The Sakaguchi Laboratory

Research Output

Article

Bipotential murine hemopoietic cell line (NFS-60) that is responsive to IL-3, GM-CSF, G-CSF, and erythropoietin

Hara, K., Suda, T., Suda, J., Eguchi, M., Ihle, J. N., Nagata, S., Miura, Y. & Saito, M., 1988 Jan 1, In : Experimental Hematology. 16, 4, p. 256-261 6 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Birbeck like granules in 3 cases of acute leukemia of children

Yamamoto, S., Eguchi, M., Kato, K., Sugiyama, S., Furukawa, T., Sekine, I. & Suda, T., 1983 Dec 1, In : Acta Haematologica Japonica. 46, 6, p. 1216-1221 6 p.

Research output: Contribution to journalArticle

Brain-specific expression of vascular endothelial growth factor 146 correlates with the blood-brain barrier induction in quail embryos

Ikeda, E., Takubo, K., Kodama, T. & Okada, Y., 2008 Sep 1, In : Developmental Neuroscience. 30, 5, p. 331-339 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Burkitt's lymphoma with granulocytosis and a high level of C-reactive protein

Muroi, K., Izumi, T., Yoshida, M., Suda, T., Miwa, A., Sakamoto, S. & Miura, Y., 1992 Apr, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 33, 4, p. 542-544 3 p.

Research output: Contribution to journalArticle

C/EBPβ and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: Implication for C/EBPβ activity in eosinophil gene expression

Yamaguchi, Y., Nishio, H., Kishi, K., Ackerman, S. J. & Suda, T., 1999 Aug 15, In : Blood. 94, 4, p. 1429-1439 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 Sep 1, In : Immunology Letters. 147, 1-2, p. 75-79 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cdx2 determines the fate of postnatal intestinal endoderm

Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J. N., Deschamps, J. & Beck, F., 2012 Feb 1, In : Development. 139, 3, p. 465-474 10 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Cell adhesion to ephrinb2 is induced by EphB4 independently of its kinase activity

Sakamoto, H., Zhang, X. Q., Suenobu, S., Ohbo, K., Ogawa, M. & Suda, T., 2004 Aug 27, In : Biochemical and Biophysical Research Communications. 321, 3, p. 681-687 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Kon, S., Ishibashi, K., Katoh, H., Kitamoto, S., Shirai, T., Tanaka, S., Kajita, M., Ishikawa, S., Yamauchi, H., Yako, Y., Kamasaki, T., Matsumoto, T., Watanabe, H., Egami, R., Sasaki, A., Nishikawa, A., Kameda, I., Maruyama, T., Narumi, R., Morita, T. & 19 others, Sasaki, Y., Enoki, R., Honma, S., Imamura, H., Oshima, M., Soga, T., Miyazaki, J. I., Duchen, M. R., Nam, J. M., Onodera, Y., Yoshioka, S., Kikuta, J., Ishii, M., Imajo, M., Nishida, E., Fujioka, Y., Ohba, Y., Sato, T. & Fujita, Y., 2017 May 1, In : Nature Cell Biology. 19, 5, p. 530-541 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

CFTR Functions as a bicarbonate channel in pancreatic duct cells

Ishiguro, H., Steward, M. C., Naruse, S., Shigeru, B. H. K., Goto, H., Case, R. M., Kondo, T. & Yamamoto, A., 2009 Mar 1, In : Journal of General Physiology. 133, 3, p. 315-326 12 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Characteristics of granulocyte-macrophage colony formation in patients with chronic myelomonocytic leukemia

Katayama, T., Miura, Y., Suda, T., Kusumoto, K., Ozawa, K., Motoyashi, K., Mizoguchi, H. & Takaku, F., 1981 Dec 1, In : Stem Cells. 1, 6, p. 345-354 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells

Sakano, S., Serizawa, R., Inada, T., Iwama, A., Itoh, A., Kato, C., Shimizu, Y., Shinkai, F., Shimizu, R., Kondo, S., Ohno, M. & Suda, T., 1996 Sep 30, In : Oncogene. 13, 4, p. 813-822 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Characterization of hemopoietic precursor cells in juvenile-type chronic myelocytic leukemia

Suda, T., Miura, Y., Mizoguchi, H., Ijima, H., Eguchi, M., Kaku, H. & Ide, C., 1982, In : Leukemia Research. 6, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Characterization of mouse non-receptor tyrosine kinase gene, HYL

Hamaguchi, I., Iwama, A., Yamaguchi, N., Sakano, S., Matsuda, Y. & Suda, T., 1994 Nov 1, In : Oncogene. 9, 11, p. 3371-3374 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Characterization of radioresistant epithelial stem cell heterogeneity in the damaged mouse intestine

Sato, T., Sase, M., Ishikawa, S., Kajita, M., Asano, J., Sato, T., Mori, Y. & Ohteki, T., 2020 Dec 1, In : Scientific reports. 10, 1, 8308.

Research output: Contribution to journalArticle

Open Access

Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells

Sato, A., Iwama, A., Takakura, N., Nishio, H., Yancopoulos, G. D. & Suda, T., 1998 Aug 17, In : International immunology. 10, 8, p. 1217-1227 11 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

Hirao, A., Cheung, A., Duncan, G., Girard, P. M., Elia, A. J., Wakeham, A., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., De Stanchina, E., Bristow, R. G., Suda, T., Lowe, S. W., Jeggo, P. A., Elledge, S. J. & Mak, T. W., 2002 Sep 1, In : Molecular and cellular biology. 22, 18, p. 6521-6532 12 p.

Research output: Contribution to journalArticle

295 Citations (Scopus)

Chromatin properties of regulatory DNA probed by manipulation of transcription factors

Sharov, A. A., Nishiyama, A., Qian, Y., Dudekula, D. B., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2014 Aug 1, In : Journal of Computational Biology. 21, 8, p. 569-577 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Kawasaki, K., Fujii, M., Sugimoto, S., Ishikawa, K., Matano, M., Ohta, Y., Toshimitsu, K., Takahashi, S., Hosoe, N., Sekine, S., Kanai, T. & Sato, T., 2020 Feb, In : Gastroenterology. 158, 3, p. 638-651.e8

Research output: Contribution to journalArticle

4 Citations (Scopus)

Classical Th1 cells obtain colitogenicity by co-existence of RORγt-expressing T cells in experimental colitis

Saigusa, K., Hisamatsu, T., Handa, T., Sujino, T., Mikami, Y., Hayashi, A., Mizuno, S., Takeshita, K., Sato, T., Matsuoka, K. & Kanai, T., 2014 Oct 1, In : Inflammatory bowel diseases. 20, 10, p. 1820-1827 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study

Sugimoto, S., Naganuma, M., Kiyohara, H., Arai, M., Ono, K., Mori, K., Saigusa, K., Nanki, K., Takeshita, K., Takeshita, T., Mutaguchi, M., Mizuno, S., Bessho, R., Nakazato, Y., Hisamatsu, T., Inoue, N., Ogata, H., Iwao, Y. & Kanai, T., 2016 Mar 10, (Accepted/In press) In : Digestion. p. 193-201 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Clonal analysis of basophil differentiation in bone marrow cultures from a Down's syndrome patient with megakaryoblastic leukemia

Suda, T., Suda, J., Miura, Y., Hayashi, Y., Eguchi, M., Tadokoro, K. & Saito, M., 1985 Dec 1, In : Blood. 66, 6, p. 1278-1283 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo

De Maximy, A. A., Nakatake, Y., Moncada, S., Itoh, N., Thiery, J. P. & Bellusci, S., 1999 Mar 1, In : Mechanisms of Development. 81, 1-2, p. 213-216 4 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)

Cnnm4 deficiency suppresses Ca2+ signaling and promotes cell proliferation in the colon epithelia

Yamazaki, D., Hasegawa, A., Funato, Y., Tran, H. N., Mori, M. X., Mori, Y., Sato, T. & Miki, H., 2019 May 16, In : Oncogene. 38, 20, p. 3962-3969 8 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Colony formation of clone-sorted human hematopoietic progenitors

Ema, H., Suda, T., Miura, Y. & Nakauchi, H., 1990 Jan 1, In : Blood. 75, 10, p. 1941-1946 6 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Combination therapy with infliximab and thiopurine compared to infliximab monotherapy in maintaining remission of postoperative crohn's disease

Sakuraba, A., Okamoto, S., Matsuoka, K., Sato, T., Naganuma, M., Hisamatsu, T., Iwao, Y., Ogata, H., Kanai, T. & Hibi, T., 2015 May 6, In : Digestion. 91, 3, p. 233-238 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells

Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T. & Suda, T., 2010 Jan 14, In : Blood. 115, 2, p. e1-e9

Research output: Contribution to journalArticle

23 Citations (Scopus)

Confirmation of bone marrow engraftment by detection of M/N blood group antigens on erythroblasts in erythroid bursts

Kitano, K., Kajii, E., Ikemoto, S., Amemiya, Y., Komatsu, N., Suda, T. & Miura, Y., 1988 Jan 1, In : British Journal of Haematology. 69, 3, p. 329-333 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor

Kodama, H., Yamasaki, A., Nose, M., Niida, S., Ohgame, Y., Abe, M., Kumegawa, M. & Suda, T., 1991 Jan 1, In : Journal of Experimental Medicine. 173, 1, p. 269-272 4 p.

Research output: Contribution to journalArticle

Open Access
320 Citations (Scopus)

Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin

Takabayashi, K., Kashiwagi, K., Kawata, T., Sato, T., Matsuoka, K., Hisamatsu, T., Takaishi, H., Hibi, T., Ogata, H., Yahagi, N., Kitagawa, Y., Shigematsu, N. & Kanai, T., 2014 Jan 1, In : Cancer Biology and Therapy. 15, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 Jan 1, In : Nature Methods. 9, 1, p. 81-83 3 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)
55 Citations (Scopus)

Cooperative interaction of Angiopoietin-like proteins 1 and 2 in vascular development

Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Nagai, N., Koh, G. Y., Watanabe, S. & Suda, T., 2005 Sep 20, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 38, p. 13502-13507 6 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Correction of Down syndrome and Edwards syndrome aneuploidies in human cell cultures

Amano, T., Jeffries, E., Amano, M., Ko, A. C., Yu, H. & Ko, M., 2015 May 6, In : DNA Research. 22, 5, p. 331-342 12 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Corticosteroids Correct Aberrant CFTR Localization in the Duct and Regenerate Acinar Cells in Autoimmune Pancreatitis

Ko, S. B. H., Mizuno, N., Yatabe, Y., Yoshikawa, T., Ishiguro, H., Yamamoto, A., Azuma, S., Naruse, S., Yamao, K., Muallem, S. & Goto, H., 2010 May, In : Gastroenterology. 138, 5, p. 1988-1996.e3

Research output: Contribution to journalArticle

79 Citations (Scopus)

Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6

Shcheynikov, N., Wang, Y., Park, M., Ko, S. B. H., Dorwart, M., Naruse, S., Thomas, P. J. & Muallem, S., 2006 May, In : Journal of General Physiology. 127, 5, p. 511-524 14 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

Takakura, N., Huang, X. L., Naruse, T., Hamaguchi, I., Dumont, D. J., Yancopoulos, G. D. & Suda, T., 1998 Nov, In : Immunity. 9, 5, p. 677-686 10 p.

Research output: Contribution to journalArticle

Open Access
252 Citations (Scopus)

Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production In Crohn's disease

Mizuno, S., Mikami, Y., Kamada, N., Handa, T., Hayashi, A., Sato, T., Matsuoka, K., Matano, M., Ohta, Y., Sugita, A., Koganei, K., Sahara, R., Takazoe, M., Hisamatsu, T. & Kanai, T., 2014 Aug, In : Inflammatory bowel diseases. 20, 8, p. 1426-1434 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Cultured human basophils with ultrastructural and ultracytochemical features of mast cells

Eguchi, M., Suda, J., Sugita, K., Suda, T. & Furukawa, T., 1989 Jan, In : European Journal of Haematology. 42, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients

Matsuoka, K., Iwao, Y., Mori, T., Sakuraba, A., Yajima, T., Hisamatsu, T., Okamoto, S., Morohoshi, Y., Izumiya, M., Ichikawa, H., Sato, T., Inoue, N., Ogata, H. & Hibi, T., 2007 Feb 1, In : American Journal of Gastroenterology. 102, 2, p. 331-337 7 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma

Mizuno, N., Yatabe, Y., Hara, K., Hijioka, S., Imaoka, H., Shimizu, Y., Ko, S. B. H. & Yamao, K., 2013 Oct 16, In : Frontiers in Physiology. 4 SEP, Article 269.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells

Sun, C., Nakatake, Y., Akagi, T., Ura, H., Matsuda, T., Nishiyama, A., Koide, H., Ko, M. S. H., Niwa, H. & Yokota, T., 2009 Aug, In : Molecular and cellular biology. 29, 16, p. 4574-4583 10 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Defective smooth muscle development in qkl-deficient mice

Li, Z., Takakura, N., Oike, Y., Imanaka, T., Araki, K., Suda, T., Kaname, T., Kondo, T., Abe, K. & Yamamura, K. I., 2003 Oct 1, In : Development Growth and Differentiation. 45, 5-6, p. 449-462 14 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO3- exchange in mouse pancreatic duct

Ishiguro, H., Song, Y., Yamamoto, A., Steward, M. C., Ko, S. B. H., Stewart, A. K., Soleimani, M., Liu, B. C., Kondo, T. & Jin, C. X., 2012 Oct 15, In : American Journal of Physiology - Cell Physiology. 303, 8, p. C815-C824

Research output: Contribution to journalArticle

12 Citations (Scopus)

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice

Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 Feb 1, In : Immunology Letters. 150, 1-2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways

Kikuchi, I., Takahashi-Kanemitsu, A., Sakiyama, N., Tang, C., Tang, P. J., Noda, S., Nakao, K., Kassai, H., Sato, T., Aiba, A. & Hatakeyama, M., 2016 Sep 21, In : Nature Communications. 7, 12887.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase.

Correll, P. H., Iwama, A., Tondat, S., Mayrhofer, G., Suda, T. & Bernstein, A., 1997 Feb, In : Genes and function. 1, 1, p. 69-83 15 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Derivation and morphological characterization of mouse spermatogonial stem cell lines

Ogawa, T., Ohmura, M., Tamura, Y., Kita, K., Ohbo, K., Suda, T. & Kubota, Y., 2004 Nov 1, In : Archives of Histology and Cytology. 67, 4, p. 297-306 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Detection of a large heterozygous deletion and a splicing defect in the CFTR transcripts from nasal swab of a Japanese case of cystic fibrosis

Nakakuki, M., Fujiki, K., Yamamoto, A., Ko, S. B., Yi, L., Ishiguro, M., Yamaguchi, M., Kondo, S., Maruyama, S., Yanagimoto, K., Naruse, S. & Ishiguro, H., 2012 Jul 1, In : Journal of Human Genetics. 57, 7, p. 427-433 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., Garcia, P., Suda, T., Frampton, J. & Ogawa, M., 2015 Feb 1, In : Stem Cells. 33, 2, p. 479-490 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)