Research Output 1973 2019

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2019

Accidental Hypothermia Treated by Hemodialysis in the Acute Phase: Three Case Reports and a Review of the Literature

Murakami, T., Yoshida, T., Kurokochi, A., Takamatsu, K., Teranishi, Y., Shigeta, K., Tamaki, S., Morita, S., Mizuno, R. & Oya, M., 2019 Sep 15, In : Internal medicine (Tokyo, Japan). 58, 18, p. 2743-2748 6 p.

Research output: Contribution to journalArticle

Open Access
Hypothermia
Renal Dialysis
Heart Arrest
Rewarming
Body Temperature

Circulating FGF23 is not associated with cardiac dysfunction, atherosclerosis, infection or inflammation in hemodialysis patients

Takashi, Y., Wakino, S., Minakuchi, H., Ishizu, M., Kuroda, A., Shima, H., Tashiro, M., Miya, K., Okada, K., Minakuchi, J., Kawashima, S., Matsuhisa, M., Matsumoto, T. & Fukumoto, S., 2019 Jan 1, (Accepted/In press) In : Journal of Bone and Mineral Metabolism.

Research output: Contribution to journalArticle

Renal Dialysis
Atherosclerosis
Inflammation
Infection
Serum
1 Citation (Scopus)

Role of Nampt-Sirt6 Axis in Renal Proximal Tubules in Extracellular Matrix Deposition in Diabetic Nephropathy

Muraoka, H., Hasegawa, K., Sakamaki, Y., Minakuchi, H., Kawaguchi, T., Yasuda, I., Kanda, T., Tokuyama, H., Wakino, S. & Itoh, H., 2019 Apr 2, In : Cell Reports. 27, 1, p. 199-212.e5

Research output: Contribution to journalArticle

Open Access
Nicotinamide Phosphoribosyltransferase
Proximal Kidney Tubule
Diabetic Nephropathies
Extracellular Matrix
Albuminuria
Twin Pregnancy
Transplants
Kidney
Darbepoetin alfa
2018
1 Citation (Scopus)

Expanding Phenotype of Nephronophthisis-Related Ciliopathy: an Elderly Patient with Homozygous RPGRIP1L Mutation

Kawaguchi, T., Yoshida, T., Hirahashi, J., Uehara, T., Takenouchi, T., Kosaki, K., Itoh, H. & Hayashi, M., 2018 Jul 10, (Accepted/In press) In : Nephron. p. 1-5 5 p.

Research output: Contribution to journalArticle

Phenotype
Mutation
Chronic Kidney Failure
Kidney
Cysts
4 Citations (Scopus)
Sirtuin 1
Sodium-Glucose Transport Proteins
Facilitative Glucose Transport Proteins
Kidney
Glucose
3 Citations (Scopus)

Long-Term effects of low calcium dialysates on the serum calcium levels during maintenance hemodialysis treatments: A systematic review and meta-Analysis

Yoshikawa, M., Takase, O., Tsujimura, T., Sano, E., Hayashi, M., Takato, T. & Hishikawa, K., 2018 Dec 1, In : Scientific Reports. 8, 1, 5310.

Research output: Contribution to journalArticle

Dialysis Solutions
Renal Dialysis
Meta-Analysis
Maintenance
Calcium
13 Citations (Scopus)

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Okubo, K., Kurosawa, M., Kamiya, M., Urano, Y., Suzuki, A., Yamamoto, K., Hase, K., Honma, K., Sasaki, J., Miyauchi, H., Hoshino, T., Hayashi, M., Mayadas, T. N. & Hirahashi, J., 2018 Feb 1, In : Nature Medicine. 24, 2, p. 232-238 7 p.

Research output: Contribution to journalArticle

Rhabdomyolysis
Macrophages
Platelet Activation
Platelets
Acute Kidney Injury

Peritoneal dialysis patient having fish bone-induced colon perforation

Endo, S., Minakuchi, H. & Yoshida, T., 2018 Jan 1, (Accepted/In press) In : Clinical and Experimental Nephrology.

Research output: Contribution to journalArticle

Peritoneal Dialysis
Sigmoid Colon
Peritonitis
Colon
Fishes
2017

Aldosterone and Insulin Resistance: Vicious Combination in Patients on Maintenance Hemodialysis

Wakino, S., Minakuchi, H., Miya, K., Takamatsu, N., Tada, H., Tani, E., Inamoto, H., Minakuchi, J., Kawashima, S. & Itoh, H., 2017 Jan 1, (Accepted/In press) In : Therapeutic Apheresis and Dialysis.

Research output: Contribution to journalArticle

Aldosterone
Renal Dialysis
Insulin Resistance
Maintenance
Cardiomegaly
3 Citations (Scopus)
Hematinics
Renal Dialysis
Anemia
Dialysis
Chronic Renal Insufficiency
9 Citations (Scopus)

Klotho suppresses the renin-angiotensin system in adriamycin nephropathy

Takenaka, T., Inoue, T., Miyazaki, T., Kobori, H., Nishiyama, A., Ishii, N., Hayashi, M. & Suzuki, H., 2017 May 1, In : Nephrology Dialysis Transplantation. 32, 5, p. 791-800 10 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Doxorubicin
Kidney
Transforming Growth Factors
Catenins
2 Citations (Scopus)

L-Carnitine improves gastrointestinal disorders and altered the intestinal microbiota in hemodialysis patients

Irie, J., Kanno, Y., Kikuchi, R., Yoshida, T., Murai, S., Watanabe, M., Itoh, H. & Hayashi, M., 2017 Jan 1, In : Bioscience of Microbiota, Food and Health. 36, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle

Open Access
hemodialysis
Carnitine
carnitine
digestive system diseases
intestinal microorganisms

Pre-operative and post-operative estimated glomerular filtration rate in Japanese patients with urological malignancies

Niwa, N., Yoshida, T., Mizuno, R., Kikuchi, E., Miyajima, A., Hayashi, M. & Oya, M., 2017 Nov 27, (Accepted/In press) In : Clinical and Experimental Nephrology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Nephrectomy
Neoplasms
Diet Therapy
Chronic Renal Insufficiency
3 Citations (Scopus)
Chronic Renal Insufficiency
Smooth Muscle
Phosphates
Smooth Muscle Myocytes
Phosphorus
2016
Glutamate Decarboxylase
Glucose Tolerance Test
Glucose Intolerance
Epitopes
Glucose
15 Citations (Scopus)

Endothelial krüppel-like factor 4 mediates the protective effect of statins against ischemic AKI

Yoshida, T., Yamashita, M., Iwai, M. & Hayashi, M., 2016 May 1, In : Journal of the American Society of Nephrology. 27, 5, p. 1379-1388 10 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Kidney
Cell Adhesion Molecules
Reperfusion Injury
Endothelial Cells
15 Citations (Scopus)

Generation of kidney tubular organoids from human pluripotent stem cells

Yamaguchi, S., Morizane, R., Honma, K., Monkawa, T., Suzuki, S., Fujii, S., Koda, M., Hiratsuka, K., Yamashita, M., Yoshida, T., Wakino, S., Hayashi, K., Sasaki, J., Hori, S. & Itoh, H., 2016 Dec 16, In : Scientific Reports. 6, 38353.

Research output: Contribution to journalArticle

Organoids
Pluripotent Stem Cells
Kidney
Proteins
Cultured Cells

Idiopathic hematocele in a patient receiving peritoneal dialysis

Niwa, N., Yoshida, T. & Mizuno, R., 2016 May 13, (Accepted/In press) In : Clinical and Experimental Nephrology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Hematocele
Testicular Neoplasms
Peritoneal Dialysis
34 Citations (Scopus)

Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation

Okubo, K., Kamiya, M., Urano, Y., Nishi, H., Herter, J. M., Mayadas, T., Hirohama, D., Suzuki, K., Kawakami, H., Tanaka, M., Kurosawa, M., Kagaya, S., Hishikawa, K., Nangaku, M., Fujita, T., Hayashi, M. & Hirahashi, J., 2016 Aug 1, In : EBioMedicine. 10, p. 204-215 12 p.

Research output: Contribution to journalArticle

Lactoferrin
Inflammation
Immune system
Pathogens
Cell membranes
1 Citation (Scopus)

Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules

Futatsugi, K., Tokuyama, H., Shibata, S., Naitoh, M., Kanda, T., Minakuchi, H., Yamaguchi, S., Hayashi, K., Minamishima, Y. A., Yanagita, M., Wakino, S. & Itoh, H., 2016 Nov 9, In : Scientific Reports. 6, 36533.

Research output: Contribution to journalArticle

High Fat Diet
Obesity
Kidney
Wounds and Injuries
Fat-Restricted Diet
2 Citations (Scopus)

Pleiotropic effects of statins on acute kidney injury: involvement of Krüppel-like factor 4

Yoshida, T. & Hayashi, M., 2016 Jun 13, (Accepted/In press) In : Clinical and Experimental Nephrology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Acute Kidney Injury
Zinc Fingers
Primary Prevention
Secondary Prevention
4 Citations (Scopus)

Podocyte NF-κB is dispensable for the pathogenesis of renal ischemia-reperfusion injury

Yamashita, M., Yoshida, T. & Hayashi, M., 2016 Aug 1, In : Physiological Reports. 4, 16, e12912.

Research output: Contribution to journalArticle

Podocytes
Reperfusion Injury
Kidney
Transgenic Mice
Ischemia
6 Citations (Scopus)

Podocyte-specific NF-κB inhibition ameliorates proteinuria in adriamycin-induced nephropathy in mice

Yamashita, M., Yoshida, T., Suzuki, S., Honma, K. & Hayashi, M., 2016 Apr 18, (Accepted/In press) In : Clinical and Experimental Nephrology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Podocytes
Proteinuria
Doxorubicin
Transgenic Mice
Diaphragm
7 Citations (Scopus)

The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats

Minakuchi, H., Wakino, S., Hosoya, K., Sueyasu, K., Hasegawa, K., Shinozuka, K., Yoshifuji, A., Futatsugi, K., Komatsu, M., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2016 Mar 1, In : Nephrology Dialysis Transplantation. 31, 3, p. 413-423 11 p.

Research output: Contribution to journalArticle

Adipose Tissue
Indican
Phenotype
Lipodystrophy
Adipocytes
14 Citations (Scopus)

Xeno-Klotho Inhibits Parathyroid Hormone Signaling

Takenaka, T., Inoue, T., Miyazaki, T., Hayashi, M. & Suzuki, H., 2016 Feb 1, In : Journal of Bone and Mineral Research. 31, 2, p. 455-462 8 p.

Research output: Contribution to journalArticle

Parathyroid Hormone
Calcitriol
Immunoprecipitation
Parathyroid Hormone Receptors
Parathyroid Hormone Receptor Type 1
2015
6 Citations (Scopus)

A case of severe osteomalacia caused by Tubulointerstitial nephritis with Fanconi syndrome in asymptomotic primary biliary cirrhosis

Yamaguchi, S., Maruyama, T., Wakino, S., Tokuyama, H., Hashiguchi, A., Tada, S., Honma, K., Monkawa, T., Thomas, J. C., Miyashita, K., Kurihara, I., Yoshida, T., Konishi, K., Hayashi, K., Hayashi, M. & Itoh, H., 2015 Nov 11, (Accepted/In press) In : BMC Nephrology.

Research output: Contribution to journalArticle

Fanconi Syndrome
Interstitial Nephritis
Osteomalacia
Biliary Liver Cirrhosis
Renal Tubular Acidosis
2 Citations (Scopus)

Aspirin and eicosapentaenoic acid may arrest progressive IgA nephropathy: A potential alternative to immunosuppression

Hirahashi, J., Hanafusa, N., Wada, T., Arita, M., Hishikawa, K., Hayashi, M. & Nangaku, M., 2015 Sep 15, In : Internal Medicine. 54, 18, p. 2377-2382 6 p.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Immunosuppression
Immunoglobulin A
Aspirin
IGA Glomerulonephritis
1 Citation (Scopus)
Hyperlipoproteinemia Type II
Hypercholesterolemia
LDL Lipoproteins
Lipoproteins
LDL Receptors
4 Citations (Scopus)
LDL Lipoproteins
Cholesterol
Lipoproteins
Hydroxymethylglutaryl-CoA Reductase Inhibitors
HDL Lipoproteins
18 Citations (Scopus)

Insulin resistance in chronic kidney disease is ameliorated by spironolactone in rats and humans

Hosoya, K., Minakuchi, H., Wakino, S., Fujimura, K., Hasegawa, K., Komatsu, M., Yoshifuji, A., Futatsugi, K., Shinozuka, K., Washida, N., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2015 Apr 8, In : Kidney International. 87, 4, p. 749-760 12 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptors
Spironolactone
Chronic Renal Insufficiency
Insulin Resistance
Adipose Tissue
5 Citations (Scopus)

Prospective randomized study of the tolerability and efficacy of combination therapy for hypertensive chronic kidney disease: results of the PROTECT-CKD study

Hayashi, M., Uchida, S., Kawamura, T., Kuwahara, M., Nangaku, M. & Iino, Y., 2015 Oct 1, In : Clinical and Experimental Nephrology. 19, 5, p. 925-932 8 p.

Research output: Contribution to journalArticle

Chronic Renal Insufficiency
Prospective Studies
Blood Pressure
Hydrochlorothiazide
Angiotensin Receptor Antagonists
7 Citations (Scopus)

Safety of warfarin therapy in chronic hemodialysis patients: a prospective cohort study

Hayashi, M., Abe, T., Iwai, M., Matsui, A., Yoshida, T., Sato, Y., Kanno, Y. & The Warfarin Study Group, W. S. G., 2015 Dec 1, (Accepted/In press) In : Clinical and Experimental Nephrology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Warfarin
Renal Dialysis
Cohort Studies
Prospective Studies
Safety
2014
22 Citations (Scopus)
Vascular System Injuries
Vascular Cell Adhesion Molecule-1
Endothelial Cells
Knockout Mice
Wounds and Injuries
3 Citations (Scopus)

Disturbed tumor necrosis factor system is linked with lower eGFR and chronic inflammation in hypertension

Eguchi, T., Maruyama, T., Ohno, Y., Morii, T., Hirose, H., Takenaka, T., Suzuki, H., Kawabe, H., Saito, I., Hayashi, M. & Itoh, H., 2014, In : International Journal of Biological Markers. 29, 1

Research output: Contribution to journalArticle

Tumor Necrosis Factor-alpha
Hypertension
Inflammation
Insulin Resistance
Insulin
20 Citations (Scopus)

Ghrelin protects against renal damages induced by angiotensin-II via an antioxidative stress mechanism in mice

Fujimura, K., Wakino, S., Minakuchi, H., Hasegawa, K., Hosoya, K., Komatsu, M., Kaneko, Y., Shinozuka, K., Washida, N., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2014 Apr 18, In : PLoS One. 9, 4, e94373.

Research output: Contribution to journalArticle

ghrelin
Ghrelin
angiotensin II
Angiotensin II
Mitochondria
7 Citations (Scopus)

Immunomodulation with eicosapentaenoic acid supports the treatment of autoimmune small-vessel vasculitis

Hirahashi, J., Kawahata, K., Arita, M., Iwamoto, R., Hishikawa, K., Honda, M., Hamasaki, Y., Tanaka, M., Okubo, K., Kurosawa, M., Takase, O., Nakakuki, M., Saiga, K., Suzuki, K., Kawachi, S., Tojo, A., Seki, G., Marumo, T., Hayashi, M. & Fujita, T., 2014, In : Scientific Reports. 4, 6406.

Research output: Contribution to journalArticle

Eicosapentaenoic Acid
Immunomodulation
Vasculitis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Antineutrophil Cytoplasmic Antibodies
10 Citations (Scopus)

Inhalation of hydrogen gas is beneficial for preventing contrast-induced acute kidney injury in rats

Honma, K., Yoshida, T., Yamashita, M., Hayashida, K., Hayashi, M. & Hori, S., 2014 Feb 17, In : Nephron - Experimental Nephrology. 128, p. 116-122 7 p.

Research output: Contribution to journalArticle

Acute Kidney Injury
Inhalation
Hydrogen
Gases
Kidney
28 Citations (Scopus)

Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity

Yoshida, T., Yamashita, M., Horimai, C. & Hayashi, M., 2014 Sep 19, In : Journal of Biological Chemistry. 289, 38, p. 26107-26118 12 p.

Research output: Contribution to journalArticle

Cardiomegaly
Isoproterenol
Proteins
Cardiac Myocytes
myocardin
27 Citations (Scopus)

Role of Krüppel-like factor 4 and its binding proteins in vascular disease

Yoshida, T. & Hayashi, M., 2014, In : Journal of Atherosclerosis and Thrombosis. 21, 5, p. 402-413 12 p.

Research output: Contribution to journalArticle

Vascular Diseases
Smooth Muscle Myocytes
Muscle
Carrier Proteins
Transcription
4 Citations (Scopus)
Aspiration Pneumonia
Serum Albumin
Renal Dialysis
Creatinine
Enteral Nutrition
2013
42 Citations (Scopus)

Calciphylaxis: Diagnosis and clinical features

Hayashi, M., 2013 Aug, In : Clinical and Experimental Nephrology. 17, 4, p. 498-503 6 p.

Research output: Contribution to journalArticle

Calciphylaxis
Dialysis
Japan
Hypoalbuminemia
Wound Infection
25 Citations (Scopus)

Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter measurement

Isobe, K., Mori, T., Asano, T., Kawaguchi, H., Nonoyama, S., Kumagai, N., Kamada, F., Morimoto, T., Hayashi, M., Sohara, E., Rai, T., Sasaki, S. & Uchida, S., 2013 Nov 1, In : American Journal of Physiology - Renal Physiology. 305, 9

Research output: Contribution to journalArticle

Member 3 Solute Carrier Family 12
Enzyme-Linked Immunosorbent Assay
Pseudohypoaldosteronism
Immunosorbents
Urine
6 Citations (Scopus)

High glucose concentration does not modulate the formation of arterial medial calcification in experimental uremic rats

Yoshida, T., Yamashita, M., Horimai, C. & Hayashi, M., 2013 Nov, In : Journal of Vascular Research. 50, 6, p. 512-520 9 p.

Research output: Contribution to journalArticle

Glucose
Smooth Muscle Myocytes
Phosphates
Adenine
Streptozocin
6 Citations (Scopus)

Immunoglobulin G deposition to nonhemidesmosomal lamina lucida and early neutrophil involvement are characteristic features in a case of anti-p200 pemphigoid

Shimizu, A., Funakoshi, T., Ishibashi, M., Yoshida, T., Koga, H., Hashimoto, T., Amagai, M. & Ishiko, A., 2013 Mar, In : British Journal of Dermatology. 168, 3, p. 647-655 9 p.

Research output: Contribution to journalArticle

Bullous Pemphigoid
Blister
Neutrophils
Immunoglobulin G
Immunoelectron Microscopy
5 Citations (Scopus)

Renal thrombotic microangiopathy in a patient with septic disseminated intravascular coagulation

Sakamaki, Y., Konishi, K., Hayashi, K., Hashiguchi, A., Hayashi, M., Kubota, E., Saruta, T. & Itoh, H., 2013 Nov 27, In : BMC Nephrology. 14, 1, 260.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Disseminated Intravascular Coagulation
Kidney
Plasma Exchange
Sepsis
159 Citations (Scopus)

Renal tubular sirt1 attenuates diabetic albuminuria by epigenetically suppressing claudin-1 overexpression in podocytes

Hasegawa, K., Wakino, S., Simic, P., Sakamaki, Y., Minakuchi, H., Fujimura, K., Hosoya, K., Komatsu, M., Kaneko, Y., Kanda, T., Kubota, E., Tokuyama, H., Hayashi, K., Guarente, L. & Itoh, H., 2013 Nov, In : Nature Medicine. 19, 11, p. 1496-1504 9 p.

Research output: Contribution to journalArticle

Sirtuin 1
Claudin-1
Podocytes
Albuminuria
Nicotinamide Mononucleotide
1 Citation (Scopus)

Severe systemic calciphylaxis with culture-negative endocarditis

Azegami, T., Wakino, S., Hayashi, M. & Itoh, H., 2013 Jun, In : Clinical Kidney Journal. 6, 3, p. 342-343 2 p.

Research output: Contribution to journalArticle

Calciphylaxis
Endocarditis
41 Citations (Scopus)
Neointima
Vascular System Injuries
Smooth Muscle Myocytes
Smooth Muscle
Cell Differentiation
16 Citations (Scopus)

The hydrolase DDAH2 enhances pancreatic insulin secretion by transcriptional regulation of secretagogin through a Sirt1-dependent mechanism in mice

Hasegawa, K., Wakino, S., Kimoto, M., Minakuchi, H., Fujimura, K., Hosoya, K., Komatsu, M., Kaneko, Y., Kanda, T., Tokuyama, H., Hayashi, K. & Itoh, H., 2013 Jun, In : FASEB Journal. 27, 6, p. 2301-2315 15 p.

Research output: Contribution to journalArticle

Hydrolases
Insulin
Glucose
High Fat Diet
Nutrition