Department of Pharmacokinetics and Pharmacodynamics

Research Output 1998 2019

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2019

Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis

Ohata, Y., Tomita, Y., Sunakawa, K., Drusano, G. L. & Tanigawara, Y., 2019 Sep 1, In : International journal of antimicrobial agents. 54, 3, p. 292-300 9 p.

Research output: Contribution to journalArticle

meropenem
Bacterial Meningitides
Cerebrospinal Fluid
Pharmacokinetics
Pediatrics

Gefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer

Kawata, T., Higashimori, M., Itoh, Y., Tomkinson, H., Johnson, M. G., Tang, W., Nyberg, F., Jiang, H. & Tanigawara, Y., 2019 Jan 1, In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

Pulmonary diseases
Interstitial Lung Diseases
Non-Small Cell Lung Carcinoma
Cells
Glycoproteins
3 Citations (Scopus)

Therapeutic drug monitoring of monoclonal antibodies: Applicability based on their pharmacokinetic properties

Imamura, C., 2019 Jan 1, (Accepted/In press) In : Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

Drug Monitoring
Pharmacokinetics
Monoclonal Antibodies
Anti-Idiotypic Antibodies
Pharmaceutical Preparations
2018

Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype-Guided Dosing of Tamoxifen

Nakamura, T., Toshimoto, K., Lee, W., Imamura, C., Tanigawara, Y. & Sugiyama, Y., 2018 Jul 1, In : CPT: Pharmacometrics and Systems Pharmacology. 7, 7, p. 474-482 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Pharmacokinetics
Tamoxifen
Genotype
Predict
1 Citation (Scopus)

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

Yamauchi, T., Fernandez, J. R. E., Imamura, C., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., Nakamura, S., Lim, B., Krishnamurthy, S., Reuben, J. M., Liu, D., Tripathy, D., Chen, H., Takebe, N., Saya, H. & Ueno, N. T., 2018 Jan 1, In : Oncotarget. 9, 6, p. 6872-6882 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Therapeutics
Biomarkers
1 Citation (Scopus)

Individualized Dosing of Axitinib Based on First-Dose Area Under the Concentration–Time Curve for Metastatic Renal-Cell Carcinoma

Miura, Y., Imamura, C., Uchino, K., Kishida, T., Matsubara, N., Shinojima, T., Kondo, K., Hongo, F., Yoshimura, K., Tanigawara, Y. & Takano, T., 2018 Jan 1, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Area Under Curve
Disease-Free Survival
Survival Rate
Confidence Intervals
6 Citations (Scopus)

Modeling and simulation of bone mineral density in Japanese osteoporosis patients treated with zoledronic acid using tartrate-resistant acid phosphatase 5b, a bone resorption marker

Mori, Y., Kasai, H., Ose, A., Serada, M., Ishiguro, M., Shiraki, M. & Tanigawara, Y., 2018 Feb 8, (Accepted/In press) In : Osteoporosis International. p. 1-9 9 p.

Research output: Contribution to journalArticle

zoledronic acid
Bone Resorption
Bone Density
Osteoporosis
Theoretical Models

Pharmacodynamic analysis of eribulin safety in breast cancer patients using real-world postmarketing surveillance data

Kawamura, T., Kasai, H., Fermanelli, V., Takahashi, T., Sakata, Y., Matsuoka, T., Ishii, M. & Tanigawara, Y., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

eribulin
Neutrophils
Breast Neoplasms
Safety
Neutropenia
7 Citations (Scopus)

Therapeutic Drug Monitoring in Oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology Recommendations for 5-Fluorouracil Therapy

Beumer, J. H., Chu, E., Allegra, C., Tanigawara, Y., Milano, G., Diasio, R., Kim, T. W., Mathijssen, R. H., Zhang, L., Arnold, D., Muneoka, K., Boku, N. & Joerger, M., 2018 Jan 1, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Drug Monitoring
Fluorouracil
Toxicology
Body Surface Area
Head and Neck Neoplasms
2017
16 Citations (Scopus)

Clinical Factors Predicting Detection of T790M Mutation in Rebiopsy for EGFR-Mutant Non-small-cell Lung Cancer

Kawamura, T., Kenmotsu, H., Omori, S., Nakashima, K., Wakuda, K., Ono, A., Naito, T., Murakami, H., Omae, K., Mori, K., Tanigawara, Y., Nakajima, T., Ohde, Y., Endo, M. & Takahashi, T., 2017, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Recurrence
5 Citations (Scopus)

Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12)

Yoshida, K., Imamura, C., Hara, K., Mochizuki, M. & Tanigawara, Y., 2017 Aug 1, In : Metabolomics. 13, 8, 98.

Research output: Contribution to journalArticle

Metabolic Networks and Pathways
Muscle Cells
Muscle
Skeletal Muscle
Cells
7 Citations (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. & 2 others, Nakanishi, Y. & Okamoto, I., 2017, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Pemetrexed
Sulfasalazine
Non-Small Cell Lung Carcinoma
Cisplatin
Neoplastic Stem Cells
1 Citation (Scopus)

Population Pharmacokinetic and Exposure-Response Analysis of Weekly Teriparatide in Osteoporosis Patients

Ose, A., Serada, M., Yamashita, K., Tsurui, K. & Tanigawara, Y., 2017, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

Teriparatide
Osteoporosis
Pharmacokinetics
Bone Density
Population
2 Citations (Scopus)

Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia

Kizu, R., Nishimura, K., Sato, R., Kosaki, K., Tanaka, T., Tanigawara, Y. & Hasegawa, T., 2017 Jul 14, (Accepted/In press) In : Hormone Research in Paediatrics.

Research output: Contribution to journalArticle

Diazoxide
Hypoglycemia
Pharmacokinetics
Population
Hyperglycemia
5 Citations (Scopus)

The effects of advanced age and serum α1-acid glycoprotein on docetaxel unbound exposure and dose-limiting toxicity in cancer patients

Kenmotsu, H., Imamura, C., Ono, A., Omori, S., Nakashima, K., Wakuda, K., Taira, T., Naito, T., Murakami, H., Takahashi, T. & Tanigawara, Y., 2017 Nov 1, In : British Journal of Clinical Pharmacology. 83, 11, p. 2416-2425 10 p.

Research output: Contribution to journalArticle

docetaxel
Glycoproteins
Acids
Serum
Neoplasms
2016
29 Citations (Scopus)

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Shitara, K., Doi, T., Nagano, O., Imamura, C., Ozeki, T., Ishii, Y., Tsuchihashi, K., Takahashi, S., Nakajima, T. E., Hironaka, S., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Einaga, Y., Kuwata, T., Saya, H. & Ohtsu, A., 2016 Apr 7, (Accepted/In press) In : Gastric Cancer. p. 1-9 9 p.

Research output: Contribution to journalArticle

Sulfasalazine
Neoplastic Stem Cells
Stomach Neoplasms
Biopsy
Oxidative Stress

Evaluation of clinical response in cancer drug therapy

Imamura, C., 2016, In : Japanese Journal of Clinical Pharmacology and Therapeutics. 47, 2, p. 62-67 6 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Drug Therapy
Neoplasms
16 Citations (Scopus)

Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole

Imamura, C., Furihata, K., Okamoto, S. & Tanigawara, Y., 2016 Apr 1, In : Journal of Clinical Pharmacology. 56, 4, p. 408-413 6 p.

Research output: Contribution to journalArticle

Tacrolimus
Cytochrome P-450 Enzyme System
Pharmacokinetics
Genotype
Healthy Volunteers
2015
3 Citations (Scopus)

Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study

Booka, E., Imamura, C., Takeuchi, H., Hamamoto, Y., Gomi, D., Mizukami, T., Ichiyama, T., Tateishi, K., Takahashi, T., Kawakubo, H., Soejima, K., Boku, N., Tanigawara, Y. & Kitagawa, Y., 2015 Aug 25, (Accepted/In press) In : Gastric Cancer.

Research output: Contribution to journalArticle

Fluorouracil
Pharmacokinetics
Prospective Studies
Kidney
Area Under Curve

Dose optimization of anticancer drugs in the elderly

Imamura, C., 2015 Jan 1, In : Gan to kagaku ryoho. Cancer & chemotherapy. 42, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

Kidney
Pharmaceutical Preparations
Creatinine
Cytotoxins
Neutropenia

Pharmacokinetic issues on cancer pharmacotherapy

Tanigawara, Y., 2015 Aug 1, In : Nihon rinsho. Japanese journal of clinical medicine. 73, 8, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Drug Therapy
Drug Delivery Systems
Pharmaceutical Preparations
Neoplasms
42 Citations (Scopus)

Pharmacokinetics, dynamics and toxicity of docetaxel: Why the Japanese dose differs from the Western dose

Kenmotsu, H. & Tanigawara, Y., 2015 May 1, In : Cancer Science. 106, 5, p. 497-504 8 p.

Research output: Contribution to journalArticle

docetaxel
Pharmacokinetics
Area Under Curve
Japan
Population

The survey for anti-emetic guideline by using questioner

Saeki, T., Tamura, K., Aiba, K., Aogi, K., Lino, K., Imamura, C., Eguchi, K., Okita, K., Kagami, Y., Tanaka, R., Nakagawa, K., Fujii, H., Boku, N., Matsuura, K., Wada, M., Akechi, T., Kakudo, Y., Kim, Y. I., Sasaki, H. N., Shima, Y. & 9 others, Takeda, M., Nagasaki, E., Nishidate, T., Saito, M., Ashikaga, Y., Tanigawara, Y., Hirata, K., Ishioka, C. & Nishiyama, M., 2015 Mar 1, In : Japanese Journal of Cancer and Chemotherapy. 42, 3, p. 305-311 7 p.

Research output: Contribution to journalArticle

Antiemetics
Guidelines
Japan
Medical Oncology
Therapeutics
2014
11 Citations (Scopus)

Clinical practice guidelines for therapeutic drug monitoring of arbekacin: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Okada, K., Kimura, T., Mikamo, H., Kasahara, K., Seki, M., Takakura, S., Tokimatsu, I., Ohmagari, N., Takahashi, Y., Matsumoto, K., Igarashi, M., Kobayashi, M., Hamada, Y., Mochizuki, T., Kimura, M., Nishi, Y., Tanigawara, Y. & Takesue, Y., 2014, In : Journal of Infection and Chemotherapy. 20, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Drug Monitoring
Practice Guidelines
Drug Therapy
Japan
Serum
7 Citations (Scopus)
oxaliplatin
Fluorouracil
Colorectal Neoplasms
Cells
Annexin A2
18 Citations (Scopus)

Sunitinib-induced severe toxicities in a japanese patient with the ABCG2 421 AA genotype

Miura, Y., Imamura, C., Fukunaga, K., Katsuyama, Y., Suyama, K., Okaneya, T., Mushiroda, T., Ando, Y., Takano, T. & Tanigawara, Y., 2014 Dec 16, In : BMC Cancer. 14, 1, 964.

Research output: Contribution to journalArticle

Genotype
sunitinib
Hand-Foot Syndrome
Vascular Endothelial Growth Factor Receptor
Pharmacogenetics
2013
4 Citations (Scopus)

Clinical and bacteriological efficacies of sitafloxacin against community-acquired pneumonia caused by Streptococcus pneumoniae: Nested cohort within a multicenter clinical trial

Fujita, J., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Watanabe, A., Aoki, N., Hori, S., Tanigawara, Y., Cash, H. L. & Kohno, S., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 472-479 8 p.

Research output: Contribution to journalArticle

Streptococcus pneumoniae
Multicenter Studies
Pneumonia
Clinical Trials
Levofloxacin
12 Citations (Scopus)

Clinical dose findings of sitafloxacin treatment: Pharmacokinetic- pharmacodynamic analysis of two clinical trial results for community-acquired respiratory tract infections

Kohno, S., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Watanabe, A., Aoki, N., Hori, S., Fujita, J. & Tanigawara, Y., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 486-494 9 p.

Research output: Contribution to journalArticle

Community-Acquired Infections
Respiratory Tract Infections
Pharmacokinetics
Clinical Trials
Microbial Sensitivity Tests

Current status of monitoring in investigator-initiated trials with IND

Imamura, C., 2013, In : Japanese Pharmacology and Therapeutics. 41, SUPPL. 2

Research output: Contribution to journalArticle

Research Personnel
41 Citations (Scopus)

Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients

Kim, H. R., Park, H. S., Kwon, W. S., Lee, J. H., Tanigawara, Y., Lim, S. M., Kim, H. S., Shin, S. J., Ahn, J. B. & Rha, S. Y., 2013 Oct, In : Cancer Chemotherapy and Pharmacology. 72, 4, p. 825-835 11 p.

Research output: Contribution to journalArticle

Hand-Foot Syndrome
Pharmacogenetics
Renal Cell Carcinoma
Toxicity
Neutropenia
12 Citations (Scopus)

Polymorphisms in the UGT1A1 gene predict adverse effects of irinotecan in the treatment of gynecologic cancer in Japanese patients

Hirasawa, A., Zama, T., Akahane, T., Nomura, H., Kataoka, F., Saito, K., Okubo, K., Tominaga, E., Makita, K., Susumu, N., Kosaki, K., Tanigawara, Y. & Aoki, D., 2013 Dec, In : Journal of Human Genetics. 58, 12, p. 794-798 5 p.

Research output: Contribution to journalArticle

irinotecan
Glucuronosyltransferase
Uridine Diphosphate
Genes
Neoplasms
9 Citations (Scopus)

Population pharmacokinetics and pharmacodynamics of sitafloxacin in patients with community-acquired respiratory tract infections

Tanigawara, Y., Kaku, M., Totsuka, K., Tsuge, H. & Saito, A., 2013 Oct, In : Journal of Infection and Chemotherapy. 19, 5, p. 858-866 9 p.

Research output: Contribution to journalArticle

Community-Acquired Infections
Respiratory Tract Infections
Pharmacokinetics
Population
sitafloxacin
61 Citations (Scopus)

Practice guidelines for therapeutic drug monitoring of vancomycin: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Matsumoto, K., Takesue, Y., Ohmagari, N., Mochizuki, T., Mikamo, H., Seki, M., Takakura, S., Tokimatsu, I., Takahashi, Y., Kasahara, K., Okada, K., Igarashi, M., Kobayashi, M., Hamada, Y., Kimura, M., Nishi, Y., Tanigawara, Y. & Kimura, T., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 365-380 16 p.

Research output: Contribution to journalArticle

Drug Monitoring
Vancomycin
Methicillin-Resistant Staphylococcus aureus
Practice Guidelines
Guidelines
54 Citations (Scopus)

Practice guidelines for therapeutic drug monitoring of voriconazole: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Hamada, Y., Tokimatsu, I., Mikamo, H., Kimura, M., Seki, M., Takakura, S., Ohmagari, N., Takahashi, Y., Kasahara, K., Matsumoto, K., Okada, K., Igarashi, M., Kobayashi, M., Mochizuki, T., Nishi, Y., Tanigawara, Y., Kimura, T. & Takesue, Y., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 381-392 12 p.

Research output: Contribution to journalArticle

Drug Monitoring
Practice Guidelines
Guidelines
Drug Therapy
Voriconazole
2012
41 Citations (Scopus)

A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese

Kiyotani, K., Mushiroda, T., Tsunoda, T., Morizono, T., Hosono, N., Kubo, M., Tanigawara, Y., Imamura, C., Flockhart, D. A., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., 2012 Apr, In : Human Molecular Genetics. 21, 7, p. 1665-1672 8 p., ddr597.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Tamoxifen
Breast Neoplasms
Survival
Recurrence
2 Citations (Scopus)

Blood-direct InvaderPlus® as a new method for genetic testing

Hirasawa, A., Akahane, T., Tanigawara, Y. & Aoki, D., 2012 Aug, In : Personalized Medicine. 9, 6, p. 657-663 7 p.

Research output: Contribution to journalArticle

Genetic Testing
Genetic Polymorphisms
Genes
64 Citations (Scopus)

Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients

Kiyotani, K., Mushiroda, T., Imamura, C., Tanigawara, Y., Hosono, N., Kubo, M., Sasa, M., Nakamura, Y. & Zembutsu, H., 2012 Jan, In : Breast Cancer Research and Treatment. 131, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Genotype
Breast Neoplasms
Alleles
17 Citations (Scopus)

Expression changes in arrestin β 1 and genetic variation in catechol-O-methyltransferase are biomarkers for the response to morphine treatment in cancer patients

Matsuoka, H., Arao, T., Makimura, C., Takeda, M., Kiyota, H., Tsurutani, J., Fujita, Y., Matsumoto, K., Kimura, H., Otsuka, M., Koyama, A., Imamura, C., Tanigawara, Y., Yamanaka, T., Tanaka, K., Nishio, K. & Nakagawa, K., 2012 May, In : Oncology Reports. 27, 5, p. 1393-1399 7 p.

Research output: Contribution to journalArticle

Arrestin
Catechol O-Methyltransferase
Morphine
Biomarkers
Neoplasms
2 Citations (Scopus)

International models of investigator-initiated trials: Implications for Japan

Trimble, E. L., Ledermann, J., Law, K., Miyata, T., Imamura, C., Nam, B. H., Kim, Y. H., Bang, Y. J., Michaels, M., Ardron, D., Amano, S., Ando, Y., Tominaga, T., Kurokawa, K. & Takebe, N., 2012 Dec, In : Annals of Oncology. 23, 12, p. 3151-3155 5 p., mds168.

Research output: Contribution to journalArticle

Japan
Research Personnel
Clinical Trials
Drug Approval
Investigational New Drug Application
17 Citations (Scopus)

Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation

Tanigawara, Y., Nozawa, K. & Tsuda, H., 2012 Jan, In : European Journal of Clinical Pharmacology. 68, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Population
Quinolones
Microbial Sensitivity Tests
Respiratory System
8 Citations (Scopus)

Pharmacokinetics of mizoribine in adult living donor liver transplantation

Shinoda, M., Tanabe, M., Kawachi, S., Ono, Y., Hayakawa, T., Iketani, O., Kojima, M., Itano, O., Obara, H., Kitago, M., Hibi, T., Matsubara, K., Shimojima, N., Fuchimoto, Y., Hoshino, K., Wakabayashi, G., Shimazu, M., Tanigawara, Y., Kuroda, T., Morikawa, Y. & 2 others, Kitajima, M. & Kitagawa, Y., 2012 Jun, In : Transplantation Proceedings. 44, 5, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

Living Donors
Liver Transplantation
Pharmacokinetics
Serum
Glomerular Filtration Rate
14 Citations (Scopus)

Phase i trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl + hematological malignancies

Bose, P., Perkins, E. B., Honeycut, C., Wellons, M. D., Stefan, T., Jacobberger, J. W., Kontopodis, E., Beumer, J. H., Egorin, M. J., Imamura, C., Figg, W. D., Karp, J. E., Koc, O. N., Cooper, B. W., Luger, S. M., Colevas, A. D., Roberts, J. D. & Grant, S., 2012 Jun, In : Cancer Chemotherapy and Pharmacology. 69, 6, p. 1657-1667 11 p.

Research output: Contribution to journalArticle

alvocidib
Hematologic Neoplasms
bcr-abl Fusion Proteins
Pharmacokinetics
Cyclin-Dependent Kinases
2011
111 Citations (Scopus)

A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures - A randomized, active comparator, double-blind study

Matsumoto, T., Ito, M., Hayashi, Y., Hirota, T., Tanigawara, Y., Sone, T., Fukunaga, M., Shiraki, M. & Nakamura, T., 2011 Oct, In : Bone. 49, 4, p. 605-612 8 p.

Research output: Contribution to journalArticle

Osteoporotic Fractures
Cholecalciferol
Double-Blind Method
Bone Density
Wrist
7 Citations (Scopus)

How can we address cancer care after a natural disaster?

Imamura, C. & Ueno, N. T., 2011 Jul, In : Nature Reviews Clinical Oncology. 8, 7, p. 387-388 2 p.

Research output: Contribution to journalArticle

Tsunamis
Earthquakes
Disasters
Japan
Chronic Disease
142 Citations (Scopus)

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Watanabe, M., Horai, Y., Houten, S. M., Morimoto, K., Sugizaki, T., Arita, E., Mataki, C., Sato, H., Tanigawara, Y., Schoonjans, K., Itoh, H. & Auwerx, J., 2011 Jul 29, In : Journal of Biological Chemistry. 286, 30, p. 26913-26920 8 p.

Research output: Contribution to journalArticle

Medical problems
Bile Acids and Salts
Energy Metabolism
Obesity
High Fat Diet
23 Citations (Scopus)
Thrombomodulin
Disseminated Intravascular Coagulation
Pharmacokinetics
Population
Hematocrit
13 Citations (Scopus)

Optimal dosage regimen of meropenem for pediatric patients based on pharmacokinetic/pharmacodynamic considerations

Ohata, Y., Tomita, Y., Nakayama, M., Kozuki, T., Sunakawa, K. & Tanigawara, Y., 2011, In : Drug Metabolism and Pharmacokinetics. 26, 5, p. 523-531 9 p.

Research output: Contribution to journalArticle

meropenem
Pharmacokinetics
Pediatrics
Bacteria
Japan
9 Citations (Scopus)

Optimal treatment schedule of meropenem for adult patients with febrile neutropenia based on pharmacokinetic-pharmacodynamic analysis

Ohata, Y., Tomita, Y., Nakayama, M., Tamura, K. & Tanigawara, Y., 2011 Dec, In : Journal of Infection and Chemotherapy. 17, 6, p. 831-841 11 p.

Research output: Contribution to journalArticle

meropenem
Febrile Neutropenia
Appointments and Schedules
Pharmacokinetics
Therapeutics
11 Citations (Scopus)

Overview of the clinical pharmacokinetics of eldecalcitol, a new active vitamin D3 derivative

Abe, M., Tsuji, N., Takahashi, F. & Tanigawara, Y., 2011 Mar, In : Japanese Pharmacology and Therapeutics. 39, 3, p. 261-274 14 p.

Research output: Contribution to journalArticle

Cholecalciferol
Pharmacokinetics
Clinical Pharmacology
Therapeutic Equivalency
Drug Interactions
6 Citations (Scopus)

Pharmacokinetics of eldecalcitol in primary osteoporosis patients - Randomized, double-blind, multicentre, long-term phase III clinical study

Miyata, K., Abe, M., Terao, K., Kawanishi, T., Tsuji, N., Shiraki, M., Nakamura, T., Matsumoto, T. & Tanigawara, Y., 2011 Mar, In : Japanese Pharmacology and Therapeutics. 39, 3, p. 299-307 9 p.

Research output: Contribution to journalArticle

Osteoporosis
Pharmacokinetics
Serum
eldecalcitol
Clinical Studies