Institute for Advanced Medical Research

Research Output 1990 2019

  • 178 Article
  • 1 Conference contribution
  • 1 Review article
2019

Cardiovascular Safety of Long-term Topical Application of a New Non-steroidal Anti-inflammatory Drug, S-flurbiprofen, in Patients with Osteoarthritis

Yataba, I., Kamada, Y., Matsushita, I., Matsumoto, H., Hoshino, Y. & Sato, A., 2019 Jan 1, In : Japanese Pharmacology and Therapeutics. 47, 3, p. 395-404 10 p.

Research output: Contribution to journalArticle

Flurbiprofen
Osteoarthritis
Anti-Inflammatory Agents
Safety
Pharmaceutical Preparations
3 Citations (Scopus)

Spinal epidural lipomatosis is a previously unrecognized manifestation of metabolic syndrome

Ishihara, S., Fujita, N., Azuma, K., Michikawa, T., Yagi, M., Tsuji, T., Takayama, M., Matsumoto, H., Nakamura, M., Matsumoto, M. & Watanabe, K., 2019 Mar 1, In : Spine Journal. 19, 3, p. 493-500 8 p.

Research output: Contribution to journalArticle

Lipomatosis
Fats
Intra-Abdominal Fat
Subcutaneous Fat
Odds Ratio
2018
1 Citation (Scopus)

Accuracy of basal metabolic rate estimated by predictive equations in Japanese with type 2 diabetes

Tabata, S., Kinoshita, N., Yamada, S. & Matsumoto, H., 2018 Jul 1, In : Asia Pacific Journal of Clinical Nutrition. 27, 4, p. 763-769 7 p.

Research output: Contribution to journalArticle

Basal Metabolism
Type 2 Diabetes Mellitus
Weights and Measures
Bone Density
Fasting
1 Citation (Scopus)

Analgesic effect of S (+)-flurbiprofen plaster in a rat model of knee arthritis: analysis of gait and synovial fluid prostaglandin E2 levels

Fukumoto, A., Tajima, K., Hori, M., Toda, Y., Kaku, S. & Matsumoto, H., 2018 Jul 1, In : Journal of Pharmacy and Pharmacology. 70, 7, p. 929-936 8 p.

Research output: Contribution to journalArticle

Flurbiprofen
Synovial Fluid
Gait
Dinoprostone
Arthritis
1 Citation (Scopus)

Elevated Creatine Kinase and Lactic Acid Dehydrogenase and Decreased Osteocalcin and Uncarboxylated Osteocalcin are Associated with Bone Stress Injuries in Young Female Athletes

Miyamoto, T., Oguma, Y., Sato, Y., Kobayashi, T., Ito, E., Tani, M., Miyamoto, K., Nishiwaki, Y., Ishida, H., Otani, T., Matsumoto, H., Matsumoto, M. & Nakamura, M., 2018 Dec 1, In : Scientific Reports. 8, 1, 18019.

Research output: Contribution to journalArticle

Stress Fractures
Osteocalcin
Creatine Kinase
Athletes
Lactic Acid
1 Citation (Scopus)

Factors affecting lower limb muscle strength and cardiopulmonary fitness after allogeneic hematopoietic stem cell transplantation

Ishikawa, A., Otaka, Y., Kamisako, M., Suzuki, T., Miyata, C., Tsuji, T., Matsumoto, H., Kato, J., Mori, T., Okamoto, S. & Liu, M., 2018 Jan 1, (Accepted/In press) In : Supportive Care in Cancer.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Muscle Strength
Lower Extremity
Torque
Leg

Practical guidance for treatment of patients with diabetes using flash glucose monitoring: a pilot study

Koide, K., Azuma, K., Nojima, J., Kodama, K. & Atsumi, Y., 2018 Aug 7, In : Diabetology and Metabolic Syndrome. 10, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Blood Glucose Self-Monitoring
Glucose
Blood Glucose
Therapeutics
Insulin
1 Citation (Scopus)

Real-time analysis of the heart rate variability during incremental exercise for the detection of the ventilatory threshold

Shiraishi, Y., Katsumata, Y., Sadahiro, T., Azuma, K., Akita, K., Isobe, S., Yashima, F., Miyamoto, K., Nishiyama, T., Tamura, Y., Kimura, T., Nishiyama, N., Aizawa, Y., Fukuda, K. & Takatsuki, S., 2018 Jan 1, In : Journal of the American Heart Association. 7, 1, e006612.

Research output: Contribution to journalArticle

Heart Rate
Exercise
Lactic Acid
Healthy Volunteers
Myocardial Infarction

Retraction Note to: Prevention of hip fractures by exposure to sunlight and pharmacotherapy in patients with Alzheimer’s disease

Iwamoto, J., Sato, Y., Tanaka, K., Takeda, T. & Matsumoto, H., 2018 Jun 5, (Accepted/In press) In : Aging clinical and experimental research. 1 p.

Research output: Contribution to journalArticle

Sunlight
Hip Fractures
Meta-Analysis
Alzheimer Disease
Drug Therapy
Vitamin K 2
Hip Fractures
Meta-Analysis
Randomized Controlled Trials
menatetrenone
2017

Acute Compartment Syndrome of Upper Extremities with Tendon Ruptures

Suzuki, T., Yamabe, E., Iwamoto, T., Suzuki, K., Yamada, H. & Satou, K., 2017 Dec 1, In : The journal of hand surgery Asian-Pacific volume. 22, 4, p. 411-415 5 p.

Research output: Contribution to journalArticle

Compartment Syndromes
Upper Extremity
Tendons
Rupture
Wounds and Injuries
3 Citations (Scopus)

A minimal impact of long-term S-flurbiprofen plaster application on kidney function in osteoarthritis patients

Otsuka, N., Yataba, I., Matsushita, I., Matsumoto, H., Hoshino, Y. & Terada, Y., 2017 Apr 4, (Accepted/In press) In : Clinical and Experimental Nephrology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Flurbiprofen
Osteoarthritis
Kidney
Creatinine
Anti-Inflammatory Agents
1 Citation (Scopus)

Clinical significance of serum complement factor 3 in patients with type 2 diabetes mellitus

Nishimura, T., Itoh, Y., Yamashita, S., Koide, K., Harada, N., Yano, Y., Ikeda, N., Azuma, K. & Atsumi, Y., 2017 May 1, In : Diabetes Research and Clinical Practice. 127, p. 132-139 8 p.

Research output: Contribution to journalArticle

Complement C3
Type 2 Diabetes Mellitus
Serum
Subcutaneous Fat
Blood Pressure
2 Citations (Scopus)

Maintenance of the paraspinal muscles may protect against radiographic knee osteoarthritis

Azuma, K., Sera, Y., Shinjo, T., Takayama, M., Shiomi, E., Momoshima, S., Iwao, Y., Ishida, H. & Matsumoto, H., 2017 Aug 10, In : Open Access Rheumatology: Research and Reviews. 9, p. 151-158 8 p.

Research output: Contribution to journalArticle

Paraspinal Muscles
Knee Osteoarthritis
Maintenance
Abdominal Muscles
Knee
3 Citations (Scopus)

Potential universal application of high-intensity interval training from athletes and sports lovers to patients

Azuma, K. & Matsumoto, H., 2017, In : Keio Journal of Medicine. 66, 2, p. 19-24 6 p.

Research output: Contribution to journalReview article

Athletes
Sports
Exercise
Exercise Test
Resistance Training
1 Citation (Scopus)

Relationships between Composition of Major Fatty Acids and Fat Distribution and Insulin Resistance in Japanese

Fujii, C., Kawai, T., Azuma, K., Oguma, Y., Katsukawa, F., Hirose, H., Tanaka, K., Meguro, S., Matsumoto, H. & Itoh, H., 2017, In : Journal of Diabetes Research. 2017, 1567467.

Research output: Contribution to journalArticle

Linoleic Acid
Intra-Abdominal Fat
Insulin Resistance
Fatty Acids
Fats
4 Citations (Scopus)

Relationships of muscle echo intensity with walking ability and physical activity in the very old population

Osawa, Y., Arai, Y., Oguma, Y., Hirata, T., Abe, Y., Azuma, K., Takayama, M. & Hirose, N., 2017 Apr 1, In : Journal of Aging and Physical Activity. 25, 2, p. 189-195 7 p.

Research output: Contribution to journalArticle

Walking
Muscles
Population
Patella
Thigh

Retraction Note to: Efficacy of Antiresorptive Agents for Preventing Fractures in Japanese Patients with an Increased Fracture Risk: Review of the Literature

Iwamoto, J., Sato, Y., Takeda, T. & Matsumoto, H., 2017 Apr 8, (Accepted/In press) In : Drugs and Aging. p. 1 1 p.

Research output: Contribution to journalArticle

Bone Density Conservation Agents
Switzerland
Pharmaceutical Preparations
3 Citations (Scopus)

The efficacy and safety of s-flurbiprofen plaster in the treatment of knee osteoarthritis: A phase ii, randomized, double-blind, placebo-controlled, dose-finding study

Yataba, I., Otsuka, N., Matsushita, I., Matsumoto, H. & Hoshino, Y., 2017 Apr 11, In : Journal of Pain Research. 10, p. 867-880 14 p.

Research output: Contribution to journalArticle

Flurbiprofen
Knee Osteoarthritis
Placebos
Safety
Pain
2016
15 Citations (Scopus)

Analgesic Effect of the Newly Developed S(+)-Flurbiprofen Plaster on Inflammatory Pain in a Rat Adjuvant-Induced Arthritis Model

Sugimoto, M., Toda, Y., Hori, M., Mitani, A., Ichihara, T., Sekine, S., Hirose, T., Endo, H., Futaki, N., Kaku, S., Otsuka, N. & Matsumoto, H., 2016 Feb 1, In : Drug Development Research. 77, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

Flurbiprofen
Experimental Arthritis
Ketoprofen
Analgesics
Pain
10 Citations (Scopus)

Efficacy of S-flurbiprofen plaster in knee osteoarthritis treatment: Results from a phase III, randomized, active-controlled, adequate, and well-controlled trial

Yataba, I., Otsuka, N., Matsushita, I., Matsumoto, H. & Hoshino, Y., 2016 May 5, (Accepted/In press) In : Modern Rheumatology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Flurbiprofen
Knee Osteoarthritis
Therapeutics
Musculoskeletal Diseases
Visual Analog Scale

Erratum to: Plasma pharmacokinetics and synovial concentrations of S-flurbiprofen plaster in humans (Eur J Clin Pharmacol (2016) 72 (53-59) DOI: 10.1007/s00228-015-1960-6)

Yataba, I., Otsuka, N., Matsushita, I., Kamezawa, M., Yamada, I., Sasaki, S., Uebaba, K., Matsumoto, H. & Hoshino, Y., 2016 Apr 1, In : European Journal of Clinical Pharmacology. 72, 4, p. 511 1 p.

Research output: Contribution to journalArticle

Flurbiprofen
Pharmacokinetics
11 Citations (Scopus)
Abdominal Obesity
Epidemiologic Studies
Atherosclerosis
Smoking
Intra-Abdominal Fat
17 Citations (Scopus)

Plasma pharmacokinetics and synovial concentrations of S-flurbiprofen plaster in humans

Yataba, I., Otsuka, N., Matsushita, I., Kamezawa, M., Yamada, I., Sasaki, S., Uebaba, K., Matsumoto, H. & Hoshino, Y., 2016 Jan 1, In : European Journal of Clinical Pharmacology. 72, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Flurbiprofen
Pharmacokinetics
Skin Absorption
Knee Osteoarthritis
Synovial Fluid
12 Citations (Scopus)

Rhabdomyolysis after performing blood flow restriction training: A case report

Tabata, S., Suzuki, Y., Azuma, K. & Matsumoto, H., 2016 Jul 1, In : Journal of Strength and Conditioning Research. 30, 7, p. 2064-2068 5 p.

Research output: Contribution to journalArticle

Rhabdomyolysis
Tonsillitis
Resistance Training
Myoglobin
Myalgia
8 Citations (Scopus)

The Long-Term Safety of S-Flurbiprofen Plaster for Osteoarthritis Patients: An Open-Label, 52-Week Study

Yataba, I., Otsuka, N., Matsushita, I., Matsumoto, H. & Hoshino, Y., 2016 May 26, (Accepted/In press) In : Clinical Drug Investigation. p. 1-10 10 p.

Research output: Contribution to journalArticle

Flurbiprofen
Osteoarthritis
Safety
Vital Signs
Dermatitis
10 Citations (Scopus)

Topical Anti-Inflammatory and Analgesic Effects of Multiple Applications of S(+)-Flurbiprofen Plaster (SFPP) in a Rat Adjuvant-Induced Arthritis Model

Sugimoto, M., Toda, Y., Hori, M., Mitani, A., Ichihara, T., Sekine, S., Kaku, S., Otsuka, N. & Matsumoto, H., 2016 Jun 1, In : Drug Development Research. p. 206-211 6 p.

Research output: Contribution to journalArticle

Flurbiprofen
Experimental Arthritis
Non-Steroidal Anti-Inflammatory Agents
Anti-Inflammatory Agents
Edema
2015
9 Citations (Scopus)

Anterior cruciate ligament reconstruction does not fully restore normal 3D knee kinematics at 12 months during walking and walk-pivoting: A longitudinal gait analysis study

Hasegawa, T., Otani, T., Takeda, K., Matsumoto, H., Harato, K., Toyama, Y. & Nagura, T., 2015 Oct 1, In : Journal of Applied Biomechanics. 31, 5, p. 330-339 10 p.

Research output: Contribution to journalArticle

Anterior Cruciate Ligament Reconstruction
Gait
Biomechanical Phenomena
Walking
Knee
1 Citation (Scopus)

Association of serum BDNF concentration with high-intensity interval training

Azuma, K., Osawa, Y., Tabata, S., Horisawa, S., Katsukawa, F., Ishida, H., Oguma, Y., Kawai, T., Oguchi, S., Ota, A., Kikuchi, H., Murata, M. & Matsumoto, H., 2015, In : Japanese Journal of Physical Fitness and Sports Medicine. 64, 2, p. 227-232 6 p.

Research output: Contribution to journalArticle

Brain-Derived Neurotrophic Factor
Serum
Exercise Tolerance
Exercise Test
Healthy Volunteers
6 Citations (Scopus)

Palmitic acid-rich diet suppresses glucose-stimulated insulin secretion (GSIS) and induces endoplasmic reticulum (ER) stress in pancreatic islets in mice

Hirata, T., Kawai, T., Hirose, H., Tanaka, K., Kurosawa, H., Fujii, C., Fujita, H., Seto, Y., Matsumoto, H. & Itoh, H., 2015 Jul 10, (Accepted/In press) In : Endocrine Research.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Palmitic Acid
Islets of Langerhans
Insulin
Diet
2014
2 Citations (Scopus)
Sutures
Joints
Minimally Invasive Surgical Procedures
Tissue
Surgery
3 Citations (Scopus)

Asymmetry of the knee extension deficit in standing affects weight-bearing distribution in patients with bilateral end-stage knee osteoarthritis

Harato, K., Nagura, T., Matsumoto, H., Otani, T., Toyama, Y. & Suda, Y., 2014 Oct 21, In : Knee Surgery, Sports Traumatology, Arthroscopy. 22, 11, p. 2608-2613 6 p.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Weight-Bearing
Knee
Gait
Aptitude
Biomechanical Phenomena
Athletes
Orthopedics
Knee
1 Citation (Scopus)

Female recreational athletes demonstrate different knee biomechanics from male counterparts during jumping rope and turning activities

Tanikawa, H., Matsumoto, H., Harato, K., Kiriyama, Y., Suda, Y., Toyama, Y. & Nagura, T., 2014, In : Journal of Orthopaedic Science. 19, 1, p. 104-111 8 p.

Research output: Contribution to journalArticle

Biomechanical Phenomena
Athletes
Knee
Running
Sports
23 Citations (Scopus)

Kinematic motion of the anterior cruciate ligament deficient knee during functionally high and low demanding tasks

Takeda, K., Hasegawa, T., Kiriyama, Y., Matsumoto, H., Otani, T., Toyama, Y. & Nagura, T., 2014 Jul 18, In : Journal of Biomechanics. 47, 10, p. 2526-2530 5 p.

Research output: Contribution to journalArticle

Anterior Cruciate Ligament
Ligaments
Biomechanical Phenomena
Knee
Kinematics
14 Citations (Scopus)

Lateral patellar retinaculum reconstruction for medial patellar instability following lateral retinacular release: A case report

Udagawa, K., Niki, Y., Matsumoto, H., Matsumoto, H., Enomoto, H., Toyama, Y. & Suda, Y., 2014 Jan, In : Knee. 21, 1, p. 336-339 4 p.

Research output: Contribution to journalArticle

Ligaments
Patellar Dislocation
Joint Instability
Collateral Ligaments
Direction compound

Vitamin K2 improves femoral bone strength without altering bone mineral density in gastrectomized rats

Iwamoto, J., Sato, Y. & Matsumoto, H., 2014, In : Journal of Nutritional Science and Vitaminology. 60, 2, p. 71-77 7 p.

Research output: Contribution to journalArticle

Vitamin K 2
Thigh
Bone Density
Diaphyses
Bone and Bones
2013
1 Citation (Scopus)

Chair rising time is longer in postmenopausal women with history of nonvertebral fracture.

Iwamoto, J., Sato, Y. & Matsumoto, H., 2013 Sep, In : Journal of musculoskeletal & neuronal interactions. 13, 3, p. 265-272 8 p.

Research output: Contribution to journalArticle

Osteoporosis
Glomerular Filtration Rate
Bone and Bones
Biomarkers
Muscles
5 Citations (Scopus)

Comparison of knee mechanics among risky athletic motions for noncontact anterior cruciate ligament injury

Tanikawa, H., Matsumoto, H., Komiyama, I., Kiriyama, Y., Toyama, Y. & Nagura, T., 2013 Dec, In : Journal of Applied Biomechanics. 29, 6, p. 749-755 7 p.

Research output: Contribution to journalArticle

Mechanics
Sports
Knee
Biomechanical Phenomena
Athletes
3 Citations (Scopus)

Effect of risedronate on speed of sound in postmenopausal women with osteoporosis

Iwamoto, J., Takada, T., Sato, Y. & Matsumoto, H., 2013 Oct 18, In : World Journal of Orthopaedics. 4, 4, p. 316-322 7 p.

Research output: Contribution to journalArticle

Osteoporosis
Calcaneus
Bone Remodeling
Alkaline Phosphatase
Therapeutics
1 Citation (Scopus)

Eleven years of experience with bisphosphonate plus alfacalcidol treatment in a man with osteogenesis imperfecta type I

Iwamoto, J., Sato, Y., Uzawa, M. & Matsumoto, H., 2013, In : Therapeutics and Clinical Risk Management. 9, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Osteogenesis Imperfecta
Diphosphonates
Spine
Bone Density
Minerals
7 Citations (Scopus)

Ethnic difference in liver fat content: A cross-sectional observation among Japanese American in Hawaii, Japanese in Japan, and non-Hispanic whites in United States

Azuma, K., Curb, J. D., Kadowaki, T., Edmundowicz, D., Kadowaki, S., Masaki, K. H., El-Saed, A., Nishio, Y., Seto, T. B., Okamura, T., Cetinel, C., Kadota, A., Sutton-Tyrrell, K., Miura, K., Evans, R. W., Takamiya, T., Maegawa, H., Miljkovic, I., Kuller, L. H., Ueshima, H. & 2 others, Kelley, D. E. & Sekikawa, A., 2013 May, In : Obesity Research and Clinical Practice. 7, 3

Research output: Contribution to journalArticle

Asian Americans
Japan
Fats
Observation
Liver
5 Citations (Scopus)

Influence of gastrectomy on cortical and cancellous bones in rats

Iwamoto, J., Sato, Y. & Matsumoto, H., 2013, In : Gastroenterology Research and Practice. 2013, 381616.

Research output: Contribution to journalArticle

Gastrectomy
Bone Resorption
Thigh
Osteogenesis
Bone and Bones
12 Citations (Scopus)

Risk factors for lumbar disc degeneration in High School American Football Players: A Prospective 2-Year Follow-up Study

Nagashima, M., Abe, H., Amaya, K., Matsumoto, H., Yanaihara, H., Nishiwaki, Y., Toyama, Y. & Matsumoto, M., 2013 Sep, In : American Journal of Sports Medicine. 41, 9, p. 2059-2064 6 p.

Research output: Contribution to journalArticle

Intervertebral Disc Degeneration
Football
Low Back Pain
Magnetic Resonance Imaging
Visual Analog Scale
2012
11 Citations (Scopus)

A method for quantifying intervertebral disc signal intensity on T2-weighted imaging

Nagashima, M., Abe, H., Amaya, K., Matsumoto, H., Yanaihara, H., Nishiwaki, Y., Toyama, Y. & Matsumoto, M., 2012 Nov, In : Acta Radiologica. 53, 9, p. 1059-1065 7 p.

Research output: Contribution to journalArticle

Intervertebral Disc
Intervertebral Disc Degeneration
Magnetic Resonance Imaging
12 Citations (Scopus)
Ankle Lateral Ligament
Knee
Transplants
Thigh
Ligaments
35 Citations (Scopus)

A quantitative assessment of varus thrust in patients with medial knee osteoarthritis

Kuroyanagi, Y., Nagura, T., Kiriyama, Y., Matsumoto, H., Otani, T., Toyama, Y. & Suda, Y., 2012 Mar, In : Knee. 19, 2, p. 130-134 5 p.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Knee
Gait
Confidence Intervals
Osteoarthritis
18 Citations (Scopus)

Effect of the posterior tibial and peroneal longus on the mechanical properties of the foot arch

Kokubo, T., Hashimoto, T., Nagura, T., Nakamura, T., Suda, Y., Matsumoto, H. & Toyama, Y., 2012 Apr, In : Foot and Ankle International. 33, 4, p. 320-325 6 p.

Research output: Contribution to journalArticle

Traction
Foot
Tendons
Muscles
Tarsal Joints
9 Citations (Scopus)

Effects of four different surgical approaches on intra-operative joint gap in posterior-stabilized total knee arthroplasty

Niki, Y., Takeda, Y., Kanagawa, H., Iwamoto, W., Matsumoto, H., Enomoto, H., Toyama, Y. & Suda, Y., 2012, In : Knee Surgery, Sports Traumatology, Arthroscopy. 20, 10, p. 2026-2031 6 p.

Research output: Contribution to journalArticle

Knee Replacement Arthroplasties
Knee
Joints
Patella
Quadriceps Muscle