Research Output 1984 2020

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Article
2014
6 Citations (Scopus)
Cystic Kidney Diseases
Renal Cell Carcinoma
Contrast Media
Fats
Cysts
2 Citations (Scopus)

Retroperitoneal low-flow vascular malformations: characteristic MRI findings correlated with histopathological findings

Akita, H., Yamada, Y., Ito, Y., Mikami, S., Sugiura, H., Okuda, S. & Jinzaki, M., 2014 Dec 10, In : Abdominal Imaging. 40, 6, p. 1713-1720 8 p.

Research output: Contribution to journalArticle

Vascular Malformations
Intra-Abdominal Fat
Capsules
Fats
7 Citations (Scopus)

Sentinel node mapping in adenocarcinoma of the esophagogastric junction

Matsuda, T., Takeuchi, H., Tsuwano, S., Nakahara, T., Mukai, M. & Kitagawa, Y., 2014, In : World Journal of Surgery. 38, 9, p. 2337-2344 8 p.

Research output: Contribution to journalArticle

Esophagogastric Junction
Adenocarcinoma
Lymph Nodes
Neoplasm Metastasis
Minimally Invasive Surgical Procedures
13 Citations (Scopus)

Short-term results of transcatheter arterial embolization for abnormal neovessels in patients with adhesive capsulitis: A pilot study

Okuno, Y., Oguro, S., Iwamoto, W., Miyamoto, T., Ikegami, H. & Matsumura, N., 2014, In : Journal of Shoulder and Elbow Surgery. 23, 9

Research output: Contribution to journalArticle

Bursitis
Pain
Shoulder Pain
Elbow
Articular Range of Motion
5 Citations (Scopus)

Spleen stiffness measurements by acoustic radiation force impulse imaging after living donor liver transplantation in children: a potential quantitative index for venous complications

Tomita, H., Fuchimoto, Y., Ohkuma, K., Hoshino, K., Fujino, A., Kato, M., Fujimura, T., Ishihama, H., Takahashi, N., Tanami, Y., Nakatsuka, S., Ebinuma, H., Saito, H., Shinoda, M., Kitagawa, Y. & Kuroda, T., 2014 Dec 12, (Accepted/In press) In : Pediatric Radiology.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Living Donors
Liver Transplantation
Spleen
Pathologic Constriction
1 Citation (Scopus)
Patent Foramen Ovale
Coronary Vessels
Aortic Valve
Aorta
Bicuspid Aortic Valve
5 Citations (Scopus)

Successful second attempt multidetector computed tomography-guided percutaneous transluminal septal myocardial ablation for an octogenarian with hypertrophic obstructive cardiomyopathy

Maekawa, Y., Jinzaki, M., Anzai, A., Tsuruta, H., Matsumura, K., Yamada, Y., Tabei, R., Kawakami, T., Hayashida, K., Yuasa, S., Murata, M., Suzuki, M., Kuribayashi, S. & Fukuda, K., 2014 Oct 20, In : International Journal of Cardiology. 176, 3, p. e131-e132

Research output: Contribution to journalArticle

Interventional Radiography
Heart Septum
Retreatment
Catheter Ablation
Multidetector Computed Tomography
27 Citations (Scopus)

Suitability of sentinel node mapping as an index of metastasis in early gastric cancer following endoscopic resection

Mayanagi, S., Takeuchi, H., Kamiya, S., Niihara, M., Nakamura, R., Takahashi, T., Wada, N., Kawakubo, H., Saikawa, Y., Omori, T., Nakahara, T., Mukai, M. & Kitagawa, Y., 2014, In : Annals of Surgical Oncology. 21, 9, p. 2987-2993 7 p.

Research output: Contribution to journalArticle

Stomach Neoplasms
Neoplasm Metastasis
Gastrectomy
Lymph Node Excision
Neoplasms
2 Citations (Scopus)

Surgical anatomy imaging associated with cervical cancer treatment: A cadaveric study

Nakamura, M., Fujii, T., Imanishi, N., Jinzaki, M., Yamada, M., Kuribayashi, S. & Aoki, D., 2014, In : Clinical Anatomy. 27, 3, p. 503-510 8 p.

Research output: Contribution to journalArticle

Peritoneum
Cadaver
Uterine Cervical Neoplasms
Anatomy
Multidetector Computed Tomography
11 Citations (Scopus)
Organized Financing
Sports
Cell Biology
Japan
Urine

The time-adjusted gradual replacement injection method enables better visualization of the right heart

Nakahara, T., Jinzaki, M., Niwamae, N., Saito, Y., Arai, M., Tsushima, Y., Kuribayashi, S. & Kurabayashi, M., 2014, In : Journal of Cardiovascular Computed Tomography. 8, 2, p. 158-165 8 p.

Research output: Contribution to journalArticle

Injections
Artifacts
Contrast Media
Aorta
Anatomy

Three-dimensional image fusion of volume rendering SPECT/CT images for evaluation of pulmonary lobe function

Nakahara, T., Koga, S., Katagiri, M., Ogata, T., Iwabuchi, Y., Matsuzaka, Y., Murakami, K. & Jinzaki, M., 2014, In : Japanese Journal of Clinical Radiology. 59, 13, p. 1821-1827 7 p.

Research output: Contribution to journalArticle

Three-Dimensional Imaging
Lung
Perfusion
Single Photon Emission Computed Tomography Computed Tomography
Perfusion Imaging
33 Citations (Scopus)

Toxicities of organs at risk in the Mediastinal and Hilar regions following stereotactic body radiotherapy for centrally located lung tumors

Nishimura, S., Takeda, A., Sanuki, N., Ishikura, S., Oku, Y., Aoki, Y., Kunieda, E. & Shigematsu, N., 2014, In : Journal of Thoracic Oncology. 9, 9, p. 1370-1376 7 p.

Research output: Contribution to journalArticle

Organs at Risk
Radiosurgery
Lung
Bronchi
Pulmonary Artery
5 Citations (Scopus)

Utility of the reverse wire technique in multidetector computed tomography-guided percutaneous transluminal septal myocardial ablation

Maekawa, Y., Jinzaki, M., Anzai, A., Matsumura, K., Tsuruta, H., Kawakami, T., Hayashida, K., Yuasa, S., Murata, M., Suzuki, M., Kuribayashi, S. & Fukuda, K., 2014 May 15, In : International Journal of Cardiology. 173, 3

Research output: Contribution to journalArticle

Heart Septum
Catheter Ablation
Multidetector Computed Tomography
Hypertrophic Cardiomyopathy
1 Citation (Scopus)

Visualization of the right adrenal vein using CT during right inferior phrenic arteriography in hepatocellular carcinoma patients

Oguro, S., Nakatsuka, S., Jinzaki, M., Misu, M., Yashiro, H., Hashimoto, S. & Kuribayashi, S., 2014 Nov 18, In : Japanese Journal of Radiology. 32, 11, p. 630-636 7 p.

Research output: Contribution to journalArticle

Diaphragm
Hepatocellular Carcinoma
Veins
Angiography
Tomography
2013
44 Citations (Scopus)

Acceptable toxicity after stereotactic body radiation therapy for liver tumors adjacent to the central biliary system

Eriguchi, T., Takeda, A., Sanuki, N., Oku, Y., Aoki, Y., Shigematsu, N. & Kunieda, E., 2013 Mar 15, In : International Journal of Radiation Oncology Biology Physics. 85, 4, p. 1006-1011 6 p.

Research output: Contribution to journalArticle

Biliary Tract
liver
toxicity
radiation therapy
Radiotherapy
20 Citations (Scopus)

Acoustic radiation force impulse imaging for assessing graft fibrosis after pediatric living donor liver transplantation: A pilot study

Tomita, H., Hoshino, K., Fuchimoto, Y., Ebinuma, H., Ohkuma, K., Tanami, Y., Du, W., Masugi, Y., Shimojima, N., Fujino, A., Kano, M., Fujimura, T., Ishihama, H., Shimizu, T., Tanabe, M., Saito, H., Sakamoto, M., Hibi, T., Kitagawa, Y. & Kuroda, T., 2013 Nov, In : Liver Transplantation. 19, 11, p. 1202-1213 12 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Living Donors
Liver Transplantation
Fibrosis
Pediatrics
88 Citations (Scopus)

Anatomical characteristics of the left atrial appendage in cardiogenic stroke with low CHADS2 scores

Kimura, T., Takatsuki, S., Inagawa, K., Katsumata, Y., Nishiyama, T., Nishiyama, N., Fukumoto, K., Aizawa, Y., Tanimoto, Y., Tanimoto, K., Jinzaki, M. & Fukuda, K., 2013 Jun, In : Heart Rhythm. 10, 6, p. 921-925 5 p.

Research output: Contribution to journalArticle

Atrial Appendage
Stroke
Brassica
Atrial Fibrillation
Anatomy
1 Citation (Scopus)

A newly introduced comprehensive consultation fee in the national health insurance system in Japan: A promotive effect of multidisciplinary medical care in the field of radiation oncology-results from a questionnaire survey

Igaki, H., Onishi, H., Nakagawa, K., Dokiya, T., Nemoto, K., Shigematsu, N., Nishimura, Y. & Hiraoka, M., 2013 Dec, In : Japanese Journal of Clinical Oncology. 43, 12, p. 1233-1237 5 p., hyt147.

Research output: Contribution to journalArticle

Radiation Oncology
Fees and Charges
National Health Programs
Japan
Referral and Consultation
14 Citations (Scopus)

A prospective longitudinal survey of erectile dysfunction in patients with localized prostate cancer treated with permanent prostate brachytherapy

Matsushima, M., Kikuchi, E., Maeda, T., Nakashima, J., Sugawara, A., Ando, T., Mizuno, R., Nagata, H., Miyajima, A., Shigematsu, N. & Oya, M., 2013 Mar, In : Journal of Urology. 189, 3, p. 1014-1018 5 p.

Research output: Contribution to journalArticle

Brachytherapy
Erectile Dysfunction
Longitudinal Studies
Prostate
Prostatic Neoplasms
8 Citations (Scopus)

A randomized, double-blind, placebo-controlled, phase II dose-finding study of the short acting β1-blocker, landiolol hydrochloride, in patients with suspected ischemic cardiac disease

Jinzaki, M., Hirano, M., Hara, K., Suzuki, T., Yamashina, A., Ikari, Y., Iino, M., Yamaguchi, T. & Kuribayashi, S., 2013 Jun, In : International Journal of Cardiovascular Imaging. 29, 1 SUPPL., p. 7-20 14 p.

Research output: Contribution to journalArticle

Heart Diseases
Placebos
Heart Rate
Safety
landiolol
4 Citations (Scopus)

Biliary Findings Assist in Predicting Enlargement of Intraductal Papillary Mucinous Neoplasms of the Pancreas

Matsuzaki, J., Suzuki, H., Okuda, S., Tanimoto, A., Asakura, K., Fukuhara, S., Okada, S., Hirata, K., Mori, H., Masaoka, T., Higuchi, H., Hozawa, S., Kuribayashi, S., Takebayashi, T. & Hibi, T., 2013 May, In : Clinical Gastroenterology and Hepatology. 11, 5, p. 548-554 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Magnetic Resonance Cholangiopancreatography
Gallbladder
Common Bile Duct
Confidence Intervals
1 Citation (Scopus)

Cerebral blood flow after hybrid distal hemiarch repair

Shimizu, H., Nakahara, T., Ohkuma, K., Kawaguchi, S., Yoshitake, A. & Yozu, R., 2013 Jul, In : Interactive Cardiovascular and Thoracic Surgery. 17, 1, p. 73-78 6 p.

Research output: Contribution to journalArticle

Cerebrovascular Circulation
Common Carotid Artery
Regional Blood Flow
Vertebral Artery
Internal Carotid Artery
2 Citations (Scopus)

Chromosome aberrations in normal human fibroblasts analyzed in G0/G1 and G2/M phases after exposure in G0 to radiation with different linear energy transfer (LET)

Liu, C., Kawata, T., Furusawa, Y., Zhou, G., Inoue, K., Fukada, J., Kota, R., George, K., Cucinotta, F. & Okayasu, R., 2013 May 30, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 756, 1-2, p. 101-107 7 p.

Research output: Contribution to journalArticle

Linear Energy Transfer
G2 Phase
Chromosome Aberrations
Cell Division
Fibroblasts
6 Citations (Scopus)

Clinical utility of preoperative evaluation of bronchial arteries by three-dimensional computed tomographic angiography for esophageal cancer surgery

Wada, T., Takeuchi, H., Kawakubo, H., Nakamura, R., Oyama, T., Takahashi, T., Wada, N., Saikawa, Y., Omori, T., Jinzaki, M., Kuribayashi, S. & Kitagawa, Y., 2013 Aug, In : Diseases of the Esophagus. 26, 6, p. 616-622 7 p.

Research output: Contribution to journalArticle

Bronchial Arteries
Esophageal Neoplasms
Angiography
Patient Rights
Lymph Nodes
15 Citations (Scopus)

Comparison of preplanning and intraoperative planning for I-125 prostate brachytherapy

Yoshida, K., Ohashi, T., Yorozu, A., Toya, K., Nishiyama, T., Saito, S., Hanada, T., Shiraishi, Y. & Shigematsu, N., 2013 Apr, In : Japanese Journal of Clinical Oncology. 43, 4, p. 383-389 7 p.

Research output: Contribution to journalArticle

Brachytherapy
Prostate
Survival
Multivariate Analysis
Planning Techniques
6 Citations (Scopus)

Comparison of the repair of potentially lethal damage after low- And high-LET radiation exposure, assessed from the kinetics and fidelity of chromosome rejoining in normal human fibroblasts

Liu, C., Kawata, T., Zhou, G., Furusawa, Y., Kota, R., Kumabe, A., Sutani, S., Fukada, J., Mishima, M., Shigematsu, N., George, K. & Cucinotta, F., 2013 Nov, In : Journal of Radiation Research. 54, 6, p. 989-997 9 p.

Research output: Contribution to journalArticle

Linear Energy Transfer
chromosomes
fibroblasts
radiation dosage
Fibroblasts
13 Citations (Scopus)

Concomitant pancreatic endocrine neoplasm and intraductal papillary mucinous neoplasm: A case report and literature review

Kadota, Y., Shinoda, M., Tanabe, M., Tsujikawa, H., Ueno, A., Masugi, Y., Oshima, G., Nishiyama, R., Tanaka, M., Mihara, K., Abe, Y., Yagi, H., Kitago, M., Itano, O., Kawachi, S., Aiura, K., Tanimoto, A., Sakamaoto, M. & Kitagawa, Y., 2013 Mar 21, In : World Journal of Surgical Oncology. 11, 75.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Pancreatic Ducts
Neoplasms
Chromogranin A
Negative Staining
11 Citations (Scopus)
Fiducial Markers
Esophageal Neoplasms
esophagus
markers
radiation therapy
3 Citations (Scopus)

Dose-Finding study of landiolol hydrochloride: A short-acting Β1-Blocker for controlling heart rate during coronary computed-Tomography angiography in japan

Hirano, M., Hara, K., Ikari, Y., Jinzaki, M., Iino, M., Hamada, C. & Kuribayashi, S., 2013 Sep, In : Advances in Therapy. 30, 9, p. 803-818 16 p.

Research output: Contribution to journalArticle

Japan
Heart Rate
Coronary Angiography
Coronary Stenosis
Artifacts
3 Citations (Scopus)

Dosimetric effects of prone and supine positions on post-implant assessments for prostate brachytherapy

Ohashi, T., Momma, T., Yamashita, S., Kanai, K., Watanabe, Y., Hanada, T. & Shigematsu, N., 2013, In : Journal of Contemporary Brachytherapy. 5, 3, p. 122-126 5 p.

Research output: Contribution to journalArticle

Prone Position
Supine Position
Brachytherapy
Prostate
Tomography
24 Citations (Scopus)

Epithelioid angiomyolipoma of the kidney: Radiological imaging

Tsukada, J., Jinzaki, M., Yao, M., Nagashima, Y., Mikami, S., Yashiro, H., Nozaki, M., Mizuno, R., Oya, M. & Kuribayashi, S., 2013 Nov, In : International Journal of Urology. 20, 11, p. 1105-1111 7 p.

Research output: Contribution to journalArticle

Angiomyolipoma
Tomography
Hemorrhage
Kidney
Necrosis
33 Citations (Scopus)

Evaluation for local failure by 18F-FDG PET/CT in comparison with CT findings after stereotactic body radiotherapy (SBRT) for localized non-small-cell lung cancer

Takeda, A., Kunieda, E., Fujii, H., Yokosuka, N., Aoki, Y., Oooka, Y., Oku, Y., Ohashi, T., Sanuki, N., Mizuno, T. & Ozawa, Y., 2013 Mar, In : Lung Cancer. 79, 3, p. 248-253 6 p.

Research output: Contribution to journalArticle

Radiosurgery
Fluorodeoxyglucose F18
Non-Small Cell Lung Carcinoma
Recurrence
Cicatrix
35 Citations (Scopus)

Factors affecting local progression after percutaneous cryoablation of lung tumors

Yashiro, H., Nakatsuka, S., Inoue, M., Kawamura, M., Tsukada, N., Asakura, K., Yamauchi, Y., Hashimoto, K. & Kuribayashi, S., 2013 Jun, In : Journal of Vascular and Interventional Radiology. 24, 6, p. 813-821 9 p.

Research output: Contribution to journalArticle

Cryosurgery
Lung
Neoplasms
Multivariate Analysis
Confidence Intervals
5 Citations (Scopus)

Large renal arteriovenous fistula with left-sided inferior vena cava

Obara, H., Tanaka, K., Matsubara, K., Miyajima, A., Inoue, M., Hashimoto, S., Kuribayashi, S. & Kitagawa, Y., 2013, In : Annals of Vascular Surgery. 27, 8

Research output: Contribution to journalArticle

Arteriovenous Fistula
Inferior Vena Cava
Kidney
Renal Veins
Renal Artery
15 Citations (Scopus)

Lymphoepithelioma-like hepatocellular carcinoma: A case report and a review of the literature

Shinoda, M., Kadota, Y., Tsujikawa, H., Masugi, Y., Itano, O., Ueno, A., Mihara, K., Hibi, T., Abe, Y., Yagi, H., Kitago, M., Kawachi, S., Tanimoto, A., Sakamoto, M., Tanabe, M. & Kitagawa, Y., 2013 May 4, In : World Journal of Surgical Oncology. 11, 97.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Bile Duct Neoplasms
Neoplasms
Lymph Nodes
Extrahepatic Bile Ducts
13 Citations (Scopus)

Modic changes of the cervical spine in patients with whiplash injury: A prospective 11-year follow-up study

Matsumoto, M., Ichihara, D., Okada, E., Toyama, Y., Fujiwara, H., Momoshima, S., Nishiwaki, Y. & Takahata, T., 2013 Jun, In : Injury. 44, 6, p. 819-824 6 p.

Research output: Contribution to journalArticle

Whiplash Injuries
Spine
Accidents
Physiological Phenomena
Intervertebral Disc Degeneration
20 Citations (Scopus)
Hepatocytes
Hepatocellular Carcinoma
Fats
Magnetic Resonance Imaging
Focal Nodular Hyperplasia
2 Citations (Scopus)
iodine 125
bleeding
Brachytherapy
Iodine
Prostate
4 Citations (Scopus)

Numerical analysis of blood flow distribution in 4- and 3-branch vascular grafts

Konoura, C., Yagi, T., Nakamura, M., Iwasaki, K., Qian, Y., Okuda, S., Yoshitake, A., Shimizu, H., Yozu, R. & Umezu, M., 2013 Jun, In : Journal of Artificial Organs. 16, 2, p. 157-163 7 p.

Research output: Contribution to journalArticle

Grafts
Blood Vessels
Numerical analysis
Blood
Transplants
26 Citations (Scopus)

OATP1B3 expression is strongly associated with Wnt/β-catenin signalling and represents the transporter of gadoxetic acid in hepatocellular carcinoma

Ueno, A., Masugi, Y., Yamazaki, K., Komuta, M., Effendi, K., Tanami, Y., Tsujikawa, H., Tanimoto, A., Okuda, S., Itano, O., Kitagawa, Y., Kuribayashi, S. & Sakamoto, M., 2013 Nov 8, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Catenins
Anions
Hepatocellular Carcinoma
Peptides
Wnt Proteins
4 Citations (Scopus)

Observer variation study of the assessment and diagnosis of incidental colonic FDG uptake

Minamimoto, R., Terauchi, T., Jinnouchi, S., Yoshida, T., Tsukamoto, E., Shimbo, T., Ito, K., Uno, K., Ohno, H., Oguchi, K., Kato, S., Kaneko, K., Satoh, Y., Tamaki, T., Nakahara, T., Morooka, M., Inoue, T. & Senda, M., 2013 Jun, In : Annals of Nuclear Medicine. 27, 5, p. 468-477 10 p.

Research output: Contribution to journalArticle

Observer Variation
Occult Blood
Neoplasms
Adenoma
Fluorodeoxyglucose F18
13 Citations (Scopus)

Outcomes following iodine-125 prostate brachytherapy with or without neoadjuvant androgen deprivation

Ohashi, T., Yorozu, A., Saito, S., Momma, T., Toya, K., Nishiyama, T., Yamashita, S., Shiraishi, Y. & Shigematsu, N., 2013 Nov, In : Radiotherapy and Oncology. 109, 2, p. 241-245 5 p.

Research output: Contribution to journalArticle

Brachytherapy
Iodine
Androgens
Prostate
Survival
7 Citations (Scopus)

Periprostatic fat area is an independent factor that prolonged operative time in laparoscopic radical prostatectomy

Kaneko, G., Miyajima, A., Yuge, K., Hasegawa, M., Takeda, T., Jinzaki, M., Kikuchi, E., Nakagawa, K. & Oya, M., 2013 Dec, In : Urology. 82, 6, p. 1304-1309 6 p.

Research output: Contribution to journalArticle

Operative Time
Prostatectomy
Abdominal Obesity
Fats
Prostate
12 Citations (Scopus)

Prediction of the critical thermal zone during pulmonary cryoablation on computed tomography from correlated experimental and clinical findings

Hashimoto, K., Izumi, Y., Yamauchi, Y., Yashiro, H., Inoue, M., Nakatsuka, S. & Nomori, H., 2013 Mar, In : Journal of Thoracic and Cardiovascular Surgery. 145, 3, p. 832-838 7 p.

Research output: Contribution to journalArticle

Cryosurgery
Hot Temperature
Tomography
Lung
Neoplasms
17 Citations (Scopus)
Frozen Sections
Endometrial Neoplasms
Magnetic Resonance Imaging
Sensitivity and Specificity
Retrospective Studies
28 Citations (Scopus)
Pericardial Effusion
Esophageal Neoplasms
therapy
cancer
dosage
31 Citations (Scopus)

Tandem age-related lumbar and cervical intervertebral disc changes in asymptomatic subjects

Matsumoto, M., Okada, E., Toyama, Y., Fujiwara, H., Momoshima, S. & Takahata, T., 2013 Apr, In : European Spine Journal. 22, 4, p. 708-713 6 p.

Research output: Contribution to journalArticle

Intervertebral Disc
Intervertebral Disc Degeneration
Spine
Magnetic Resonance Imaging
Volunteers
8 Citations (Scopus)

Three-dimensional demonstration of the lymphatic system in the lower extremities with multi-detector-row computed tomography: A study in a cadaver model

Yamazaki, S., Suami, H., Imanishi, N., Aiso, S., Yamada, M., Jinzaki, M., Kuribayashi, S., Chang, D. W. & Kishi, K., 2013, In : Clinical Anatomy. 26, 2, p. 258-266 9 p.

Research output: Contribution to journalArticle

Lymphatic System
Cadaver
Lower Extremity
Tomography
Contrast Media
7 Citations (Scopus)

Three-dimensional imaging and mapping of the right and left phrenic nerves: Relevance to interventional cardiovascular therapy

Fukumoto, K., Takatsuki, S., Jinzaki, M., Yamada, M., Tanimoto, K., Nishiyama, N., Aizawa, Y., Hagiwara, Y., Fukuda, Y., Kimura, T., Miyoshi, S., Kuribayashi, S. & Fukuda, K., 2013 Jul, In : Europace. 15, 7, p. 937-943 7 p.

Research output: Contribution to journalArticle

Phrenic Nerve
Three-Dimensional Imaging
Tomography
Anatomy
Therapeutics