The Sakaguchi Laboratory

Research Output

Arginine vasopressin inhibits fluid secretion in guinea pig pancreatic duct cells

Ko, S. B. H., Naruse, S., Kitagawa, M., Ishiguro, H., Murakami, M. & Hayakawa, T., 1999 Jul, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 277, 1 40-1, p. G48-G54

Research output: Contribution to journalArticle

16 Citations (Scopus)

A role for hematopoietic stem cells in promoting angiogenesis

Takakura, N., Watanabe, T., Suenobu, S., Yamada, Y., Noda, T., Ito, Y., Satake, M. & Suda, T., 2000 Jul 21, In : Cell. 102, 2, p. 199-209 11 p.

Research output: Contribution to journalArticle

Open Access
432 Citations (Scopus)

A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis

Suenobu, S., Takakura, N., Inada, T., Yamada, Y., Yuasa, H., Zhang, X. Q., Sakano, S., Oike, Y. & Suda, T., 2002 Jan 1, In : Biochemical and Biophysical Research Communications. 293, 3, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Asian diagnostic criteria for autoimmune pancreatitis: Consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis

Otsuki, M., Chung, J. B., Okazaki, K., Kim, M. H., Kamisawa, T., Kawa, S., Park, S. W., Shimosegawa, T., Lee, K., Ito, T., Nishimori, I., Notohara, K., Naruse, S., Ko, S. B. H. & Kihara, Y., 2008 Jun 1, In : Journal of gastroenterology. 43, 6, p. 403-408 6 p.

Research output: Contribution to journalArticle

361 Citations (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 Jun 12, In : Cell Host and Microbe. 13, 6, p. 711-722 12 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

A stimulatory effect of recombinant murine interleukin-7 (IL-7) on B-cell colony formation and an inhibitory effect of IL-1α

Suda, T., Okada, S., Suda, J., Miura, Y., Ito, M., Sudo, T., Hayashi, S. I., Nishikawa, S. I. & Nakauchi, H., 1989, In : Blood. 74, 6, p. 1936-1941 6 p.

Research output: Contribution to journalArticle

Open Access
60 Citations (Scopus)

ASYNCHRONOUS EXPRESSION OF c‐kit AND CD34 ON LEUKAEMIC BLASTS

MUROI, K., Nakamura, M., Amemiya, Y., Suda, T. & Miura, Y., 1993 Nov, In : British Journal of Haematology. 85, 3, p. 633-634 2 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)

A systematic molecular genetic approach to study mammalian germline development

Abe, K., Ko, M. S. H. & Macgregor, G. R., 1998, In : International Journal of Developmental Biology. 42, 7, p. 1051-1065 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation

Watanuki, S., Kobayashi, H., Sorimachi, Y., Yamamoto, M., Okamoto, S. & Takubo, K., 2019 Jun 18, In : Biochemical and Biophysical Research Communications. 514, 1, p. 287-294 8 p.

Research output: Contribution to journalArticle

Back to 2D Culture for Ground State of Intestinal Stem Cells

Shimokawa, M. & Sato, T., 2015, In : Cell Stem Cell. 17, 1, p. 5-7 3 p.

Research output: Contribution to journalReview article

5 Citations (Scopus)

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium

Yamaguchi, M., Steward, M. C., Smallbone, K., Sohma, Y., Yamamoto, A., Ko, S. B. H., Kondo, T. & Ishiguro, H., 2017 Mar 15, In : Journal of Physiology. 595, 6, p. 1947-1972 26 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Bicarbonate transport in microperfused pancreatic ducts.

Ishiguro, H., Naruse, S., Kitagawa, M., Suzuki, A., Yamamoto, A., Ko, S. B., Hayakawa, T., Case, M. & Steward, M., 2000 Aug, In : Journal of Korean medical science. 15 Suppl, p. S16

Research output: Contribution to journalReview article

Open Access

Bipotential murine hemopoietic cell line (NFS-60) that is responsive to IL-3, GM-CSF, G-CSF, and erythropoietin

Hara, K., Suda, T., Suda, J., Eguchi, M., Ihle, J. N., Nagata, S., Miura, Y. & Saito, M., 1988 Jan 1, In : Experimental Hematology. 16, 4, p. 256-261 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Birbeck like granules in 3 cases of acute leukemia of children

Yamamoto, S., Eguchi, M., Kato, K., Sugiyama, S., Furukawa, T., Sekine, I. & Suda, T., 1983 Dec 1, In : Acta Haematologica Japonica. 46, 6, p. 1216-1221 6 p.

Research output: Contribution to journalArticle

Brain-specific expression of vascular endothelial growth factor 146 correlates with the blood-brain barrier induction in quail embryos

Ikeda, E., Takubo, K., Kodama, T. & Okada, Y., 2008 Sep 1, In : Developmental Neuroscience. 30, 5, p. 331-339 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Burkitt's lymphoma with granulocytosis and a high level of C-reactive protein

Muroi, K., Izumi, T., Yoshida, M., Suda, T., Miwa, A., Sakamoto, S. & Miura, Y., 1992 Apr, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 33, 4, p. 542-544 3 p.

Research output: Contribution to journalArticle

C/EBPβ and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: Implication for C/EBPβ activity in eosinophil gene expression

Yamaguchi, Y., Nishio, H., Kishi, K., Ackerman, S. J. & Suda, T., 1999 Aug 15, In : Blood. 94, 4, p. 1429-1439 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., 2010 Mar 5, In : Cell stem cell. 6, 3, p. 194-198 5 p.

Research output: Contribution to journalLetter

71 Citations (Scopus)

Cancer stem cell concepts--lesson from leukemia

Nitta, E. & Suda, T., 2009 Oct, In : Nippon rinsho. Japanese journal of clinical medicine. 67, 10, p. 1863-1867 5 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Cancer stem cells and their niche

Iwasaki, H. & Suda, T., 2009 Jun 23, In : Cancer science. 100, 7, p. 1166-1172 7 p.

Research output: Contribution to journalReview article

106 Citations (Scopus)

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 Sep 1, In : Immunology Letters. 147, 1-2, p. 75-79 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cdx2 determines the fate of postnatal intestinal endoderm

Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J. N., Deschamps, J. & Beck, F., 2012 Feb 1, In : Development. 139, 3, p. 465-474 10 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity

Sakamoto, H., Zhang, X. Q., Suenobu, S., Ohbo, K., Ogawa, M. & Suda, T., 2004 Aug 27, In : Biochemical and Biophysical Research Communications. 321, 3, p. 681-687 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. & 19 others, Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 May 1, In : Nature Cell Biology. 19, 5, p. 530-541 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

CFTR Functions as a bicarbonate channel in pancreatic duct cells

Ishiguro, H., Steward, M. C., Naruse, S., Shigeru, B. H. K., Goto, H., Case, R. M., Kondo, T. & Yamamoto, A., 2009 Mar 1, In : Journal of General Physiology. 133, 3, p. 315-326 12 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Characteristics of granulocyte-macrophage colony formation in patients with chronic myelomonocytic leukemia

Katayama, T., Miura, Y., Suda, T., Kusumoto, K., Ozawa, K., Motoyashi, K., Mizoguchi, H. & Takaku, F., 1981 Dec 1, In : Stem Cells. 1, 6, p. 345-354 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells

Sakano, S., Serizawa, R., Inada, T., Iwama, A., Itoh, A., Kato, C., Shimizu, Y., Shinkai, F., Shimizu, R., Kondo, S., Ohno, M. & Suda, T., 1996 Sep 30, In : Oncogene. 13, 4, p. 813-822 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Characterization of hemopoietic precursor cells in juvenile-type chronic myelocytic leukemia

Suda, T., Miura, Y., Mizoguchi, H., Ijima, H., Eguchi, M., Kaku, H. & Ide, C., 1982, In : Leukemia Research. 6, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Characterization of mouse non-receptor tyrosine kinase gene, HYL

Hamaguchi, I., Iwama, A., Yamaguchi, N., Sakano, S., Matsuda, Y. & Suda, T., 1994 Nov 1, In : Oncogene. 9, 11, p. 3371-3374 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 Dec 1, In : Scientific reports. 10, 1, 8308.

Research output: Contribution to journalArticle

Open Access

Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells

Sato, A., Iwama, A., Takakura, N., Nishio, H., Yancopoulos, G. D. & Suda, T., 1998 Aug 17, In : International immunology. 10, 8, p. 1217-1227 11 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

Hirao, A., Cheung, A., Duncan, G., Girard, P. M., Elia, A. J., Wakeham, A., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., De Stanchina, E., Bristow, R. G., Suda, T., Lowe, S. W., Jeggo, P. A., Elledge, S. J. & Mak, T. W., 2002 Sep 1, In : Molecular and cellular biology. 22, 18, p. 6521-6532 12 p.

Research output: Contribution to journalArticle

295 Citations (Scopus)

Chromatin properties of regulatory DNA probed by manipulation of transcription factors

Sharov, A. A., Nishiyama, A., Qian, Y., Dudekula, D. B., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2014 Aug 1, In : Journal of Computational Biology. 21, 8, p. 569-577 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 Feb, In : Gastroenterology. 158, 3, p. 638-651.e8

Research output: Contribution to journalArticle

4 Citations (Scopus)

Classical Th1 cells obtain colitogenicity by co-existence of RORγt-expressing T cells in experimental colitis

Saigusa, K., Hisamatsu, T., Handa, T., Sujino, T., Mikami, Y., Hayashi, A., Mizuno, S., Takeshita, K., Sato, T., Matsuoka, K. & Kanai, T., 2014 Oct 1, In : Inflammatory bowel diseases. 20, 10, p. 1820-1827 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012

Ohara, H., Okazaki, K., Tsubouchi, H., Inui, K., Kawa, S., Kamisawa, T., Tazuma, S., Uchida, K., Hirano, K., Yoshida, H., Nishino, T., Ko, S. B. H., Mizuno, N., Hamano, H., Kanno, A., Notohara, K., Hasebe, O., Nakazawa, T., Nakanuma, Y. & Takikawa, H., 2012 Sep, In : Journal of Hepato-Biliary-Pancreatic Sciences. 19, 5, p. 536-542 7 p.

Research output: Contribution to journalReview article

220 Citations (Scopus)

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto, S., Naganuma, M., Kiyohara, H., Arai, M., Ono, K., Mori, K., Saigusa, K., Nanki, K., Takeshita, K., Takeshita, T., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hisamatsu, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016 Mar 10, (Accepted/In press) In : Digestion. p. 193-201 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Clonal analysis of basophil differentiation in bone marrow cultures from a Down's syndrome patient with megakaryoblastic leukemia

Suda, T., Suda, J., Miura, Y., Hayashi, Y., Eguchi, M., Tadokoro, K. & Saito, M., 1985 Dec 1, In : Blood. 66, 6, p. 1278-1283 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo

De Maximy, A. A., Nakatake, Y., Moncada, S., Itoh, N., Thiery, J. P. & Bellusci, S., 1999 Mar 1, In : Mechanisms of Development. 81, 1-2, p. 213-216 4 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 May 16, In : Oncogene. 38, 20, p. 3962-3969 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Colony formation of clone-sorted human hematopoietic progenitors

Ema, H., Suda, T., Miura, Y. & Nakauchi, H., 1990 Jan 1, In : Blood. 75, 10, p. 1941-1946 6 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease

Sakuraba, A., Okamoto, S., Matsuoka, K., Sato, T., Naganuma, M., Hisamatsu, T., Iwao, Y., Ogata, H., Kanai, T. & Hibi, T., 2015 May 6, In : Digestion. 91, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells

Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T. & Suda, T., 2010 Jan 14, In : Blood. 115, 2, p. e1-e9

Research output: Contribution to journalArticle

23 Citations (Scopus)

Confirmation of bone marrow engraftment by detection of M/N blood group antigens on erythroblasts in erythroid bursts

Kitano, K., Kajii, E., Ikemoto, S., Amemiya, Y., Komatsu, N., Suda, T. & Miura, Y., 1988 Jan 1, In : British Journal of Haematology. 69, 3, p. 329-333 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor

Kodama, H., Yamasaki, A., Nose, M., Niida, S., Ohgame, Y., Abe, M., Kumegawa, M. & Suda, T., 1991 Jan 1, In : Journal of Experimental Medicine. 173, 1, p. 269-272 4 p.

Research output: Contribution to journalArticle

Open Access
320 Citations (Scopus)

Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin

Takabayashi, K., Kashiwagi, K., Kawata, T., Sato, T., Matsuoka, K., Hisamatsu, T., Takaishi, H., Hibi, T., Ogata, H., Yahagi, N., Kitagawa, Y., Shigematsu, N. & Kanai, T., 2014 Jan 1, In : Cancer Biology and Therapy. 15, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 Jan 1, In : Nature Methods. 9, 1, p. 81-83 3 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)
55 Citations (Scopus)

Conversion of primordial germ cells to pluripotent stem cells: Methods for cell tracking and culture conditions

Nagamatsu, G. & Suda, T., 2013 Sep 4, Imaging and Tracking Stem Cells: Methods and Protocols. p. 49-56 8 p. (Methods in Molecular Biology; vol. 1052).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Cooperative interaction of Angiopoietin-like proteins 1 and 2 in vascular development

Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Nagai, N., Koh, G. Y., Watanabe, S. & Suda, T., 2005 Sep 20, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 38, p. 13502-13507 6 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)