Institute for Advanced Medical Research

Research Output

2020

A potent blood–brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model

Machida, Y., Nakagawa, M., Matsunaga, H., Yamaguchi, M., Ogawara, Y., Shima, Y., Yamagata, K., Katsumoto, T., Hattori, A., Itoh, M., Seki, T., Nishiya, Y., Nakamura, K., Suzuki, K., Imaoka, T., Baba, D., Suzuki, M., Sampetrean, O., Saya, H., Ichimura, K. & 1 others, Kitabayashi, I., 2020 Feb, In : Molecular cancer therapeutics. 19, 2, p. 375-383 9 p.

Research output: Contribution to journalArticle

Author Correction: A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2 (Nature Communications, (2019), 10, 1, (5758), 10.1038/s41467-019-13640-1)

Tamura, R., Fujioka, M., Morimoto, Y., Ohara, K., Kosugi, K., Oishi, Y., Sato, M., Ueda, R., Fujiwara, H., Hikichi, T., Noji, S., Oishi, N., Ogawa, K., Kawakami, Y., Ohira, T., Yoshida, K. & Toda, M., 2020 Dec 1, In : Nature communications. 11, 1, 2028.

Research output: Contribution to journalComment/debate

Open Access

Gene Therapy Using Neural Stem/Progenitor Cells Derived from Human Induced Pluripotent Stem Cells: Visualization of Migration and Bystander Killing Effect

Tamura, R., Miyoshi, H., Morimoto, Y., Oishi, Y., Sampetrean, O., Iwasawa, C., Mine, Y., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2020 Mar, In : Human Gene Therapy. 31, 5-6, p. 352-366 15 p.

Research output: Contribution to journalArticle

Open Access

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 ab

Kato, D., Yaguchi, T., Iwata, T., Katoh, Y., Morii, K., Tsubota, K., Takise, Y., Tamiya, M., Kamada, H., Akiba, H., Tsumoto, K., Serada, S., Naka, T., Nishimura, R., Nakagawa, T. & Kawakami, Y., 2020 Mar, In : eLife. 9, e49392.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Identification of kit-ligand a as the gene responsible for the medaka pigment cell mutant few melanophore

Otsuki, Y., Okuda, Y., Naruse, K. & Saya, H., 2020 Jan 1, In : G3: Genes, Genomes, Genetics. 10, 1, p. 311-319 9 p.

Research output: Contribution to journalArticle

Open Access

Immune-resistant mechanisms in cancer immunotherapy

Kawakami, Y., Ohta, S., Sayem, M. A., Tsukamoto, N. & Yaguchi, T., 2020 May 1, In : International Journal of Clinical Oncology. 25, 5, p. 810-817 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

In Vitro Blood-Brain Barrier Permeability and Cytotoxicity of an Atorvastatin-Loaded Nanoformulation against Glioblastoma in 2D and 3D Models

Lübtow, M. M., Oerter, S., Quader, S., Jeanclos, E., Jeanclos, E., Cubukova, A., Krafft, M., Haider, M. S., Schulte, C., Meier, L., Rist, M., Sampetrean, O., Kinoh, H., Gohla, A., Kataoka, K., Kataoka, K., Appelt-Menzel, A., Appelt-Menzel, A., Luxenhofer, R. & Luxenhofer, R., 2020 Jun 1, In : Molecular Pharmaceutics. 17, 6, p. 1835-1847 13 p.

Research output: Contribution to journalArticle

Molecular and cellular mechanisms underlying brain metastasis of breast cancer

Hosonaga, M., Saya, H. & Arima, Y., 2020 Jan 1, (Accepted/In press) In : Cancer and Metastasis Reviews.

Research output: Contribution to journalReview article

Open Access

NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP

Al-Busani, H., Al-Sobaihi, S., Nojima, K., Tanemura, A., Yaguchi, T., Kawakami, Y., Matsumura, H., Nishimura, E. K., Yokozeki, H. & Namiki, T., 2020 Feb, In : Journal of Dermatological Science. 97, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

Padthaisong, S., Thanee, M., Namwat, N., Phetcharaburanin, J., Klanrit, P., Khuntikeo, N., Titapun, A., Sungkhamanon, S., Saya, H. & Loilome, W., 2020 Feb 10, In : Journal of Translational Medicine. 18, 1, 64.

Research output: Contribution to journalArticle

Open Access

Phosphorylation of the Anaphase Promoting Complex activator FZR1/CDH1 is required for Meiosis II entry in mouse male germ cell

Tanno, N., Kuninaka, S., Fujimura, S., Takemoto, K., Okamura, K., Takeda, N., Araki, K., Araki, M., Saya, H. & Ishiguro, K. I., 2020 Dec 1, In : Scientific reports. 10, 1, 10094.

Research output: Contribution to journalArticle

Open Access

Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans

Yamane, M., Sato, S., Shimizu, E., Shibata, S., Hayano, M., Yaguchi, T., Kamijuku, H., Ogawa, M., Suzuki, T., Mukai, S., Shimmura, S., Okano, H., Takeuchi, T., Kawakami, Y., Ogawa, Y. & Tsubota, K., 2020, (Accepted/In press) In : FASEB Journal.

Research output: Contribution to journalArticle

Targeting of cancer stem cells by differentiation therapy

Arima, Y., Nobusue, H. & Saya, H., 2020, (Accepted/In press) In : Cancer science.

Research output: Contribution to journalArticle

Open Access

The insulin-PI3K-Rac1 axis contributes to terminal adipocyte differentiation through regulation of actin cytoskeleton dynamics

Kunitomi, H., Oki, Y., Onishi, N., Kano, K., Banno, K., Aoki, D., Saya, H. & Nobusue, H., 2020 Mar 1, In : Genes to Cells. 25, 3, p. 165-174 10 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. & 8 others, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 Jan 31, In : Nature. 565, 7741, p. 600-605 6 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Analysis of the Tumor Reactivity of Tumor-Infiltrating Lymphocytes in a Metastatic Melanoma Lesion that Lost Major Histocompatibility Complex Class I Expression after Anti–PD-1 Therapy

Inozume, T., Yaguchi, T., Ariyasu, R., Togashi, Y., Ohnuma, T., Honobe, A., Nishikawa, H., Kawakami, Y. & Kawamura, T., 2019 Jul, In : Journal of Investigative Dermatology. 139, 7, p. 1490-1496 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Karaminejadranjbar, M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H. & Ahmed, A. A., 2019 Apr 18, In : Oncogene. 38, 16, p. 2885-2898 14 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease

Hirai, I., Tanese, K., Nakamura, Y., Ishii, M., Kawakami, Y. & Funakoshi, T., 2019 Jun, In : Oncologist. 24, 6, p. e394-e396

Research output: Contribution to journalArticle

2 Citations (Scopus)

Endothelial-mesenchymal transition drives expression of CD44 variant and xCT in pulmonary hypertension

Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., Shimoda, M., Chiba, T., Masuko, T., Hakamata, Y., Kobayashi, E., Saya, H., Fukuda, K. & Sano, M., 2019 Jan 1, In : American journal of respiratory cell and molecular biology. 61, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma

Sato, T., Yoo, S., Kong, R., Sinha, A., Chandramani-Shivalingappa, P., Patel, A., Fridrikh, M., Nagano, O., Masuko, T., Beasley, M. B., Powell, C. A., Zhu, J. & Watanabe, H., 2019 Dec 15, In : Cancer Research. 79, 24, p. 6084-6100 17 p.

Research output: Contribution to journalArticle

Open Access

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

Suzuki, K., Miura, Y., Mochida, Y., Miyazaki, T., Toh, K., Anraku, Y., Melo, V., Liu, X., Ishii, T., Nagano, O., Saya, H., Cabral, H. & Kataoka, K., 2019 May 10, In : Journal of Controlled Release. 301, p. 28-41 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Okazaki, S., Umene, K., Yamasaki, J., Suina, K., Otsuki, Y., Yoshikawa, M., Minami, Y., Masuko, T., Kawaguchi, S., Nakayama, H., Banno, K., Aoki, D., Saya, H. & Nagano, O., 2019 Nov 1, In : Cancer science. 110, 11, p. 3453-3463 11 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Identification of KLRC2 as a candidate marker for brain tumor-initiating cells

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K. & Toda, M., 2019 Nov 2, In : Neurological Research. 41, 11, p. 1043-1049 7 p.

Research output: Contribution to journalArticle

IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma

Kofuji, S., Hirayama, A., Eberhardt, A. O., Kawaguchi, R., Sugiura, Y., Sampetrean, O., Ikeda, Y., Warren, M., Sakamoto, N., Kitahara, S., Yoshino, H., Yamashita, D., Sumita, K., Wolfe, K., Lange, L., Ikeda, S., Shimada, H., Minami, N., Malhotra, A., Morioka, S. & 37 others, Ban, Y., Asano, M., Flanary, V. L., Ramkissoon, A., Chow, L. M. L., Kiyokawa, J., Mashimo, T., Lucey, G., Mareninov, S., Ozawa, T., Onishi, N., Okumura, K., Terakawa, J., Daikoku, T., Wise-Draper, T., Majd, N., Kofuji, K., Sasaki, M., Mori, M., Kanemura, Y., Smith, E. P., Anastasiou, D., Wakimoto, H., Holland, E. C., Yong, W. H., Horbinski, C., Nakano, I., DeBerardinis, R. J., Bachoo, R. M., Mischel, P. S., Yasui, W., Suematsu, M., Saya, H., Soga, T., Grummt, I., Bierhoff, H. & Sasaki, A. T., 2019 Aug 1, In : Nature Cell Biology. 21, 8, p. 1003-1014 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Neuroprotective effects of memantine via enhancement of autophagy

Hirano, K., Fujimaki, M., Sasazawa, Y., Yamaguchi, A., Ishikawa, K. I., Miyamoto, K., Souma, S., Furuya, N., Imamichi, Y., Yamada, D., Saya, H., Akamatsu, W., Saiki, S. & Hattori, N., 2019 Oct 8, In : Biochemical and Biophysical Research Communications. 518, 1, p. 161-170 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers

Osawa, Y., Kojika, E., Nishikawa, K., Kimura, M., Osakaya, S., Miyauchi, H., Kanto, T., Kawakami, Y. & Kimura, K., 2019 Apr 30, In : Oncotarget. 10, 32, p. 3013-3026 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

ROCK inhibition induces terminal adipocyte differentiation and suppresses tumorigenesis in chemoresistant osteosarcoma cells

Takahashi, N., Nobusue, H., Shimizu, T., Sugihara, E., Yamaguchi-Iwai, S., Onishi, N., Kunitomi, H., Kuroda, T. & Saya, H., 2019 Jun 15, In : Cancer Research. 79, 12, p. 3088-3099 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
Open Access
3 Citations (Scopus)

"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu, E., Ogawa, Y., Yazu, H., Aketa, N., Yang, F., Yamane, M., Sato, Y., Kawakami, Y. & Tsubota, K., 2019 May, In : PloS one. 14, 5, e0215130.

Research output: Contribution to journalArticle

Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer

Ogihara, K., Kikuchi, E., Okazaki, S., Hagiwara, M., Takeda, T., Matsumoto, K., Kosaka, T., Mikami, S., Saya, H. & Oya, M., 2019 Apr 1, In : Cancer Science. 110, 4, p. 1431-1441 11 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery

Yamamoto, K., Kokubun, T., Sato, K., Akaishi, T., Shimazaki, A., Nakamura, M., Shiga, Y., Tsuda, S., Omodaka, K., Saya, H. & Nakazawa, T., 2019 Dec 1, In : Scientific reports. 9, 1, 19288.

Research output: Contribution to journalArticle

Open Access

Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter

Hirao, N., Iwata, T., Tanaka, K., Nishio, H., Nakamura, M., Morisada, T., Morii, K., Maruyama, N., Katoh, Y., Yaguchi, T., Ohta, S., Kukimoto, I., Aoki, D. & Kawakami, Y., 2019 Nov, In : Gynecologic Oncology. 155, 2, p. 340-348 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy

Otsuki, Y., Yamasaki, J., Suina, K., Okazaki, S., Koike, N., Saya, H. & Nagano, O., 2019 Jan 1, (Accepted/In press) In : Cancer science.

Research output: Contribution to journalArticle

Open Access

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

Tamura, R., Miyoshi, H., Sampetrean, O., Shinozaki, M., Morimoto, Y., Iwasawa, C., Fukaya, R., Mine, Y., Masuda, H., Maruyama, T., Narita, M., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2019 May 6, In : Molecular brain. 12, 1, 45.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)
2018

A pilot study of peptide vaccines for VEGF receptor 1 and 2 in patients with recurrent/progressive high grade glioma

Shibao, S., Ueda, R., Saito, K., Kikuchi, R., Nagashima, H., Kojima, A., Kagami, H., Pareira, E. S., Sasaki, H., Noji, S., Kawakami, Y., Yoshida, K. & Toda, M., 2018 Apr 20, In : Oncotarget. 9, 30, p. 21569-21579 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma

Kamamoto, D., Ohara, K., Kitamura, Y., Yoshida, K., Kawakami, Y. & Sasaki, H., 2018 Apr 19, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Carboplatin and epirubicin combination therapy for advanced malignant epithelial skin tumors: Retrospective study of six patients

Nakamura, Y., Tanese, K., Hirai, I., Kawakami, Y. & Funakoshi, T., 2018 Jul 1, In : Journal of Dermatology. 45, 7, p. 874-875 2 p.

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

Kobayashi, N., Okazaki, S., Sampetrean, O., Irie, J., Itoh, H. & Saya, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2785.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Development of a functional thyroid model based on an organoid culture system

Saito, Y., Onishi, N., Takami, H., Seishima, R., Inoue, H., Hirata, Y., Kameyama, K., Tsuchihashi, K., Sugihara, E., Uchino, S., Ito, K., Kawakubo, H., Takeuchi, H., Kitagawa, Y., Saya, H. & Nagano, O., 2018 Mar 4, In : Biochemical and Biophysical Research Communications. 497, 2, p. 783-789 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

Yamauchi, T., Fernandez, J. R. E., Imamura, C. K., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., Nakamura, S., Lim, B., Krishnamurthy, S., Reuben, J. M., Liu, D., Tripathy, D., Chen, H., Takebe, N., Saya, H. & Ueno, N. T., 2018, In : Oncotarget. 9, 6, p. 6872-6882 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., 2018 Dec, In : Cancer science. 109, 12, p. 3874-3882 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease

Yamane, M., Ogawa, Y., Mukai, S., Yaguchi, S., Kamijuku, H., Inaba, T., Asai, K., Morikawa, S., Kawakami, Y., Shimmura, S. & Tsubota, K., 2018 Jan 1, In : Cornea. 37, 1, p. 102-108 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Generation of human immunosuppressive myeloid cell populations in human interleukin-6 transgenic NOG mice

Hanazawa, A., Ito, R., Katano, I., Kawai, K., Goto, M., Suemizu, H., Kawakami, Y., Ito, M. & Takahashi, T., 2018 Feb 2, In : Frontiers in Immunology. 9, FEB, 152.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

26 Citations (Scopus)

HER2 heterogeneity is associated with poor survival in HER2-positive breast cancer

Hosonaga, M., Arima, Y., Sampetrean, O., Komura, D., Koya, I., Sasaki, T., Sato, E., Okano, H., Kudoh, J., Ishikawa, S., Saya, H. & Ishikawa, T., 2018 Aug, In : International journal of molecular sciences. 19, 8, 2158.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

Yaguchi, T., Kobayashi, A., Inozume, T., Morii, K., Nagumo, H., Nishio, H., Iwata, T., Ka, Y., Katano, I., Ito, R., Ito, M. & Kawakami, Y., 2018 Nov 1, In : Cellular and Molecular Immunology. 15, 11, p. 953-962 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

IgG response to MHC class I epitope peptides is a quantitative predictive biomarker in the early course of treatment of colorectal cancer using therapeutic peptides

Kanekiyo, S., Hazama, S., Takenouchi, H., Nakajima, M., Shindo, Y., MATSuI, H., Tokumitsu, Y., Tomochika, S., Tsunedomi, R., Tokuhisa, Y., Iida, M., Sakamoto, K., SuzukI, N., Takeda, S., Yamamoto, S., Yoshino, S., Okuno, K., Udaka, K., Kawakami, Y., Matsueda, S. & 2 others, Ito, K. & Nagano, H., 2018 May, In : Oncology reports. 39, 5, p. 2385-2392 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 Nov 1, In : Anticancer Research. 38, 11, p. 6163-6170 8 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)