Institute for Advanced Medical Research

Research Output

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Review article
2020

Immune-resistant mechanisms in cancer immunotherapy

Kawakami, Y., Ohta, S., Sayem, M. A., Tsukamoto, N. & Yaguchi, T., 2020 May 1, In : International Journal of Clinical Oncology. 25, 5, p. 810-817 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Molecular and cellular mechanisms underlying brain metastasis of breast cancer

Hosonaga, M., Saya, H. & Arima, Y., 2020 Jan 1, (Accepted/In press) In : Cancer and Metastasis Reviews.

Research output: Contribution to journalReview article

Open Access
2019

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Karaminejadranjbar, M., Hu, Z., Artibani, M., Gonzalez, L. S., Katabuchi, H., Saya, H. & Ahmed, A. A., 2019 Apr 18, In : Oncogene. 38, 16, p. 2885-2898 14 p.

Research output: Contribution to journalReview article

13 Citations (Scopus)
2018

Modeling phenotypes of malignant gliomas

Sampetrean, O. & Saya, H., 2018 Jan 1, In : Cancer Science. 109, 1, p. 6-14 9 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Prospects for new lung cancer treatments that target EMT signaling

Otsuki, Y., Saya, H. & Arima, Y., 2018 Mar 1, In : Developmental Dynamics. 247, 3, p. 462-472 11 p.

Research output: Contribution to journalReview article

30 Citations (Scopus)
2017

Epithelial-mesenchymal transition is predetermined by the epigenetic state of the skin tumor cell of origin

Semba, T. & Arima, Y., 2017 May 1, In : Stem Cell Investigation. 2017, MAY, 37.

Research output: Contribution to journalReview article

2014

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours

Galon, J., Mlecnik, B., Bindea, G., Angell, H. K., Berger, A., Lagorce, C., Lugli, A., Zlobec, I., Hartmann, A., Bifulco, C., Nagtegaal, I. D., Palmqvist, R., Masucci, G. V., Botti, G., Tatangelo, F., Delrio, P., Maio, M., Laghi, L., Grizzi, F., Asslaber, M. & 28 others, D'Arrigo, C., Vidal-Vanaclocha, F., Zavadova, E., Chouchane, L., Ohashi, P. S., Hafezi-Bakhtiari, S., Wouters, B. G., Roehrl, M., Nguyen, L., Kawakami, Y., Hazama, S., Okuno, K., Ogino, S., Gibbs, P., Waring, P., Sato, N., Torigoe, T., Itoh, K., Patel, P. S., Shukla, S. N., Wang, Y., Kopetz, S., Sinicrope, F. A., Scripcariu, V., Ascierto, P. A., Marincola, F. M., Fox, B. A. & Pagès, F., 2014 Jan 1, In : Journal of Pathology. 232, 2, p. 199-209 11 p.

Research output: Contribution to journalReview article

626 Citations (Scopus)
2013

Redox regulation in stem-like cancer cells by CD44 variant isoforms

Nagano, O., Okazaki, S. & Saya, H., 2013 Oct 31, In : Oncogene. 32, 44, p. 5191-5198 8 p.

Research output: Contribution to journalReview article

158 Citations (Scopus)
2012

[Biomarkers for cancer immunotherapy].

Kawakami, Y., Kawase, Y., Ohizumi, A., Noji, S., Sakurai, T. & Fujita, T., 2012 May, In : Nihon rinsho. Japanese journal of clinical medicine. 70, 5, p. 759-766 8 p.

Research output: Contribution to journalReview article

[Immunotherapy targeting cancer stem cells].

Kawakami, Y., Matsushita, M., Ueda, R., Tsukamoto, N. & Ohta, S., 2012 Dec, In : Nihon rinsho. Japanese journal of clinical medicine. 70, 12, p. 2142-2146 5 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Cancer classification using the Immunoscore: A worldwide task force

Galon, J., Pagès, F., Marincola, F. M., Angell, H. K., Thurin, M., Lugli, A., Zlobec, I., Berger, A., Bifulco, C., Botti, G., Tatangelo, F., Britten, C. M., Kreiter, S., Chouchane, L., Delrio, P., Arndt, H., Asslaber, M., Maio, M., Masucci, G. V., Mihm, M. & 44 others, Vidal-Vanaclocha, F., Allison, J. P., Gnjatic, S., Hakansson, L., Huber, C., Singh-Jasuja, H., Ottensmeier, C., Zwierzina, H., Laghi, L., Grizzi, F., Ohashi, P. S., Shaw, P. A., Clarke, B. A., Wouters, B. G., Kawakami, Y., Hazama, S., Okuno, K., Wang, E., O'Donnell-Tormey, J., Lagorce, C., Pawelec, G., Nishimura, M. I., Hawkins, R., Lapointe, R., Lundqvist, A., Khleif, S. N., Ogino, S., Gibbs, P., Waring, P., Sato, N., Torigoe, T., Itoh, K., Patel, P. S., Shukla, S. N., Palmqvist, R., Nagtegaal, I. D., Wang, Y., D'Arrigo, C., Kopetz, S., Sinicrope, F. A., Trinchieri, G., Gajewski, T. F., Ascierto, P. A. & Fox, B. A., 2012 Oct 3, In : Journal of Translational Medicine. 10, 1, 205.

Research output: Contribution to journalReview article

455 Citations (Scopus)

Pyruvate kinase M2: Multiple faces for conferring benefits on cancer cells

Tamada, M., Suematsu, M. & Saya, H., 2012 Oct 15, In : Clinical Cancer Research. 18, 20, p. 5554-5561 8 p.

Research output: Contribution to journalReview article

137 Citations (Scopus)
2010

Breast cancer stem cells

Kai, K., Arima, Y., Kamiya, T. & Saya, H., 2010 Apr 1, In : Breast Cancer. 17, 2, p. 80-85 6 p.

Research output: Contribution to journalReview article

65 Citations (Scopus)

Cancer stem cells in malignant glioma - The mechanism of cancer initiation and the therapeutic development

Nakano, I. & Saya, H., 2010 Oct 1, In : Neurological Surgery. 38, 10, p. 879-889 11 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Cancer treatment by comprehensive regulation of anti-tumor immune network

Kawakami, Y., 2010 Jun, In : Nippon rinsho. Japanese journal of clinical medicine. 68, 6, p. 1094-1099 6 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)
2009

Current clinical trials using new targeted therapies for myeloid leukemia and the research trends

Ishizawa, J. & Saya, H., 2009 Oct, In : Nippon rinsho. Japanese journal of clinical medicine. 67, 10, p. 1932-1937 6 p.

Research output: Contribution to journalReview article

Molecularly targeted therapies for glioma

Yamanaka, R. & Saya, H., 2009 Dec 1, In : Annals of Neurology. 66, 6, p. 717-729 13 p.

Research output: Contribution to journalReview article

22 Citations (Scopus)

Molecular mechanism of cell death induced by chemotherapeutic agents

Saya, H., 2009 Jul 1, In : Brain and Nerve. 61, 7, p. 843-847 5 p.

Research output: Contribution to journalReview article

Molecular mechanism regulating effect of anti-cancer agents

Saya, H., 2009 Jan, In : Japanese Journal of Cancer and Chemotherapy. 36, 1, p. 1-5 5 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2008

Dendritic cell based personalized immunotherapy based on cancer antigen research

Kawakami, Y., Fujita, T., Kudo, C., Sakurai, T., Udagawa, M., Yaguchi, T., Hasegawa, G., Hayashi, E., Ueda, Y., Iwata, T., Wang, Q., Okada, S., Tsukamoto, N., Matsuzaki, Y. & Sumimoto, H., 2008 May 5, In : Frontiers in Bioscience. 13, 5, p. 1952-1958 7 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)
2007

Aurora kinases: Functions and roles in tumorigenesis

Saya, H., 2007 Dec 1, In : Seikagaku. 79, 2, p. 131-139 9 p.

Research output: Contribution to journalReview article

Current status of gene therapy for cancers

Kudo-Saito, C., 2007 Sep, In : Gan to kagaku ryoho. Cancer & chemotherapy. 34, 9, p. 1341-1346 6 p.

Research output: Contribution to journalReview article

Lentiviral vector-mediated RNAi and its use for cancer research

Sumimoto, H. & Kawakami, Y., 2007 Dec 1, In : Future Oncology. 3, 6, p. 655-664 10 p.

Research output: Contribution to journalReview article

38 Citations (Scopus)
2006

Costimulatory molecules as adjuvants for immunotherapy

Hodge, J. W., Greiner, J. W., Tsang, K. Y., Sabzevari, H., Kudo-Saito, C., Grosenbach, D. W., Gulley, J. L., Arlen, P. M., Marshall, J. L., Panicali, D. & Schlom, J., 2006 Feb 24, In : Frontiers in Bioscience. 11, 1 P.447-888, p. 788-803 16 p.

Research output: Contribution to journalReview article

43 Citations (Scopus)

TRICOM vector based cancer vaccines

Garnett, C. T., Greiner, J. W., Tsang, K. Y., Kudo-Saito, C., Grosenbach, D. W., Chakraborty, M., Gulley, J. L., Arlen, P. M., Schlom, J. & Hodge, J. W., 2006 Jan 1, In : Current Pharmaceutical Design. 12, 3, p. 351-361 11 p.

Research output: Contribution to journalReview article

48 Citations (Scopus)
2005

Identification of human tumor antigens recognized by T cells

Kawakami, Y., 2005 Apr, In : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 4, p. 562-567 6 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
2004

Identification of human tumor antigens and its implications for diagnosis and treatment of cancer

Kawakami, Y., Fujita, T., Matsuzaki, Y., Sakurai, T., Tsukamoto, M., Toda, M. & Sumimoto, H., 2004 Oct 1, In : Cancer science. 95, 10, p. 784-791 8 p.

Research output: Contribution to journalReview article

65 Citations (Scopus)

Recent progress in identification methods for human tumor antigens recognized by T cells

Hayashi, E., Matsuzaki, Y. & Kawakami, Y., 2004 Nov 1, In : Biotherapy. 18, 6, p. 497-502 6 p.

Research output: Contribution to journalReview article

2003

Cellular immunotherapy of cancer

Kawakami, Y., 2003 Jun, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 44, 6, p. 358-367 10 p.

Research output: Contribution to journalReview article

Preferentially expressed antigen of melanoma (PRAME) in the development of diagnostic and therapeutic methods for hematological malignancies

Matsushita, M., Yamazaki, R., Ikeda, H. & Kawakami, Y., 2003 Mar 1, In : Leukemia and Lymphoma. 44, 3, p. 439-444 6 p.

Research output: Contribution to journalReview article

30 Citations (Scopus)
2000

Immuno-gene therapy for cancer

Kawakami, Y., 2000 Jan 1, In : Biotherapy. 14, 4, p. 345-350 6 p.

Research output: Contribution to journalReview article

1999

Identification of human melanoma antigens recognized by tumor infiltrating T lymphocytes and their use for immunotherapy

Kawakami, Y., 1999 Dec 1, In : Gann Monographs on Cancer Research. 48, p. 179-189 11 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)
1998

Development of new immunotherapies using melanoma antigens recognized by T cells

Kawakami, Y., 1998 Jan 1, In : Biotherapy. 12, 9, p. 1187-1194 8 p.

Research output: Contribution to journalReview article

1997

Human tumor antigens recognized by T-cells

Kawakami, Y. & Rosenberg, S. A., 1997 Jan 1, In : Immunologic Research. 16, 4, p. 313-339 27 p.

Research output: Contribution to journalReview article

122 Citations (Scopus)

Immunobiology of human melanoma antigens MART-1 and gp100 and their use for immuno-gene therapy

Kawakami, Y. & Rosenberg, S. A., 1997, In : International Reviews of Immunology. 14, 2-3, p. 173-192 20 p.

Research output: Contribution to journalReview article

91 Citations (Scopus)

Melanosomal proteins as melanoma-specific immune targets

Sakai, C., Kawakami, Y., Law, L. W., Furumura, M. & Hearing, V. J., 1997 Jun 19, In : Melanoma Research. 7, 2, p. 83-95 13 p.

Research output: Contribution to journalReview article

48 Citations (Scopus)
1996

Human melanoma antigens recognized by T lymphocytes

Kawakami, Y., Robbins, P. F. & Rosenberg, S. A., 1996 Jun, In : Keio Journal of Medicine. 45, 2, p. 100-108 9 p.

Research output: Contribution to journalReview article

Open Access
33 Citations (Scopus)

Identification of tumor-regression antigens in melanoma.

Kawakami, Y., Robbins, P. F., Wang, R. F. & Rosenberg, S. A., 1996, In : Important advances in oncology. p. 3-21 19 p.

Research output: Contribution to journalReview article

24 Citations (Scopus)