Research Output

2020

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 ab

Kato, D., Yaguchi, T., Iwata, T., Katoh, Y., Morii, K., Tsubota, K., Takise, Y., Tamiya, M., Kamada, H., Akiba, H., Tsumoto, K., Serada, S., Naka, T., Nishimura, R., Nakagawa, T. & Kawakami, Y., 2020 Mar, In : eLife. 9, e49392.

Research output: Contribution to journalArticle

Open Access

Immune-resistant mechanisms in cancer immunotherapy

Kawakami, Y., Ohta, S., Sayem, M. A., Tsukamoto, N. & Yaguchi, T., 2020 May 1, In : International Journal of Clinical Oncology. 25, 5, p. 810-817 8 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

NUAK2 localization in normal skin and its expression in a variety of skin tumors with YAP

Al-Busani, H., Al-Sobaihi, S., Nojima, K., Tanemura, A., Yaguchi, T., Kawakami, Y., Matsumura, H., Nishimura, E. K., Yokozeki, H. & Namiki, T., 2020 Feb, In : Journal of Dermatological Science. 97, 2, p. 143-151 9 p.

Research output: Contribution to journalArticle

2019

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. & 8 others, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 Jan 31, In : Nature. 565, 7741, p. 600-605 6 p.

Research output: Contribution to journalArticle

101 Citations (Scopus)

Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease

Hirai, I., Tanese, K., Nakamura, Y., Ishii, M., Kawakami, Y. & Funakoshi, T., 2019 Jan 1, In : Oncologist.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Identification of KLRC2 as a candidate marker for brain tumor-initiating cells

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K. & Toda, M., 2019 Nov 2, In : Neurological Research. 41, 11, p. 1043-1049 7 p.

Research output: Contribution to journalArticle

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers

Osawa, Y., Kojika, E., Nishikawa, K., Kimura, M., Osakaya, S., Miyauchi, H., Kanto, T., Kawakami, Y. & Kimura, K., 2019 Apr 30, In : Oncotarget. 10, 32, p. 3013-3026 14 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu, E., Ogawa, Y., Yazu, H., Aketa, N., Yang, F., Yamane, M., Sato, Y., Kawakami, Y. & Tsubota, K., 2019 May 1, In : PloS one. 14, 5, e0215130.

Research output: Contribution to journalArticle

Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter

Hirao, N., Iwata, T., Tanaka, K., Nishio, H., Nakamura, M., Morisada, T., Morii, K., Maruyama, N., Katoh, Y., Yaguchi, T., Ohta, S., Kukimoto, I., Aoki, D. & Kawakami, Y., 2019 Nov, In : Gynecologic Oncology. 155, 2, p. 340-348 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

A pilot study of peptide vaccines for VEGF receptor 1 and 2 in patients with recurrent/progressive high grade glioma

Shibao, S., Ueda, R., Saito, K., Kikuchi, R., Nagashima, H., Kojima, A., Kagami, H., Pareira, E. S., Sasaki, H., Noji, S., Kawakami, Y., Yoshida, K. & Toda, M., 2018 Apr 20, In : Oncotarget. 9, 30, p. 21569-21579 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma

Kamamoto, D., Ohara, K., Kitamura, Y., Yoshida, K., Kawakami, Y. & Sasaki, H., 2018 Apr 19, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Carboplatin and epirubicin combination therapy for advanced malignant epithelial skin tumors: Retrospective study of six patients

Nakamura, Y., Tanese, K., Hirai, I., Kawakami, Y. & Funakoshi, T., 2018 Jul 1, In : Journal of Dermatology. 45, 7, p. 874-875 2 p.

Research output: Contribution to journalComment/debate

3 Citations (Scopus)

Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease

Yamane, M., Ogawa, Y., Mukai, S., Yaguchi, S., Kamijuku, H., Inaba, T., Asai, K., Morikawa, S., Kawakami, Y., Shimmura, S. & Tsubota, K., 2018 Jan 1, In : Cornea. 37, 1, p. 102-108 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Generation of human immunosuppressive myeloid cell populations in human interleukin-6 transgenic NOG mice

Hanazawa, A., Ito, R., Katano, I., Kawai, K., Goto, M., Suemizu, H., Kawakami, Y., Ito, M. & Takahashi, T., 2018 Feb 2, In : Frontiers in Immunology. 9, FEB, 152.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

Yaguchi, T., Kobayashi, A., Inozume, T., Morii, K., Nagumo, H., Nishio, H., Iwata, T., Ka, Y., Katano, I., Ito, R., Ito, M. & Kawakami, Y., 2018 Nov 1, In : Cellular and Molecular Immunology. 15, 11, p. 953-962 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

IgG response to MHC class I epitope peptides is a quantitative predictive biomarker in the early course of treatment of colorectal cancer using therapeutic peptides

Kanekiyo, S., Hazama, S., Takenouchi, H., Nakajima, M., Shindo, Y., MATSuI, H., Tokumitsu, Y., Tomochika, S., Tsunedomi, R., Tokuhisa, Y., Iida, M., Sakamoto, K., SuzukI, N., Takeda, S., Yamamoto, S., Yoshino, S., Okuno, K., Udaka, K., Kawakami, Y., Matsueda, S. & 2 others, Ito, K. & Nagano, H., 2018 May 1, In : Oncology Reports. 39, 5, p. 2385-2392 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice

Mukai, S., Ogawa, Y., Kawakami, Y., Mashima, Y. & Tsubota, K., 2018 Aug 1, In : FASEB Journal. 32, 8, p. 4085-4095 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

Pagès, F., Mlecnik, B., Marliot, F., Bindea, G., Ou, F. S., Bifulco, C., Lugli, A., Zlobec, I., Rau, T. T., Berger, M. D., Nagtegaal, I. D., Vink-Börger, E., Hartmann, A., Geppert, C., Kolwelter, J., Merkel, S., Grützmann, R., Van den Eynde, M., Jouret-Mourin, A., Kartheuser, A. & 79 others, Léonard, D., Remue, C., Wang, J. Y., Bavi, P., Roehrl, M. H. A., Ohashi, P. S., Nguyen, L. T., Han, S. J., MacGregor, H. L., Hafezi-Bakhtiari, S., Wouters, B. G., Masucci, G. V., Andersson, E. K., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M., Laghi, L., Grizzi, F., Fredriksen, T., Buttard, B., Angelova, M., Vasaturo, A., Maby, P., Church, S. E., Angell, H. K., Lafontaine, L., Bruni, D., El Sissy, C., Haicheur, N., Kirilovsky, A., Berger, A., Lagorce, C., Meyers, J. P., Paustian, C., Feng, Z., Ballesteros-Merino, C., Dijkstra, J., van de Water, C., van Lent-van Vliet, S., Knijn, N., Mușină, A. M., Scripcariu, D. V., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Torigoe, T., Sato, N., Furuhata, T., Takemasa, I., Itoh, K., Patel, P. S., Vora, H. H., Shah, B., Patel, J. B., Rajvik, K. N., Pandya, S. J., Shukla, S. N., Wang, Y., Zhang, G., Kawakami, Y., Marincola, F. M., Ascierto, P. A., Sargent, D. J., Fox, B. A. & Galon, J., 2018 May 26, In : The Lancet. 391, 10135, p. 2128-2139 12 p.

Research output: Contribution to journalArticle

302 Citations (Scopus)

Involvement of local renin-angiotensin system in immunosuppression of tumor microenvironment

Nakamura, K., Yaguchi, T., Ohmura, G., Kobayashi, A., Kawamura, N., Iwata, T., Kiniwa, Y., Okuyama, R. & Kawakami, Y., 2018 Jan, In : Cancer science. 109, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Novel elucidation and treatment of pancreatic chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Urano, F., Kawakami, Y. & Tsubota, K., 2018 Oct 1, In : Royal Society Open Science. 5, 10, 181067.

Research output: Contribution to journalArticle

Ocular Surface and Tear Film Characteristics in a Sclerodermatous Chronic Graft-Versus-Host Disease Mouse Model

He, J., Yamane, M., Shibata, S., Fukui, M., Shimizu, E., Yano, T., Mukai, S., Kawakami, Y., Li, S., Tsubota, K. & Ogawa, Y., 2018 Apr 1, In : Cornea. 37, 4, p. 486-494 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Pilot study of WT1 peptide-pulsed dendritic cell vaccination with docetaxel in esophageal cancer

Matsuda, T., Takeuchi, H., Sakurai, T., Mayanagi, S., Booka, E., Fujita, T., Higuchi, H., Taguchi, J., Hamamoto, Y., Takaishi, H., Kawakubo, H., Okamoto, M., Sunamura, M., Kawakami, Y. & Kitagawa, Y., 2018 Jul 1, In : Oncology Letters. 16, 1, p. 1348-1356 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Saya, H., Kawakami, Y. & Tsubota, K., 2018 Oct 1, In : PLoS One. 13, 10, e0203742.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms

Hegab, A. E., Ozaki, M., Kagawa, S., Hamamoto, J., Yasuda, H., Naoki, K., Soejima, K., Yin, Y., Kinoshita, T., Yaguchi, T., Kawakami, Y., Ornitz, D. M. & Betsuyaku, T., 2018 May 1, In : Lung Cancer. 119, p. 25-35 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

A Randomized Phase II Study Comparing Nivolumab With Carboplatin-Pemetrexed for Patients With EGFR Mutation–Positive Nonsquamous Non–Small-Cell Lung Cancer Who Acquire Resistance to Tyrosine Kinase Inhibitors Not Due to a Secondary T790M Mutation: Rationale and Protocol Design for the WJOG8515L Study

Hayashi, H., Chiba, Y., Sakai, K., Fujita, T., Yoshioka, H., Sakai, D., Kitagawa, C., Naito, T., Takeda, K., Okamoto, I., Mitsudomi, T., Kawakami, Y., Nishio, K., Nakamura, S., Yamamoto, N. & Nakagawa, K., 2017 Nov 1, In : Clinical Lung Cancer. 18, 6, p. 719-723 5 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Autophagy-dependent regulation of tumor metastasis by myeloid cells

Jinushi, M., Morita, T., Xu, Z., Kinoshita, I., Dosaka-Akita, H., Yagita, H. & Kawakami, Y., 2017 Jul 1, In : PLoS One. 12, 7, e0179357.

Research output: Contribution to journalArticle

4 Citations (Scopus)

CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

Okuno, H., Mihara, F. R., Ota, S., Fukuda, K., Kurosawa, K., Akamatsu, W., Sanosaka, T., Kohyama, J., Hayashi, K., Nakajima, K., Takahashi, T., Wysocka, J., Kosaki, K. & Okano, H., 2017 Nov 28, In : eLife. 6, e21114.

Research output: Contribution to journalArticle

16 Citations (Scopus)

CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients

Matsushita, M., Ozawa, K., Suzuki, T., Nakamura, M., Nakano, N., Kanchi, S., Ichikawa, D., Matsuki, E., Sakurai, M., Karigane, D., Kasahara, H., Tsukamoto, N., Shimizu, T., Mori, T., Nakajima, H., Okamoto, S., Kawakami, Y. & Hattori, Y., 2017 Sep 1, In : Blood cancer journal. 7, 9, e601.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma

Kinoshita, T., Kudo-Saito, C., Muramatsu, R., Fujita, T., Saito, M., Nagumo, H., Sakurai, T., Noji, S., Takahata, E., Yaguchi, T., Tsukamoto, N., Hayashi, Y., Kaseda, K., Kamiyama, I., Ohtsuka, T., Tomizawa, K., Shimoji, M., Mitsudomi, T., Asamura, H. & Kawakami, Y., 2017 Nov 1, In : European Journal of Cancer. 86, p. 15-27 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Functional analysis of KIF20A, a potential immunotherapeutic target for glioma

Saito, K., Ota, S., Kawakami, Y., Yoshida, K. & Toda, M., 2017 Jan 9, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-12 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Inter-patient and intra-tumor heterogeneity in the sensitivity to tumor-targeted immunity in colorectal cancer

Miyauchi, T., Yaguchi, T. & Kawakami, Y., 2017, In : Japanese Journal of Clinical Immunology. 40, 1, p. 54-59 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Lack of XAGE-1b and NY-ESO-1 in metastatic lymph nodes may predict the potential survival of stage III melanoma patients

Mori, M., Funakoshi, T., Kameyama, K., Kawakami, Y., Sato, E., Nakayama, E., Amagai, M. & Tanese, K., 2017, (Accepted/In press) In : Journal of Dermatology.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

Katano, I., Nishime, C., Ito, R., Kamisako, T., Mizusawa, T., Ka, Y., Ogura, T., Suemizu, H., Kawakami, Y., Ito, M. & Takahashi, T., 2017 Dec 1, In : Scientific Reports. 7, 1, 17230.

Research output: Contribution to journalArticle

6 Citations (Scopus)

MIF: Functions in brain and glioblastoma

Ohta, S., Kawakami, Y. & Okano, H., 2017 Jan 1, In : Oncotarget. 8, 29, p. 46706-46707 2 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

miR-196b, miR-378a and miR-486 are predictive biomarkers for the efficacy of vaccine treatment in colorectal cancer

Shindo, Y., Hazama, S., Nakamura, Y., Inoue, Y., Kanekiyo, S., Suzuki, N., Takenouchi, H., Tsunedomi, R., Nakajima, M., Ueno, T., Takeda, S., Yoshino, S., Okuno, K., Fujita, Y., Hamamoto, Y., Kawakami, Y., Oka, M. & Nagano, H., 2017, In : Oncology Letters. 14, 2, p. 1355-1362 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid

Mukai, S., Ogawa, Y., Urano, F., Kudo-Saito, C., Kawakami, Y. & Tsubota, K., 2017 Feb 6, In : Scientific reports. 7, 41939.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Peptide-pulsed dendritic cell vaccine in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma

Fukuda, K., Funakoshi, T., Sakurai, T., Nakamura, Y., Mori, M., Tanese, K., Tanikawa, A., Taguchi, J., Fujita, T., Okamoto, M., Amagai, M. & Kawakami, Y., 2017 Mar 3, (Accepted/In press) In : Melanoma Research.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Progression of Human Renal Cell Carcinoma via Inhibition of RhoA-ROCK Axis by PARG1

Miyazaki, J., Ito, K., Fujita, T., Matsuzaki, Y., Asano, T., Hayakawa, M., Asano, T. & Kawakami, Y., 2017 Apr 1, In : Translational Oncology. 10, 2, p. 142-152 11 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Prospects for personalized combination immunotherapy for solid tumors based on adoptive cell therapies and immune checkpoint blockade therapies

Kato, D., Yaguchi, T., Iwata, T., Morii, K., Nakagawa, T., Nishimura, R. & Kawakami, Y., 2017, In : Japanese Journal of Clinical Immunology. 40, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease

Fukui, M., Ogawa, Y., Mukai, S., Kamoi, M., Asato, T., Kawakami, Y. & Tsubota, K., 2017, In : Journal of Ophthalmology. 2017, 1639012.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Cancer-induced heterogeneous immunosuppressive tumor microenvironments and their personalized modulation

Yaguchi, T. & Kawakami, Y., 2016, In : International Immunology. 28, 8, p. 393-399 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

CHD7 promotes proliferation of neural stem cells mediated by MIF

Ohta, S., Yaguchi, T., Okuno, H., Chneiweiss, H., Kawakami, Y. & Okano, H., 2016 Dec 13, In : Molecular brain. 9, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Identification of novel HLA-A∗24: 02-restricted epitope derived from a homeobox protein expressed in hematological malignancies

Matsushita, M., Otsuka, Y., Tsutsumida, N., Tanaka, C., Uchiumi, A., Ozawa, K., Suzuki, T., Ichikawa, D., Aburatani, H., Okamoto, S., Kawakami, Y. & Hattori, Y., 2016 Jan 1, In : PLoS One. 11, 1, e0146371.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Introduction: Cancer Immunology Special Issue-Immunotherapy

Kawakami, Y., 2016 Jul 1, In : International Immunology. 28, 7, 1 p.

Research output: Contribution to journalArticle

Introduction: Cancer immunology special issue-immunopathology

Kawakami, Y., 2016, In : International Immunology. 28, 8, 1 p.

Research output: Contribution to journalEditorial

Melanoma cells control antimelanoma CTL responses via interaction between TIGIT and CD155 in the effector phase

Inozume, T., Yaguchi, T., Furuta, J., Harada, K., Kawakami, Y. & Shimada, S., 2016 Jan 1, In : Journal of Investigative Dermatology. 136, 1, p. 255-263 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

Ogawa, Y., Morikawa, S., Okano, H., Mabuchi, Y., Suzuki, S., Yaguchi, T., Sato, Y., Mukai, S., Yaguchi, S., Inaba, T., Okamoto, S., Kawakami, Y., Tsubota, K., Matsuzaki, Y. & Shimmura, S., 2016 Jan 26, In : eLife. 5, JANUARY2016, e09394.

Research output: Contribution to journalArticle

15 Citations (Scopus)

MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p53

Fukaya, R., Ota, S., Yaguchi, T., Matsuzaki, Y., Sugihara, E., Okano, H., Saya, H., Kawakami, Y., Kawase, T., Yoshida, K. & Toda, M., 2016 May 1, In : Cancer Research. 76, 9, p. 2813-2823 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Personalized cancer immunotherapy: Immune biomarkers and combination immunotherapy

Kawakami, Y., Popivanova, B., Nuchsupha, S., Hayakawa, T., Nakamura, K., Nagumo, H., Katano, I., Kinoshita, T., Tsubota, K., Kamijuku, H., Kawamura, N., Miyazaki, J., Satomi, R., Sugiyama, J., Nishio, H., Noji, S., Kudo-Saito, C., Tsukamoto, N., Sakurai, T., Fujita, T. & 1 others, Yaguchi, T., 2016 Feb 22, Immunotherapy of Cancer: An Innovative Treatment Comes of Age. Springer Japan, p. 349-358 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small-cell lung cancer

Kinoshita, T., Muramatsu, R., Fujita, T., Nagumo, H., Sakurai, T., Noji, S., Takahata, E., Yaguchi, T., Tsukamoto, N., Kudo-Saito, C., Hayashi, Y., Kamiyama, I., Ohtsuka, T., Asamura, H. & Kawakami, Y., 2016 Nov 1, In : Annals of oncology : official journal of the European Society for Medical Oncology. 27, 11, p. 2117-2123 7 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)