Research Output 1984 2019

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2019

Agaricus brasiliensis KA21 May Prevent Diet-Induced Nash through Its Antioxidant, Anti-Inflammatory, and Anti-Fibrotic Activities in the Liver

Nakamura, A., Zhu, Q., Yokoyama, Y., Kitamura, N., Uchida, S., Kumadaki, K., Tsubota, K. & Watanabe, M., 2019 Jan 1, In : Foods. 8, 11, 546.

Research output: Contribution to journalArticle

Open Access
Agaricus subrufescens
Agaricus
Fatty Liver
alcoholism
Anti-Inflammatory Agents

Age-Related Conjunctival P2Y2 Receptor Alterations in the Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Dry Eye Model Mice

Dogru, M., Shinzawa, M., Kojima, T., Shimizu, T. & Tsubota, K., 2019 Nov 1, In : Eye & contact lens. 45, 6, p. 405-409 5 p.

Research output: Contribution to journalArticle

Purinergic P2Y2 Receptors
Tears
Staining and Labeling
Fluorescein
Messenger RNA

Analysis of the association between the severity of ocular and systemic pain

Yamanishi, R., Uchino, M., Kawashima, M., Dogru, M., Matsuguma, S. & Tsubota, K., 2019 Jan 1, In : Ocular Surface.

Research output: Contribution to journalArticle

Eye Pain
Eye Diseases
Pain Measurement
Visual Analog Scale
Quality of Life
2 Citations (Scopus)

A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion

Kunimi, H., Miwa, Y., Inoue, H., Tsubota, K. & Kurihara, T., 2019 Jun 28, In : International journal of molecular sciences. 20, 13

Research output: Contribution to journalArticle

Open Access
ischemia
hypoxia
inhibitors
Reperfusion
Screening
Open Access
Aquaporin 4
Synaptic Transmission
Fatigue
Retina
Knockout Mice

Association between retinal nerve fiber layer thickness and eye fatigue

Ayaki, M., Kuze, M., Kondo, M., Tsubota, K. & Negishi, K., 2019 Jan 1, In : BioMed Research International. 2019, 3014567.

Research output: Contribution to journalArticle

Open Access
Asthenopia
Nerve Fibers
Fatigue of materials
Fibers
Ganglia
1 Citation (Scopus)

Changes in Murine Subbasal Corneal Nerves After Scopolamine-Induced Dry Eye Stress Exposure

Simsek, C., Kojima, T., Nagata, T., Dogru, M. & Tsubota, K., 2019 Feb 1, In : Investigative ophthalmology & visual science. 60, 2, p. 615-623 9 p.

Research output: Contribution to journalArticle

Open Access
Scopolamine Hydrobromide
Tears
Dendritic Cells
Staining and Labeling
Fluorescein

Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake Disease): East Asia Occult Macular Dystrophy Studies Report Number 1

Fujinami, K., Yang, L., Joo, K., Tsunoda, K., Kameya, S., Hanazono, G., Fujinami-Yokokawa, Y., Arno, G., Kondo, M., Nakamura, N., Kurihara, T., Tsubota, K., Zou, X., Li, H., Park, K. H., Iwata, T., Miyake, Y., Woo, S. J. & Sui, R., 2019 Jan 1, In : Ophthalmology.

Research output: Contribution to journalArticle

Far East
Macular Degeneration
Visual Acuity
Republic of Korea
China

Cluster of differentiation 30 expression in lacrimal gland and conjunctival tissues in patients with Sjögren's syndrome: Case series

Ogawa, A., Ogawa, Y., Mukai, S., Shimizu, E., Kuwana, M., Kawakami, Y. & Tsubota, K., 2019 Jul 1, In : Medicine. 98, 29, p. e16390

Research output: Contribution to journalArticle

Open Access
Lacrimal Apparatus
Conjunctiva
Graft vs Host Disease
Lymphoma
Interferons

Commensal microflora in human conjunctiva; characteristics of microflora in the patients with chronic ocular graft-versus-host disease

Shimizu, E., Ogawa, Y., Saijo, Y., Yamane, M., Uchino, M., Kamoi, M., Fukui, M., Yang, F., He, J., Mukai, S. & Tsubota, K., 2019 Jan 1, In : Ocular Surface.

Research output: Contribution to journalArticle

Conjunctiva
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Gram-Positive Rods
Propionibacterium acnes
Intraocular Lenses
History
Denmark
Cataract
Germany

Corneal higher-order aberrations in eyes with chronic ocular graft-versus-host disease

Shimizu, E., Aketa, N., Yazu, H., Uchino, M., Kamoi, M., Sato, Y., Tsubota, K. & Ogawa, Y., 2019 Jan 1, (Accepted/In press) In : Ocular Surface.

Research output: Contribution to journalArticle

Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Visual Acuity
Vision Disorders
Optical Coherence Tomography
2 Citations (Scopus)

Corneal Higher-Order Aberrations in Eyes with Corneal Scar after Traumatic Perforation

Shimizu, E., Yamaguchi, T., Tsubota, K. & Shimazaki, J., 2019 Mar 1, In : Eye and Contact Lens. 45, 2, p. 124-131 8 p.

Research output: Contribution to journalArticle

Corneal Perforation
Cornea
Visual Acuity
Corneal Opacity
Tokyo
1 Citation (Scopus)

Corneal higher-order aberrations in Stevens-Johnson syndrome and toxic epidermal necrolysis

Ibrahim, O. M. A., Yagi-Yaguchi, Y., Noma, H., Tsubota, K., Shimazaki, J. & Yamaguchi, T., 2019 Jan 1, In : Ocular Surface.

Research output: Contribution to journalArticle

Stevens-Johnson Syndrome
Pathologic Dilatations
Optical Coherence Tomography
Cornea
Visual Acuity

Corneal Sensory Experience via Transient Receptor Potential Vanilloid 1 Accelerates the Maturation of Neonatal Tearing

Jin, K., Imada, T., Nakamura, S., Izuta, Y., Oonishi, E., Shibuya, M., Sakaguchi, H., Tanabe, H., Ito, M., Katanosaka, K. & Tsubota, K., 2019 Sep 1, In : American Journal of Pathology. 189, 9, p. 1699-1710 12 p.

Research output: Contribution to journalArticle

Tears
Parturition
Transient Receptor Potential Channels
Lacrimal Apparatus
vanilloid receptor subtype 1

Current Prevalence of Myopia and Association of Myopia with Environmental Factors among Schoolchildren in Japan

Yotsukura, E., Torii, H., Inokuchi, M., Tokumura, M., Uchino, M., Nakamura, K., Hyodo, M., Mori, K., Jiang, X., Ikeda, S. I., Kondo, S., Negishi, K., Kurihara, T. & Tsubota, K., 2019 Jan 1, (Accepted/In press) In : JAMA Ophthalmology.

Research output: Contribution to journalArticle

Myopia
Japan
Students
Eye Diseases
Refractive Errors
1 Citation (Scopus)

Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy

Suzuki, N., Yamaguchi, T., Shibata, S., Nagai, T., Noma, H., Tsubota, K. & Shimazaki, J., 2019 Feb 1, In : American Journal of Ophthalmology. 198, p. 174-180 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
Intercellular Adhesion Molecule-1
Cytokines
Interferons
P-Selectin

Diurnal variation of human tear meniscus volume measured with tear strip meniscometry self-examination

Ayaki, M., Tachi, N., Hashimoto, Y., Kawashima, M., Tsubota, K. & Negishi, K., 2019 Apr 1, In : PloS one. 14, 4, e0215922.

Research output: Contribution to journalArticle

Open Access
Self-Examination
diurnal variation
Tears
Optical tomography
Mirrors

Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy

Nagai, N., Suzuki, M., Minami, S., Kurihara, T., Kamoshita, M., Sonobe, H., Watanabe, K., Uchida, A., Shinoda, H., Tsubota, K. & Ozawa, Y., 2019 Dec 1, In : Scientific reports. 9, 1, 11389.

Research output: Contribution to journalArticle

Open Access
Vascular Endothelial Growth Factor A
Therapeutics
Injections
Choroid
Optical Coherence Tomography

Effect of eyelid hygiene detergent on obstructive meibomian gland dysfunction

Tanabe, H., Kaido, M., Kawashima, M., Ishida, R., Ayaki, M. & Tsubota, K., 2019 Jan 1, In : Journal of Oleo Science. 68, 1, p. 67-78 12 p.

Research output: Contribution to journalArticle

Detergents
Water
Fluorescein

Effect of midazolam, medetomidine, and butorphanol tartrate combination anesthetic on electroretinograms of mice

Miwa, Y., Tsubota, K. & Kurihara, T., 2019 Jan 1, In : Molecular vision. 25, p. 645-653 9 p.

Research output: Contribution to journalArticle

Medetomidine
Butorphanol
Midazolam
Pentobarbital
Xylazine
3 Citations (Scopus)

Efficacy of Plate Expression of Meibum on Tear Function and Ocular Surface Findings in Meibomian Gland Disease

Aketa, N., Shinzawa, M., Kawashima, M., Dogru, M., Okamoto, S., Tsubota, K. & Shimazaki, J., 2019 Jan 1, In : Eye & contact lens. 45, 1, p. 19-22 4 p.

Research output: Contribution to journalArticle

Meibomian Glands
Tears
Therapeutics
Quality of Life
Staining and Labeling

Enriched environment alleviates stress-induced dry-eye through the BDNF axis

Sano, K., Kawashima, M., Imada, T., Suzuki, T., Nakamura, S., Mimura, M., Tanaka, K. & Tsubota, K., 2019 Dec 1, In : Scientific reports. 9, 1, 3422.

Research output: Contribution to journalArticle

Open Access
Brain-Derived Neurotrophic Factor
Tears
Eye Diseases
Gene Knockdown Techniques
Mental Disorders
1 Citation (Scopus)

Evaluation of AAV-DJ vector for retinal gene therapy

Katada, Y., Kobayashi, K., Tsubota, K. & Kurihara, T., 2019 Jan 1, In : PeerJ. 2019, 1, e6317.

Research output: Contribution to journalArticle

Dependovirus
Gene therapy
gene therapy
Viruses
retina
4 Citations (Scopus)

Global Consensus on Definition, Classification, Diagnosis, and Staging of Limbal Stem Cell Deficiency

and The International Limbal Stem Cell Deficiency Working Group, 2019 Mar 1, In : Cornea. 38, 3, p. 364-375 12 p.

Research output: Contribution to journalArticle

Stem Cells
Deficiency Diseases
Telecommunications
Manuscripts
Research

HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model

Kunimi, H., Miwa, Y., Katada, Y., Tsubota, K. & Kurihara, T., 2019 Jan 1, In : PeerJ. 2019, 10, e7849.

Research output: Contribution to journalArticle

Open Access
Topotecan
neuroprotective effect
Retinal Ganglion Cells
Neuroprotective Agents
ischemia

Hydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals

Kawashima, M., Tsuno, S., Matsumoto, M. & Tsubota, K., 2019 Oct, In : Ocular Surface. 17, 4, p. 714-721 8 p.

Research output: Contribution to journalArticle

Tears
Hydrogen
Milk
Fluorescein
Placebos
6 Citations (Scopus)

IMI – Clinical myopia control trials and instrumentation report

Wolffsohn, J. S., Kollbaum, P. S., Berntsen, D. A., Atchison, D. A., Benavente, A., Bradley, A., Buckhurst, H., Collins, M., Fujikado, T., Hiraoka, T., Hirota, M., Jones, D., Logan, N. S., Lundström, L., Torii, H., Read, S. A. & Naidoo, K., 2019 Feb 1, In : Investigative Ophthalmology and Visual Science. 60, p. M132-M160

Research output: Contribution to journalArticle

Open Access
Myopia
Clinical Protocols
Clinical Trials
Refractive Errors
Pupil
1 Citation (Scopus)

Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells

Fujii, S., Yoshida, S., Inagaki, E., Hatou, S., Tsubota, K., Takahashi, M., Shimmura, S. & Sugita, S., 2019 Jan 1, In : Stem Cells and Development. 28, 1, p. 28-43 16 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Neural Crest
Immunosuppressive Agents
T-Lymphocytes
Wound Healing

Impact of Corneal Higher-Order Aberrations on Visual Acuity After Deep Anterior Lamellar Keratoplasty in Treating Keratoconus

Suzuki, N., Yamaguchi, T., Tomida, D., Tsubota, K. & Shimazaki, J., 2019 Jul 1, In : Eye & contact lens. 45, 4, p. 238-245 8 p.

Research output: Contribution to journalArticle

Descemet Membrane
Keratoconus
Corneal Transplantation
Visual Acuity
Cornea

Inducement and Evaluation of a Murine Model of Experimental Myopia

Jiang, X., Kurihara, T., Ikeda, S. I., Kunimi, H., Mori, K., Torii, H. & Tsubota, K., 2019 Jan 22, In : Journal of visualized experiments : JoVE. 143

Research output: Contribution to journalArticle

Myopia
Lenses
Theoretical Models
Eyeglasses
Refraction

Lack of social support and social trust as potential risk factors for dry eye disease: JPHC-NEXT study

for the JPHC-NEXT Study Group, 2019 Apr 1, In : Ocular Surface. 17, 2, p. 278-284 7 p.

Research output: Contribution to journalArticle

Eye Diseases
Social Support
Odds Ratio
Japan
Public Health

Latanoprost could exacerbate the progression of presbyopia

Ayaki, M., Tsuneyoshi, Y., Yuki, K., Tsubota, K. & Negishi, K., 2019 Jan 1, In : PLoS One. 14, 1, e0211631.

Research output: Contribution to journalArticle

latanoprost
Presbyopia
glaucoma
Glaucoma
Synthetic Prostaglandins

Melon GliSODin® prevents diet-induced NASH onset by reducing fat synthesis and improving liver function

Nakamura, A., Kitamura, N., Yokoyama, Y., Uchida, S., Kumadaki, K., Tsubota, K. & Watanabe, M., 2019 Aug 1, In : Nutrients. 11, 8, 1779.

Research output: Contribution to journalArticle

Open Access
Cucurbitaceae
liver function
Fatty Liver
melons
Fats

Nationwide Prospective Cohort Study on Cataract Surgery With Multifocal Intraocular Lens Implantation in Japan

Survey Working Group of the Japanese Society of Cataract and Refractive Surgery, 2019 Dec 1, In : American Journal of Ophthalmology. 208, p. 133-144 12 p.

Research output: Contribution to journalArticle

Open Access
Intraocular Lens Implantation
Cataract
Japan
Cohort Studies
Prospective Studies
Open Access
Biometry
Refractometry
Optical Coherence Tomography
Anterior Chamber
Intraocular Lenses

Ocular-component-specific miRNA expression in a murine model of lens-induced myopia

Tanaka, Y., Kurihara, T., Hagiwara, Y., Ikeda, S. I., Mori, K., Jiang, X., Torii, H. & Tsubota, K., 2019 Aug 1, In : International journal of molecular sciences. 20, 15, 3629.

Research output: Contribution to journalArticle

Open Access
myopia
Myopia
MicroRNAs
Lenses
lenses
6 Citations (Scopus)

Oral crocetin administration suppressed refractive shift and axial elongation in a murine model of lens-induced myopia

Mori, K., Kurihara, T., Miyauchi, M., Ishida, A., Jiang, X., Ikeda, S. I., Torii, H. & Tsubota, K., 2019 Dec 1, In : Scientific Reports. 9, 1, 295.

Research output: Contribution to journalArticle

Myopia
Lenses
Oral Administration
Early Growth Response Protein 1
Refractive Errors
5 Citations (Scopus)

Pharmacological HIF inhibition prevents retinal neovascularization with improved visual function in a murine oxygen-induced retinopathy model

Miwa, Y., Hoshino, Y., Shoda, C., Jiang, X., Tsubota, K. & Kurihara, T., 2019 Sep 1, In : Neurochemistry International. 128, p. 21-31 11 p.

Research output: Contribution to journalArticle

Retinal Neovascularization
Vascular Endothelial Growth Factor A
Pharmacology
Oxygen
Topotecan

Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease: JPHC-NEXT study

JPHC-NEXT Study Group, 2019 Jan 1, (Accepted/In press) In : Ocular Surface.

Research output: Contribution to journalArticle

Eye Diseases
Exercise
Leisure Activities
Confidence Intervals
Life Style
Open Access
Retinal Vein Occlusion
Macular Edema
Vascular Endothelial Growth Factor A
Visual Acuity
Recurrence

Protective effects of blue light-blocking shades on phototoxicity in human ocular surface cells

Niwano, Y., Iwasawa, A., Tsubota, K., Ayaki, M. & Negishi, K., 2019 May 1, In : BMJ Open Ophthalmology. 4, 1, e000217.

Research output: Contribution to journalArticle

Open Access
Phototoxic Dermatitis
Light
Retina
Eye Banks
Crystalline Lens

QD laser eyewear as a visual field aid in a visual field defect model

Iyama, C., Shigeno, Y., Hirano, E., Kamoshita, M., Nagai, N., Suzuki, M., Minami, S., Kurihara, T., Sonobe, H., Watanabe, K., Shinoda, H., Tsubota, K. & Ozawa, Y., 2019 Dec 1, In : Scientific Reports. 9, 1, 1010.

Research output: Contribution to journalArticle

Audiovisual Aids
Visual Fields
Lasers
Equipment and Supplies
Optical Devices

Quantitative Assessment of the Retina Using OCT and Associations with Cognitive Function

Ito, Y., Sasaki, M., Takahashi, H., Nozaki, S., Matsuguma, S., Motomura, K., Ui, R., Shikimoto, R., Kawasaki, R., Yuki, K., Sawada, N., Mimura, M., Tsubota, K. & Tsugane, S., 2019 Jan 1, In : Ophthalmology.

Research output: Contribution to journalArticle

Nerve Fibers
Cognition
Retina
Dementia
Ganglia

Reply

Deng, S. X., Borderie, V., Chan, C. C., Dana, R., Figueiredo, F. C., Gomes, J. A. P., Pellegrini, G., Shimmura, S. & Kruse, F. E., 2019 Dec 1, In : Cornea. 38, 12, p. e56-e57

Research output: Contribution to journalArticle

Retinal Perforations
Inflammation
Recurrence
Temazepam
Fluorescein Angiography

Risk Factors for Severe Dry Eye Disease: Crowdsourced Research Using DryEyeRhythm

Inomata, T., Nakamura, M., Iwagami, M., Shiang, T., Yoshimura, Y., Fujimoto, K., Okumura, Y., Eguchi, A., Iwata, N., Miura, M., Hori, S., Hiratsuka, Y., Uchino, M., Tsubota, K., Dana, R. & Murakami, A., 2019 Jan 1, (Accepted/In press) In : Ophthalmology.

Research output: Contribution to journalArticle

Eye Diseases
Research

Safety and efficacy of wiping lid margins with lid hygiene shampoo using the "eye brush", a novel lid hygiene item, in healthy subjects: A pilot study

Tanabe, H., Kawashima, M., Kaido, M., Ishida, R., Kawakita, T. & Tsubota, K., 2019 Feb 4, In : BMC Ophthalmology. 19, 1, 41.

Research output: Contribution to journalArticle

Hygiene
Healthy Volunteers
Safety
Water
Asthenopia

Shortened Measurement Time of Functional Visual Acuity for Screening Visual Function

Hidaka, Y., Masui, S., Nishi, Y., Ayaki, M., Kaido, M., Mimura, M., Tsubota, K. & Negishi, K., 2019 Jan 1, In : Journal of Ophthalmology. 2019, 8950418.

Research output: Contribution to journalArticle

Open Access
Visual Acuity
Reaction Time
Observational Studies
Healthy Volunteers
Maintenance

"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu, E., Ogawa, Y., Yazu, H., Aketa, N., Yang, F., Yamane, M., Sato, Y., Kawakami, Y. & Tsubota, K., 2019 May 1, In : PloS one. 14, 5, e0215130.

Research output: Contribution to journalArticle

eye diseases
Eye Diseases
disease models
Tears
cameras