The Sakaguchi Laboratory

Research Output

Article

[Regulation of hematopoietic stem cells in niche signaling].

Matsumoto, Y. & Suda, T., 2012 Apr, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression

Sakai, S., Takaishi, H., Matsuzaki, K., Kaneko, H., Furukawa, M., Miyauchi, Y., Shiraishi, A., Saito, K., Tanaka, A., Taniguchi, T., Suda, T., Miyamoto, T. & Toyama, Y., 2009 Nov, In : Journal of Bone and Mineral Metabolism. 27, 6, p. 643-652 10 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

5-Hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells

Suzuki, A., Naruse, S., Kitagawa, M., Ishiguro, H., Yoshikawa, T., Ko, S. B. H., Yamamoto, A., Hamada, H. & Hayakawa, T., 2001, In : Journal of Clinical Investigation. 108, 5, p. 749-756 8 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)

Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria

Kamada, N., Hisamatsu, T., Okamoto, S., Sato, T., Matsuoka, K., Arai, K., Nakai, T., Hasegawa, A., Inoue, N., Watanabe, N., Akagawa, K. S. & Hibi, T., 2005 Nov 15, In : Journal of Immunology. 175, 10, p. 6900-6908 9 p.

Research output: Contribution to journalArticle

Open Access
169 Citations (Scopus)

A case of acute promyelocytic leukemia (APL) with myeloblastoma in the oral cavity developing after receiving all-trans retinoic acid (ATRA)

Izumi, T., Hatake, K., Imagawa, S., Yoshikda, M., Ohta, M., Sasaki, R., Miwa, A., Suda, T., Sakamoto, S. & Miura, Y., 1994 Jun, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 35, 6, p. 598-602 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A case of lung cancer associated with granulocytosis and production of colony-stimulating activity by the tumour

Suda, T., Miura, Y., Mizoguchi, H., Kubota, K. & Takaku, F., 1980 Jun, In : British Journal of Cancer. 41, 6, p. 980-984 5 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

Fujii, M., Shimokawa, M., Date, S., Takano, A., Matano, M., Nanki, K., Ohta, Y., Toshimitsu, K., Nakazato, Y., Kawasaki, K., Uraoka, T., Watanabe, T., Kanai, T. & Sato, T., 2016 Jun 2, In : Cell stem cell. 18, 6, p. 827-838 12 p.

Research output: Contribution to journalArticle

216 Citations (Scopus)

A common signaling pathway via Syk and Lyn tyrosine kinases generated from capping of the sialomucins CD34 and CD43 in immature hematopoietic cells

Tada, J. I., Omine, M., Suda, T. & Yamaguchi, N., 1999 Jun 1, In : Blood. 93, 11, p. 3723-3735 13 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance

Livigni, A., Peradziryi, H., Sharov, A. A., Chia, G., Hammachi, F., Migueles, R. P., Sukparangsi, W., Pernagallo, S., Bradley, M., Nichols, J., Ko, M. S. H. & Brickman, J. M., 2013 Nov 18, In : Current Biology. 23, 22, p. 2233-2244 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function

Nagamachi, A., Nakata, Y., Ueda, T., Yamasaki, N., Ebihara, Y., Tsuji, K., Honda, Z. I., Takubo, K., Suda, T., Oda, H., Inaba, T. & Honda, H., 2014 Jan 31, In : PloS one. 9, 1, e87425.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo

Uchiba, M., Okajima, K., Oike, Y., Ito, Y., Fukudome, K., Isobe, H. & Suda, T., 2004 Jul 9, In : Circulation research. 95, 1, p. 34-41 8 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress

Nishiyama, A., Dey, A., Tamura, T., Ko, M. & Ozato, K., 2012 May 2, In : PloS one. 7, 5, e34719.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Active and water-soluble form of lipidated wnt protein is maintained by a serum glycoprotein afamin/α-albumin

Mihara, E., Hirai, H., Yamamoto, H., Tamura-Kawakami, K., Matano, M., Kikuchi, A., Sato, T. & Takagi, J., 2016 Feb 23, In : eLife. 5, FEBRUARY2016, e11621.

Research output: Contribution to journalArticle

59 Citations (Scopus)

A CTX family cell adhesion molecule, JAM4, is expressed in stem cell and progenitor cell populations of both male germ cell and hematopoietic cell lineages

Nagamatsu, G., Ohmura, M., Mizukami, T., Hamaguchi, I., Hirabayashi, S., Yoshida, S., Hata, Y., Suda, T. & Ohbo, K., 2006 Nov, In : Molecular and cellular biology. 26, 22, p. 8498-8506 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Acute Idiopathic Polyneuritis with Ophthalmoplegia, Ataxia, and Areflexia (Fisher's Syndrome). A Case Report and a Review of the Literature

Suda, T., Nihei, K. & Kamoshita, S., 1979 Jan 1, In : NO TO HATTATSU. 11, 4, p. 321-327 7 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function

Cui, D., Arima, M., Takubo, K., Kimura, T., Horiuchi, K., Minagawa, T., Matsuda, S. & Ikeda, E., 2015 Aug 5, In : Scientific reports. 5, 12796.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey

INDIGO survey Group, 2019 Oct 1, In : Journal of gastroenterology. 54, 10, p. 891-896 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

AE4 is a DIDS-sensitive Cl-/HCO3- exchanger in the basolateral membrane of the renal CCD and the SMG duct

Ko, S. B. H., Luo, X., Hager, H., Rojek, A., Choi, J. Y., Licht, C., Suzuki, M., Muallem, S., Nielsen, S. & Ishibashi, K., 2002 Oct, In : American Journal of Physiology - Cell Physiology. 283, 4 52-4, p. C1206-C1218

Research output: Contribution to journalArticle

88 Citations (Scopus)

A finger sweat chloride test for the detection of a high-risk group of chronic pancreatitis

Naruse, S., Ishiguro, H., Suzuki, Y., Fujiki, K., Ko, S. B. H., Mizuno, N., Takemura, T., Yamamoto, A., Yoshikawa, T., Jin, C., Suzuki, R., Kitagawa, M., Tsuda, T., Kondo, T. & Hayakawa, T., 2004 Mar, In : Pancreas. 28, 3, p. e80-e85

Research output: Contribution to journalArticle

14 Citations (Scopus)

AGEMAP: A gene expression database for aging in mice

Zahn, J. M., Poosala, S., Owen, A. B., Ingram, D. K., Lustig, A., Carter, A., Weeraratna, A. T., Taub, D. D., Gorospe, M., Mazan-Mamczarz, K., Lakatta, E. G., Boheler, K. R., Xu, X., Mattson, M. P., Falco, G., Ko, M. S. H., Schlessinger, D., Firman, J., Kummerfeld, S. K., Wood, W. H. & 3 others, Zonderman, A. B., Kim, S. K. & Becker, K. G., 2007 Nov, In : PLoS Genetics. 3, 11, p. 2326-2337 12 p.

Research output: Contribution to journalArticle

248 Citations (Scopus)

A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development

Sherman-Baust, C. A., Kuhn, E., Valle, B. L., Shih, I. M., Kurman, R. J., Wang, T. L., Amano, T., Ko, M. S., Miyoshi, I., Araki, Y., Lehrmann, E., Zhang, Y., Becker, K. G. & Morin, P. J., 2014 Jul, In : Journal of Pathology. 233, 3, p. 228-237 10 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

A germ cell-specific gene, Prmt5, works in somatic cell reprogramming

Nagamatsu, G., Kosaka, T., Kawasumi, M., Kinoshita, T., Takubo, K., Akiyama, H., Sudo, T., Kobayashi, T., Oya, M. & Suda, T., 2011 Mar 25, In : Journal of Biological Chemistry. 286, 12, p. 10641-10648 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Aging and cancer in hematopoietic stem cells

Nitta, E. & Suda, T., 2009 May 1, In : Japanese Journal of Geriatrics. 46, 3, p. 195-199 5 p.

Research output: Contribution to journalArticle

Aging of oocyte, ovary, and human reproduction

Ottolenghi, C., Uda, M., Hamatani, T., Crisponi, L., Garcia, J. E., Ko, M., Pilia, G., Sforza, C., Schlessinger, D. & Forabosco, A., 2004, In : Annals of the New York Academy of Sciences. 1034, p. 117-131 15 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

A Highly Inducible System of Gene Expression by Positive Feedback Production of Glucocorticoid Receptors

Ko, M. S. H. & Takano, T., 1989 Mar, In : DNA. 8, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 I. Concept and diagnosis of autoimmune pancreatitis

Okazaki, K., Kawa, S., Kamisawa, T., Ito, T., Inui, K., Irie, H., Nishino, T., Notohara, K., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T., Kubo, K., Ohara, H., Irisawa, A., Fujinaga, Y., Hasebe, O. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014 Apr, In : Journal of gastroenterology. 49, 4, p. 567-588 22 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 II. Extrapancreatic lesions, differential diagnosis

Kawa, S., Okazaki, K., Kamisawa, T., Kubo, K., Ohara, H., Hasebe, O., Fujinaga, Y., Irisawa, A., Notohara, K., Ito, T., Inui, K., Irie, H., Nishino, T., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014 May, In : Journal of gastroenterology. 49, 5, p. 765-784 20 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 III. Treatment and prognosis of autoimmune pancreatitis

Kamisawa, T., Okazaki, K., Kawa, S., Ito, T., Inui, K., Irie, H., Nishino, T., Notohara, K., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T., Kubo, K., Ohara, H., Irisawa, A., Fujinaga, Y., Hasebe, O. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014 Jun, In : Journal of gastroenterology. 49, 6, p. 961-970 10 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

A molecular mechanism for aberrant CFTR-dependent HCO3- transport in cystic fibrosis

Ko, S. B. H., Shcheynikov, N., Choi, J. Y., Luo, X., Ishibashi, K., Thomas, P. J., Kim, J. Y., Kim, K. H., Lee, M. G., Naruse, S. & Muallem, S., 2002 Nov 1, In : EMBO Journal. 21, 21, p. 5662-5672 11 p.

Research output: Contribution to journalArticle

263 Citations (Scopus)

A murine dopamine neuron-specific cDNA library and microarray: Increased COX1 expression during methamphetamine neurotoxicity

Barrett, T., Xie, T., Piao, Y., Dillon-Carter, O., Kargul, G. J., Lim, M. K., Chrest, F. J., Wersto, R., Rowley, D. L., Juhaszova, M., Zhou, L., Vawter, M. P., Becker, K. G., Cheadle, C., Wood, W. H., McCann, U. D., Freed, W. J., Ko, M. S., Ricaurte, G. A. & Donovan, D. M., 2001, In : Neurobiology of Disease. 8, 5, p. 822-833 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Analysis of C-KIT, TIE and HTK expression on leukemic cells using flow cytometry: A preliminary report

Muroi, K., Suda, T., Kawano, C., Amemiya, Y., Eguchi, M., Miura, Y. & Ozawa, K., 1998 Sep 1, In : Leukemia Research. 22, 9, p. 827-830 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice

Hamaguchi, I., Yamaguchi, N., Suda, J., Iwama, A., Hirao, A., Hashiyama, M., Aizawa, S. I. & Suda, T., 1996 Jul 5, In : Biochemical and Biophysical Research Communications. 224, 1, p. 172-179 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Analysis of eosinophil-predominant colonies formed by human hemopoietic precursor cells in the presence of purified interleukin-5

Yamaguchi, Y., Suda, T., Suda, J., Eguchi, M., Miura, Y., Mita Hitoshi, S. Y., Tominaga, A. & Takatsu, K., 1990 Jan 1, In : Acta Haematologica Japonica. 53, 4, p. 688-698 11 p.

Research output: Contribution to journalArticle

Analysis of the survival of mature human eosinophils: Interleukin-5 prevents apoptosis in mature human eosinophils

Yamaguchi, Y., Suda, T., Ohta, S., Tominaga, K., Miura, Y. & Kasahara, T., 1991 Jan 1, In : Blood. 78, 10, p. 2542-2547 6 p.

Research output: Contribution to journalArticle

Open Access
256 Citations (Scopus)

An auto-inducible vector conferring high glucocorticoid inducibility upon stable transformant cells

Ko, M. S. H., Naomi, T., Norifumi, S. & Toshiya, T., 1989 Dec 14, In : Gene. 84, 2, p. 383-389 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

An Autopsy Case of Reye Syndrome during a Remission of Malignant Lymphoma

Hamano, Y., Suda, T., Kamoshita, S. & Koike, M., 1983 Jan, In : NO TO HATTATSU. 15, 5, p. 438-444 7 p.

Research output: Contribution to journalArticle

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity

Shirakawa, T., Yaman-Deveci, R., Tomizawa, S. I., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T. & Ohbo, K., 2013 Sep 1, In : Development (Cambridge). 140, 17, p. 3565-3576 12 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs

Ko, M. S. H., 1990 Oct 11, In : Nucleic acids research. 18, 19, p. 5705-5711 7 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

A new hematopoietic cell line, KMT-2, having human interleukin-3 receptors

Tamura, S., Sugawara, M., Tanaka, H., Tezuka, E., Nihira, S., Miyamoto, C., Suda, T. & Ohta, Y., 1990, In : Blood. 76, 3, p. 501-507 7 p.

Research output: Contribution to journalArticle

Open Access
8 Citations (Scopus)

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy

Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang, W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O. J. & Koh, G. Y., 2013 Sep 18, In : Science translational medicine. 5, 203, 203ra127.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Angiopoietin-like protein 2 is a multistep regulator of inflammatory neovascularization in a murine model of age-related macular degeneration

Hirasawa, M., Takubo, K., Osada, H., Miyake, S., Toda, E., Endo, M., Umezawa, K., Tsubota, K., Oike, Y. & Ozawa, Y., 2016 Apr 1, In : Journal of Biological Chemistry. 291, 14, p. 7373-7385 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Angiopoietin-like Protein 2 Promotes Chronic Adipose Tissue Inflammation and Obesity-Related Systemic Insulin Resistance

Tabata, M., Kadomatsu, T., Fukuhara, S., Miyata, K., Ito, Y., Endo, M., Urano, T., Zhu, H. J., Tsukano, H., Tazume, H., Kaikita, K., Miyashita, K., Iwawaki, T., Shimabukuro, M., Sakaguchi, K., Ito, T., Nakagata, N., Yamada, T., Katagiri, H., Kasuga, M. & 6 others, Ando, Y., Ogawa, H., Mochizuki, N., Itoh, H., Suda, T. & Oike, Y., 2009 Sep 2, In : Cell Metabolism. 10, 3, p. 178-188 11 p.

Research output: Contribution to journalArticle

224 Citations (Scopus)

Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration

Oike, Y., Yasunaga, K., Ito, Y., Matsumoto, S. I., Maekawa, H., Morisada, T., Arai, F., Nakagata, N., Takeya, M., Masuho, Y. & Suda, T., 2003 Aug 5, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 16, p. 9494-9499 6 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Angiopoietin-related growth factor enhances blood flow via activation of the ERK1/2-eNOS-NO pathway in a mouse hind-limb ischemia model

Urano, T., Ito, Y., Akao, M., Sawa, T., Miyata, K., Tabata, M., Morisada, T., Hato, T., Yano, M., Kadomatsu, T., Yasunaga, K., Shibata, R., Murohara, T., Akaike, T., Tanihara, H., Suda, T. & Oike, Y., 2008 May, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 5, p. 827-834 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

Adachi, H., Fujiwara, Y., Kondo, T., Nishikawa, T., Ogawa, R., Matsumura, T., Ishii, N., Nagai, R., Miyata, K., Tabata, M., Motoshima, H., Furukawa, N., Tsuruzoe, K., Kawashima, J., Takeya, M., Yamashita, S., Koh, G. Y., Nagy, A., Suda, T., Oike, Y. & 1 others, Araki, E., 2009 Feb 20, In : Biochemical and Biophysical Research Communications. 379, 4, p. 806-811 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium

Pin, C., Parker, A., Gunning, A. P., Ohta, Y., Johnson, I. T., Carding, S. R. & Sato, T., 2015 Feb 1, In : Integrative Biology (United Kingdom). 7, 2, p. 213-228 16 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Antibacterial activity of highly negative charged polyoxotungstates, K 27[KAs4W40O140] and K 18[KSb9W21O86], and Keggin-structural polyoxotungstates against Helicobacter pylori

Inoue, M., Segawa, K., Matsunaga, S., Matsumoto, N., Oda, M. & Yamase, T., 2005 May, In : Journal of Inorganic Biochemistry. 99, 5, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

A pilot open-labeled prospective randomized study between weekly and intensive treatment of granulocyte and monocyte adsorption apheresis for active ulcerative colitis

Sakuraba, A., Sato, T., Naganuma, M., Morohoshi, Y., Matsuoka, K., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2008 Jan 1, In : Journal of gastroenterology. 43, 1, p. 51-56 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., 2012 Sep, In : Nature medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

353 Citations (Scopus)

A quantitative matrigel assay for assessing repopulating capacity of prostate stem cells

Azuma, M., Hirao, A., Takubo, K., Hamaguchi, I., Kitamura, T. & Suda, T., 2005 Dec 16, In : Biochemical and Biophysical Research Communications. 338, 2, p. 1164-1170 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)