The Sakaguchi Laboratory

Research Output

2015

Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells

Akiyama, T., Xin, L., Oda, M., Sharov, A. A., Amano, M., Piao, Y., Cadet, J. S., Dudekula, D. B., Qian, Y., Wang, W., Ko, S. & Ko, M., 2015 May 6, In : DNA Research. 22, 5, p. 307-318 12 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2014

Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function

Nagamachi, A., Nakata, Y., Ueda, T., Yamasaki, N., Ebihara, Y., Tsuji, K., Honda, Z. I., Takubo, K., Suda, T., Oda, H., Inaba, T. & Honda, H., 2014 Jan 31, In : PloS one. 9, 1, e87425.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Aging of the hematopoietic stem cells niche

Nakamura-Ishizu, A. & Suda, T., 2014 Oct 9, In : International journal of hematology. 100, 4, p. 317-325 9 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 I. Concept and diagnosis of autoimmune pancreatitis

Okazaki, K., Kawa, S., Kamisawa, T., Ito, T., Inui, K., Irie, H., Nishino, T., Notohara, K., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T., Kubo, K., Ohara, H., Irisawa, A., Fujinaga, Y., Hasebe, O. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014 Apr, In : Journal of gastroenterology. 49, 4, p. 567-588 22 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 II. Extrapancreatic lesions, differential diagnosis

Kawa, S., Okazaki, K., Kamisawa, T., Kubo, K., Ohara, H., Hasebe, O., Fujinaga, Y., Irisawa, A., Notohara, K., Ito, T., Inui, K., Irie, H., Nishino, T., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014 May, In : Journal of gastroenterology. 49, 5, p. 765-784 20 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 III. Treatment and prognosis of autoimmune pancreatitis

Kamisawa, T., Okazaki, K., Kawa, S., Ito, T., Inui, K., Irie, H., Nishino, T., Notohara, K., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T., Kubo, K., Ohara, H., Irisawa, A., Fujinaga, Y., Hasebe, O. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014 Jun, In : Journal of gastroenterology. 49, 6, p. 961-970 10 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Chromatin properties of regulatory DNA probed by manipulation of transcription factors

Sharov, A. A., Nishiyama, A., Qian, Y., Dudekula, D. B., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2014 Aug 1, In : Journal of Computational Biology. 21, 8, p. 569-577 9 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Classical Th1 cells obtain colitogenicity by co-existence of RORγt-expressing T cells in experimental colitis

Saigusa, K., Hisamatsu, T., Handa, T., Sujino, T., Mikami, Y., Hayashi, A., Mizuno, S., Takeshita, K., Sato, T., Matsuoka, K. & Kanai, T., 2014 Oct 1, In : Inflammatory bowel diseases. 20, 10, p. 1820-1827 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Continuous low-dose irradiation by I-125 seeds induces apoptosis of gastric cancer cells regardless of histological origin

Takabayashi, K., Kashiwagi, K., Kawata, T., Sato, T., Matsuoka, K., Hisamatsu, T., Takaishi, H., Hibi, T., Ogata, H., Yahagi, N., Kitagawa, Y., Shigematsu, N. & Kanai, T., 2014 Jan 1, In : Cancer Biology and Therapy. 15, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production In Crohn's disease

Mizuno, S., Mikami, Y., Kamada, N., Handa, T., Hayashi, A., Sato, T., Matsuoka, K., Matano, M., Ohta, Y., Sugita, A., Koganei, K., Sahara, R., Takazoe, M., Hisamatsu, T. & Kanai, T., 2014 Aug, In : Inflammatory bowel diseases. 20, 8, p. 1426-1434 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Culturing intestinal stem cells: Applications for colorectal cancer research

Fujii, M. & Sato, T., 2014 Jan 1, In : Frontiers in Genetics. 5, JUN, 169.

Research output: Contribution to journalShort survey

4 Citations (Scopus)

Direct reprogramming of fibroblasts and preadipocytes into functional megakaryocytes.

Matsubara, Y., 2014 Apr, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 55, 4, p. 387-395 9 p.

Research output: Contribution to journalReview article

Effectiveness and clinical results of endoscopic management of sigmoid volvulus using unsedated water-immersion colonoscopy

Sugimoto, S., Hosoe, N., Mizukami, T., Tsunoda, Y., Ito, T., Imamura, S., Tamura, T., Nagakubo, S., Morohoshi, Y., Koike, Y., Fujita, Y., Komatsu, H., Ogata, H. & Kanai, T., 2014 Jul, In : Digestive Endoscopy. 26, 4, p. 564-568 5 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Efficient generation of integration-free human induced pluripotent stem cells from keratinocytes by simple transfection of episomal vectors

Piao, Y., Hung, S. S. C., Lim, S. Y., Wong, R. C. B. & Ko, M. S. H., 2014, In : Stem Cells Translational Medicine. 3, 7, p. 787-791 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Endoscopic ultrasound-guided drainage for a mediastinal pancreatic pseudocyst

Sugimoto, S., Yamagishi, Y., Higuchi, H. & Kanai, T., 2014 Jan 1, In : Internal Medicine. 53, 22, p. 2651-2652 2 p.

Research output: Contribution to journalArticle

Heterogeneity and hierarchy of hematopoietic stem cells

Ema, H., Morita, Y. & Suda, T., 2014 Feb, In : Experimental Hematology. 42, 2, p. 74-82.e2

Research output: Contribution to journalReview article

70 Citations (Scopus)

Homeostatic regulation of hematopoiesis by the hematopoietic stem cell niche

Takubo, K., 2014 Jan 1, In : Seikagaku. 86, 6, p. 755-765 11 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Intestinal tumor in a dish

Ohta, Y. & Sato, T., 2014 Jan 1, In : Frontiers in Medicine. 1, MAY, 14.

Research output: Contribution to journalShort survey

Open Access
10 Citations (Scopus)

Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Kobayashi, I., Kobayashi-Sun, J., Kim, A. D., Pouget, C., Fujita, N., Suda, T. & Traver, D., 2014 Aug 21, In : Nature. 512, 7514, p. 319-323 5 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

KLF5 regulates the integrity and oncogenicity of intestinal stem cells

Nakaya, T., Ogawa, S., Manabe, I., Tanaka, M., Sanada, M., Sato, T., Taketo, M. M., Nakao, K., Clevers, H., Fukayama, M., Kuroda, M. & Nagai, R., 2014 May 15, In : Cancer Research. 74, 10, p. 2882-2891 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 Jan 2, In : PloS one. 9, 1, e84619.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Metabolic requirements for the maintenance of self-renewing stem cells

Ito, K. & Suda, T., 2014 Apr, In : Nature Reviews Molecular Cell Biology. 15, 4, p. 243-256 14 p.

Research output: Contribution to journalReview article

472 Citations (Scopus)

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

Tai-Nagara, I., Matsuoka, S., Ariga, H. & Suda, T., 2014 Jan 2, In : Blood. 123, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Not merely quiescent: Telomeres in quiescent HSCs

Nakamura-Ishizu, A. & Suda, T., 2014 Nov 20, In : Blood. 124, 22, p. 3179-3180 2 p.

Research output: Contribution to journalComment/debate

Opening the door for HIF1α tuning

Takubo, K. & Suda, T., 2014 Jan 9, In : Blood. 123, 2, p. 151-152 2 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

R-spondins/Lgrs expression in tooth development

kawasaki, M., Porntaveetus, T., Kawasaki, K., Oommen, S., Otsuka-Tanaka, Y., Hishinuma, M., Nomoto, T., Maeda, T., Takubo, K., Suda, T., Sharpe, P. T. & Ohazama, A., 2014 Jun, In : Developmental Dynamics. 243, 6, p. 844-851 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1)

Yamamizu, K., Schlessinger, D. & Ko, M. S. H., 2014 Nov 1, In : Development (Cambridge). 141, 22, p. 4254-4266 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Kinoshita, T., Nagamatsu, G., Saito, S., Takubo, K., Horimoto, K. & Suda, T., 2014 May 30, In : Journal of Biological Chemistry. 289, 22, p. 15776-15787 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells

Kobayashi, C. I., Takubo, K., Kobayashi, H., Nakamura-Ishizu, A., Honda, H., Kataoka, K., Kumano, K., Akiyama, H., Sudo, T., Kurokawa, M. & Suda, T., 2014 Apr 17, In : Blood. 123, 16, p. 2540-2549 10 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Transformation of intestinal stem cells into gastric stem cells on loss of transcription factor Cdx2

Simmini, S., Bialecka, M., Huch, M., Kester, L., Van De Wetering, M., Sato, T., Beck, F., Van Oudenaarden, A., Clevers, H. & Deschamps, J., 2014, In : Nature communications. 5, 6728.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Unprecedented cell-selection using ultra-quick freezing combined with aquaporin expression

Kato, Y., Miyauchi, T., Abe, Y., Kojić, D., Tanaka, M., Chikazawa, N., Nakatake, Y., Ko, S. B. H., Kobayashi, D., Hazama, A., Fujiwara, S., Uchida, T. & Yasui, M., 2014 Feb 18, In : PloS one. 9, 2, e87644.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2013

[Induction of megakaryocytes and platelet production from mouse and human fibroblasts by p45 NF-E2/Maf].

Ono, Y. & Matsubara, Y., 2013 Nov 1, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 54, 11, p. 2025-2030 6 p.

Research output: Contribution to journalReview article

[Intestinal stem cells].

Sato, T., 2013 Sep, In : Seikagaku. The Journal of Japanese Biochemical Society. 85, 9, p. 743-748 6 p.

Research output: Contribution to journalReview article

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance

Livigni, A., Peradziryi, H., Sharov, A. A., Chia, G., Hammachi, F., Migueles, R. P., Sukparangsi, W., Pernagallo, S., Bradley, M., Nichols, J., Ko, M. S. H. & Brickman, J. M., 2013 Nov 18, In : Current Biology. 23, 22, p. 2233-2244 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity

Shirakawa, T., Yaman-Deveci, R., Tomizawa, S. I., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T. & Ohbo, K., 2013 Sep 1, In : Development (Cambridge). 140, 17, p. 3565-3576 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy

Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang, W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O. J. & Koh, G. Y., 2013 Sep 18, In : Science translational medicine. 5, 203, 203ra127.

Research output: Contribution to journalArticle

69 Citations (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 Jun 12, In : Cell Host and Microbe. 13, 6, p. 711-722 12 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Conversion of primordial germ cells to pluripotent stem cells: Methods for cell tracking and culture conditions

Nagamatsu, G. & Suda, T., 2013 Sep 4, Imaging and Tracking Stem Cells: Methods and Protocols. p. 49-56 8 p. (Methods in Molecular Biology; vol. 1052).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma

Mizuno, N., Yatabe, Y., Hara, K., Hijioka, S., Imaoka, H., Shimizu, Y., Ko, S. B. H. & Yamao, K., 2013 Oct 16, In : Frontiers in Physiology. 4 SEP, Article 269.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice

Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 Feb 1, In : Immunology Letters. 150, 1-2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Endoscopic detorsion for sigmoid volvulus using unsedated water-immersion colonoscopy

Sugimoto, S., Mizukami, T., Ito, T., Tsunoda, Y., Imamura, S., Tamura, T., Nagakubo, S., Morohoshi, Y., Koike, Y., Fujita, Y. & Komatsu, H., 2013 Sep 17, In : Endoscopy. 45, SUPPL2, p. E263-E264

Research output: Contribution to journalComment/debate

Open Access
3 Citations (Scopus)

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

Miyake, M., Toguchi, H., Nishibayashi, T., Higaki, K., Sugita, A., Koganei, K., Kamada, N., Kitazume, M. T., Hisamatsu, T., Sato, T., Okamoto, S., Kanai, T. & Hibi, T., 2013 Aug, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2564-2571 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications

Sato, T. & Clevers, H., 2013 Jan 1, In : Science. 340, 6137, p. 1190-1194 5 p.

Research output: Contribution to journalReview article

517 Citations (Scopus)

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

Nagamachi, A., Matsui, H., Asou, H., Ozaki, Y., Aki, D., Kanai, A., Takubo, K., Suda, T., Nakamura, T., Wolff, L., Honda, H. & Inaba, T., 2013 Sep 9, In : Cancer Cell. 24, 3, p. 305-317 13 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches

Nakamura-Ishizu, A. & Suda, T., 2013 Feb, In : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2404-2409 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Identification of transcription factors for lineage-specific ESC differentiation

Yamamizu, K., Piao, Y., Sharov, A. A., Zsiros, V., Yu, H., Nakazawa, K., Schlessinger, D. & Ko, M. S. H., 2013 Dec 17, In : Stem cell reports. 1, 6, p. 545-559 15 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Chu, P. S., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PloS one. 8, 4, e62853.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

Ko, S. B. H., Azuma, S., Yokoyama, Y., Yamamoto, A., Kyokane, K., Niida, S., Ishiguro, H. & Ko, M. S. H., 2013 Jun 16, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 12, p. G1103-G1116

Research output: Contribution to journalArticle

8 Citations (Scopus)

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 Feb 14, In : Nature. 494, 7436, p. 247-250 4 p.

Research output: Contribution to journalArticle

660 Citations (Scopus)

Kinetics of drug selection systems in mouse embryonic stem cells

Nakatake, Y., Fujii, S., Masui, S., Sugimoto, T., Torikai-Nishikawa, S., Adachi, K. & Niwa, H., 2013 Aug 7, In : BMC Biotechnology. 13, 64.

Research output: Contribution to journalArticle

13 Citations (Scopus)