The Sakaguchi Laboratory

Research Output

2013

Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients

Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 Dec 15, In : Journal of Crohn's and Colitis. 7, 12, p. e609-e614

Research output: Contribution to journalArticle

35 Citations (Scopus)

No more sugar-coating it: Mucins and platelet biology

Matsubara, Y., 2013 Aug 29, In : Blood. 122, 9, p. 1537-1538 2 p.

Research output: Contribution to journalReview article

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013 Jan 1, In : Blood. 121, 16, p. 3267-3273 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 2013 Nov 8, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Primary mouse small intestinal epithelial cell cultures

Sato, T. & Clevers, H., 2013 Jan 1, Epithelial Cell Culture Protocols: Second Edition. Randell, S. & Fulcher, L. (eds.). p. 319-328 10 p. (Methods in Molecular Biology; vol. 945).

Research output: Chapter in Book/Report/Conference proceedingChapter

124 Citations (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 2013 Jan 1, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells

Hung, S. S. C., Wong, R. C. B., Sharov, A. A., Nakatake, Y., Yu, H. & Ko, M. S. H., 2013 Aug 1, In : DNA Research. 20, 4, p. 391-401 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Role of iPSC-Producing Factors in Pre-Implantation Embryos

Amano, T. & Ko, M. S. H., 2013 Oct 1, Principles of Cloning: Second Edition. Elsevier Inc., p. 473-484 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Spur cell anemia associated with alcoholic cirrhosis

Sugimoto, S., Yamagishi, Y., Ebinuma, H. & Kanai, T., 2013 Dec 23, In : Internal Medicine. 52, 24, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Nishiyama, A., Sharov, A. A., Piao, Y., Amano, M., Amano, T., Hoang, H. G., Binder, B. Y., Tapnio, R., Bassey, U., Malinou, J. N., Correa-Cerro, L. S., Yu, H., Xin, L., Meyers, E., Zalzman, M., Nakatake, Y., Stagg, C., Sharova, L., Qian, Y., Dudekula, D. & 9 others, Sheer, S., Cadet, J. S., Hirata, T., Yang, H. T., Goldberg, I., Evans, M. K., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2013 Mar 25, In : Scientific reports. 3, 1390.

Research output: Contribution to journalArticle

37 Citations (Scopus)

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Yoneno, K., Hisamatsu, T., Shimamura, K., Kamada, N., Ichikawa, R., Kitazume, M. T., Mori, M., Uo, M., Namikawa, Y., Matsuoka, K., Sato, T., Koganei, K., Sugita, A., Kanai, T. & Hibi, T., 2013 May 1, In : Immunology. 139, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Morgani, S. M., Canham, M. A., Nichols, J., Sharov, A. A., Migueles, R. P., Ko, M. S. H. & Brickman, J. M., 2013 Mar 27, In : Cell Reports. 3, 6, p. 1945-1957 13 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J. M., Van De Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., Van Es, J. H., De Koning, E., Vries, R. G. J., Heimberg, H. & Clevers, H., 2013 Oct 16, In : EMBO Journal. 32, 20, p. 2708-2721 14 p.

Research output: Contribution to journalArticle

298 Citations (Scopus)

Zscan4 restores the developmental potency of embryonic stem cells

Amano, T., Hirata, T., Falco, G., Monti, M., Sharova, L. V., Amano, M., Sheer, S., Hoang, H. G., Piao, Y., Stagg, C. A., Yamamizu, K., Akiyama, T. & Ko, M. S. H., 2013 Jun 6, In : Nature communications. 4, 1966.

Research output: Contribution to journalArticle

Open Access
59 Citations (Scopus)
2012

[Regulation of hematopoietic stem cells in niche signaling].

Matsumoto, Y. & Suda, T., 2012 Apr, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Activation of JNK triggers release of Brd4 from mitotic chromosomes and mediates protection from drug-induced mitotic stress

Nishiyama, A., Dey, A., Tamura, T., Ko, M. & Ozato, K., 2012 May 2, In : PloS one. 7, 5, e34719.

Research output: Contribution to journalArticle

4 Citations (Scopus)

A Meg by any other name

Matsubara, Y., 2012 Sep 6, In : Blood. 120, 10, p. 1970-1971 2 p.

Research output: Contribution to journalComment/debate

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., 2012 Sep 1, In : Nature medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

327 Citations (Scopus)

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 Sep 1, In : Immunology Letters. 147, 1-2, p. 75-79 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012

Ohara, H., Okazaki, K., Tsubouchi, H., Inui, K., Kawa, S., Kamisawa, T., Tazuma, S., Uchida, K., Hirano, K., Yoshida, H., Nishino, T., Ko, S. B. H., Mizuno, N., Hamano, H., Kanno, A., Notohara, K., Hasebe, O., Nakazawa, T., Nakanuma, Y. & Takikawa, H., 2012 Sep 1, In : Journal of Hepato-Biliary-Pancreatic Sciences. 19, 5, p. 536-542 7 p.

Research output: Contribution to journalReview article

219 Citations (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 Jan 1, In : Nature Methods. 9, 1, p. 81-83 3 p.

Research output: Contribution to journalArticle

177 Citations (Scopus)

Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO3- exchange in mouse pancreatic duct

Ishiguro, H., Song, Y., Yamamoto, A., Steward, M. C., Ko, S. B. H., Stewart, A. K., Soleimani, M., Liu, B. C., Kondo, T. & Jin, C. X., 2012 Oct 15, In : American Journal of Physiology - Cell Physiology. 303, 8, p. C815-C824

Research output: Contribution to journalArticle

11 Citations (Scopus)

Detection of a large heterozygous deletion and a splicing defect in the CFTR transcripts from nasal swab of a Japanese case of cystic fibrosis

Nakakuki, M., Fujiki, K., Yamamoto, A., Ko, S. B., Yi, L., Ishiguro, M., Yamaguchi, M., Kondo, S., Maruyama, S., Yanagimoto, K., Naruse, S. & Ishiguro, H., 2012 Jul 1, In : Journal of Human Genetics. 57, 7, p. 427-433 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Dynamic regulation of T h17 differentiation by oxygen concentrations

Ikejiri, A., Nagai, S., Goda, N., Kurebayashi, Y., Osada-Oka, M., Takubo, K., Suda, T. & Koyasu, S., 2012 Mar 5, In : International immunology. 24, 3, p. 137-146 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 + stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H. & Watanabe, M., 2012 Apr 1, In : Nature medicine. 18, 4, p. 618-623 6 p.

Research output: Contribution to journalArticle

420 Citations (Scopus)

Gene expression profiling and regulatory networks in single cells

Arai, F., Hosokawa, K., Matsumoto, Y., Toyama, H. & Suda, T., 2012 Feb 1, New Frontiers of Network Analysis in Systems Biology. Springer Netherlands, p. 1-13 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects

Kodo, K., Nishizawa, T., Furutani, M., Arai, S., Ishihara, K., Oda, M., Makino, S., Fukuda, K., Takahashi, T., Matsuoka, R., Nakanishi, T. & Yamagishi, H., 2012 Jul 5, In : Circulation Journal. 76, 7, p. 1703-1711 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis: A Pilot Study

Sakuraba, A., Sato, T., Morohoshi, Y., Matsuoka, K., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2012 Jun 1, In : Therapeutic Apheresis and Dialysis. 16, 3, p. 213-218 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

International workshop: Radiation effects on mutation in somatic and germline stem cells

Kodama, Y., Noda, A., Booth, C., Breault, D., Suda, T., Hendry, J., Shinohara, T., Rübe, C., Nishimura, E. K., Mitani, H., Nakamura, N. & Niwa, O., 2012 Jun 1, In : International Journal of Radiation Biology. 88, 6, p. 501-506 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Molecular mechanisms of pancreatic stone formation in chronic pancreatitis

Ko, S. B. H., Azuma, S., Yoshikawa, T., Yamamoto, A., Kyokane, K., Ko, M. S. H. & Ishiguro, H., 2012 Dec 17, In : Frontiers in Physiology. 3 NOV, Article 415.

Research output: Contribution to journalArticle

10 Citations (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 Nov 23, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 Jul 20, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 Nov 1, In : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

On the biomechanics of stem cell niche formation in the gut - Modelling growing organoids

Buske, P., Przybilla, J., Loeffler, M., Sachs, N., Sato, T., Clevers, H. & Galle, J., 2012 Sep 1, In : FEBS Journal. 279, 18, p. 3475-3487 13 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Passing a baton to the next generation

Suda, T. & Kitamura, S., 2012 Nov 1, In : International journal of hematology. 96, 5, p. 529-530 2 p.

Research output: Contribution to journalEditorial

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I. & Suda, T., 2012 Jan 1, In : Journal of Cellular Physiology. 227, 2, p. 421-430 10 p.

Research output: Contribution to journalShort survey

151 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 Aug, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 May 1, In : International journal of hematology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration

Xie, H., Sun, X., Piao, Y., Jegga, A. G., Handwerger, S., Ko, M. S. H. & Dey, S. K., 2012 Sep 14, In : Journal of Biological Chemistry. 287, 38, p. 32288-32297 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Structure and function of the pancreas in the polycystic kidney rat

Yi, L., Naruse, S., Furuya, S., Yamamoto, A., Nakakuki, M., Nagao, S., Yoshihara, D., Ko, S. B. H., Wei, M., Kondo, T. & Ishiguro, H., 2012 Nov 1, In : Pancreas. 41, 8, p. 1292-1298 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Three cases of bronchial asthma preceding IgG4-related autoimmune pancreatitis

Ito, S., Ko, S. B. H., Morioka, M., Imaizumi, K., Kondo, M., Mizuno, N. & Hasegawa, Y., 2012 Jan 1, In : Allergology International. 61, 1, p. 171-174 4 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Two anatomically distinct niches regulate stem cell activity

Ema, H. & Suda, T., 2012 Sep 13, In : Blood. 120, 11, p. 2174-2181 8 p.

Research output: Contribution to journalReview article

49 Citations (Scopus)

Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis

Mayumi, T., Inui, K., Maetani, I., Yokoe, M., Sakamoto, T., Yoshida, M., Ko, S., Hirata, K. & Takada, T., 2012 Aug 1, In : Pancreas. 41, 6, p. 869-875 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells

Ko, S. B. H., Yamamoto, A., Azuma, S., Song, H., Kamimura, K., Nakakuki, M., Gray, M. A., Becq, F., Ishiguro, H. & Goto, H., 2011 Jul 15, In : Biochemical and Biophysical Research Communications. 410, 4, p. 904-909 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., 2011 Feb 24, In : Blood. 117, 8, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Hematopoiesis and bone remodeling

Suda, T., 2011 May 26, In : Blood. 117, 21, p. 5556-5557 2 p.

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., 2011 Sep 29, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Intravenous fluid therapy successfully prevents renal injury by gemcitabine in patients with pancreatic cancer

Ko, S. B. H., Azuma, S., Kamimura, K., Goto, H., Anzai, N., Yamamoto, A., Ishiguro, H. & Mizuno, N., 2011 Jul 1, In : Pancreas. 40, 5, p. 784-787 4 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., Clevers, H. & Batlle, E., 2011 Oct 1, In : Nature medicine. 17, 10, p. 1225-1227 3 p.

Research output: Contribution to journalArticle

369 Citations (Scopus)