The Sakaguchi Laboratory

Research Output

2020

Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 Dec 1, In : Scientific reports. 10, 1, 8308.

Research output: Contribution to journalArticle

Open Access

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 Feb, In : Gastroenterology. 158, 3, p. 638-651.e8

Research output: Contribution to journalArticle

6 Citations (Scopus)

Development of an Indigo Naturalis Suppository for Topical Induction Therapy in Patients with Ulcerative Colitis

Yoshimatsu, Y., Naganuma, M., Sugimoto, S., Tanemoto, S., Umeda, S., Fukuda, T., Nomura, E., Yoshida, K., Ono, K., Mutaguchi, M., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Takabayashi, K., Ogata, H., Iwao, Y. & Kanai, T., 2020 Jul 1, In : Digestion. 101, 4, p. 492-498 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium

Sasaki, N., Miyamoto, K., Maslowski, K. M., Ohno, H., Kanai, T. & Sato, T., 2020 Jul, In : Gastroenterology. 159, 1, p. 388-390.e5

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Efficacy of apheresis as maintenance therapy for patients with ulcerative colitis in an open-label prospective multicenter randomised controlled trial

for the CAPTAIN study Group, 2020 Apr 1, In : Journal of gastroenterology. 55, 4, p. 390-400 11 p.

Research output: Contribution to journalArticle

Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors

Nakatake, Y., Ko, S. B. H., Sharov, A. A., Wakabayashi, S., Murakami, M., Sakota, M., Chikazawa, N., Ookura, C., Sato, S., Ito, N., Ishikawa-Hirayama, M., Mak, S. S., Jakt, L. M., Ueno, T., Hiratsuka, K., Matsushita, M., Goparaju, S. K., Akiyama, T., Ishiguro, K. I., Oda, M. & 7 others, Gouda, N., Umezawa, A., Akutsu, H., Nishimura, K., Matoba, R., Ohara, O. & Ko, M. S. H., 2020 May 19, In : Cell Reports. 31, 7, 107655.

Research output: Contribution to journalArticle

Open Access

Identification and local manipulation of bone marrow vasculature during intravital imaging

Morikawa, T., Tamaki, S., Fujita, S., Suematsu, M. & Takubo, K., 2020 Dec 1, In : Scientific reports. 10, 1, 6422.

Research output: Contribution to journalArticle

Open Access

Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study

For the INDIGO Study Group, 2020 Feb 1, In : Journal of gastroenterology. 55, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells

Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 Feb 24, In : Developmental Cell. 52, 4, p. 429-445.e10

Research output: Contribution to journalArticle

6 Citations (Scopus)

Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine

Fukuda, T., Naganuma, M., Takabayashi, K., Hagihara, Y., Tanemoto, S., Nomura, E., Yoshimatsu, Y., Sugimoto, S., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Mutaguchi, M., Inoue, N., Ogata, H., Iwao, Y., Abe, T. & Kanai, T., 2020, (Accepted/In press) In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Nagauma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2020, In : International journal of clinical pharmacology and therapeutics. 58, 2, p. 89-102 14 p.

Research output: Contribution to journalArticle

Organoid derivation and orthotopic xenotransplantation for studying human intestinal stem cell dynamics

Sugimoto, S., Fujii, M. & Sato, T., 2020, Methods in Molecular Biology. Humana Press Inc., p. 303-320 18 p. (Methods in Molecular Biology; vol. 2171).

Research output: Chapter in Book/Report/Conference proceedingChapter

Racial disparities in COVID-19 deaths reveal harsh truths about structural inequality in America

Anyane-Yeboa, A., Sato, T. & Sakuraba, A., 2020, (Accepted/In press) In : Journal of Internal Medicine.

Research output: Contribution to journalLetter

Open Access
2 Citations (Scopus)

Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 Aug 1, In : Nature Cell Biology. 22, 8, p. 919-926 8 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Significance of Conducting 2 Types of Fecal Tests in Patients With Ulcerative Colitis

Naganuma, M., Kobayashi, T., Nasuno, M., Motoya, S., Kato, S., Matsuoka, K., Hokari, R., Watanabe, C., Sakamoto, H., Yamamoto, H., Sasaki, M., Watanabe, K., Iijima, H., Endo, Y., Ichikawa, H., Ozeki, K., Tanida, S., Ueno, N., Fujiya, M., Sako, M. & 6 others, Takeuchi, K., Sugimoto, S., Abe, T., Hibi, T., Suzuki, Y. & Kanai, T., 2020 May, In : Clinical Gastroenterology and Hepatology. 18, 5, p. 1102-1111.e5

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases

Fujii, M. & Sato, T., 2020, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalReview article

Open Access

Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Nanki, K., Fujii, M., Shimokawa, M., Matano, M., Nishikori, S., Date, S., Takano, A., Toshimitsu, K., Ohta, Y., Takahashi, S., Sugimoto, S., Ishimaru, K., Kawasaki, K., Nagai, Y., Ishii, R., Yoshida, K., Sasaki, N., Hibi, T., Ishihara, S., Kanai, T. & 1 others, Sato, T., 2020 Jan 9, In : Nature. 577, 7789, p. 254-259 6 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2019

Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey

INDIGO survey Group, 2019 Oct 1, In : Journal of gastroenterology. 54, 10, p. 891-896 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation

Watanuki, S., Kobayashi, H., Sorimachi, Y., Yamamoto, M., Okamoto, S. & Takubo, K., 2019 Jun 18, In : Biochemical and Biophysical Research Communications. 514, 1, p. 287-294 8 p.

Research output: Contribution to journalArticle

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 May 16, In : Oncogene. 38, 20, p. 3962-3969 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Fukuda, T., Naganuma, M., Sugimoto, S., Ono, K., Nanki, K., Mizuno, S., Kimura, K., Mutaguchi, M., Nakazato, Y., Takabayashi, K., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2019 Mar 14, In : Inflammatory bowel diseases. 25, 4, p. 782-788 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 2019 Jul 2, In : Cell Reports. 28, 1, p. 145-158.e9

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses

Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y. I., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S. & 3 others, Takubo, K., Dohi, T. & Hase, K., 2019 Aug 22, In : Cell. 178, 5, p. 1072-1087.e14

Research output: Contribution to journalArticle

20 Citations (Scopus)

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P. S., Taniki, N., Yamaguchi, A., Kanamori, M., Kamada, N., Hattori, M., Ashida, H., Sakamoto, M., Atarashi, K., Narushima, S., Yoshimura, A., Honda, K. & 2 others, Sato, T. & Kanai, T., 2019 Mar 1, In : Nature Microbiology. 4, 3, p. 492-503 12 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H. & Akamatsu, W., 2019 Feb 12, In : Stem cell reports. 12, 2, p. 305-318 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S. B. H., Itoh, H. & Ko, M. S. H., 2019 Dec 1, In : Scientific reports. 9, 1, 913.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 Jul, In : Cancer science. 110, 7, p. 2156-2165 10 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia

Sugimoto, S., Shimoda, M., Iwao, Y., Mutaguchi, M., Nanki, K., Mizuno, S., Kameyama, K., Ogata, H., Naganuma, M. & Kanai, T., 2019 Nov 1, In : Digestive Endoscopy. 31, 6, p. 706-711 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019, In : eNeuro. 6, 5, ENEURO.0403-18.2019.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. & 5 others, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 Oct 1, In : Journal of Gastroenterology and Hepatology (Australia). 34, 10, p. 1751-1757 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 Jan 1, In : International immunology. 31, 5, p. 335-347 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids

Fujii, M., Clevers, H. & Sato, T., 2019 Feb 1, In : Gastroenterology. 156, 3, p. 562-576 15 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Higashikuse, Y., Mittal, N., Arimura, T., Yoon, S. H., Oda, M., Enomoto, H., Kaneda, R., Hattori, F., Suzuki, T., Kawakami, A., Gasch, A., Furukawa, T., Labeit, S., Fukuda, K., Kimura, A. & Makino, S., 2019, In : DMM Disease Models and Mechanisms. 12, 11, dmm.041103.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

Advancing Intestinal Organoid Technology Toward Regenerative Medicine

Nakamura, T. & Sato, T., 2018, In : CMGH. 5, 1, p. 51-60 10 p.

Research output: Contribution to journalReview article

36 Citations (Scopus)

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

Kanaya, T., Sakakibara, S., Jinnohara, T., Hachisuka, M., Tachibana, N., Hidano, S., Kobayashi, T., Kimura, S., Iwanaga, T., Nakagawa, T., Katsuno, T., Kato, N., Akiyama, T., Sato, T., Williams, I. R. & Ohno, H., 2018 Feb 1, In : Journal of Experimental Medicine. 215, 2, p. 501-519 19 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis

Nanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S. & 3 others, Koo, B. K., Kanai, T. & Sato, T., 2018 Aug 9, In : Cell. 174, 4, p. 856-869.e17

Research output: Contribution to journalArticle

44 Citations (Scopus)

Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis

INDIGO Study Group, 2018 Mar 1, In : Gastroenterology. 154, 4, p. 935-947 13 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. B. H. & Ko, M. S. H., 2018 Dec 1, In : Scientific reports. 8, 1, 1189.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors 10 Technology 1004 Medical Biotechnology

Ida, H., Akiyama, T., Ishiguro, K., Goparaju, S. K., Nakatake, Y., Chikazawa-Nohtomi, N., Sato, S., Kimura, H., Yokoyama, Y., Nagino, M., Ko, M. S. H. & Ko, S. B. H., 2018 Oct 25, In : Stem Cell Research and Therapy. 9, 1, 277.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential

Loomans, C. J. M., Williams Giuliani, N., Balak, J., Ringnalda, F., van Gurp, L., Huch, M., Boj, S. F., Sato, T., Kester, L., de Sousa Lopes, S. M. C., Roost, M. S., Bonner-Weir, S., Engelse, M. A., Rabelink, T. J., Heimberg, H., Vries, R. G. J., van Oudenaarden, A., Carlotti, F., Clevers, H. & de Koning, E. J. P., 2018 Mar 13, In : Stem cell reports. 10, 3, p. 712-724 13 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Factors predicting the therapeutic response to infliximab during maintenance therapy in Japanese patients with Crohn's disease

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2018 Oct, In : PloS one. 13, 10, e0204632.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki, K., Mizuno, S., Matsuoka, K., Ono, K., Sugimoto, S., Kiyohara, H., Arai, M., Nakashima, M., Takeshita, K., Saigusa, K., Senoh, M., Fukuda, T., Naganuma, M., Kato, H., Suda, W., Hattori, M. & Kanai, T., 2018, In : Intestinal Research. 16, 1, p. 142-146 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation

Baba, M., Endoh, M., Ma, W., Toyama, H., Hirayama, A., Nishikawa, K., Takubo, K., Hano, H., Hasumi, H., Umemoto, T., Hashimoto, M., Irie, N., Esumi, C., Kataoka, M., Nakagata, N., Soga, T., Yao, M., Kamba, T., Minami, T., Ishii, M. & 1 others, Suda, T., 2018 Oct, In : Journal of Bone and Mineral Research. 33, 10, p. 1785-1798 14 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models

Kawasaki, K., Fujii, M. & Sato, T., 2018 Feb 26, In : Disease models & mechanisms. 11, 2

Research output: Contribution to journalReview article

9 Citations (Scopus)

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells

Si, S., Nakajima-Takagi, Y., Iga, T., Tsuji, M., Hou, L., Oshima, M., Koide, S., Saraya, A., Yamazaki, S., Takubo, K., Kubota, Y., Minamino, T. & Iwama, A., 2018 Jul, In : Experimental Hematology. 63, p. 41-51.e1

Research output: Contribution to journalArticle

4 Citations (Scopus)

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 Dec 6, In : Cell Stem Cell. 23, 6, p. 787-793.e6

Research output: Contribution to journalArticle

45 Citations (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 Mar 1, In : Cell stem cell. 22, 3, p. 454-467.e6

Research output: Contribution to journalArticle

107 Citations (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 Dec 1, In : Scientific reports. 8, 1, 2821.

Research output: Contribution to journalArticle

13 Citations (Scopus)