The Sakaguchi Laboratory

Research Output

1992

Two types of murine CD34 mRNA generated by alternative splicing

Suda, J., Sudo, T., Ito, M., Ohno, N., Yamaguchi, Y. & Suda, T., 1992, In : Blood. 79, 9, p. 2288-2295 8 p.

Research output: Contribution to journalArticle

Open Access
59 Citations (Scopus)
1993

ASYNCHRONOUS EXPRESSION OF c‐kit AND CD34 ON LEUKAEMIC BLASTS

MUROI, K., Nakamura, M., Amemiya, Y., Suda, T. & Miura, Y., 1993 Nov, In : British Journal of Haematology. 85, 3, p. 633-634 2 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)

Expression of c-kit mRNA and protein during the differentiation of human hematopoietic progenitor cells

Yamaguchi, Y., Gunji, Y., Nakamura, M., Hayakawa, K., Maeda, M., Osawa, H., Nagayoshi, K., Kasahara, T. & Suda, T., 1993 Dec 1, In : Experimental Hematology. 21, 9, p. 1233-1238 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Expression of sialyl-Lewis(x) in CD34-positive leukemic blasts [3]

Muroi, K., Suda, T., Nojiri, H., Amemiya, Y., Miura, Y. & Hakomori, S. I., 1993 Jan 1, In : Leukemia. 7, 2, p. 336-337 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Expression of sialyl-lewisx on CD10-positive normal bone marrow cells

Muroi, K., Nakamura, M., Suda, T., Miura, Y. & Hakomori, S. I., 1993 Apr, In : Leukemia Research. 17, 4, p. 389-390 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Human primitive hematopoietic progenitor cells are more enriched in KIT(low) cells than in KIT(high) cells

Gunji, Y., Nakamura, M., Osawa, H., Nagayoshi, K., Nakauchi, H., Miura, Y., Yanagisawa, M. & Suda, T., 1993 Jan 1, In : Blood. 82, 11, p. 3283-3289 7 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells

Iwama, A., Hamaguchi, I., Hashiyama, M., Murayama, Y., Yasunaga, K. & Suda, T., 1993 Aug 31, In : Biochemical and Biophysical Research Communications. 195, 1, p. 301-309 9 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)

Rat stem cell factor and IL-6 preferentially support the proliferation of c-kit-positive murine hemopoietic cells rather than their differentiation

Miura, N., Okada, S., Zsebo, K. M., Miura, Y. & Suda, T., 1993 Dec 1, In : Experimental Hematology. 21, 1, p. 143-149 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation

Hoshino, Y., Hatake, K., Mimuro, J., Nakamura, Y., Ashizawa, N., Tsunoda, S., Muroi, K., Suda, T., Yoshida, M. & Miwa, A., 1993 Jun, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 34, 6, p. 718-722 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Role of c-kit receptor in the diagnosis of leukemia: A relationship between expression of c-kit receptor and that of CD33 in leukemic blasts

Muroi, K., Amemiya, Y., Miura, Y., Nakamura, M. & Suda, T., 1993 Aug, In : Leukemia Research. 17, 8, p. 725-726 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Sequential analysis of hematopoietic reconstitution achieved by transplantation of hematopoietic stem cells

Okada, S., Nagayoshi, K., Nakauchi, H., Nishikawa, S. I., Miura, Y. & Suda, T., 1993, In : Blood. 81, 7, p. 1720-1725 6 p.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Treatment of 71 adult acute lymphoblastic leukemia

Yoshida, M., Kurata, H., Tsunoda, S., Iwama, A., Suzuki, T., Akutsu, M., Imagawa, S., Tsunoda, J., Furukawa, Y., Komatsu, N., Muroi, K., Ohta, M., Ohsaka, A., Hatake, K., Suda, K., Takagi, S., Sato, Y., Suda, T. & Kitagawa, S., 1993 Jan 1, In : Japanese Journal of Cancer and Chemotherapy. 20, 12, p. 1827-1833 7 p.

Research output: Contribution to journalArticle

1994

A case of acute promyelocytic leukemia (APL) with myeloblastoma in the oral cavity developing after receiving all-trans retinoic acid (ATRA)

Izumi, T., Hatake, K., Imagawa, S., Yoshikda, M., Ohta, M., Sasaki, R., Miwa, A., Suda, T., Sakamoto, S. & Miura, Y., 1994 Jun, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 35, 6, p. 598-602 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization of mouse non-receptor tyrosine kinase gene, HYL

Hamaguchi, I., Iwama, A., Yamaguchi, N., Sakano, S., Matsuda, Y. & Suda, T., 1994 Nov 1, In : Oncogene. 9, 11, p. 3371-3374 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Expression of sialosyl-Tn in colony-forming unit-erythroid, erythroblasts, B cells, and a subset of CD4+ cells

Muroi, K., Suda, T., Nakamura, M., Okada, S., Nojiri, H., Amemiya, Y., Miura, Y. & Hakomori, S. I., 1994 Jan 1, In : Blood. 83, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

Maps from two interspecific backcross DNA panels available as a community genetic mapping resource

Rowe, L. B., Nadeau, J. H., Turner, R., Frankel, W. N., Letts, V. A., Eppig, J. T., Ko, M. S. H., Thurston, S. J. & Birkenmeier, E. H., 1994 May, In : Mammalian Genome. 5, 5, p. 253-274 22 p.

Research output: Contribution to journalArticle

626 Citations (Scopus)

Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase)

Sakano, S., Iwama, A., Inazawa, J., Ariyama, T., Ohno, M. & Suda, T., 1994 Apr 1, In : Oncogene. 9, 4, p. 1155-1161 7 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
1995

Expression of c-kit receptor (CD 117) and CD34 in leukemic cells

Muroi, K., Nakamurat, M., Amemiya, Y., Suda, T. & Miura, Y., 1995 Jan 1, In : Leukemia and Lymphoma. 16, 3-4, p. 297-305 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells

Ilic, D., Furuta, Y., Suda, T., Atsumi, T., Fujimoto, J., Ikawa, Y., Yamamoto, T. & Aizawa, S., 1995 Apr 6, In : Biochemical and Biophysical Research Communications. 209, 1, p. 300-309 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Functional molecules expressed in hematopoietic stem cells

Suda, T., 1995 Mar, In : Seikagaku. The Journal of Japanese Biochemical Society. 67, 3, p. 190-203 14 p.

Research output: Contribution to journalReview article

Interleukin-13 selectively suppresses the growth of human macrophage progenitors at the late stage

Sakamoto, O., Hashiyama, M., Minty, A., Ando, M. & Suda, T., 1995, In : Blood. 85, 12, p. 3487-3493 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils

Koyanagi, H., Wakasugi, N., Yoshimatsu, K., Takashima, Y., Yodoi, J. J., Momoi, M., Suda, T., Kasahara, T. & Yamaguchi, Y., 1995 Jan 1, In : Biochemical and Biophysical Research Communications. 213, 3, p. 1140-1147 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein

Iwama, A., Wang, M. H., Yamaguchi, N., Ohno, N., Okano, K., Sudo, T., Takeya, M., Gervais, F., Morissette, C., Leonard, E. J. & Suda, T., 1995 Nov 1, In : Blood. 86, 9, p. 3394-3403 10 p.

Research output: Contribution to journalArticle

Open Access
92 Citations (Scopus)

The murine stk gene product, a transmembrane protein tyrosine kinase, is a receptor for macrophage-stimulating protein

Wang, M. H., Iwama, A., Skeel, A., Suda, T. & Leonard, E. J., 1995 Apr 25, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 9, p. 3933-3937 5 p.

Research output: Contribution to journalArticle

Open Access
71 Citations (Scopus)

Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome

Yamagata, T., Miwa, A., Eguchi, M., Kitagawa, S., Muroi, K., Hatake, K., Suda, T., Sakamoto, S. & Miura, Y., 1995 Mar, In : British Journal of Haematology. 89, 3, p. 650-652 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
1996

Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice

Hamaguchi, I., Yamaguchi, N., Suda, J., Iwama, A., Hirao, A., Hashiyama, M., Aizawa, S. I. & Suda, T., 1996 Jul 5, In : Biochemical and Biophysical Research Communications. 224, 1, p. 172-179 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells

Sakano, S., Serizawa, R., Inada, T., Iwama, A., Itoh, A., Kato, C., Shimizu, Y., Shinkai, F., Shimizu, R., Kondo, S., Ohno, M. & Suda, T., 1996 Sep 30, In : Oncogene. 13, 4, p. 813-822 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Impaired development of CD4+ CD8+ thymocytes by csk-'knock-in' into fyn locus

Kanazawa, S., Ilić, D., Hashiyama, M., Okada, M., Noumura, T., Aizawa, S. & Suda, T., 1996 Aug 10, In : Oncogene. 13, 1, p. 199-204 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells

Kurihara, N., Iwama, A., Tatsumi, J., Ikeda, K. & Suda, T., 1996 May 1, In : Blood. 87, 9, p. 3704-3710 7 p.

Research output: Contribution to journalArticle

Open Access
75 Citations (Scopus)

Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes

Wang, M. H., Dlugosz, A. A., Sun, Y., Suda, T., Skeel, A. & Leonard, E. J., 1996 Jul 10, In : Experimental Cell Research. 226, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain

Ohbo, K., Suda, T., Hashiyama, M., Mantani, A., Ikebe, M., Miyakawa, K., Moriyama, M., Nakamura, M., Katsuki, M., Takahashi, K., Yamamura, K. I. & Sugamura, K., 1996 Feb 1, In : Blood. 87, 3, p. 956-967 12 p.

Research output: Contribution to journalArticle

Open Access
196 Citations (Scopus)

Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system

Ohshiro, K., Iwama, A., Matsuno, K., Ezaki, T., Sakamoto, O., Hamaguchi, I., Takasu, N. & Suda, T., 1996 Oct 3, In : Biochemical and Biophysical Research Communications. 227, 1, p. 273-280 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

p59fyn-p125FAK cooperation in Development of CD4+CD8+ Thymocytes

Kanazawa, S., Ilić, D., Hashiyama, M., Noumura, T., Yamamoto, T., Suda, T. & Aizawa, S., 1996 Feb 1, In : Blood. 87, 3, p. 865-870 6 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice

Iwamoto, N., Kawaguchi, T., Horikawa, K., Nagakura, S., Kagimoto, T., Suda, T., Takatsuki, K. & Nakakuma, H., 1996 Jun 15, In : Blood. 87, 12, p. 4944-4948 5 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Selkctive expression of a receptor tyrosine kinase, HTK on human erythroid progenitor cells

Inada, T., Iwama, A., Sakano, S., Ohno, M. & Suda, T., 1996 Dec 1, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development

Ohta, K., Nakamura, M., Hirokawa, K., Tanaka, S., Iwama, A., Suda, T., Ando, M. & Tanaka, H., 1996 Jan, In : Mechanisms of Development. 54, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
1997

Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase.

Correll, P. H., Iwama, A., Tondat, S., Mayrhofer, G., Suda, T. & Bernstein, A., 1997 Feb, In : Genes and function. 1, 1, p. 69-83 15 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Expression and characterization of endothelial cell receptors in hematopietic cells

Hamaauchi, I., Nisflio, H., Inada, T., Sato, A., Takakura, N., Iwama, A., Suda, J. & Suda, T., 1997 Dec 1, In : Experimental Hematology. 25, 8, 1 p.

Research output: Contribution to journalArticle

Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells

Yano, M., Iwama, A., Nishio, H., Suda, J., Takada, G. & Suda, T., 1997 Jun 15, In : Blood. 89, 12, p. 4317-4326 10 p.

Research output: Contribution to journalArticle

Open Access
79 Citations (Scopus)

Focal adhesion kinase upregulated by granulocyte-macrophage colony- stimulating factor but not by interleukin-3 in differentiating myeloid cells

Kume, A., Nishiura, H., Suda, J. & Suda, T., 1997 May 1, In : Blood. 89, 9, p. 3434-3442 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Functional characterization of the promoter for the gene encoding murine CD34

Yamaguchia, Y., Tenen, D. G. & Suda, T., 1997 Feb 7, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1350, 2, p. 141-146 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice

Ikebe, M., Miyakawa, K., Takahashi, K., Ohbo, K., Nakamura, M., Sugamura, K., Suda, T., Yamamura, K. I. & Tomita, K., 1997, In : International Journal of Experimental Pathology. 78, 3, p. 133-148 16 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Receptor tyrosine kinases involved in hematopoietic progenitor cells

Suda, T., Iwama, A., Hashiyama, M., Sakano, S. & Ohno, M., 1997 Jan 1, In : Leukemia. 11, SUPPL. 3, p. 451-453 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility

Sakamoto, O., Iwama, A., Amitani, R., Takehara, T., Yamaguchi, N., Yamamoto, T., Masuyama, K., Yamanaka, T., Ando, M. & Suda, T., 1997 Feb 15, In : Journal of Clinical Investigation. 99, 4, p. 701-709 9 p.

Research output: Contribution to journalArticle

Open Access
67 Citations (Scopus)

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains

Srivastava, A. K., Pispa, J., Hartung, A. J., Du, Y., Ezer, S., Jenks, T., Shimada, T., Pekkanen, M., Mikkola, M. L., Ko, M. S. H., Thesleff, I., Kere, J. & Schlessinger, D., 1997 Nov 25, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 24, p. 13069-13074 6 p.

Research output: Contribution to journalArticle

230 Citations (Scopus)

Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets

Hirao, A., Hamaguchi, I., Suda, T. & Yamaguchi, N., 1997 May 1, In : EMBO Journal. 16, 9, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
1998

Analysis of C-KIT, TIE and HTK expression on leukemic cells using flow cytometry: A preliminary report

Muroi, K., Suda, T., Kawano, C., Amemiya, Y., Eguchi, M., Miura, Y. & Ozawa, K., 1998 Sep 1, In : Leukemia Research. 22, 9, p. 827-830 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A systematic molecular genetic approach to study mammalian germline development

Abe, K., Ko, M. S. H. & Macgregor, G. R., 1998, In : International Journal of Developmental Biology. 42, 7, p. 1051-1065 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells

Sato, A., Iwama, A., Takakura, N., Nishio, H., Yancopoulos, G. D. & Suda, T., 1998 Aug 17, In : International immunology. 10, 8, p. 1217-1227 11 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

Takakura, N., Huang, X. L., Naruse, T., Hamaguchi, I., Dumont, D. J., Yancopoulos, G. D. & Suda, T., 1998 Nov, In : Immunity. 9, 5, p. 677-686 10 p.

Research output: Contribution to journalArticle

Open Access
252 Citations (Scopus)