with Diagnosed and Undiagnosed Symptomatic Dry Eye Using a Smartphone Application

Inomata, T., Iwagami, M., Nakamura, M., Shiang, T., Yoshimura, Y., Fujimoto, K., Okumura, Y., Eguchi, A., Iwata, N., Miura, M., Hori, S., Hiratsuka, Y., Uchino, M., Tsubota, K., Dana, R. & Murakami, A., 2020 Jan, In : JAMA Ophthalmology. 138, 1, p. 58-68 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Clinical and genetic characteristics of 15 affected patients from 12 Japanese families with GUCY2D-associated retinal disorder

Liu, X., Fujinami, K., Kuniyoshi, K., Kondo, M., Ueno, S., Hayashi, T., Mochizuki, K., Kameya, S., Yang, L., Fujinami-Yokokawa, Y., Arno, G., Pontikos, N., Sakuramoto, H., Kominami, T., Terasaki, H., Katagiri, S., Mizobuchi, K., Nakamura, N., Yoshitake, K., Miyake, Y. & 6 others, Li, S., Kurihara, T., Tsubota, K., Iwata, T., Tsunoda, K. & Consortium, J. E. G., 2020 May, In : Translational Vision Science and Technology. 9, 6, 2.

Research output: Contribution to journalArticle

Open Access
Open Access

Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease

Shimizu, E., Aketa, N., Yazu, H., Uchino, M., Kamoi, M., Sato, Y., Tsubota, K. & Ogawa, Y., 2020 Jan, In : Ocular Surface. 18, 1, p. 98-107 10 p.

Research output: Contribution to journalArticle

Correlation between macular pigment optical density and neural thickness and volume of the retina

Nagai, N., Asato, T., Minami, S., Suzuki, M., Shinoda, H., Kurihara, T., Sonobe, H., Watanabe, K., Uchida, A., Ban, N., Tsubota, K. & Ozawa, Y., 2020 Apr, In : Nutrients. 12, 4, p. 1-10 10 p., 888.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Dietary saturated fatty acid intake and early age-related macular degeneration in a Japanese population

Sasaki, M., Harada, S., Tsubota, K., Yasukawa, T., Takebayashi, T., Nishiwaki, Y. & Kawasaki, R., 2020 Mar, In : Investigative Ophthalmology and Visual Science. 61, 3, 23.

Research output: Contribution to journalArticle

Open Access

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., Okano, H., Nabeshima, Y. I., Imai, S. I., Yasui, M., Tsubota, K. & Itoh, H., 2020, In : Endocrine journal. 67, 2, p. 153-160 8 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Estimation of the minimum effective dose of dietary supplement crocetin for prevention of myopia progression in mice

Mori, K., Kurihara, T., Jiang, X., Ikeda, S. I., Yotsukura, E., Torii, H. & Tsubota, K., 2020 Jan 1, In : Nutrients. 12, 1, 180.

Research output: Contribution to journalArticle

Open Access

Evaluation of fear of falling in patients with primary open-angle glaucoma and the importance of inferior visual field damage

Yuki, K., Asaoka, R., Ono, T., Awano-Tanabe, S., Murata, H. & Tsubota, K., 2020 Mar, In : Investigative Ophthalmology and Visual Science. 61, 3, 52.

Research output: Contribution to journalArticle

Open Access
Open Access

Hypoxia-inducible factor inhibitors derived from marine products suppress a murine model of neovascular retinopathy

Shoda, C., Miwa, Y., Nimura, K., Okamoto, K., Yamagami, S., Tsubota, K. & Kurihara, T., 2020 Apr, In : Nutrients. 12, 4, 1055.

Research output: Contribution to journalArticle

Open Access

Identification of Lacrimal Gland Postganglionic Innervation and Its Regulation of Tear Secretion

Jin, K., Imada, T., Hisamura, R., Ito, M., Toriumi, H., Tanaka, K. F., Nakamura, S. & Tsubota, K., 2020 May, In : American Journal of Pathology. 190, 5, p. 1068-1079 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization

Ibuki, M., Shoda, C., Miwa, Y., Ishida, A., Tsubota, K. & Kurihara, T., 2020 Feb 28, In : Frontiers in Pharmacology. 11, 174.

Research output: Contribution to journalArticle

Open Access

Loss of concentration may occur by blink inhibition in DED simulation models

Mitsukura, Y., Negishi, K., Ayaki, M., Santo, M., Kawashima, M. & Tsubota, K., 2020 May, In : Life. 10, 5, 61.

Research output: Contribution to journalArticle

Open Access

Low-carbohydrate-diet scores and the risk of primary open-angle glaucoma: data from three US cohorts

Hanyuda, A., Rosner, B. A., Wiggs, J. L., Willett, W. C., Tsubota, K., Pasquale, L. R. & Kang, J. H., 2020 Aug 1, In : Eye (Basingstoke). 34, 8, p. 1465-1475 11 p.

Research output: Contribution to journalArticle

N-3 fatty acid and its metabolite 18-HEPE ameliorate retinal neuronal cell dysfunction by enhancing Müller BDNF in diabetic retinopathy

Suzumura, A., Kaneko, H., Funahashi, Y., Takayama, K., Nagaya, M., Ito, S., Okuno, T., Hirakata, T., Nonobe, N., Kataoka, K., Shimizu, H., Namba, R., Yamada, K., Ye, F., Ozawa, Y., Yokomizo, T. & Terasaki, H., 2020 Apr 1, In : Diabetes. 69, 4, p. 724-735 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator

Kawashima, H., Ozawa, Y., Toda, E., Homma, K., Osada, H., Narimatsu, T., Nagai, N. & Tsubota, K., 2020 Apr 1, In : FASEB Journal. 34, 4, p. 5016-5026 11 p.

Research output: Contribution to journalArticle

Open Access

Ocular and systemic effects of antioxidative supplement use in young and healthy adults: Real-world cross-sectional data

Minami, S., Nagai, N., Suzuki, M., Uchida, A., Shinoda, H., Tsubota, K. & Ozawa, Y., 2020 Jun, In : Antioxidants. 9, 6, 487.

Research output: Contribution to journalArticle

Open Access

Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice

Yamaguchi, T., Higa, K., Yagi-Yaguchi, Y., Ueda, K., Noma, H., Shibata, S., Nagai, T., Tomida, D., Yasu-Mimura, R., Ibrahim, O., Matoba, R., Tsubota, K., Hamrah, P., Yamada, J., Kanekura, K. & Shimazaki, J., 2020 May, In : Science Advances. 6, 20, eaaz5195.

Research output: Contribution to journalArticle

Open Access

Persistently worsened tear break-up time and keratitis in unilateral pseudophakic eyes after a longpostoperative period

Hanyuda, A., Negishi, K., Tsubota, K. & Ayaki, M., 2020 Apr 1, In : Biomedicines. 8, 4, 77.

Research output: Contribution to journalArticle

Open Access

Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease: JPHC-NEXT study

JPHC-NEXT Study Group, 2020 Jan, In : Ocular Surface. 18, 1, p. 56-63 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy

Suzuki, M., Nagai, N., Minami, S., Kurihara, T., Kamoshita, M., Sonobe, H., Watanabe, K., Shinoda, H., Tsubota, K. & Ozawa, Y., 2020 Jan 1, In : Graefe's Archive for Clinical and Experimental Ophthalmology. 258, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

Open Access

Quantitative Assessment of the Retina Using OCT and Associations with Cognitive Function

Ito, Y., Sasaki, M., Takahashi, H., Nozaki, S., Matsuguma, S., Motomura, K., Ui, R., Shikimoto, R., Kawasaki, R., Yuki, K., Sawada, N., Mimura, M., Tsubota, K. & Tsugane, S., 2020 Jan, In : Ophthalmology. 127, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Ratio of Axial Length to Corneal Radius in Japanese Patients and Accuracy of Intraocular Lens Power Calculation Based on Biometric Data

Omoto, M. K., Torii, H., Hayashi, K., Ayaki, M., Tsubota, K. & Negishi, K., 2020 Jan 1, (Accepted/In press) In : American Journal of Ophthalmology.

Research output: Contribution to journalArticle

Open Access

Relationship between Indoor Daytime Light Exposure and Circadian Phase Response under Laboratory Free-Living Conditions

Yoshimura, M., Kitamura, S., Eto, N., Hida, A., Katsunuma, R., Ayabe, N., Motomura, Y., Nishiwaki, Y., Negishi, K., Tsubota, K. & Mishima, K., 2020, (Accepted/In press) In : Biological Rhythm Research.

Research output: Contribution to journalArticle

Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study

Uchida, A., Sasaki, M., Motomura, K., Yuki, K., Kurihara, T., Tomita, Y., Ozawa, Y., Yamagishi, K., Kawasaki, R., Hanyuda, A., Sawada, N., Tsubota, K., Tsugane, S. & Iso, H., 2020 Dec 1, In : Scientific reports. 10, 1, 779.

Research output: Contribution to journalArticle

Open Access

Relationship between visual function and cognitive function in the elderly: A crosssectional observational study

Kaido, M., Fukui, M., Kawashima, M., Negishi, K. & Tsubota, K., 2020 May, In : PloS one. 15, 5, e0233381.

Research output: Contribution to journalArticle

Open Access

Relationships of diabetes and hyperglycaemia with intraocular pressure in a Japanese population: the JPHC-NEXT Eye Study

Hanyuda, A., Sawada, N., Yuki, K., Uchino, M., Ozawa, Y., Sasaki, M., Yamagishi, K., Iso, H., Tsubota, K. & Tsugane, S., 2020 Dec 1, In : Scientific reports. 10, 1, 5355.

Research output: Contribution to journalArticle

Open Access

Retinal microglia are critical for subretinal neovascular formation

Usui-Ouchi, A., Usui, Y., Kurihara, T., Aguilar, E., Dorrell, M. I., Ideguchi, Y., Sakimoto, S., Bravo, S. & Friedlander, M., 2020 Jun 18, In : JCI Insight. 5, 12

Research output: Contribution to journalArticle

Open Access

Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans

Yamane, M., Sato, S., Shimizu, E., Shibata, S., Hayano, M., Yaguchi, T., Kamijuku, H., Ogawa, M., Suzuki, T., Mukai, S., Shimmura, S., Okano, H., Takeuchi, T., Kawakami, Y., Ogawa, Y. & Tsubota, K., 2020, (Accepted/In press) In : FASEB Journal.

Research output: Contribution to journalArticle

Stratification of Individual Symptoms of Contact Lens-Associated Dry Eye Using the iPhone App DryEyeRhythm: Crowdsourced Cross-Sectional Study

Inomata, T., Nakamura, M., Iwagami, M., Midorikawa-Inomata, A., Sung, J., Fujimoto, K., Okumura, Y., Eguchi, A., Iwata, N., Miura, M., Fujio, K., Nagino, K., Hori, S., Tsubota, K., Dana, R. & Murakami, A., 2020 Jun 26, In : Journal of medical Internet research. 22, 6, p. e18996

Research output: Contribution to journalArticle

Open Access

Tear break-up time and seasonal variation in intraocular pressure in a Japanese population

Ayaki, M., Negishi, K., Yuki, K., Kawashima, M., Uchino, M. & Tsubota, K., 2020, In : Diagnostics. 10, 2, 124.

Research output: Contribution to journalArticle

Open Access

Tear Film Dynamics of Soft Contact Lens-Induced Dry Eye

Kaido, M., Kawashima, M., Ishida, R. & Tsubota, K., 2020 Jul 2, In : Current Eye Research. 45, 7, p. 782-788 7 p.

Research output: Contribution to journalArticle

The effects of 3% diquafosol sodium eye drops on tear function and the ocular surface of Cu, Zn-superoxide dismutase-1 (SOD1) knockout mice treated with antiglaucoma eye medications

Yagi-Yaguchi, Y., Kojima, T., Higa, K., Dogru, M., Ibrahim, O. M. A., Shimizu, T., Tsubota, K. & Shimazaki, J., 2020 Jan 1, In : Diagnostics. 10, 1, 20.

Research output: Contribution to journalArticle

Open Access

The effects of high molecular weight hyaluronic acid eye drop application in environmental dry eye stress model mice

Kojima, T., Nagata, T., Kudo, H., Müller-Lierheim, W. G. K., Setten, G. B. V., Dogru, M. & Tsubota, K., 2020 May 2, In : International journal of molecular sciences. 21, 10, 3516.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Use of OCTA capillary perfusion density measurements to detect and grade macular ischemia

Babiuch, A. S., Uchida, A., Hu, M., Khan, M., Srivastava, S. K., Singh, R. P., Kaiser, P. K., Rachtiskaya, A., Reese, J. L. & Ehlers, J. P., 2020 Apr, In : Ophthalmic Surgery Lasers and Imaging Retina. 51, 4, p. S30-S36

Research output: Contribution to journalArticle

2019

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver

Nakamura, A., Zhu, Q., Yokoyama, Y., Kitamura, N., Uchida, S., Kumadaki, K., Tsubota, K. & Watanabe, M., 2019 Jan 1, In : Foods. 8, 11, 546.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Age-Related Conjunctival P2Y2 Receptor Alterations in the Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Dry Eye Model Mice

Dogru, M., Shinzawa, M., Kojima, T., Shimizu, T. & Tsubota, K., 2019 Nov 1, In : Eye and Contact Lens. 45, 6, p. 405-409 5 p.

Research output: Contribution to journalArticle

Analysis of the association between the severity of ocular and systemic pain

Yamanishi, R., Uchino, M., Kawashima, M., Dogru, M., Matsuguma, S. & Tsubota, K., 2019 Jan 1, In : Ocular Surface.

Research output: Contribution to journalArticle

1 Citation (Scopus)
Open Access
5 Citations (Scopus)

Aquaporin 4 Suppresses Neural Hyperactivity and Synaptic Fatigue and Fine-Tunes Neurotransmission to Regulate Visual Function in the Mouse Retina

Ozawa, Y., Toda, E., Kawashima, H., Homma, K., Osada, H., Nagai, N., Abe, Y., Yasui, M. & Tsubota, K., 2019 Dec 1, In : Molecular Neurobiology. 56, 12, p. 8124-8135 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Association between retinal nerve fiber layer thickness and eye fatigue

Ayaki, M., Kuze, M., Kondo, M., Tsubota, K. & Negishi, K., 2019 Jan 1, In : BioMed Research International. 2019, 3014567.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)