Institute for Advanced Medical Research

Research Output 1984 2019

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2019
52 Citations (Scopus)

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. & 8 others, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 Jan 31, In : Nature. 565, 7741, p. 600-605 6 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Listeriosis
Histocompatibility
Microbiota
1 Citation (Scopus)

Cancer Stem-Cell Marker CD44v9-Positive Cells Arise From Helicobacter pylori–Infected CAPZA1-Overexpressing Cells

Tsugawa, H., Kato, C., Mori, H., Matsuzaki, J., Kameyama, K., Saya, H., Hatakeyama, M., Suematsu, M. & Suzuki, H., 2019 Jan 1, In : CMGH. 8, 3, p. 319-334 16 p.

Research output: Contribution to journalArticle

Open Access
Helicobacter
Neoplastic Stem Cells
Catenins
Protein Splicing
Histones
1 Citation (Scopus)

Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease

Hirai, I., Tanese, K., Nakamura, Y., Ishii, M., Kawakami, Y. & Funakoshi, T., 2019 Jan 1, In : Oncologist.

Research output: Contribution to journalArticle

Extramammary Paget's Disease
Epirubicin
Anthracyclines
Breast Neoplasms
Cytotoxins
2 Citations (Scopus)

Endothelial-mesenchymal transition drives expression of CD44 variant and xCT in pulmonary hypertension

Isobe, S., Kataoka, M., Endo, J., Moriyama, H., Okazaki, S., Tsuchihashi, K., Katsumata, Y., Yamamoto, T., Shirakawa, K., Yoshida, N., Shimoda, M., Chiba, T., Masuko, T., Hakamata, Y., Kobayashi, E., Saya, H., Fukuda, K. & Sano, M., 2019 Jan 1, In : American journal of respiratory cell and molecular biology. 61, 3, p. 367-379 13 p.

Research output: Contribution to journalArticle

Sulfasalazine
Pulmonary Hypertension
Glutathione
Antioxidants
Chemotherapy
2 Citations (Scopus)

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors

Suzuki, K., Miura, Y., Mochida, Y., Miyazaki, T., Toh, K., Anraku, Y., Melo, V., Liu, X., Ishii, T., Nagano, O., Saya, H., Cabral, H. & Kataoka, K., 2019 May 10, In : Journal of Controlled Release. 301, p. 28-41 14 p.

Research output: Contribution to journalArticle

Nanomedicine
Facilitative Glucose Transport Proteins
Blood Vessels
Micelles
Neoplasms

Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma

Okazaki, S., Umene, K., Yamasaki, J., Suina, K., Otsuki, Y., Yoshikawa, M., Minami, Y., Masuko, T., Kawaguchi, S., Nakayama, H., Banno, K., Aoki, D., Saya, H. & Nagano, O., 2019 Nov 1, In : Cancer science. 110, 11, p. 3453-3463 11 p.

Research output: Contribution to journalArticle

Open Access
Sulfasalazine
Glutamate Dehydrogenase
Glutamine
Genes
Neoplasms

Identification of KLRC2 as a candidate marker for brain tumor-initiating cells

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K. & Toda, M., 2019 Nov 2, In : Neurological Research. 41, 11, p. 1043-1049 7 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Brain Neoplasms
Glioma
Neural Stem Cells
Brain

Neuroprotective effects of memantine via enhancement of autophagy

Hirano, K., Fujimaki, M., Sasazawa, Y., Yamaguchi, A., Ishikawa, K. I., Miyamoto, K., Souma, S., Furuya, N., Imamichi, Y., Yamada, D., Saya, H., Akamatsu, W., Saiki, S. & Hattori, N., 2019 Oct 8, In : Biochemical and Biophysical Research Communications. 518, 1, p. 161-170 10 p.

Research output: Contribution to journalArticle

Memantine
Autophagy
Neuroprotective Agents
Mitochondrial Degradation
N-Methyl-D-Aspartate Receptors

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers

Osawa, Y., Kojika, E., Nishikawa, K., Kimura, M., Osakaya, S., Miyauchi, H., Kanto, T., Kawakami, Y. & Kimura, K., 2019 Apr 30, In : Oncotarget. 10, 32, p. 3013-3026 14 p.

Research output: Contribution to journalArticle

Catenins
Cyclic AMP Response Element-Binding Protein
Protein Binding
Colonic Neoplasms
Carrier Proteins
1 Citation (Scopus)

ROCK inhibition induces terminal adipocyte differentiation and suppresses tumorigenesis in chemoresistant osteosarcoma cells

Takahashi, N., Nobusue, H., Shimizu, T., Sugihara, E., Yamaguchi-Iwai, S., Onishi, N., Kunitomi, H., Kuroda, T. & Saya, H., 2019 Jun 15, In : Cancer Research. 79, 12, p. 3088-3099 12 p.

Research output: Contribution to journalArticle

Osteosarcoma
Adipocytes
Carcinogenesis
Stem Cells
Neoplastic Stem Cells
Open Access
Clinical Trials, Phase I
Amyotrophic Lateral Sclerosis
Labels
Placebos
Stem cells

"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu, E., Ogawa, Y., Yazu, H., Aketa, N., Yang, F., Yamane, M., Sato, Y., Kawakami, Y. & Tsubota, K., 2019 May 1, In : PloS one. 14, 5, e0215130.

Research output: Contribution to journalArticle

eye diseases
Eye Diseases
disease models
Tears
cameras

Sulfasalazine could modulate the CD44v9-xCT system and enhance cisplatin-induced cytotoxic effects in metastatic bladder cancer

Ogihara, K., Kikuchi, E., Okazaki, S., Hagiwara, M., Takeda, T., Matsumoto, K., Kosaka, T., Mikami, S., Saya, H. & Oya, M., 2019 Apr 1, In : Cancer Science. 110, 4, p. 1431-1441 11 p.

Research output: Contribution to journalArticle

Open Access
Sulfasalazine
Urinary Bladder Neoplasms
Cisplatin
p38 Mitogen-Activated Protein Kinases
Muscles

Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter

Hirao, N., Iwata, T., Tanaka, K., Nishio, H., Nakamura, M., Morisada, T., Morii, K., Maruyama, N., Katoh, Y., Yaguchi, T., Ota, S., Kukimoto, I., Aoki, D. & Kawakami, Y., 2019 Jan 1, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Homeobox Genes
Oncogenes
Uterine Cervical Neoplasms
Transcription Factors
Phenotype

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

Tamura, R., Miyoshi, H., Sampetrean, O., Shinozaki, M., Morimoto, Y., Iwasawa, C., Fukaya, R., Mine, Y., Masuda, H., Maruyama, T., Narita, M., Saya, H., Yoshida, K., Okano, H. & Toda, M., 2019 May 6, In : Molecular brain. 12, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Glioma
Stem Cells
Glioblastoma
Axons
Time-Lapse Imaging
2018
4 Citations (Scopus)

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Karaminejadranjbar, M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H. & Ahmed, A. A., 2018 Jan 1, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Omentum
Tropism
Tumor Microenvironment
Stromal Cells
5 Citations (Scopus)

A pilot study of peptide vaccines for VEGF receptor 1 and 2 in patients with recurrent/progressive high grade glioma

Shibao, S., Ueda, R., Saito, K., Kikuchi, R., Nagashima, H., Kojima, A., Kagami, H., Pareira, E. S., Sasaki, H., Noji, S., Kawakami, Y., Yoshida, K. & Toda, M., 2018 Apr 20, In : Oncotarget. 9, 30, p. 21569-21579 11 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Subunit Vaccines
Glioma
Vascular Endothelial Growth Factor Receptor
1 Citation (Scopus)

Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma

Kamamoto, D., Ohara, K., Kitamura, Y., Yoshida, K., Kawakami, Y. & Sasaki, H., 2018 Apr 19, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Solitary Fibrous Tumors
Hemangiopericytoma
Cell Death
Neoplasm Metastasis
Ligands
2 Citations (Scopus)

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

Kobayashi, N., Okazaki, S., Sampetrean, O., Irie, J., Itoh, H. & Saya, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 2785.

Research output: Contribution to journalArticle

Insulin
Amino Acids
Neutral Amino Acids
Antiporters
Amino Acid Transport Systems
4 Citations (Scopus)

Development of a functional thyroid model based on an organoid culture system

Saito, Y., Onishi, N., Takami, H., Seishima, R., Inoue, H., Hirata, Y., Kameyama, K., Tsuchihashi, K., Sugihara, E., Uchino, S., Ito, K., Kawakubo, H., Takeuchi, H., Kitagawa, Y., Saya, H. & Nagano, O., 2018 Mar 4, In : Biochemical and Biophysical Research Communications. 497, 2, p. 783-789 7 p.

Research output: Contribution to journalArticle

Organoids
Thyroglobulin
Iodides
Cell culture
Thyroid Gland
1 Citation (Scopus)

Dynamic changes in CD44v-positive cells after preoperative anti-HER2 therapy and its correlation with pathologic complete response in HER2-positive breast cancer

Yamauchi, T., Fernandez, J. R. E., Imamura, C., Yamauchi, H., Jinno, H., Takahashi, M., Kitagawa, Y., Nakamura, S., Lim, B., Krishnamurthy, S., Reuben, J. M., Liu, D., Tripathy, D., Chen, H., Takebe, N., Saya, H. & Ueno, N. T., 2018 Jan 1, In : Oncotarget. 9, 6, p. 6872-6882 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Epithelial-Mesenchymal Transition
Neoplastic Stem Cells
Therapeutics
Biomarkers
1 Citation (Scopus)

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate–sensitive glutamate receptor signaling

Suina, K., Tsuchihashi, K., Yamasaki, J., Kamenori, S., Shintani, S., Hirata, Y., Okazaki, S., Sampetrean, O., Baba, E., Akashi, K., Mitsuishi, Y., Takahashi, F., Takahashi, K., Saya, H. & Nagano, O., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Glutamate Receptors
Epidermal Growth Factor Receptor
Glioma
Glutamic Acid
Epidermal Growth Factor
3 Citations (Scopus)

Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease

Yamane, M., Ogawa, Y., Mukai, S., Yaguchi, S., Kamijuku, H., Inaba, T., Asai, K., Morikawa, S., Kawakami, Y., Shimmura, S. & Tsubota, K., 2018 Jan 1, In : Cornea. 37, 1, p. 102-108 7 p.

Research output: Contribution to journalArticle

Lacrimal Apparatus
Graft vs Host Disease
Fibroblasts
Fibrosis
Immunohistochemistry
5 Citations (Scopus)

Generation of human immunosuppressive myeloid cell populations in human interleukin-6 transgenic NOG mice

Hanazawa, A., Ito, R., Katano, I., Kawai, K., Goto, M., Suemizu, H., Kawakami, Y., Ito, M. & Takahashi, T., 2018 Feb 2, In : Frontiers in Immunology. 9, FEB, 152.

Research output: Contribution to journalArticle

Myeloid Cells
Immunosuppressive Agents
Transgenic Mice
Interleukin-6
Hematopoietic Stem Cells
17 Citations (Scopus)

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., Kabe, Y., Sugiura, Y., Hiraoka, N., Morikawa, T., Takubo, K., Suina, K., Nagashima, H., Sampetrean, O., Nagano, O., Saya, H. & 3 others, Yamazoe, S., Watanabe, H. & Suematsu, M., 2018 Dec 1, In : Nature Communications. 9, 1, 1561.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Oxidants
Gold
Raman spectroscopy
tumors
2 Citations (Scopus)

HER2 heterogeneity is associated with poor survival in HER2-positive breast cancer

Hosonaga, M., Arima, Y., Sampetrean, O., Komura, D., Koya, I., Sasaki, T., Sato, E., Okano, H., Kudo, J., Ishikawa, S., Saya, H. & Ishikawa, T., 2018 Aug 1, In : International Journal of Molecular Sciences. 19, 8, 2158.

Research output: Contribution to journalArticle

breast
cancer
Breast Neoplasms
mice
RNA Sequence Analysis
3 Citations (Scopus)

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

Yaguchi, T., Kobayashi, A., Inozume, T., Morii, K., Nagumo, H., Nishio, H., Iwata, T., Ka, Y., Katano, I., Ito, R., Ito, M. & Kawakami, Y., 2018 Nov 1, In : Cellular and Molecular Immunology. 15, 11, p. 953-962 10 p.

Research output: Contribution to journalArticle

Blood Cells
T-Lymphocytes
Graft vs Host Disease
Cell- and Tissue-Based Therapy
Melanoma
1 Citation (Scopus)

IgG response to MHC class I epitope peptides is a quantitative predictive biomarker in the early course of treatment of colorectal cancer using therapeutic peptides

Kanekiyo, S., Hazama, S., Takenouchi, H., Nakajima, M., Shindo, Y., MATSuI, H., Tokumitsu, Y., Tomochika, S., Tsunedomi, R., Tokuhisa, Y., Iida, M., Sakamoto, K., SuzukI, N., Takeda, S., Yamamoto, S., Yoshino, S., Okuno, K., Udaka, K., Kawakami, Y., Matsueda, S. & 2 others, Ito, K. & Nagano, H., 2018 May 1, In : Oncology Reports. 39, 5, p. 2385-2392 8 p.

Research output: Contribution to journalArticle

Epitopes
Colorectal Neoplasms
Immunoglobulin G
Biomarkers
Peptides
4 Citations (Scopus)

Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression

Miyoshi, S., Tsugawa, H., Matsuzaki, J., Hirata, K., Mori, H., Saya, H., Kanai, T. & Suzuki, H., 2018 Nov 1, In : Anticancer Research. 38, 11, p. 6163-6170 8 p.

Research output: Contribution to journalArticle

Fluorouracil
Stomach Neoplasms
Neoplastic Stem Cells
Antiporters
Drug Therapy
3 Citations (Scopus)

Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice

Mukai, S., Ogawa, Y., Kawakami, Y., Mashima, Y. & Tsubota, K., 2018 Aug 1, In : FASEB Journal. 32, 8, p. 4085-4095 11 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
Blood Vessels
Adhesion
Proteins
207 Citations (Scopus)

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

Pagès, F., Mlecnik, B., Marliot, F., Bindea, G., Ou, F. S., Bifulco, C., Lugli, A., Zlobec, I., Rau, T. T., Berger, M. D., Nagtegaal, I. D., Vink-Börger, E., Hartmann, A., Geppert, C., Kolwelter, J., Merkel, S., Grützmann, R., Van den Eynde, M., Jouret-Mourin, A., Kartheuser, A. & 79 others, Léonard, D., Remue, C., Wang, J. Y., Bavi, P., Roehrl, M. H. A., Ohashi, P. S., Nguyen, L. T., Han, S. J., MacGregor, H. L., Hafezi-Bakhtiari, S., Wouters, B. G., Masucci, G. V., Andersson, E. K., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M., Laghi, L., Grizzi, F., Fredriksen, T., Buttard, B., Angelova, M., Vasaturo, A., Maby, P., Church, S. E., Angell, H. K., Lafontaine, L., Bruni, D., El Sissy, C., Haicheur, N., Kirilovsky, A., Berger, A., Lagorce, C., Meyers, J. P., Paustian, C., Feng, Z., Ballesteros-Merino, C., Dijkstra, J., van de Water, C., van Lent-van Vliet, S., Knijn, N., Mușină, A. M., Scripcariu, D. V., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Torigoe, T., Sato, N., Furuhata, T., Takemasa, I., Itoh, K., Patel, P. S., Vora, H. H., Shah, B., Patel, J. B., Rajvik, K. N., Pandya, S. J., Shukla, S. N., Wang, Y., Zhang, G., Kawakami, Y., Marincola, F. M., Ascierto, P. A., Sargent, D. J., Fox, B. A. & Galon, J., 2018 May 26, In : The Lancet. 391, 10135, p. 2128-2139 12 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Neoplasms
Recurrence
Colon
Neoplasm Staging
9 Citations (Scopus)

Involvement of local renin-angiotensin system in immunosuppression of tumor microenvironment

Nakamura, K., Yaguchi, T., Ohmura, G., Kobayashi, A., Kawamura, N., Iwata, T., Kiniwa, Y., Okuyama, R. & Kawakami, Y., 2018 Jan 1, In : Cancer Science. 109, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Angiotensin Receptor Antagonists
Immunosuppressive Agents
Renin-Angiotensin System
Immunosuppression
4 Citations (Scopus)

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

Shibao, S., Minami, N., Koike, N., Fukui, N., Yoshida, K., Saya, H. & Sampetrean, O., 2018 Feb 19, In : Neuro-Oncology. 20, 3, p. 343-354 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Stem Cells
Lactic Acid
Oxidative Phosphorylation
13 Citations (Scopus)

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

Fujimori, K., Ishikawa, M., Otomo, A., Atsuta, N., Nakamura, R., Akiyama, T., Hadano, S., Aoki, M., Saya, H., Sobue, G. & Okano, H., 2018 Jan 1, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Amyotrophic Lateral Sclerosis
Motor Neurons
Stem cells
Neurons

Novel elucidation and treatment of pancreatic chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Urano, F., Kawakami, Y. & Tsubota, K., 2018 Oct 1, In : Royal Society Open Science. 5, 10, 181067.

Research output: Contribution to journalArticle

Graft vs Host Disease
Endoplasmic Reticulum Stress
Pancreas
Epithelial-Mesenchymal Transition
Therapeutics
3 Citations (Scopus)

Ocular Surface and Tear Film Characteristics in a Sclerodermatous Chronic Graft-Versus-Host Disease Mouse Model

He, J., Yamane, M., Shibata, S., Fukui, M., Shimizu, E., Yano, T., Mukai, S., Kawakami, Y., Li, S., Tsubota, K. & Ogawa, Y., 2018 Apr 1, In : Cornea. 37, 4, p. 486-494 9 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Tears
Conjunctiva
Eyelids
Microvilli
3 Citations (Scopus)

Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma

Semba, T., Sugihara, E., Kamoshita, N., Ueno, S., Fukuda, K., Yoshino, M., Takao, K., Yoshikawa, K., Izuhara, K., Arima, Y., Suzuki, M. & Saya, H., 2018 Jan 1, (Accepted/In press) In : Cancer Science.

Research output: Contribution to journalArticle

Antisense Oligonucleotides
Bleomycin
Melanoma
Lung
Neoplasm Metastasis
1 Citation (Scopus)

Pilot study of WT1 peptide-pulsed dendritic cell vaccination with docetaxel in esophageal cancer

Matsuda, T., Takeuchi, H., Sakurai, T., Mayanagi, S., Booka, E., Fujita, T., Higuchi, H., Taguchi, J., Hamamoto, Y., Takaishi, H., Kawakubo, H., Okamoto, M., Sunamura, M., Kawakami, Y. & Kitagawa, Y., 2018 Jul 1, In : Oncology Letters. 16, 1, p. 1348-1356 9 p.

Research output: Contribution to journalArticle

docetaxel
Wilms' Tumor Genes
Wilms Tumor
Esophageal Neoplasms
Dendritic Cells

Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells

Ouchi, T., Morikawa, S., Shibata, S., Takahashi, M., Yoshikawa, M., Soma, T., Miyashita, H., Muraoka, W., Kameyama, K., Kawana, H., Arima, Y., Saya, H., Okano, H., Nakagawa, T. & Asoda, S., 2018 Feb 1, (Accepted/In press) In : Journal of Dental Research.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Carcinoma
Cell Death
Platelet-Derived Growth Factor Receptors
Drug Therapy
3 Citations (Scopus)

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

Okazaki, S., Shintani, S., Hirata, Y., Suina, K., Semba, T., Yamasaki, J., Umene, K., Ishikawa, M., Saya, H. & Nagano, O., 2018 Sep 1, In : Oncotarget. 9, 73, p. 33832-33843 12 p.

Research output: Contribution to journalArticle

Sulfasalazine
Glutathione
Neoplasms
Antiporters
Aldehyde Dehydrogenase
1 Citation (Scopus)

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Saya, H., Kawakami, Y. & Tsubota, K., 2018 Oct 1, In : PLoS One. 13, 10, e0203742.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
therapeutics
mice
bone marrow transplant
4 Citations (Scopus)

Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells

Harigai, R., Sakai, S., Nobusue, H., Hirose, C., Sampetrean, O., Minami, N., Hata, Y., Kasama, T., Hirose, T., Takenouchi, T., Kosaki, K., Kishi, K., Saya, H. & Arima, Y., 2018 Dec 1, In : Scientific Reports. 8, 1, 6069.

Research output: Contribution to journalArticle

Neurofibromin 1
Neurofibromatosis 1
Epithelial-Mesenchymal Transition
Neurofibroma
Gene Expression
6 Citations (Scopus)

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease

Tabata, Y., Imaizumi, Y., Sugawara, M., Andoh-Noda, T., Banno, S., Chai, M. C., Sone, T., Yamazaki, K., Ito, M., Tsukahara, K., Saya, H., Hattori, N., Kohyama, J. & Okano, H., 2018 Nov 13, In : Stem Cell Reports. 11, 5, p. 1171-1184 14 p.

Research output: Contribution to journalArticle

T-Type Calcium Channels
Dopaminergic Neurons
Neurons
Parkinson Disease
Rotenone
4 Citations (Scopus)

Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms

Hegab, A. E., Ozaki, M., Kagawa, S., Hamamoto, J., Yasuda, H., Naoki, K., Soejima, K., Yin, Y., Kinoshita, T., Yaguchi, T., Kawakami, Y., Ornitz, D. M. & Betsuyaku, T., 2018 May 1, In : Lung Cancer. 119, p. 25-35 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Macrophages
Growth
Neoplasms
Adenocarcinoma of lung
4 Citations (Scopus)
Cisplatin
Protein Isoforms
Population
Neoplasms
Glutathione
2017
32 Citations (Scopus)

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells

Ishimoto, T., Miyake, K., Nandi, T., Yashiro, M., Onishi, N., Huang, K. K., Lin, S. J., Kalpana, R., Tay, S. T., Suzuki, Y., Cho, B. C., Kuroda, D., Arima, K., Izumi, D., Iwatsuki, M., Baba, Y., Oki, E., Watanabe, M., Saya, H., Hirakawa, K. & 2 others, Baba, H. & Tan, P., 2017 Jul 1, In : Gastroenterology. 153, 1, p. 191-204.e16

Research output: Contribution to journalArticle

Transforming Growth Factor beta
Stomach Neoplasms
Fibroblasts
Nude Mice
Extracellular Matrix
6 Citations (Scopus)

A Randomized Phase II Study Comparing Nivolumab With Carboplatin-Pemetrexed for Patients With EGFR Mutation–Positive Nonsquamous Non–Small-Cell Lung Cancer Who Acquire Resistance to Tyrosine Kinase Inhibitors Not Due to a Secondary T790M Mutation: Rationale and Protocol Design for the WJOG8515L Study

Hayashi, H., Chiba, Y., Sakai, K., Fujita, T., Yoshioka, H., Sakai, D., Kitagawa, C., Naito, T., Takeda, K., Okamoto, I., Mitsudomi, T., Kawakami, Y., Nishio, K., Nakamura, S., Yamamoto, N. & Nakagawa, K., 2017 Nov 1, In : Clinical Lung Cancer. 18, 6, p. 719-723 5 p.

Research output: Contribution to journalArticle

Pemetrexed
erbB-1 Genes
Carboplatin
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
3 Citations (Scopus)

Autophagy-dependent regulation of tumor metastasis by myeloid cells

Jinushi, M., Morita, T., Xu, Z., Kinoshita, I., Dosaka-Akita, H., Yagita, H. & Kawakami, Y., 2017 Jul 1, In : PLoS One. 12, 7, e0179357.

Research output: Contribution to journalArticle

autophagy
Autophagy
Myeloid Cells
metastasis
Tumors
7 Citations (Scopus)

Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma

Sato, A., Mizobuchi, Y., Nakajima, K., Shono, K., Fujihara, T., Kageji, T., Kitazato, K., Matsuzaki, K., Mure, H., Kuwayama, K., Sumi, A., Saya, H., Sampetrean, O. & Nagahirao, S., 2017 Apr 1, In : Journal of Neuro-Oncology. 132, 2, p. 231-238 8 p.

Research output: Contribution to journalArticle

Celecoxib
Glioma
Cell Proliferation
Apoptosis
Cyclooxygenase 2 Inhibitors
4 Citations (Scopus)

Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response

Shimizu, T., Kamel, W. A., Yamaguchi-Iwai, S., Fukuchi, Y., Muto, A. & Saya, H., 2017 Sep 1, In : Cancer Science. 108, 9, p. 1793-1802 10 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Calcitriol
Osteosarcoma
Neoplasms
Therapeutics