The Sakaguchi Laboratory

Research Output

Article

Hemopoietic colony-forming cells in shwachman’s syndrome

Suda, T., Ikuta, K., Mizoguchi, H., Sasaki, H., Miura, Y., Nagao, T. & Kubota, K., 1982 Jan 1, In : American Journal of Pediatric Hematology/Oncology. 4, 2, p. 129-133 5 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Hemopoietic stem cells in nude mice transplanted with colony-stimulating factor-producing tumors

Mizoguchi, H., Suda, T., Miura, Y., Kubota, K. & Takaku, F., 1982 Dec 1, In : Experimental Hematology. 10, 10, p. 874-880 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation

Honda, H., Takubo, K., Oda, H., Kosaki, K., Tazaki, T., Yamasaki, N., Miyazaki, K., Moore, K. A., Honda, Z. I., Suda, T. & Lemischka, I. R., 2011 Feb 8, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 6, p. 2468-2473 6 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Herbimycin A, an Inhibitor of Tyrosine Kinase, Prolongs Survival of Mice Inoculated with Myeloid Leukemia CI Cells with High Expression of v-abl Tyrosine Kinase

Honma, Y., Okabe-Kado, J., Kasukabe, T., Hozumi, M., Kodama, H., Kajigaya, S., Suda, T. & Miura, Y., 1992 Jul, In : Cancer Research. 52, 14, p. 4017-4020 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

High glucose inhibits HCO3 and fluid secretion in rat pancreatic ducts

Futakuchi, S., Ishiguro, H., Naruse, S., Ko, S. B. H., Fujiki, K., Yamamoto, A., Nakakuki, M., Song, Y., Steward, M. C., Kondo, T. & Goto, H., 2009 Nov 1, In : Pflugers Archiv European Journal of Physiology. 459, 1, p. 215-226 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival: IL-5 as an eosinophil chemotactic factor

Yamaguchi, Y., Hayashi, Y., Sugama, Y., Miura, Y., Kasahara, T., Kitamura, S., Torisu, M., Mita, S., Tominaga, A., Takatsu, K. & Suda, T., 1988 May 1, In : Journal of Experimental Medicine. 167, 5, p. 1737-1742 6 p.

Research output: Contribution to journalArticle

Open Access
537 Citations (Scopus)

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers

Oda, M., Glass, J. L., Thompson, R. F., Mo, Y., Olivier, E. N., Figueroa, M. E., Selzer, R. R., Richmond, T. A., Zhang, X., Dannenberg, L., Green, R. D., Melnick, A., Hatchwell, E., Bouhassira, E. E., Verma, A., Suzuki, M. & Greally, J. M., 2009, In : Nucleic acids research. 37, 12, p. 3829-3839 11 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Histological diagnosis of autoimmune pancreatitis using EUS-guided trucut biopsy: A comparison study with EUS-FNA

Mizuno, N., Bhatia, V., Hosoda, W., Sawaki, A., Hoki, N., Hara, K., Takagi, T., Ko, S. B. H., Yatabe, Y., Goto, H. & Yamao, K., 2009 May 12, In : Journal of gastroenterology. 44, 7, p. 742-750 9 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice

Ninomiya, M., Abe, A., Katsumi, A., Xu, J., Ito, M., Arai, F., Suda, T., Ito, M., Kiyoi, H., Kinoshita, T. & Naoe, T., 2007 Jan, In : Leukemia. 21, 1, p. 136-142 7 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes

Okazawa, A., Kanai, T., Nakamaru, K., Sato, T., Inoue, N., Ogata, H., Iwao, Y., Ikeda, M., Kawamura, T., Makita, S., Uraushihara, K., Okamoto, R., Yamazaki, M., Kurimoto, M., Ishii, H., Watanabe, M. & Hibi, T., 2004 May 1, In : Clinical and Experimental Immunology. 136, 2, p. 269-276 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

Fujii, M., Matano, M., Toshimitsu, K., Takano, A., Mikami, Y., Nishikori, S., Sugimoto, S. & Sato, T., 2018 Dec 6, In : Cell Stem Cell. 23, 6, p. 787-793.e6

Research output: Contribution to journalArticle

33 Citations (Scopus)

Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

Seino, T., Kawasaki, S., Shimokawa, M., Tamagawa, H., Toshimitsu, K., Fujii, M., Ohta, Y., Matano, M., Nanki, K., Kawasaki, K., Takahashi, S., Sugimoto, S., Iwasaki, E., Takagi, J., Itoi, T., Kitago, M., Kitagawa, Y., Kanai, T. & Sato, T., 2018 Mar 1, In : Cell stem cell. 22, 3, p. 454-467.e6

Research output: Contribution to journalArticle

101 Citations (Scopus)

Human primitive hematopoietic progenitor cells are more enriched in KIT(low) cells than in KIT(high) cells

Gunji, Y., Nakamura, M., Osawa, H., Nagayoshi, K., Nakauchi, H., Miura, Y., Yanagisawa, M. & Suda, T., 1993 Jan 1, In : Blood. 82, 11, p. 3283-3289 7 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

Hyperexpression of Inducible Costimulator and Its Contribution on Lamina Propria T Cells in Inflammatory Bowel Disease

Sato, T., Kanai, T., Watanabe, M., Sakuraba, A., Okamoto, S., Nakai, T., Okazawa, A., Inoue, N., Totsuka, T., Yamazaki, M., Kroczek, R. A., Fukushima, T., Ishii, H. & Hibi, T., 2004 Mar, In : Gastroenterology. 126, 3, p. 829-839 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells

Koto, T., Takubo, K., Ishida, S., Shinoda, H., Inoue, M., Tsubota, K., Okada, Y. & Ikeda, E., 2007 Apr, In : American Journal of Pathology. 170, 4, p. 1389-1397 9 p.

Research output: Contribution to journalArticle

172 Citations (Scopus)

Identification and characterization of stem cells in prepubertal spermatogenesis in mice

Ohbo, K., Yoshida, S., Ohmura, M., Ohneda, O., Ogawa, T., Tsuchiya, H., Kuwana, T., Kehler, J., Abe, K., Schöler, H. R. & Suda, T., 2003 Jun 1, In : Developmental Biology. 258, 1, p. 209-225 17 p.

Research output: Contribution to journalArticle

174 Citations (Scopus)

Identification and local manipulation of bone marrow vasculature during intravital imaging

Morikawa, T., Tamaki, S., Fujita, S., Suematsu, M. & Takubo, K., 2020 Dec 1, In : Scientific reports. 10, 1, 6422.

Research output: Contribution to journalArticle

Open Access

Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells

Itoh, T., Rai, T., Kuwahara, M., Ko, S. B. H., Uchida, S., Sasaki, S. & Ishibashi, K., 2005 May 13, In : Biochemical and Biophysical Research Communications. 330, 3, p. 832-838 7 p.

Research output: Contribution to journalArticle

139 Citations (Scopus)

Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data

Sharov, A. A., Masui, S., Sharova, L. V., Piao, Y., Aiba, K., Matoba, R., Xin, L., Niwa, H. & Ko, M. S. H., 2008 Jun 3, In : BMC Genomics. 9, 269.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity

Ohmura, M., Naka, K., Hoshii, T., Muraguchi, T., Shugo, H., Tamase, A., Uema, N., Ooshio, T., Arai, F., Takubo, K., Nagamatsu, G., Hamaguchi, I., Takagi, M., Ishihara, M., Sakurada, K., Miyaji, H., Suda, T. & Hirao, A., 2008 Dec, In : Stem Cells. 26, 12, p. 3237-3246 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages

Tamura, T., Thotakura, P., Tanaka, T. S., Ko, M. S. H. & Ozato, K., 2005 Sep 15, In : Blood. 106, 6, p. 1938-1947 10 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: Functional roles of HoxD8 in lymphangiogenesis

Harada, K., Yamazaki, T., Iwata, C., Yoshimatsu, Y., Sase, H., Mishima, K., Morishita, Y., Hirashima, M., Oike, Y., Suda, T., Miura, N., Watabe, T. & Miyazono, K., 2009, In : Journal of Cell Science. 122, 21, p. 3923-3930 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Identification of transcription factors for lineage-specific ESC differentiation

Yamamizu, K., Piao, Y., Sharov, A. A., Zsiros, V., Yu, H., Nakazawa, K., Schlessinger, D. & Ko, M. S. H., 2013 Dec 17, In : Stem cell reports. 1, 6, p. 545-559 15 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells

Hirayama, M., Ko, S., Kawakita, T., Akiyama, T., Goparaju, S. K., Soma, A., Nakatake, Y., Sakota, M., Chikazawa-Nohtomi, N., Shimmura, S., Tsubota, K. & Ko, M. S. H., 2017 Dec 1, In : npj Aging and Mechanisms of Disease. 3, 1, 1.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin

Tamase, A., Muraguchi, T., Naka, K., Tanaka, S., Kinoshita, M., Hoshii, T., Ohmura, M., Shugo, H., Ooshio, T., Nakada, M., Sawamoto, K., Onodera, M., Matsumoto, K., Oshima, M., Asano, M., Saya, H., Okano, H., Suda, T., Hamada, J. I. & Hirao, A., 2009 Oct 6, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 40, p. 17163-17168 6 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells

Akagi, T., Usuda, M., Matsuda, T., Ko, M. S. H., Niwa, H., Asano, M., Koide, H. & Yokota, T., 2005 May 27, In : Biochemical and Biophysical Research Communications. 331, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

IL-22BP dictates characteristics of Peyer's patch follicleassociated epithelium for antigen uptake

Jinnohara, T., Kanaya, T., Hase, K., Sakakibara, S., Kato, T., Tachibana, N., Sasaki, T., Hashimoto, Y., Sato, T., Watarai, H., Kunisawa, J., Shibata, N., Williams, I. R., Kiyono, H. & Ohno, H., 2017 Jun 1, In : Journal of Experimental Medicine. 214, 6, p. 1607-1618 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Chu, P. S., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PloS one. 8, 4, e62853.

Research output: Contribution to journalArticle

20 Citations (Scopus)

IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release

Kurihara, N., Bertolini, D., Suda, T., Akiyama, Y. & Roodman, G. D., 1990 Jan 1, In : Journal of Immunology. 144, 11, p. 4226-4230 5 p.

Research output: Contribution to journalArticle

365 Citations (Scopus)

Impaired development of CD4+ CD8+ thymocytes by csk-'knock-in' into fyn locus

Kanazawa, S., Ilić, D., Hashiyama, M., Okada, M., Noumura, T., Aizawa, S. & Suda, T., 1996 Aug 10, In : Oncogene. 13, 1, p. 199-204 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Increased renal angiopoietin-1 expression in folic acid-induced nephrotoxicity in mice

Long, D. A., Woolf, A. S., Suda, T. & Yuan, H. T., 2001 Dec 17, In : Journal of the American Society of Nephrology. 12, 12, p. 2721-2731 11 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the α/β hydrolase domain containing 2 gene

Miyata, K., Oike, Y., Hoshii, T., Maekawa, H., Ogawa, H., Suda, T., Araki, K. & Yamamura, K. I., 2005 Apr 1, In : Biochemical and Biophysical Research Communications. 329, 1, p. 296-304 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study

For the INDIGO Study Group, 2020 Feb 1, In : Journal of gastroenterology. 55, 2, p. 169-180 12 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Indole compounds may be promising medicines for ulcerative colitis

Sugimoto, S., Naganuma, M. & Kanai, T., 2016 May 9, (Accepted/In press) In : Journal of Gastroenterology. p. 1-9 9 p.

Research output: Contribution to journalArticle

49 Citations (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M. S. H., Tada, N., Okano, H. & Akamatsu, W., 2019 Feb 12, In : Stem cell reports. 12, 2, p. 305-318 14 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Induction by some protein kinase inhibitors of differentiation of a mouse megakaryoblastic cell line established by coinfection with Abelson murine leukemia virus and recombinant SV40 retrovirus

Honma, Y., Okabe-Kado, J., Kasukabe, T., Hozumi, M., Kajigaya, S., Suda, T. & Miura, Y., 1991 Sep 1, In : Cancer Research. 51, 17, p. 4649-4655 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Induction of cell shape changes through activation of the interleukin-3 common β chain receptor by the RON receptor-type tyrosine kinase

Mera, A., Suga, M., Ando, M., Suda, T. & Yamaguchi, N., 1999 May 28, In : Journal of Biological Chemistry. 274, 22, p. 15766-15774 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

Saito, Y., Nakaoka, T., Muramatsu, T., Ojima, H., Sukeda, A., Sugiyama, Y., Uchida, R., Furukawa, R., Kitahara, A., Sato, T., Kanai, Y. & Saito, H., 2018 Dec 1, In : Scientific reports. 8, 1, 2821.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf

Ono, Y., Wang, Y., Suzuki, H., Okamoto, S., Ikeda, Y., Murata, M., Poncz, M. & Matsubara, Y., 2012 Nov 1, In : Blood. 120, 18, p. 3812-3821 10 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S. B. H., Itoh, H. & Ko, M. S. H., 2019 Dec 1, In : Scientific reports. 9, 1, 913.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Induction of specific neuron types by overexpression of single transcription factors

Teratani-Ota, Y., Yamamizu, K., Piao, Y., Sharova, L., Amano, M., Yu, H., Schlessinger, D., Ko, M. S. H. & Sharov, A. A., 2016 Oct 1, In : In Vitro Cellular and Developmental Biology - Animal. 52, 9, p. 961-973 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

In early development of the rat mRNA for the major myelin protein P0 is expressed in nonsensory areas of the embryonic inner ear, notochord, enteric nervous system, and olfactory ensheathing cells

Kolatsi-Joannou, M., Li, X. Z., Suda, T., Yuan, H. T. & Woolf, A. S., 2001, In : Developmental Dynamics. 222, 1, p. 40-51 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

Ko, S. B. H., Azuma, S., Yokoyama, Y., Yamamoto, A., Kyokane, K., Niida, S., Ishiguro, H. & Ko, M. S. H., 2013 Jun 16, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 12, p. G1103-G1116

Research output: Contribution to journalArticle

8 Citations (Scopus)

Inhibition of Angiogenesis and Vascular Leakiness by Angiopoietin-Related Protein 4

Ito, Y., Oike, Y., Yasunaga, K., Hamada, K., Miyata, K., Matsumoto, S. I., Sugano, S., Tanihara, H., Masuho, Y. & Suda, T., 2003 Oct 15, In : Cancer Research. 63, 20, p. 6651-6657 7 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response

Saito, Y., Nakaoka, T., Sakai, K., Muramatsu, T., Toshimitsu, K., Kimura, M., Kanai, T., Sato, T. & Saito, H., 2016 May 4, In : Scientific reports. 6, 25311.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Inhibition of human granulocytic colony formation in culture by treatment with β 2-microglobulin antisera

Suda, T., Mizoguchi, H., Miura, Y., Kubota, K. & Takaku, F., 1980 Dec 1, In : Acta Haematologica Japonica. 43, 4, p. 747-748 2 p.

Research output: Contribution to journalArticle

Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis

Morohoshi, Y., Matsuoka, K., Chinen, H., Kamada, N., Sato, T., Hisamatsu, T., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2006 Apr 1, In : Journal of gastroenterology. 41, 4, p. 318-324 7 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Ink4a/arf-dependent loss of parietal cells induced by oxidative stress promotes CD44-dependent gastric tumorigenesis

Seishima, R., Wada, T., Tsuchihashi, K., Okazaki, S., Yoshikawa, M., Oshima, H., Oshima, M., Sato, T., Hasegawa, H., Kitagawa, Y., Goldenring, J. R., Saya, H. & Nagano, O., 2015 Jun 1, In : Cancer Prevention Research. 8, 6, p. 492-501 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

In situ-synthesized novel microarray optimized for mouse stem cell and early developmental expression profiling

Carter, M. G., Hamatani, T., Sharov, A. A., Carmack, C. E., Qian, Y., Aiba, K., Ko, N. T., Dudekula, D. B., Brzoska, P. M., Hwang, S. S. & Ko, M. S. H., 2003 May 1, In : Genome Research. 13, 5, p. 1011-1021 11 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Insulinoma with Subsequent Association of Zollinger-Ellison Syndrome

Mizuno, N., Naruse, S., Kitagawa, M., Ishiguro, H., Ito, O., Ko, S. B. H., Yoshikawa, T., Tanahashi, C., Ito, M. & Hayakawa, T., 2001 May, In : Internal Medicine. 40, 5, p. 386-390 5 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)