Research Output 1984 2019

2019
52 Citations (Scopus)

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

Tanoue, T., Morita, S., Plichta, D. R., Skelly, A. N., Suda, W., Sugiura, Y., Narushima, S., Vlamakis, H., Motoo, I., Sugita, K., Shiota, A., Takeshita, K., Yasuma-Mitobe, K., Riethmacher, D., Kaisho, T., Norman, J. M., Mucida, D., Suematsu, M., Yaguchi, T., Bucci, V. & 8 others, Inoue, T., Kawakami, Y., Olle, B., Roberts, B., Hattori, M., Xavier, R. J., Atarashi, K. & Honda, K., 2019 Jan 31, In : Nature. 565, 7741, p. 600-605 6 p.

Research output: Contribution to journalArticle

Immunity
T-Lymphocytes
Listeriosis
Histocompatibility
Microbiota
1 Citation (Scopus)

Combination Cisplatin-Epirubicin-Paclitaxel Therapy for Metastatic Extramammary Paget's Disease

Hirai, I., Tanese, K., Nakamura, Y., Ishii, M., Kawakami, Y. & Funakoshi, T., 2019 Jan 1, In : Oncologist.

Research output: Contribution to journalArticle

Extramammary Paget's Disease
Epirubicin
Anthracyclines
Breast Neoplasms
Cytotoxins

Identification of KLRC2 as a candidate marker for brain tumor-initiating cells

Ishihara, E., Takahashi, S., Fukaya, R., Ohta, S., Yoshida, K. & Toda, M., 2019 Nov 2, In : Neurological Research. 41, 11, p. 1043-1049 7 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Brain Neoplasms
Glioma
Neural Stem Cells
Brain

Programmed cell death ligand 1 (PD-L1) blockade attenuates metastatic colon cancer growth in cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin inhibitor-treated livers

Osawa, Y., Kojika, E., Nishikawa, K., Kimura, M., Osakaya, S., Miyauchi, H., Kanto, T., Kawakami, Y. & Kimura, K., 2019 Apr 30, In : Oncotarget. 10, 32, p. 3013-3026 14 p.

Research output: Contribution to journalArticle

Catenins
Cyclic AMP Response Element-Binding Protein
Protein Binding
Colonic Neoplasms
Carrier Proteins

"Smart Eye Camera": An innovative technique to evaluate tear film breakup time in a murine dry eye disease model

Shimizu, E., Ogawa, Y., Yazu, H., Aketa, N., Yang, F., Yamane, M., Sato, Y., Kawakami, Y. & Tsubota, K., 2019 May 1, In : PloS one. 14, 5, e0215130.

Research output: Contribution to journalArticle

eye diseases
Eye Diseases
disease models
Tears
cameras

Transcription factor homeobox D9 is involved in the malignant phenotype of cervical cancer through direct binding to the human papillomavirus oncogene promoter

Hirao, N., Iwata, T., Tanaka, K., Nishio, H., Nakamura, M., Morisada, T., Morii, K., Maruyama, N., Katoh, Y., Yaguchi, T., Ota, S., Kukimoto, I., Aoki, D. & Kawakami, Y., 2019 Jan 1, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Homeobox Genes
Oncogenes
Uterine Cervical Neoplasms
Transcription Factors
Phenotype
2018
5 Citations (Scopus)

A pilot study of peptide vaccines for VEGF receptor 1 and 2 in patients with recurrent/progressive high grade glioma

Shibao, S., Ueda, R., Saito, K., Kikuchi, R., Nagashima, H., Kojima, A., Kagami, H., Pareira, E. S., Sasaki, H., Noji, S., Kawakami, Y., Yoshida, K. & Toda, M., 2018 Apr 20, In : Oncotarget. 9, 30, p. 21569-21579 11 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor Receptor-1
Vascular Endothelial Growth Factor Receptor-2
Subunit Vaccines
Glioma
Vascular Endothelial Growth Factor Receptor
1 Citation (Scopus)

Association between programmed cell death ligand-1 expression and extracranial metastasis in intracranial solitary fibrous tumor/hemangiopericytoma

Kamamoto, D., Ohara, K., Kitamura, Y., Yoshida, K., Kawakami, Y. & Sasaki, H., 2018 Apr 19, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Solitary Fibrous Tumors
Hemangiopericytoma
Cell Death
Neoplasm Metastasis
Ligands
1 Citation (Scopus)

Carboplatin and epirubicin combination therapy for advanced malignant epithelial skin tumors: Retrospective study of six patients

Nakamura, Y., Tanese, K., Hirai, I., Kawakami, Y. & Funakoshi, T., 2018 Jul 1, In : Journal of Dermatology. 45, 7, p. 874-875 2 p.

Research output: Contribution to journalComment/debate

Epirubicin
Carboplatin
Retrospective Studies
Carcinoma
Skin
3 Citations (Scopus)

Functional Role of Lacrimal Gland Fibroblasts in a Mouse Model of Chronic Graft-Versus-Host Disease

Yamane, M., Ogawa, Y., Mukai, S., Yaguchi, S., Kamijuku, H., Inaba, T., Asai, K., Morikawa, S., Kawakami, Y., Shimmura, S. & Tsubota, K., 2018 Jan 1, In : Cornea. 37, 1, p. 102-108 7 p.

Research output: Contribution to journalArticle

Lacrimal Apparatus
Graft vs Host Disease
Fibroblasts
Fibrosis
Immunohistochemistry
5 Citations (Scopus)

Generation of human immunosuppressive myeloid cell populations in human interleukin-6 transgenic NOG mice

Hanazawa, A., Ito, R., Katano, I., Kawai, K., Goto, M., Suemizu, H., Kawakami, Y., Ito, M. & Takahashi, T., 2018 Feb 2, In : Frontiers in Immunology. 9, FEB, 152.

Research output: Contribution to journalArticle

Myeloid Cells
Immunosuppressive Agents
Transgenic Mice
Interleukin-6
Hematopoietic Stem Cells
3 Citations (Scopus)

Human PBMC-transferred murine MHC class I/II-deficient NOG mice enable long-term evaluation of human immune responses

Yaguchi, T., Kobayashi, A., Inozume, T., Morii, K., Nagumo, H., Nishio, H., Iwata, T., Ka, Y., Katano, I., Ito, R., Ito, M. & Kawakami, Y., 2018 Nov 1, In : Cellular and Molecular Immunology. 15, 11, p. 953-962 10 p.

Research output: Contribution to journalArticle

Blood Cells
T-Lymphocytes
Graft vs Host Disease
Cell- and Tissue-Based Therapy
Melanoma
1 Citation (Scopus)

IgG response to MHC class I epitope peptides is a quantitative predictive biomarker in the early course of treatment of colorectal cancer using therapeutic peptides

Kanekiyo, S., Hazama, S., Takenouchi, H., Nakajima, M., Shindo, Y., MATSuI, H., Tokumitsu, Y., Tomochika, S., Tsunedomi, R., Tokuhisa, Y., Iida, M., Sakamoto, K., SuzukI, N., Takeda, S., Yamamoto, S., Yoshino, S., Okuno, K., Udaka, K., Kawakami, Y., Matsueda, S. & 2 others, Ito, K. & Nagano, H., 2018 May 1, In : Oncology Reports. 39, 5, p. 2385-2392 8 p.

Research output: Contribution to journalArticle

Epitopes
Colorectal Neoplasms
Immunoglobulin G
Biomarkers
Peptides
3 Citations (Scopus)

Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice

Mukai, S., Ogawa, Y., Kawakami, Y., Mashima, Y. & Tsubota, K., 2018 Aug 1, In : FASEB Journal. 32, 8, p. 4085-4095 11 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
Blood Vessels
Adhesion
Proteins
207 Citations (Scopus)

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

Pagès, F., Mlecnik, B., Marliot, F., Bindea, G., Ou, F. S., Bifulco, C., Lugli, A., Zlobec, I., Rau, T. T., Berger, M. D., Nagtegaal, I. D., Vink-Börger, E., Hartmann, A., Geppert, C., Kolwelter, J., Merkel, S., Grützmann, R., Van den Eynde, M., Jouret-Mourin, A., Kartheuser, A. & 79 others, Léonard, D., Remue, C., Wang, J. Y., Bavi, P., Roehrl, M. H. A., Ohashi, P. S., Nguyen, L. T., Han, S. J., MacGregor, H. L., Hafezi-Bakhtiari, S., Wouters, B. G., Masucci, G. V., Andersson, E. K., Zavadova, E., Vocka, M., Spacek, J., Petruzelka, L., Konopasek, B., Dundr, P., Skalova, H., Nemejcova, K., Botti, G., Tatangelo, F., Delrio, P., Ciliberto, G., Maio, M., Laghi, L., Grizzi, F., Fredriksen, T., Buttard, B., Angelova, M., Vasaturo, A., Maby, P., Church, S. E., Angell, H. K., Lafontaine, L., Bruni, D., El Sissy, C., Haicheur, N., Kirilovsky, A., Berger, A., Lagorce, C., Meyers, J. P., Paustian, C., Feng, Z., Ballesteros-Merino, C., Dijkstra, J., van de Water, C., van Lent-van Vliet, S., Knijn, N., Mușină, A. M., Scripcariu, D. V., Popivanova, B., Xu, M., Fujita, T., Hazama, S., Suzuki, N., Nagano, H., Okuno, K., Torigoe, T., Sato, N., Furuhata, T., Takemasa, I., Itoh, K., Patel, P. S., Vora, H. H., Shah, B., Patel, J. B., Rajvik, K. N., Pandya, S. J., Shukla, S. N., Wang, Y., Zhang, G., Kawakami, Y., Marincola, F. M., Ascierto, P. A., Sargent, D. J., Fox, B. A. & Galon, J., 2018 May 26, In : The Lancet. 391, 10135, p. 2128-2139 12 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Neoplasms
Recurrence
Colon
Neoplasm Staging
9 Citations (Scopus)

Involvement of local renin-angiotensin system in immunosuppression of tumor microenvironment

Nakamura, K., Yaguchi, T., Ohmura, G., Kobayashi, A., Kawamura, N., Iwata, T., Kiniwa, Y., Okuyama, R. & Kawakami, Y., 2018 Jan 1, In : Cancer Science. 109, 1, p. 54-64 11 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Angiotensin Receptor Antagonists
Immunosuppressive Agents
Renin-Angiotensin System
Immunosuppression

Novel elucidation and treatment of pancreatic chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Urano, F., Kawakami, Y. & Tsubota, K., 2018 Oct 1, In : Royal Society Open Science. 5, 10, 181067.

Research output: Contribution to journalArticle

Graft vs Host Disease
Endoplasmic Reticulum Stress
Pancreas
Epithelial-Mesenchymal Transition
Therapeutics
3 Citations (Scopus)

Ocular Surface and Tear Film Characteristics in a Sclerodermatous Chronic Graft-Versus-Host Disease Mouse Model

He, J., Yamane, M., Shibata, S., Fukui, M., Shimizu, E., Yano, T., Mukai, S., Kawakami, Y., Li, S., Tsubota, K. & Ogawa, Y., 2018 Apr 1, In : Cornea. 37, 4, p. 486-494 9 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Tears
Conjunctiva
Eyelids
Microvilli
1 Citation (Scopus)

Pilot study of WT1 peptide-pulsed dendritic cell vaccination with docetaxel in esophageal cancer

Matsuda, T., Takeuchi, H., Sakurai, T., Mayanagi, S., Booka, E., Fujita, T., Higuchi, H., Taguchi, J., Hamamoto, Y., Takaishi, H., Kawakubo, H., Okamoto, M., Sunamura, M., Kawakami, Y. & Kitagawa, Y., 2018 Jul 1, In : Oncology Letters. 16, 1, p. 1348-1356 9 p.

Research output: Contribution to journalArticle

docetaxel
Wilms' Tumor Genes
Wilms Tumor
Esophageal Neoplasms
Dendritic Cells
1 Citation (Scopus)

Therapeutic potential of tranilast for the treatment of chronic graft-versus-host disease in mice

Mukai, S., Ogawa, Y., Saya, H., Kawakami, Y. & Tsubota, K., 2018 Oct 1, In : PLoS One. 13, 10, e0203742.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
therapeutics
mice
bone marrow transplant
4 Citations (Scopus)

Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms

Hegab, A. E., Ozaki, M., Kagawa, S., Hamamoto, J., Yasuda, H., Naoki, K., Soejima, K., Yin, Y., Kinoshita, T., Yaguchi, T., Kawakami, Y., Ornitz, D. M. & Betsuyaku, T., 2018 May 1, In : Lung Cancer. 119, p. 25-35 11 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 9
Macrophages
Growth
Neoplasms
Adenocarcinoma of lung
2017
6 Citations (Scopus)

A Randomized Phase II Study Comparing Nivolumab With Carboplatin-Pemetrexed for Patients With EGFR Mutation–Positive Nonsquamous Non–Small-Cell Lung Cancer Who Acquire Resistance to Tyrosine Kinase Inhibitors Not Due to a Secondary T790M Mutation: Rationale and Protocol Design for the WJOG8515L Study

Hayashi, H., Chiba, Y., Sakai, K., Fujita, T., Yoshioka, H., Sakai, D., Kitagawa, C., Naito, T., Takeda, K., Okamoto, I., Mitsudomi, T., Kawakami, Y., Nishio, K., Nakamura, S., Yamamoto, N. & Nakagawa, K., 2017 Nov 1, In : Clinical Lung Cancer. 18, 6, p. 719-723 5 p.

Research output: Contribution to journalArticle

Pemetrexed
erbB-1 Genes
Carboplatin
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
3 Citations (Scopus)

Autophagy-dependent regulation of tumor metastasis by myeloid cells

Jinushi, M., Morita, T., Xu, Z., Kinoshita, I., Dosaka-Akita, H., Yagita, H. & Kawakami, Y., 2017 Jul 1, In : PLoS One. 12, 7, e0179357.

Research output: Contribution to journalArticle

autophagy
Autophagy
Myeloid Cells
metastasis
Tumors
14 Citations (Scopus)

CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations

Okuno, H., Mihara, F. R., Ota, S., Fukuda, K., Kurosawa, K., Akamatsu, W., Sanosaka, T., Kohyama, J., Hayashi, K., Nakajima, K., Takahashi, T., Wysocka, J., Kosaki, K. & Okano, H., 2017 Nov 28, In : eLife. 6, e21114.

Research output: Contribution to journalArticle

CHARGE Syndrome
Induced Pluripotent Stem Cells
Neural Crest
Stem cells
Mutation
1 Citation (Scopus)

CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients

Matsushita, M., Ozawa, K., Suzuki, T., Nakamura, M., Nakano, N., Kanchi, S., Ichikawa, D., Matsuki, E., Sakurai, M., Karigane, D., Kasahara, H., Tsukamoto, N., Shimizu, T., Mori, T., Nakajima, H., Okamoto, S., Kawakami, Y. & Hattori, Y., 2017 Sep 1, In : Blood Cancer Journal. 7, 9, e601.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Stem Cells
Therapeutics
T-Lymphocytes
12 Citations (Scopus)

Determination of poor prognostic immune features of tumour microenvironment in non-smoking patients with lung adenocarcinoma

Kinoshita, T., Kudo-Saito, C., Muramatsu, R., Fujita, T., Saito, M., Nagumo, H., Sakurai, T., Noji, S., Takahata, E., Yaguchi, T., Tsukamoto, N., Hayashi, Y., Kaseda, K., Kamiyama, I., Ohtsuka, T., Tomizawa, K., Shimoji, M., Mitsudomi, T., Asamura, H. & Kawakami, Y., 2017 Nov 1, In : European Journal of Cancer. 86, p. 15-27 13 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
T-Lymphocytes
Adenocarcinoma
Non-Small Cell Lung Carcinoma
Immunosuppressive Agents
9 Citations (Scopus)

Functional analysis of KIF20A, a potential immunotherapeutic target for glioma

Saito, K., Ota, S., Kawakami, Y., Yoshida, K. & Toda, M., 2017 Jan 9, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Kinesin
Glioma
Cytokinesis
Pancreatic Neoplasms
Subunit Vaccines
2 Citations (Scopus)

Inter-patient and intra-tumor heterogeneity in the sensitivity to tumor-targeted immunity in colorectal cancer

Miyauchi, T., Yaguchi, T. & Kawakami, Y., 2017, In : Japanese Journal of Clinical Immunology. 40, 1, p. 54-59 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Immunity
Microsatellite Repeats
Microsatellite Instability
Neoplasms
3 Citations (Scopus)

Lack of XAGE-1b and NY-ESO-1 in metastatic lymph nodes may predict the potential survival of stage III melanoma patients

Mori, M., Funakoshi, T., Kameyama, K., Kawakami, Y., Sato, E., Nakayama, E., Amagai, M. & Tanese, K., 2017, (Accepted/In press) In : Journal of Dermatology.

Research output: Contribution to journalArticle

Melanoma
Lymph Nodes
Testicular Neoplasms
Survival
Antigens
3 Citations (Scopus)

Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

Katano, I., Nishime, C., Ito, R., Kamisako, T., Mizusawa, T., Ka, Y., Ogura, T., Suemizu, H., Kawakami, Y., Ito, M. & Takahashi, T., 2017 Dec 1, In : Scientific Reports. 7, 1, 17230.

Research output: Contribution to journalArticle

Natural Killer Cells
Transgenic Mice
Interleukin-15
KIR Receptors
Antibody-Dependent Cell Cytotoxicity
1 Citation (Scopus)

MIF: Functions in brain and glioblastoma

Ota, S., Kawakami, Y. & Okano, H., 2017, In : Oncotarget. 8, 29, p. 46706-46707 2 p.

Research output: Contribution to journalEditorial

7 Citations (Scopus)

miR-196b, miR-378a and miR-486 are predictive biomarkers for the efficacy of vaccine treatment in colorectal cancer

Shindo, Y., Hazama, S., Nakamura, Y., Inoue, Y., Kanekiyo, S., Suzuki, N., Takenouchi, H., Tsunedomi, R., Nakajima, M., Ueno, T., Takeda, S., Yoshino, S., Okuno, K., Fujita, Y., Hamamoto, Y., Kawakami, Y., Oka, M. & Nagano, H., 2017, In : Oncology Letters. 14, 2, p. 1355-1362 8 p.

Research output: Contribution to journalArticle

MicroRNAs
Colorectal Neoplasms
Vaccines
Biomarkers
HLA Antigens
8 Citations (Scopus)

Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid

Mukai, S., Ogawa, Y., Urano, F., Kudo-Saito, C., Kawakami, Y. & Tsubota, K., 2017 Feb 6, In : Scientific Reports. 7, 41939.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Graft vs Host Disease
Therapeutics
Fibroblasts
Macrophages
8 Citations (Scopus)

Peptide-pulsed dendritic cell vaccine in combination with carboplatin and paclitaxel chemotherapy for stage IV melanoma

Fukuda, K., Funakoshi, T., Sakurai, T., Nakamura, Y., Mori, M., Tanese, K., Tanikawa, A., Taguchi, J., Fujita, T., Okamoto, M., Amagai, M. & Kawakami, Y., 2017 Mar 3, (Accepted/In press) In : Melanoma Research.

Research output: Contribution to journalArticle

Combined Vaccines
Wilms' Tumor Genes
Carboplatin
Wilms Tumor
Paclitaxel
3 Citations (Scopus)

Progression of Human Renal Cell Carcinoma via Inhibition of RhoA-ROCK Axis by PARG1

Miyazaki, J., Ito, K., Fujita, T., Matsuzaki, Y., Asano, T., Hayakawa, M., Asano, T. & Kawakami, Y., 2017 Apr 1, In : Translational Oncology. 10, 2, p. 142-152 11 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Recurrence
Cell Proliferation
Cell Line
G1 Phase Cell Cycle Checkpoints
4 Citations (Scopus)

Prospects for personalized combination immunotherapy for solid tumors based on adoptive cell therapies and immune checkpoint blockade therapies

Kato, D., Yaguchi, T., Iwata, T., Morii, K., Nakagawa, T., Nishimura, R. & Kawakami, Y., 2017, In : Japanese Journal of Clinical Immunology. 40, 1, p. 68-77 10 p.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Immunotherapy
Neoplasms
T-Lymphocytes
Therapeutics

Reduced Expression of VAMP8 in Lacrimal Gland Affected by Chronic Graft-versus-Host Disease

Fukui, M., Ogawa, Y., Mukai, S., Kamoi, M., Asato, T., Kawakami, Y. & Tsubota, K., 2017, In : Journal of Ophthalmology. 2017, 1639012.

Research output: Contribution to journalArticle

R-SNARE Proteins
Lacrimal Apparatus
Graft vs Host Disease
Tears
SNARE Proteins
2016
13 Citations (Scopus)

Cancer-induced heterogeneous immunosuppressive tumor microenvironments and their personalized modulation

Yaguchi, T. & Kawakami, Y., 2016, In : International Immunology. 28, 8, p. 393-399 7 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Immunosuppressive Agents
Neoplasms
Immunotherapy
Immunosuppression
11 Citations (Scopus)

CHD7 promotes proliferation of neural stem cells mediated by MIF

Ota, S., Yaguchi, T., Okuno, H., Chneiweiss, H., Kawakami, Y. & Okano, H., 2016 Dec 13, In : Molecular Brain. 9, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Neural Stem Cells
DNA-Binding Proteins
Cell Movement
Stem Cells
Chromatin
3 Citations (Scopus)

Identification of novel HLA-A∗24: 02-restricted epitope derived from a homeobox protein expressed in hematological malignancies

Matsushita, M., Otsuka, Y., Tsutsumida, N., Tanaka, C., Uchiumi, A., Ozawa, K., Suzuki, T., Ichikawa, D., Aburatani, H., Okamoto, S., Kawakami, Y. & Hattori, Y., 2016 Jan 1, In : PLoS One. 11, 1, e0146371.

Research output: Contribution to journalArticle

HLA-A24 Antigen
decitabine
homeodomain proteins
Homeodomain Proteins
T-cells

Introduction: Cancer immunology special issue-immunopathology

Kawakami, Y., 2016, In : International Immunology. 28, 8, 1 p.

Research output: Contribution to journalEditorial

Allergy and Immunology
Neoplasms

Introduction: Cancer Immunology Special Issue-Immunotherapy

Kawakami, Y., 2016 Jul 1, In : International Immunology. 28, 7, 1 p.

Research output: Contribution to journalArticle

Allergy and Immunology
Immunotherapy
Neoplasms
42 Citations (Scopus)

Melanoma cells control antimelanoma CTL responses via interaction between TIGIT and CD155 in the effector phase

Inozume, T., Yaguchi, T., Furuta, J., Harada, K., Kawakami, Y. & Shimada, S., 2016 Jan 1, In : Journal of Investigative Dermatology. 136, 1, p. 255-263 9 p.

Research output: Contribution to journalArticle

T-cells
Melanoma
Cytotoxic T-Lymphocytes
T-Lymphocytes
Tumors
14 Citations (Scopus)

MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model

Ogawa, Y., Morikawa, S., Okano, H., Mabuchi, Y., Suzuki, S., Yaguchi, T., Sato, Y., Mukai, S., Yaguchi, S., Inaba, T., Okamoto, S., Kawakami, Y., Tsubota, K., Matsuzaki, Y. & Shimmura, S., 2016 Jan 26, In : eLife. 5, JANUARY2016, e09394.

Research output: Contribution to journalArticle

T-cells
Stem cells
Mesenchymal Stromal Cells
Bone
Fibrosis
21 Citations (Scopus)

MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p53

Fukaya, R., Ota, S., Yaguchi, T., Matsuzaki, Y., Sugihara, E., Okano, H., Saya, H., Kawakami, Y., Kawase, T., Yoshida, K. & Toda, M., 2016 May 1, In : Cancer Research. 76, 9, p. 2813-2823 11 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Brain Neoplasms
Cell Line
Macrophage Migration-Inhibitory Factors
Heterografts

Personalized cancer immunotherapy: Immune biomarkers and combination immunotherapy

Kawakami, Y., Popivanova, B., Nuchsupha, S., Hayakawa, T., Nakamura, K., Nagumo, H., Katano, I., Kinoshita, T., Tsubota, K., Kamijuku, H., Kawamura, N., Miyazaki, J., Satomi, R., Sugiyama, J., Nishio, H., Noji, S., Kudo-Saito, C., Tsukamoto, N., Sakurai, T., Fujita, T. & 1 others, Yaguchi, T., 2016 Feb 22, Immunotherapy of Cancer: An Innovative Treatment Comes of Age. Springer Japan, p. 349-358 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Immunotherapy
Biomarkers
Neoplasms
T-Lymphocytes
Mutation
42 Citations (Scopus)

Prognostic value of tumor-infiltrating lymphocytes differs depending on histological type and smoking habit in completely resected non-small-cell lung cancer

Kinoshita, T., Muramatsu, R., Fujita, T., Nagumo, H., Sakurai, T., Noji, S., Takahata, E., Yaguchi, T., Tsukamoto, N., Kudo-Saito, C., Hayashi, Y., Kamiyama, I., Ohtsuka, T., Asamura, H. & Kawakami, Y., 2016 Nov 1, In : Annals of oncology : official journal of the European Society for Medical Oncology. 27, 11, p. 2117-2123 7 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Non-Small Cell Lung Carcinoma
Habits
Smoking
Survival
5 Citations (Scopus)

Targeting ALCAM in the cryo-treated tumour microenvironment successfully induces systemic anti-tumour immunity

Kudo-Saito, C., Fuwa, T. & Kawakami, Y., 2016 Jul 1, In : European Journal of Cancer. 62, p. 54-61 8 p.

Research output: Contribution to journalArticle

Activated-Leukocyte Cell Adhesion Molecule
Tumor Microenvironment
Immunity
Neoplasms
Cryosurgery
2015
8 Citations (Scopus)

2015 Guidance on cancer immunotherapy development in early-phase clinical studies

Guidance Development Review Committee, Working Group for Clinical Studies of Cancer Immunotherapy, Working Group for Effector Cell Therapy, Working Group for CMC/Non-clinical Studies, Working Group for Cancer Vaccines and Adjuvants & Working Group for Anti-immune Checkpoint Therapy and Comprehensive Cancer Immunotherapy, and Biostatistics Subcommittee, 2015 Dec 1, In : Cancer Science. 106, 12, p. 1761-1771 11 p.

Research output: Contribution to journalArticle

Immunotherapy
Neoplasms
Cancer Vaccines
Cell- and Tissue-Based Therapy
Immunosuppression
16 Citations (Scopus)

Aberrant myosin 1b expression promotes cell migration and lymph node metastasis of HNSCC

Ohmura, G., Tsujikawa, T., Yaguchi, T., Kawamura, N., Mikami, S., Sugiyama, J., Nakamura, K., Kobayashi, A., Iwata, T., Nakano, H., Shimada, T., Hisa, Y. & Kawakami, Y., 2015 Apr 1, In : Molecular Cancer Research. 13, 4, p. 721-731 11 p.

Research output: Contribution to journalArticle

Myosins
Cell Movement
Lymph Nodes
Neoplasm Metastasis
Cell Surface Extensions