Department of Pharmacokinetics and Pharmacodynamics

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2020

CYP2D6 genotype-guided tamoxifen dosing in hormone receptor-positive metastatic breast cancer (TARGET-1): A randomized, open-label, Phase II study

Tamura, K., Imamura, C., Takano, T., Saji, S., Yamanaka, T., Yonemori, K., Takahashi, M., Tsurutani, J., Nishimura, R., Sato, K., Kitani, A., Ueno, N. T., Mushiroda, T., Kubo, M., Fujiwara, Y. & Tanigawara, Y., 2020 Feb 20, In : Journal of Clinical Oncology. 38, 6, p. 558-566 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of gefitinib systemic exposure in EGFR-mutated non-small cell lung cancer patients with gefitinib-induced severe hepatotoxicity

Kawamura, T., Imamura, C., Kenmotsu, H., Taira, T., Omori, S., Nakashima, K., Wakuda, K., Ono, A., Naito, T., Murakami, H., Mushiroda, T., Takahashi, T. & Tanigawara, Y., 2020 Mar 1, In : Cancer Chemotherapy and Pharmacology. 85, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

Open Access
2019

Cerebrospinal pharmacokinetic and pharmacodynamic analysis of efficacy of meropenem in paediatric patients with bacterial meningitis

Ohata, Y., Tomita, Y., Sunakawa, K., Drusano, G. L. & Tanigawara, Y., 2019 Sep, In : International journal of antimicrobial agents. 54, 3, p. 292-300 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Gefitinib exposure and occurrence of interstitial lung disease in Japanese patients with non-small-cell lung cancer

Kawata, T., Higashimori, M., Itoh, Y., Tomkinson, H., Johnson, M. G., Tang, W., Nyberg, F., Jiang, H. & Tanigawara, Y., 2019 Jan 1, In : Cancer Chemotherapy and Pharmacology.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Individualized Dosing of Axitinib Based on First-Dose Area Under the Concentration–Time Curve for Metastatic Renal-Cell Carcinoma

Miura, Y., Imamura, C. K., Uchino, K., Kishida, T., Matsubara, N., Shinojima, T., Kondo, K., Hongo, F., Yoshimura, K., Tanigawara, Y. & Takano, T., 2019 Feb, In : Clinical Genitourinary Cancer. 17, 1, p. e1-e11

Research output: Contribution to journalArticle

1 Citation (Scopus)

The Japanese Lung Cancer Society Guideline for non-small cell lung cancer, stage IV

Akamatsu, H., Ninomiya, K., Kenmotsu, H., Morise, M., Daga, H., Goto, Y., Kozuki, T., Miura, S., Sasaki, T., Tamiya, A., Teraoka, S., Tsubata, Y., Yoshioka, H., Hattori, Y., Imamura, C. K., Katsuya, Y., Matsui, R., Minegishi, Y., Mizugaki, H., Nosaki, K. & 13 others, Okuma, Y., Sakamoto, S., Sone, T., Tanaka, K., Umemura, S., Yamanaka, T., Amano, S., Hasegawa, K., Morita, S., Nakajima, K., Maemondo, M., Seto, T. & Yamamoto, N., 2019 Jul 12, In : International Journal of Clinical Oncology. 24, 7, p. 731-770 40 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Therapeutic drug monitoring of monoclonal antibodies: Applicability based on their pharmacokinetic properties

Imamura, C., 2019 Jan 1, (Accepted/In press) In : Drug Metabolism and Pharmacokinetics.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype-Guided Dosing of Tamoxifen

Nakamura, T., Toshimoto, K., Lee, W., Imamura, C., Tanigawara, Y. & Sugiyama, Y., 2018 Jul 1, In : CPT: Pharmacometrics and Systems Pharmacology. 7, 7, p. 474-482 9 p.

Research output: Contribution to journalArticle

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

Yamauchi, T., Fernandez, J. R. E., Imamura, C. K., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., Nakamura, S., Lim, B., Krishnamurthy, S., Reuben, J. M., Liu, D., Tripathy, D., Chen, H., Takebe, N., Saya, H. & Ueno, N. T., 2018, In : Oncotarget. 9, 6, p. 6872-6882 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Modeling and simulation of bone mineral density in Japanese osteoporosis patients treated with zoledronic acid using tartrate-resistant acid phosphatase 5b, a bone resorption marker

Mori, Y., Kasai, H., Ose, A., Serada, M., Ishiguro, M., Shiraki, M. & Tanigawara, Y., 2018 Feb 8, (Accepted/In press) In : Osteoporosis International. p. 1-9 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Pharmacodynamic analysis of eribulin safety in breast cancer patients using real-world postmarketing surveillance data

Kawamura, T., Kasai, H., Fermanelli, V., Takahashi, T., Sakata, Y., Matsuoka, T., Ishii, M. & Tanigawara, Y., 2018 Sep, In : Cancer science. 109, 9, p. 2822-2829 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2017

Clinical Factors Predicting Detection of T790M Mutation in Rebiopsy for EGFR-Mutant Non-small-cell Lung Cancer

Kawamura, T., Kenmotsu, H., Omori, S., Nakashima, K., Wakuda, K., Ono, A., Naito, T., Murakami, H., Omae, K., Mori, K., Tanigawara, Y., Nakajima, T., Ohde, Y., Endo, M. & Takahashi, T., 2017, (Accepted/In press) In : Clinical Lung Cancer.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Effect of everolimus on the glucose metabolic pathway in mouse skeletal muscle cells (C2C12)

Yoshida, K., Imamura, C., Hara, K., Mochizuki, M. & Tanigawara, Y., 2017 Aug 1, In : Metabolomics. 13, 8, 98.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Guidelines for therapeutic drug monitoring of cardiovascular drugs clinical use of blood drug concentration monitoring (Jcs 2015) ― digest version ―

Japanese Circulation Society & Japanese Society of Therapeutic Drug Monitoring Joint Working Group, 2017, In : Circulation Journal. 81, 4, p. 581-612 32 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer

Otsubo, K., Nosaki, K., Imamura, C., Ogata, H., Fujita, A., Sakata, S., Hirai, F., Toyokawa, G., Iwama, E., Harada, T., Seto, T., Takenoyama, M., Ozeki, T., Mushiroda, T., Inada, M., Kishimoto, J., Tsuchihashi, K., Suina, K., Nagano, O., Saya, H. & 2 others, Nakanishi, Y. & Okamoto, I., 2017, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Population Pharmacokinetic and Exposure-Response Analysis of Weekly Teriparatide in Osteoporosis Patients

Ose, A., Serada, M., Yamashita, K., Tsurui, K. & Tanigawara, Y., 2017, (Accepted/In press) In : Journal of Clinical Pharmacology.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Population Pharmacokinetics of Diazoxide in Children with Hyperinsulinemic Hypoglycemia

Kizu, R., Nishimura, K., Sato, R., Kosaki, K., Tanaka, T., Tanigawara, Y. & Hasegawa, T., 2017 Nov 1, In : Hormone Research in Paediatrics. 88, 5, p. 316-323 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

The effects of advanced age and serum α1-acid glycoprotein on docetaxel unbound exposure and dose-limiting toxicity in cancer patients

Kenmotsu, H., Imamura, C., Ono, A., Omori, S., Nakashima, K., Wakuda, K., Taira, T., Naito, T., Murakami, H., Takahashi, T. & Tanigawara, Y., 2017 Nov 1, In : British Journal of Clinical Pharmacology. 83, 11, p. 2416-2425 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2016

Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study

Booka, E., Imamura, C. K., Takeuchi, H., Hamamoto, Y., Gomi, D., Mizukami, T., Ichiyama, T., Tateishi, K., Takahashi, T., Kawakubo, H., Soejima, K., Boku, N., Tanigawara, Y. & Kitagawa, Y., 2016 Jul 1, In : Gastric Cancer. 19, 3, p. 876-886 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Dose-escalation study for the targeting of CD44v+ cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205)

Shitara, K., Doi, T., Nagano, O., Imamura, C., Ozeki, T., Ishii, Y., Tsuchihashi, K., Takahashi, S., Nakajima, T. E., Hironaka, S., Fukutani, M., Hasegawa, H., Nomura, S., Sato, A., Einaga, Y., Kuwata, T., Saya, H. & Ohtsu, A., 2016 Apr 7, (Accepted/In press) In : Gastric Cancer. p. 1-9 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Evaluation of clinical response in cancer drug therapy

Imamura, C., 2016, In : Japanese Journal of Clinical Pharmacology and Therapeutics. 47, 2, p. 62-67 6 p.

Research output: Contribution to journalArticle

Impact of cytochrome P450 2C19 polymorphisms on the pharmacokinetics of tacrolimus when coadministered with voriconazole

Imamura, C., Furihata, K., Okamoto, S. & Tanigawara, Y., 2016 Apr 1, In : Journal of Clinical Pharmacology. 56, 4, p. 408-413 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2015

Dose optimization of anticancer drugs in the elderly

Imamura, C. K., 2015 Jan 1, In : Japanese Journal of Cancer and Chemotherapy. 42, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

Pharmacokinetic issues on cancer pharmacotherapy

Tanigawara, Y., 2015 Aug 1, In : Nihon rinsho. Japanese journal of clinical medicine. 73, 8, p. 1357-1363 7 p.

Research output: Contribution to journalArticle

2014

Clinical practice guidelines for therapeutic drug monitoring of arbekacin: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Okada, K., Kimura, T., Mikamo, H., Kasahara, K., Seki, M., Takakura, S., Tokimatsu, I., Ohmagari, N., Takahashi, Y., Matsumoto, K., Igarashi, M., Kobayashi, M., Hamada, Y., Mochizuki, T., Kimura, M., Nishi, Y., Tanigawara, Y. & Takesue, Y., 2014 Jan, In : Journal of Infection and Chemotherapy. 20, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
11 Citations (Scopus)

Sunitinib-induced severe toxicities in a japanese patient with the ABCG2 421 AA genotype

Miura, Y., Imamura, C. K., Fukunaga, K., Katsuyama, Y., Suyama, K., Okaneya, T., Mushiroda, T., Ando, Y., Takano, T. & Tanigawara, Y., 2014 Dec 16, In : BMC Cancer. 14, 1, 964.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2013

Clinical and bacteriological efficacies of sitafloxacin against community-acquired pneumonia caused by Streptococcus pneumoniae: Nested cohort within a multicenter clinical trial

Fujita, J., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Watanabe, A., Aoki, N., Hori, S., Tanigawara, Y., Cash, H. L. & Kohno, S., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 472-479 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Clinical dose findings of sitafloxacin treatment: Pharmacokinetic- pharmacodynamic analysis of two clinical trial results for community-acquired respiratory tract infections

Kohno, S., Niki, Y., Kadota, J. I., Yanagihara, K., Kaku, M., Watanabe, A., Aoki, N., Hori, S., Fujita, J. & Tanigawara, Y., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 486-494 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Current status of monitoring in investigator-initiated trials with IND

Imamura, C. K., 2013 Nov 4, In : Japanese Pharmacology and Therapeutics. 41, SUPPL. 2, p. S84-S87

Research output: Contribution to journalArticle

Pharmacogenetic determinants associated with sunitinib-induced toxicity and ethnic difference in Korean metastatic renal cell carcinoma patients

Kim, H. R., Park, H. S., Kwon, W. S., Lee, J. H., Tanigawara, Y., Lim, S. M., Kim, H. S., Shin, S. J., Ahn, J. B. & Rha, S. Y., 2013 Oct 1, In : Cancer Chemotherapy and Pharmacology. 72, 4, p. 825-835 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Polymorphisms in the UGT1A1 gene predict adverse effects of irinotecan in the treatment of gynecologic cancer in Japanese patients

Hirasawa, A., Zama, T., Akahane, T., Nomura, H., Kataoka, F., Saito, K., Okubo, K., Tominaga, E., Makita, K., Susumu, N., Kosaki, K., Tanigawara, Y. & Aoki, D., 2013 Dec 1, In : Journal of Human Genetics. 58, 12, p. 794-798 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Population pharmacokinetics and pharmacodynamics of sitafloxacin in patients with community-acquired respiratory tract infections

Tanigawara, Y., Kaku, M., Totsuka, K., Tsuge, H. & Saito, A., 2013 Oct, In : Journal of Infection and Chemotherapy. 19, 5, p. 858-866 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Practice guidelines for therapeutic drug monitoring of vancomycin: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Matsumoto, K., Takesue, Y., Ohmagari, N., Mochizuki, T., Mikamo, H., Seki, M., Takakura, S., Tokimatsu, I., Takahashi, Y., Kasahara, K., Okada, K., Igarashi, M., Kobayashi, M., Hamada, Y., Kimura, M., Nishi, Y., Tanigawara, Y. & Kimura, T., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 365-380 16 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Practice guidelines for therapeutic drug monitoring of voriconazole: A consensus review of the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring

Hamada, Y., Tokimatsu, I., Mikamo, H., Kimura, M., Seki, M., Takakura, S., Ohmagari, N., Takahashi, Y., Kasahara, K., Matsumoto, K., Okada, K., Igarashi, M., Kobayashi, M., Mochizuki, T., Nishi, Y., Tanigawara, Y., Kimura, T. & Takesue, Y., 2013 Jun, In : Journal of Infection and Chemotherapy. 19, 3, p. 381-392 12 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2012

A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese

Kiyotani, K., Mushiroda, T., Tsunoda, T., Morizono, T., Hosono, N., Kubo, M., Tanigawara, Y., Imamura, C. K., Flockhart, D. A., Aki, F., Hirata, K., Takatsuka, Y., Okazaki, M., Ohsumi, S., Yamakawa, T., Sasa, M., Nakamura, Y. & Zembutsu, H., 2012 Apr 1, In : Human molecular genetics. 21, 7, p. 1665-1672 8 p., ddr597.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Blood-direct InvaderPlus® as a new method for genetic testing

Hirasawa, A., Akahane, T., Tanigawara, Y. & Aoki, D., 2012 Aug 1, In : Personalized Medicine. 9, 6, p. 657-663 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients

Kiyotani, K., Mushiroda, T., Imamura, C. K., Tanigawara, Y., Hosono, N., Kubo, M., Sasa, M., Nakamura, Y. & Zembutsu, H., 2012 Jan 1, In : Breast Cancer Research and Treatment. 131, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Expression changes in arrestin β 1 and genetic variation in catechol-O-methyltransferase are biomarkers for the response to morphine treatment in cancer patients

Matsuoka, H., Arao, T., Makimura, C., Takeda, M., Kiyota, H., Tsurutani, J., Fujita, Y., Matsumoto, K., Kimura, H., Otsuka, M., Koyama, A., Imamura, C. K., Tanigawara, Y., Yamanaka, T., Tanaka, K., Nishio, K. & Nakagawa, K., 2012 May 1, In : Oncology reports. 27, 5, p. 1393-1399 7 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

International models of investigator-initiated trials: Implications for Japan

Trimble, E. L., Ledermann, J., Law, K., Miyata, T., Imamura, C. K., Nam, B. H., Kim, Y. H., Bang, Y. J., Michaels, M., Ardron, D., Amano, S., Ando, Y., Tominaga, T., Kurokawa, K. & Takebe, N., 2012 Dec, In : Annals of Oncology. 23, 12, p. 3151-3155 5 p., mds168.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation

Tanigawara, Y., Nozawa, K. & Tsuda, H., 2012 Jan 1, In : European Journal of Clinical Pharmacology. 68, 1, p. 39-53 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Pharmacokinetics of mizoribine in adult living donor liver transplantation

Shinoda, M., Tanabe, M., Kawachi, S., Ono, Y., Hayakawa, T., Iketani, O., Kojima, M., Itano, O., Obara, H., Kitago, M., Hibi, T., Matsubara, K., Shimojima, N., Fuchimoto, Y., Hoshino, K., Wakabayashi, G., Shimazu, M., Tanigawara, Y., Kuroda, T., Morikawa, Y. & 2 others, Kitajima, M. & Kitagawa, Y., 2012 Jun 1, In : Transplantation Proceedings. 44, 5, p. 1329-1335 7 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Phase i trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl + hematological malignancies

Bose, P., Perkins, E. B., Honeycut, C., Wellons, M. D., Stefan, T., Jacobberger, J. W., Kontopodis, E., Beumer, J. H., Egorin, M. J., Imamura, C. K., Figg, W. D., Karp, J. E., Koc, O. N., Cooper, B. W., Luger, S. M., Colevas, A. D., Roberts, J. D. & Grant, S., 2012 Jun 1, In : Cancer Chemotherapy and Pharmacology. 69, 6, p. 1657-1667 11 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2011

A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures - A randomized, active comparator, double-blind study

Matsumoto, T., Ito, M., Hayashi, Y., Hirota, T., Tanigawara, Y., Sone, T., Fukunaga, M., Shiraki, M. & Nakamura, T., 2011 Oct 1, In : Bone. 49, 4, p. 605-612 8 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure

Watanabe, M., Horai, Y., Houten, S. M., Morimoto, K., Sugizaki, T., Arita, E., Mataki, C., Sato, H., Tanigawara, Y., Schoonjans, K., Itoh, H. & Auwerx, J., 2011 Jul 29, In : Journal of Biological Chemistry. 286, 30, p. 26913-26920 8 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)
25 Citations (Scopus)

Optimal dosage regimen of meropenem for pediatric patients based on pharmacokinetic/pharmacodynamic considerations

Ohata, Y., Tomita, Y., Nakayama, M., Kozuki, T., Sunakawa, K. & Tanigawara, Y., 2011 Jan 1, In : Drug Metabolism And Pharmacokinetics. 26, 5, p. 523-531 9 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Optimal treatment schedule of meropenem for adult patients with febrile neutropenia based on pharmacokinetic-pharmacodynamic analysis

Ohata, Y., Tomita, Y., Nakayama, M., Tamura, K. & Tanigawara, Y., 2011 Dec, In : Journal of Infection and Chemotherapy. 17, 6, p. 831-841 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Pharmacokinetics of eldecalcitol in primary osteoporosis patients - Randomized, double-blind, multicentre, long-term phase III clinical study

Miyata, K., Abe, M., Terao, K., Kawanishi, T., Tsuji, N., Shiraki, M., Nakamura, T., Matsumoto, T. & Tanigawara, Y., 2011 Mar 1, In : Japanese Pharmacology and Therapeutics. 39, 3, p. 299-307 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)