Laboratory Animal Center

Research Output 1980 2017

2017
4 Citations (Scopus)

Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy

Yang, M., Arai, A., Udagawa, N., Hiraga, T., Lijuan, Z., Ito, S., Komori, T., Moriishi, T., Matsuo, K., Shimoda, K., Zahalka, A. H., Kobayashi, Y., Takahashi, N. & Mizoguchi, T., 2017 Dec 1, In : Scientific Reports. 7, 1, 4928.

Research output: Contribution to journalArticle

Leptin Receptors
Mesenchymal Stromal Cells
Osteoblasts
Population
Bone and Bones
2015
10 Citations (Scopus)

Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus

Matsuo, K., Kuroda, Y., Nango, N., Shimoda, K., Kubota, Y., Ema, M., Bakiri, L., Wagner, E. F., Takeda, Y., Yashiro, W. & Momose, A., 2015 Nov 15, In : Development (Cambridge). 142, 22, p. 3912-3920 9 p.

Research output: Contribution to journalArticle

Malleus
Growth Plate
Osteogenesis
Osteoblasts
Bone Matrix
2014
11 Citations (Scopus)

MiR-212 and miR-132 are dispensable for mouse mammary gland development

Kayo, H., Kiga, K., Fukuda-Yuzawa, Y., Hedlund, S., Murakami, K., De La Rosa-Velazquez, I. A., Kimura, T., Shimoda, K., Tanabe, M. & Fukao, T., 2014, In : Nature Genetics. 46, 8, p. 802-804 3 p.

Research output: Contribution to journalArticle

Animal Mammary Glands
Human Mammary Glands
MicroRNAs
Cell Communication
Epithelial Cells
2012
5 Citations (Scopus)

Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo

Yoshida, R., Suzuki, M., Sakaguchi, R., Hasegawa, E., Kimura, A., Shichita, T., Sekiya, T., Shiraishi, H., Shimoda, K. & Yoshimura, A., 2012 Jun 29, In : Biochemical and Biophysical Research Communications. 423, 2, p. 247-252 6 p.

Research output: Contribution to journalArticle

Dendritic Cells
Cytokines
Proto-Oncogene Proteins c-fos
Phosphorylation
T-cells
2011
7 Citations (Scopus)

Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris

Hata, T., Nishifuji, K., Shimoda, K., Sasaki, T., Yamada, T., Nishikawa, T., Koyasu, S. & Amagai, M., 2011 Jul, In : Journal of Dermatological Science. 63, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Desmoglein 3
Desmoglein 1
Pemphigus
Keratin-5
Histology
2010
30 Citations (Scopus)

Fibroblast expression of an IκB dominant-negative transgene attenuates renal fibrosis

Inoue, T., Takenaka, T., Hayashi, M., Monkawa, T., Yoshino, J., Shimoda, K., Neilson, E. G., Suzuki, H. & Okada, H., 2010 Dec, In : Journal of the American Society of Nephrology. 21, 12, p. 2047-2052 6 p.

Research output: Contribution to journalArticle

Transgenes
Fibrosis
Fibroblasts
Kidney
Epithelium
2009
20 Citations (Scopus)

Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing

Yamaguchi, T., Takada, Y., Maruyama, K., Shimoda, K., Arai, Y., Nango, N., Kosaki, N., Takaishi, H., Toyama, Y. & Matsuo, K., 2009 Dec, In : Journal of Bone and Mineral Research. 24, 12, p. 2056-2065 10 p.

Research output: Contribution to journalArticle

Chondrogenesis
Fracture Healing
Transcription Factor AP-1
Dinoprostone
Osteogenesis
2007
56 Citations (Scopus)

Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart

Yada, H., Murata, M., Shimoda, K., Yuasa, S., Kawaguchi, H., Ieda, M., Adachi, T., Murata, M., Ogawa, S. & Fukuda, K., 2007 Jul, In : Circulation Research. 101, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Cardiac Arrhythmias
Transgenic Mice
Ventricular Premature Complexes
Ventricular Tachycardia
Action Potentials
134 Citations (Scopus)

Sema3a maintains normal heart rhythm through sympathetic innervation patterning

Ieda, M., Kanazawa, H., Kimura, K., Hattori, F., Ieda, Y., Taniguchi, M., Lee, J. K., Matsumura, K., Tomita, Y., Miyoshi, S., Shimoda, K., Makino, S., Sano, M., Kodama, I., Ogawa, S. & Fukuda, K., 2007 May, In : Nature Medicine. 13, 5, p. 604-612 9 p.

Research output: Contribution to journalArticle

Semaphorin-3A
Transgenic Mice
Stellate Ganglion
Purkinje Fibers
Bradycardia
43 Citations (Scopus)

SHP2-mediated signaling cascade through gp130 is essential for LIF-dependent ICaL, [Ca2+]i transient, and APD increase in cardiomyocytes

Hagiwara, Y., Miyoshi, S., Fukuda, K., Nishiyama, N., Ikegami, Y., Tanimoto, K., Murata, M., Takahashi, E., Shimoda, K., Hirano, T., Mitamura, H. & Ogawa, S., 2007 Dec, In : Journal of Molecular and Cellular Cardiology. 43, 6, p. 710-716 7 p.

Research output: Contribution to journalArticle

Leukemia Inhibitory Factor
Cardiac Myocytes
Action Potentials
Interleukin-6
Interleukin-6 Receptors
2006
458 Citations (Scopus)

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T. & Matsuo, K., 2006 Aug, In : Cell Metabolism. 4, 2, p. 111-121 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Osteoblasts
Homeostasis
Bone and Bones
Ephrins
2004
89 Citations (Scopus)

Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression

Ieda, M., Fukuda, K., Hisaka, Y., Kimura, K., Kawaguchi, H., Fujita, J., Shimoda, K., Takeshita, E., Okano, H., Kurihara, Y., Kurihara, H., Ishida, J., Fukamizu, A., Federoff, H. J. & Ogawa, S., 2004 Mar, In : Journal of Clinical Investigation. 113, 6, p. 876-884 9 p.

Research output: Contribution to journalArticle

Endothelin-1
Nerve Growth Factor
Rodentia
Cardiac Myocytes
Stellate Ganglion
2003
9 Citations (Scopus)

Islet cell hyperplasia in transgenic mice overexpressing EAT/mcl-1, a bcl-2 related gene

Matsushita, K., Okita, H., Suzuki, A., Shimoda, K., Fukuma, M., Yamada, T., Urano, F., Honda, T., Sano, M., Iwanaga, S., Ogawa, S., Hata, J. I. & Umezawa, A., 2003 May 30, In : Molecular and Cellular Endocrinology. 203, 1-2, p. 105-116 12 p.

Research output: Contribution to journalArticle

bcl-2 Genes
Islets of Langerhans
Transgenic Mice
Hyperplasia
Genes
2002
2 Citations (Scopus)

Penetration of drug resistance in Escherichia coli isolated from laboratory animals

Shimoda, K., Kimura, J., Oguri, S., Nakamura, N., Urano, T. & Kazuyoshi, M., 2002 Dec, In : Journal of Veterinary Medical Science. 64, 12, p. 1133-1135 3 p.

Research output: Contribution to journalArticle

Sulfadimethoxine
sulfadimethoxine
Laboratory Animals
drug resistance
Streptomycin
2 Citations (Scopus)

Three synonymous genes encode calmodulin in a reptile, the Japanese tortoise, Clemmys japonica

Shimoda, K., Miyake, T., Kimura, J. & Maejima, K., 2002 Mar, In : Genetics and Molecular Biology. 25, 1, p. 43-47 5 p.

Research output: Contribution to journalArticle

Turtles
Reptiles
Calmodulin
Genes
Complementary DNA
2001
2 Citations (Scopus)

Light induced apoptosis is accelerated in transgenic retina overexpressing human EAT/mcl-1, an anti-apoptotic bcl-2 related gene

Shinoda, K., Nakamura, Y., Matsushita, K., Shimoda, K., Okita, H., Fukuma, M., Yamada, T., Ohde, H., Oguchi, Y., Hata, J. I. & Umezawa, A., 2001, In : British Journal of Ophthalmology. 85, 10, p. 1237-1243 7 p.

Research output: Contribution to journalArticle

bcl-2 Genes
Retina
Apoptosis
Light
Transgenic Mice
2000
13 Citations (Scopus)

A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord

Aruga, J., Shimoda, K. & Mikoshiba, K., 2000 May 31, In : Molecular Brain Research. 78, 1-2, p. 15-25 11 p.

Research output: Contribution to journalArticle

Rhombencephalon
Spinal Cord
Transgenes
Genes
Galactosidases
14 Citations (Scopus)

Involvement of EAT/mcl-1, an anti-apoptotic bcl-2-related gene, in murine embryogenesis and human development

Sano, M., Umezawa, A., Suzuki, A., Shimoda, K., Fukuma, M. & Hata, J. I., 2000 Aug 25, In : Experimental Cell Research. 259, 1, p. 127-139 13 p.

Research output: Contribution to journalArticle

bcl-2 Genes
Human Development
Embryonic Development
Wolffian Ducts
Apoptosis
1996
31 Citations (Scopus)

Functional expression of the type 1 inositol 1,4,5-trisphosphate receptor promoter-lacZ fusion genes in transgenic mice

Furutama, D., Shimoda, K., Yoshikawa, S., Miyawaki, A., Furuichi, T. & Mikoshiba, K., 1996 May, In : Journal of Neurochemistry. 66, 5, p. 1793-1801 9 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Lac Operon
5' Flanking Region
Galactosidases
Transgenic Mice
10 Citations (Scopus)

Hematological and Serum Biochemical Values in Pregnant and Postpartum Females of the Squirrel Monkey (Saimiri sciureus)

Suzuki, T., Suzuki, N., Shimoda, K. & Nagasawa, H., 1996 Jan, In : Experimental Animals. 45, 1, p. 39-43 5 p.

Research output: Contribution to journalArticle

Saimiri sciureus
Saimiri
Nursing
Postpartum Period
pregnancy
16 Citations (Scopus)

Translocation of bacteria from the gastrointestinal tract in immunodef icient mice

Ohsugi, T., Kiuchi, Y., Shimoda, K., Oguri, S. & Maejima, K., 1996, In : Laboratory Animals. 30, 1, p. 46-50 5 p.

Research output: Contribution to journalArticle

SCID Mice
gastrointestinal system
Gastrointestinal Tract
Bacteria
bacteria
1995
4 Citations (Scopus)

Deodorization of laboratory animal facilities by ozone.

Pan, T. M., Shimoda, K., Cai, Y., Kiuchi, Y., Nakama, K., Akimoto, T., Nagashima, Y., Kai, M., Ohira, M. & Saegusa, J., 1995 Jul, In : Experimental animals / Japanese Association for Laboratory Animal Science. 44, 3, p. 255-259 5 p.

Research output: Contribution to journalArticle

animal rooms
deodorization
trimethylamine
Ozone
Laboratory Animals
35 Citations (Scopus)

Expression of a MADS box gene, MEF2D, in neurons of the mouse central nervous system: implication of its binary function in myogenic and neurogenic cell lineages

Ikeshimaa, H., Imai, S. I., Shimoda, K., Hata, J. I. & Takano, T., 1995 Nov 17, In : Neuroscience Letters. 200, 2, p. 117-120 4 p.

Research output: Contribution to journalArticle

Cell Lineage
Central Nervous System
Neurons
MEF2 Transcription Factors
Genes
16 Citations (Scopus)
Calmodulin
Transgenes
Transgenic Mice
Central Nervous System
Neurons
1994
14 Citations (Scopus)

Spermatocyte-specific transcription by calmodulin gene II promoter in transgenic mice

Ikeshima, H., Shimoda, K., Matsuo, K., Hata, J., Maejima, K. & Takano, T., 1994, In : Molecular and Cellular Endocrinology. 99, 1, p. 49-53 5 p.

Research output: Contribution to journalArticle

Spermatocytes
Transcription
Calmodulin
Transgenic Mice
Genes
1993
41 Citations (Scopus)

Expression of the rat calmodulin gene II in the central nervous system: a 294-base promoter and 68-base leader segment mediates neuron-specific gene expression in transgenic mice

Matsuo, K., Ikeshima, H., Shimoda, K., Umezawa, A., Hata, J. I., Maejima, K., Nojima, H. & Takano, T., 1993, In : Molecular Brain Research. 20, 1-2, p. 9-20 12 p.

Research output: Contribution to journalArticle

Calmodulin
Transgenes
Transgenic Mice
Central Nervous System
Gene Expression
2 Citations (Scopus)

Isolation of acinetobacter calcoaceticus from the gastrointestinal tracts of SCID mice

Ohsugi, T., Shimoda, K., Maejima, K., Kagiyama, N., Takagi, H. & Nomura, T., 1993, In : Laboratory Animals. 27, 3, p. 226-228 3 p.

Research output: Contribution to journalArticle

Acinetobacter calcoaceticus
SCID Mice
gastrointestinal system
Gastrointestinal Tract
mice
1992
2 Citations (Scopus)

Efficacy of ozone fumigation for laboratory animal sanitation

Pan, T. M., Shimoda, K., Maejima, K., Kuhara, T., Tsukumi, K. & Urano, T., 1992 Apr, In : Jikken dobutsu. Experimental animals. 41, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

Fumigation
Sanitation
Ozone
Laboratory Animals
sanitation
28 Citations (Scopus)

Four synonymous genes encode calmodulin in the teleost fish, medaka (Oryzias latipes): conservation of the multigene one-protein principle

Matsuo, K., Sato, K., Ikeshima, H., Shimoda, K. & Takano, T., 1992 Oct 1, In : Gene. 119, 2, p. 279-281 3 p.

Research output: Contribution to journalArticle

Oryzias
Calmodulin
Fishes
Genes
Proteins
1991
1 Citation (Scopus)

Colonization of R plasmid-bearing Escherichia coli strains in the mouse alimentary tract.

Shimoda, K., Kuhara, T. & Maejima, K., 1991 Oct, In : Jikken dobutsu. Experimental animals. 40, 4, p. 425-430 6 p.

Research output: Contribution to journalArticle

Bearings (structural)
R Factors
Escherichia coli
plasmids
mice
6 Citations (Scopus)

Reconstruction of a large DNA fragment from coninjected small fragments by homologous recombination in fertilized mouse eggs

Shimoda, K., Cai, X., Kuhara, T. & Maejima, K., 1991 Dec 11, In : Nucleic Acids Research. 19, 23, p. 6654 1 p.

Research output: Contribution to journalArticle

Mice (computer peripherals)
Transgenic Mice
Oocyte
Recombination
Mouse
13 Citations (Scopus)

Stability of pathogenic bacteria from laboratory animals in various transport media

Shimoda, K., Maejima, K., Kuhara, T. & Nakagawa, M., 1991, In : Laboratory Animals. 25, 3, p. 228-231 4 p.

Research output: Contribution to journalArticle

Biological Transport
physiological transport
animal transport
Brucella canis
Laboratory Animals
1990
2 Citations (Scopus)

Heat and ozone resistance of Bacillus spores isolated from laboratory animals

Pan, T. M., Liu, Y. X., Shimoda, K., Maejima, K., Kuhara, T., Urano, T., Ishihara, T. & Kasai, N., 1990 Jul, In : Jikken dobutsu. Experimental animals. 39, 3, p. 371-376 6 p.

Research output: Contribution to journalArticle

Ozone resistance
Ozone
Laboratory Animals
Bacilli
Spores
1980
4 Citations (Scopus)

Colonization and pathogenicity of Saccharomyces cerevisiae, MC16, in mice and cynomolgus monkeys after oral and intravenous administration

Maejima, K., Shimoda, K., Morita, C., Fujiwara, T. & Kitamura, T., 1980, In : Japanese Journal of Medical Science and Biology. 33, 5, p. 271-276 6 p.

Research output: Contribution to journalArticle

Yeast
Animals
Cells
Recombinant DNA
Escherichia coli