Electron Microscope Laboratory

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2020

Distribution of tight junctions in the primate cochlear lateral wall

Saeki, T., Hosoya, M., Shibata, S., Okano, H., Fujioka, M. & Ogawa, K., 2020 Jan 19, In : Neuroscience Letters. 717, 134686.

Research output: Contribution to journalArticle

1 Citation (Scopus)

GDNF rescues the fate of neural progenitor grafts by attenuating Notch signals in the injured spinal cord in rodents

Khazaei, M., Ahuja, C. S., Nakashima, H., Nagoshi, N., Li, L., Wang, J., Chio, J., Badner, A., Seligman, D., Ichise, A., Shibata, S. & Fehlings, M. G., 2020 Jan 8, In : Science translational medicine. 12, 525

Research output: Contribution to journalArticle

5 Citations (Scopus)

Lem2 and Lnp1 maintain the membrane boundary between the nuclear envelope and endoplasmic reticulum

Hirano, Y., Kinugasa, Y., Osakada, H., Shindo, T., Kubota, Y., Shibata, S., Haraguchi, T. & Hiraoka, Y., 2020 Dec 1, In : Communications biology. 3, 1, 276.

Research output: Contribution to journalArticle

Open Access

Macrophages fine-tune pupil shape during development

Takahashi, M., Misaki, M., Shibata, S., Iga, T., Shindo, T., Tai-Nagara, I., Hirata, A., Ogawa, M., Miyamoto, T., Nakagawa, T., Ema, M., Ichiyama, Y., Shima, D. T., Hozumi, K., Nishimura, S. & Kubota, Y., 2020 Aug 15, In : Developmental Biology. 464, 2, p. 137-144 8 p.

Research output: Contribution to journalArticle

Open Access

Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice

Yamaguchi, T., Higa, K., Yagi-Yaguchi, Y., Ueda, K., Noma, H., Shibata, S., Nagai, T., Tomida, D., Yasu-Mimura, R., Ibrahim, O., Matoba, R., Tsubota, K., Hamrah, P., Yamada, J., Kanekura, K. & Shimazaki, J., 2020 May, In : Science Advances. 6, 20, eaaz5195.

Research output: Contribution to journalArticle

Open Access

Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans

Yamane, M., Sato, S., Shimizu, E., Shibata, S., Hayano, M., Yaguchi, T., Kamijuku, H., Ogawa, M., Suzuki, T., Mukai, S., Shimmura, S., Okano, H., Takeuchi, T., Kawakami, Y., Ogawa, Y. & Tsubota, K., 2020, (Accepted/In press) In : FASEB Journal.

Research output: Contribution to journalArticle

YAP-dependent necrosis occurs in early stages of Alzheimer’s disease and regulates mouse model pathology

Tanaka, H., Homma, H., Fujita, K., Kondo, K., Yamada, S., Jin, X., Waragai, M., Ohtomo, G., Iwata, A., Tagawa, K., Atsuta, N., Katsuno, M., Tomita, N., Furukawa, K., Saito, Y., Saito, T., Ichise, A., Shibata, S., Arai, H., Saido, T. & 7 others, Sudol, M., Muramatsu, S. I., Okano, H., Mufson, E. J., Sobue, G., Murayama, S. & Okazawa, H., 2020 Dec 1, In : Nature communications. 11, 1, 507.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

A Human Induced Pluripotent Stem Cell-Derived Tissue Model of a Cerebral Tract Connecting Two Cortical Regions

Kirihara, T., Luo, Z., Chow, S. Y. A., Misawa, R., Kawada, J., Shibata, S., Khoyratee, F., Vollette, C. A., Volz, V., Levi, T., Fujii, T. & Ikeuchi, Y., 2019 Apr 26, In : iScience. 14, p. 301-311 11 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy

Suzuki, N., Yamaguchi, T., Shibata, S., Nagai, T., Noma, H., Tsubota, K. & Shimazaki, J., 2019 Feb 1, In : American Journal of Ophthalmology. 198, p. 174-180 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Decreased Activity of the Ghrhr and Gh Promoters Causes Dominantly Inherited GH Deficiency in Humanized GH1 Mouse Models

Ariyasu, D., Kubo, E., Higa, D., Shibata, S., Takaoka, Y., Sugimoto, M., Imaizumi, K., Hasegawa, T. & Araki, K., 2019 Nov 1, In : Endocrinology. 160, 11, p. 2673-2691 19 p.

Research output: Contribution to journalArticle

Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers

Serizawa, T., Isotani, A., Matsumura, T., Nakanishi, K., Nonaka, S., Shibata, S., Ikawa, M. & Okano, H., 2019, In : Development (Cambridge). 146, 21, dev174938.

Research output: Contribution to journalArticle

Open Access

Innervation of the tibial epiphysis through the intercondylar foramen

Matsuo, K., Ji, S., Miya, A., Yoda, M., Hamada, Y., Tanaka, T., Takao-Kawabata, R., Kawaai, K., Kuroda, Y. & Shibata, S., 2019 Mar 1, In : Bone. 120, p. 297-304 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Large-area fluorescence and electron microscopic correlative imaging with multibeam scanning electron microscopy

Shibata, S., Iseda, T., Mitsuhashi, T., Oka, A., Shindo, T., Moritoki, N., Nagai, T., Otsubo, S., Inoue, T., Sasaki, E., Akazawa, C., Takahashi, T., Schalek, R., Lichtman, J. W. & Okano, H., 2019 Apr 24, In : Frontiers in Neural Circuits. 13, 29.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Region- and cell type-specific facilitation of synaptic function at destination synapses induced by oligodendrocyte depolarization

Yamazaki, Y., Abe, Y., Shibata, S., Shindo, T., Fujii, S., Ikenaka, K. & Tanaka, K. F., 2019 May 22, In : Journal of Neuroscience. 39, 21, p. 4036-4050 15 p.

Research output: Contribution to journalArticle

Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury

Kojima, K., Miyoshi, H., Nagoshi, N., Kohyama, J., Itakura, G., Kawabata, S., Ozaki, M., Iida, T., Sugai, K., Ito, S., Fukuzawa, R., Yasutake, K., Renault-Mihara, F., Shibata, S., Matsumoto, M., Nakamura, M. & Okano, H., 2019 Mar, In : Stem Cells Translational Medicine. 8, 3, p. 260-270 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Stain-free resolution of unmyelinated axons in transgenic mice using fluorescence microscopy

Mohan, S., Hernandez, I. C., Selig, M. K., Shibata, S. & Jowett, N., 2019 Dec 1, In : Journal of Neuropathology and Experimental Neurology. 78, 12, p. 1178-1180 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury

Hoshino, Y., Nishide, K., Nagoshi, N., Shibata, S., Moritoki, N., Kojima, K., Tsuji, O., Matsumoto, M., Kohyama, J., Nakamura, M. & Okano, H., 2019 Dec 1, In : Scientific reports. 9, 1, 9844.

Research output: Contribution to journalArticle

Open Access

The orientation of a decellularized uterine scaffold determines the tissue topology and architecture of the regenerated uterus in rats

Miki, F., Maruyama, T., Miyazaki, K., Takao, T., Yoshimasa, Y., Katakura, S., Hihara, H., Uchida, S., Masuda, H., Uchida, H., Nagai, T., Shibata, S. & Tanaka, M., 2019 Jan 1, In : Biology of reproduction. 100, 5, p. 1215-1227 13 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

The very-long-chain fatty acid elongase Elo2 rescues lethal defects associated with loss of the nuclear barrier function in fission yeast cells

Kinugasa, Y., Hirano, Y., Sawai, M., Ohno, Y., Shindo, T., Asakawa, H., Chikashige, Y., Shibata, S., Kihara, A., Haraguchi, T. & Hiraoka, Y., 2019 May 1, In : Journal of Cell Science. 132, 10, jcs229021.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Human Oligodendrogenic Neural Progenitor Cells Delivered with Chondroitinase ABC Facilitate Functional Repair of Chronic Spinal Cord Injury

Nori, S., Khazaei, M., Ahuja, C. S., Yokota, K., Ahlfors, J. E., Liu, Y., Wang, J., Shibata, S., Chio, J., Hettiaratchi, M. H., Führmann, T., Shoichet, M. S. & Fehlings, M. G., 2018 Dec 11, In : Stem Cell Reports. 11, 6, p. 1433-1448 16 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Human Spinal Oligodendrogenic Neural Progenitor Cells Promote Functional Recovery After Spinal Cord Injury by Axonal Remyelination and Tissue Sparing

Nagoshi, N., Khazaei, M., Ahlfors, J. E., Ahuja, C. S., Nori, S., Wang, J., Shibata, S. & Fehlings, M. G., 2018 Nov 1, In : Stem cells translational medicine. 7, 11, p. 806-818 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

LOTUS inhibits neuronal apoptosis and promotes tract regeneration in contusive spinal cord injury model mice

Ito, S., Nagoshi, N., Tsuji, O., Shibata, S., Shinozaki, M., Kawabata, S., Kojima, K., Yasutake, K., Hirokawa, T., Matsumoto, M., Takei, K., Nakamura, M. & Okano, H., 2018 Sep 1, In : eNeuro. 5, 5, e0303.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Ocular Surface and Tear Film Characteristics in a Sclerodermatous Chronic Graft-Versus-Host Disease Mouse Model

He, J., Yamane, M., Shibata, S., Fukui, M., Shimizu, E., Yano, T., Mukai, S., Kawakami, Y., Li, S., Tsubota, K. & Ogawa, Y., 2018 Apr 1, In : Cornea. 37, 4, p. 486-494 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Recurrent Spindle Cell Carcinoma Shows Features of Mesenchymal Stem Cells

Ouchi, T., Morikawa, S., Shibata, S., Takahashi, M., Yoshikawa, M., Soma, T., Miyashita, H., Muraoka, W., Kameyama, K., Kawana, H., Arima, Y., Saya, H., Okano, H., Nakagawa, T. & Asoda, S., 2018 Feb 1, (Accepted/In press) In : Journal of Dental Research.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The Japan Monkey Centre Primates Brain Imaging Repository for comparative neuroscience: an archive of digital records including records for endangered species

Sakai, T., Hata, J., Ohta, H., Shintaku, Y., Kimura, N., Ogawa, Y., Sogabe, K., Mori, S., Okano, H. J., Hamada, Y., Shibata, S., Okano, H. & Oishi, K., 2018 Nov 1, In : Primates. 59, 6, p. 553-570 18 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury

Okubo, T., Nagoshi, N., Kohyama, J., Tsuji, O., Shinozaki, M., Shibata, S., Kase, Y., Matsumoto, M., Nakamura, M. & Okano, H., 2018 Dec 11, In : Stem Cell Reports. 11, 6, p. 1416-1432 17 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2017

Enteric Glial Dysfunction Evoked by Apolipoprotein E Deficiency Contributes to Delayed Gastric Emptying

Fukuhara, S., Masaoka, T., Nishimura, S., Nakamura, M., Matsuzaki, J., Tsugawa, H., Miyoshi, S., Mori, H., Kawase, S., Shibata, S., Okano, H., Kanai, T. & Suzuki, H., 2017 Nov 2, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-11 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neural stem cell mediated recovery is enhanced by Chondroitinase ABC pretreatment in chronic cervical spinal cord injury

Suzuki, H., Ahuja, C. S., Salewski, R. P., Li, L., Satkunendrarajah, K., Nagoshi, N., Shibata, S. & Fehlings, M. G., 2017 Aug, In : PloS one. 12, 8, e0182339.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

Morizawa, Y. M., Hirayama, Y., Ohno, N., Shibata, S., Shigetomi, E., Sui, Y., Nabekura, J., Sato, K., Okajima, F., Takebayashi, H., Okano, H. & Koizumi, S., 2017 Dec 1, In : Nature Communications. 8, 1, 28.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development

Kodo, K., Shibata, S., Miyagawa-Tomita, S., Ong, S. G., Takahashi, H., Kume, T., Okano, H., Matsuoka, R. & Yamagishi, H., 2017 Dec 1, In : Scientific Reports. 7, 1, 6771.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Skin-derived precursors as a source of progenitors for corneal endothelial regeneration

Inagaki, E., Hatou, S., Higa, K., Yoshida, S., Shibata, S., Okano, H., Tsubota, K. & Shimmura, S., 2017 Mar 1, In : Stem cells translational medicine. 6, 3, p. 788-798 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

SOX10 expression as well as BRAF and GNAQ/11 mutations distinguish pigmented ciliary epithelium neoplasms from uveal melanomas

Mori, T., Sukeda, A., Sekine, S., Shibata, S., Ryo, E., Okano, H., Suzuki, S. & Hiraoka, N., 2017 Oct, In : Investigative Ophthalmology and Visual Science. 58, 12, p. 5445-5451 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Application of q-space diffusion MRI for the visualization of white matter

Fujiyoshi, K., Hikishima, K., Nakahara, J., Tsuji, O., Hata, J., Konomi, T., Nagai, T., Shibata, S., Kaneko, S., Iwanami, A., Momoshima, S., Takahashi, S., Jinzaki, M., Suzuki, N., Toyama, Y., Nakamura, M. & Okano, H., 2016 Mar 2, In : Journal of Neuroscience. 36, 9, p. 2796-2808 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research

Morikawa, S., Ouchi, T., Shibata, S., Fujimura, T., Kawana, H., Okano, H. & Nakagawa, T., 2016, In : Stem Cells International. 2016, 2849879.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats

Shinozaki, M., Iwanami, A., Fujiyoshi, K., Tashiro, S., Kitamura, K., Shibata, S., Fujita, H., Nakamura, M. & Okano, H., 2016 Dec 1, In : Neuroscience Research. 113, p. 37-47 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Enhanced Functional Recovery from Spinal Cord Injury in Aged Mice after Stem Cell Transplantation through HGF Induction

Takano, M., Kawabata, S., Shibata, S., Yasuda, A., Nori, S., Tsuji, O., Nagoshi, N., Iwanami, A., Ebise, H., Horiuchi, K., Okano, H. & Nakamura, M., 2016 Dec 11, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Fluorescence visualization of the enteric nervous network in a chemically induced aganglionosis model

Fujimura, T., Shibata, S., Shimojima, N., Morikawa, Y., Okano, H. & Kuroda, T., 2016 Mar 1, In : PLoS One. 11, 3, e0150579.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Functional brain mapping using specific sensory-circuit stimulation and a theoretical graph network analysis in mice with neuropathic allodynia

Komaki, Y., Hikishima, K., Shibata, S., Konomi, T., Seki, F., Yamada, M., Miyasaka, N., Fujiyoshi, K., Okano, H. J., Nakamura, M. & Okano, H., 2016 Nov 29, In : Scientific reports. 6, 37802.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury

Kawabata, S., Takano, M., Numasawa-Kuroiwa, Y., Itakura, G., Kobayashi, Y., Nishiyama, Y., Sugai, K., Nishimura, S., Iwai, H., Isoda, M., Shibata, S., Kohyama, J., Iwanami, A., Toyama, Y., Matsumoto, M., Nakamura, M. & Okano, H., 2016 Jan 12, In : Stem Cell Reports. 6, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

In utero exposure to valproic acid induces neocortical dysgenesis via dysregulation of neural progenitor cell proliferation/differentiation

Fujimura, K., Mitsuhashi, T., Shibata, S., Shimozato, S. & Takahashi, T., 2016 Oct 19, In : Journal of Neuroscience. 36, 42, p. 10908-10919 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Obesity-induced kidney injury is attenuated by amelioration of aberrant PHD2 activation in proximal tubules

Futatsugi, K., Tokuyama, H., Shibata, S., Naitoh, M., Kanda, T., Minakuchi, H., Yamaguchi, S., Hayashi, K., Minamishima, Y. A., Yanagita, M., Wakino, S. & Itoh, H., 2016 Nov 9, In : Scientific Reports. 6, 36533.

Research output: Contribution to journalArticle

4 Citations (Scopus)

SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7

Narumi, S., Amano, N., Ishii, T., Katsumata, N., Muroya, K., Adachi, M., Toyoshima, K., Tanaka, Y., Fukuzawa, R., Miyako, K., Kinjo, S., Ohga, S., Ihara, K., Inoue, H., Kinjo, T., Hara, T., Kohno, M., Yamada, S., Urano, H., Kitagawa, Y. & 19 others, Tsugawa, K., Higa, A., Miyawaki, M., Okutani, T., Kizaki, Z., Hamada, H., Kihara, M., Shiga, K., Yamaguchi, T., Kenmochi, M., Kitajima, H., Fukami, M., Shimizu, A., Kudoh, J., Shibata, S., Okano, H., Miyake, N., Matsumoto, N. & Hasegawa, T., 2016 Jul 1, In : Nature genetics. 48, 7, p. 792-797 6 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Sustained effect of hyaluronic acid in subcutaneous administration to the cochlear spiral ganglion

Inagaki, Y., Fujioka, M., Kanzaki, S., Watanabe, K., Oishi, N., Itakura, G., Yasuda, A., Shibata, S., Nakamura, M., James Okano, H., Okano, H. & Ogawa, K., 2016 Apr, In : PloS one. 11, 4, e0153957.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2015

Allogeneic neural stem/progenitor cells derived from embryonic stem cells promote functional recovery after transplantation into injured spinal cord of nonhuman primates

Iwai, H., Shimada, H., Nishimura, S., Kobayashi, Y., Itakura, G., Hori, K., Hikishima, K., Ebise, H., Negishi, N., Shibata, S., Habu, S., Toyama, Y., Nakamura, M. & Okano, H., 2015 Jul 1, In : Stem cells translational medicine. 4, 7, p. 708-719 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development

Lin, Z. Y. C., Hirano, T., Shibata, S., Seki, N. M., Kitajima, R., Sedohara, A., Siomi, M. C., Sasaki, E., Siomi, H., Imamura, M. & Okano, H., 2015 Apr 1, In : Developmental Biology. 400, 1, p. 43-58 16 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

LNGFR+THY-1+ human pluripotent stem cell-derived neural crest-like cells have the potential to develop into mesenchymal stem cells

Ouchi, T., Morikawa, S., Shibata, S., Fukuda, K., Okuno, H., Fujimura, T., Kuroda, T., Ohyama, M., Akamatsu, W., Nakagawa, T. & Okano, H., 2015 Oct 14, (Accepted/In press) In : Differentiation.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Migration and differentiation of transplanted enteric neural crest-derived cells in murine model of Hirschsprung’s disease

Nishikawa, R., Hotta, R., Shimojima, N., Shibata, S., Nagoshi, N., Nakamura, M., Matsuzaki, Y., Okano, H. J., Kuroda, T., Okano, H. & Morikawa, Y., 2015 Aug 23, In : Cytotechnology. 67, 4, p. 661-670 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)