The Sakaguchi Laboratory

Research Output 1979 2020

2013
16 Citations (Scopus)

Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells

Hung, S. S. C., Wong, R. C. B., Sharov, A. A., Nakatake, Y., Yu, H. & Ko, M., 2013 Aug, In : DNA Research. 20, 4, p. 391-401 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Embryonic Stem Cells
Embryonic Structures
Genes
Proteins

Role of iPSC-Producing Factors in Pre-Implantation Embryos

Amano, T. & Ko, M., 2013 Oct, Principles of Cloning: Second Edition. Elsevier Inc., p. 473-484 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Induced Pluripotent Stem Cells
Stem Cell Factor
Stem cells
Embryonic Stem Cells
Pluripotent Stem Cells

Spur cell anemia associated with alcoholic cirrhosis

Sugimoto, S., Yamagishi, Y., Ebinuma, H. & Kanai, T., 2013, In : Internal Medicine. 52, 24, p. 2831 1 p.

Research output: Contribution to journalArticle

Acanthocytes
Alcoholic Liver Cirrhosis
Hemolytic Anemia
Liver Failure
Anemia
34 Citations (Scopus)

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Nishiyama, A., Sharov, A. A., Piao, Y., Amano, M., Amano, T., Hoang, H. G., Binder, B. Y., Tapnio, R., Bassey, U., Malinou, J. N., Correa-Cerro, L. S., Yu, H., Xin, L., Meyers, E., Zalzman, M., Nakatake, Y., Stagg, C., Sharova, L., Qian, Y., Dudekula, D. & 9 others, Sheer, S., Cadet, J. S., Hirata, T., Yang, H. T., Goldberg, I., Evans, M. K., Longo, D. L., Schlessinger, D. & Ko, M., 2013, In : Scientific Reports. 3, 1390.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Transcription Factors
Gene Expression
Gene Regulatory Networks
Transcriptome
67 Citations (Scopus)

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Yoneno, K., Hisamatsu, T., Shimamura, K., Kamada, N., Ichikawa, R., Kitazume, M. T., Mori, M., Uo, M., Namikawa, Y., Matsuoka, K., Sato, T., Koganei, K., Sugita, A., Kanai, T. & Hibi, T., 2013 May, In : Immunology. 139, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Crohn Disease
Mucous Membrane
Macrophages
Cytokines
121 Citations (Scopus)

Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Morgani, S. M., Canham, M. A., Nichols, J., Sharov, A. A., Migueles, R., Ko, M. & Brickman, J. M., 2013 Mar 27, In : Cell Reports. 3, 6, p. 1945-1957 13 p.

Research output: Contribution to journalArticle

Totipotent Stem Cells
Embryonic Stem Cells
Stem cells
Cell culture
Ground state
267 Citations (Scopus)

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis

Huch, M., Bonfanti, P., Boj, S. F., Sato, T., Loomans, C. J. M., Van De Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., Van Es, J. H., De Koning, E., Vries, R. G. J., Heimberg, H. & Clevers, H., 2013 Oct 16, In : EMBO Journal. 32, 20, p. 2708-2721 14 p.

Research output: Contribution to journalArticle

Organoids
Ducts
Pancreas
Stem cells
Stem Cells
56 Citations (Scopus)

Zscan4 restores the developmental potency of embryonic stem cells.

Amano, T., Hirata, T., Falco, G., Monti, M., Sharova, L. V., Amano, M., Sheer, S., Hoang, H. G., Piao, Y., Stagg, C. A., Yamamizu, K., Akiyama, T. & Ko, M. S. H., 2013, In : Nature Communications. 4, 1966.

Research output: Contribution to journalArticle

stem cells
Embryonic Stem Cells
Stem cells
embryos
Embryonic Structures
2012
1 Citation (Scopus)

[Regulation of hematopoietic stem cells in niche signaling].

Matsumoto, Y. & Suda, T., 2012 Apr, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Neoplastic Stem Cells
Hematopoietic Stem Cells
Bone Marrow Cells
302 Citations (Scopus)

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., 2012 Sep, In : Nature Medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Hematopoietic Stem Cells
Stem cells
Leukemia
Fatty Acids
5 Citations (Scopus)

CCR9+ macrophages are required for eradication of peritoneal bacterial infections and prevention of polymicrobial sepsis

Mizukami, T., Kanai, T., Mikami, Y., Hayashi, A., Doi, T., Handa, T., Matsumoto, A., Jun, L., Matsuoka, K., Sato, T., Hisamatsu, T. & Hibi, T., 2012 Sep, In : Immunology Letters. 147, 1-2, p. 75-79 5 p.

Research output: Contribution to journalArticle

Bacterial Infections
Sepsis
Peritoneal Macrophages
Macrophages
Punctures
169 Citations (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 Jan, In : Nature Methods. 9, 1, p. 81-83 3 p.

Research output: Contribution to journalArticle

Organoids
Retroviridae
Cell culture
Gene expression
Small Intestine
11 Citations (Scopus)

Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO3 - exchange in mouse pancreatic duct

Ishiguro, H., Song, Y., Yamamoto, A., Steward, M. C., Ko, S., Stewart, A. K., Soleimani, M., Liu, B. C., Kondo, T. & Jin, C. X., 2012 Oct 15, In : American Journal of Physiology - Cell Physiology. 303, 8

Research output: Contribution to journalArticle

Chloride-Bicarbonate Antiporters
Pancreatic Ducts
Membranes
Cystic Fibrosis Transmembrane Conductance Regulator
Alkalies
39 Citations (Scopus)

Dynamic regulation of T h17 differentiation by oxygen concentrations

Ikejiri, A., Nagai, S., Goda, N., Kurebayashi, Y., Osada-Oka, M., Takubo, K., Suda, T. & Koyasu, S., 2012, In : International Immunology. 24, 3, p. 137-146 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Oxygen
Cell Differentiation
Von Hippel-Lindau Tumor Suppressor Protein
Spleen
402 Citations (Scopus)

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 + stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H. & Watanabe, M., 2012 Apr, In : Nature Medicine. 18, 4, p. 618-623 6 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Stem cells
Colon
Epithelium
Organoids

Gene expression profiling and regulatory networks in single cells

Arai, F., Hosokawa, K., Matsumoto, Y., Toyama, H. & Suda, T., 2012 Feb 1, New Frontiers of Network Analysis in Systems Biology. Springer Netherlands, Vol. 9789400743304. p. 1-13 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gene Expression Profiling
Gene Expression
Population
Complementary DNA
DNA Sequence Analysis
61 Citations (Scopus)

Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells

Krohne, T. U., Westenskow, P. D., Kurihara, T., Friedlander, D. F., Lehmann, M., Dorsey, A. L., Li, W., Zhu, S., Schultz, A., Wang, J., Siuzdak, G., Ding, S. & Friedlander, M., 2012, In : Stem cells translational medicine. 1, 2, p. 96-109 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Retinal Pigments
Retinal Pigment Epithelium
Epithelial Cells
Transplants
37 Citations (Scopus)

Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects

Kodo, K., Nishizawa, T., Furutani, M., Arai, S., Ishihara, K., Oda, M., Makino, S., Fukuda, K., Takahashi, T., Matsuoka, R., Nakanishi, T. & Yamagishi, H., 2012, In : Circulation Journal. 76, 7, p. 1703-1711 9 p.

Research output: Contribution to journalArticle

Congenital Heart Defects
Transcription Factors
GATA4 Transcription Factor
Mutation
Proteins
7 Citations (Scopus)

Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis: A Pilot Study

Sakuraba, A., Sato, T., Morohoshi, Y., Matsuoka, K., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2012 Jun, In : Therapeutic Apheresis and Dialysis. 16, 3, p. 213-218 6 p.

Research output: Contribution to journalArticle

6-Mercaptopurine
Blood Component Removal
Ulcerative Colitis
Granulocytes
Adsorption
9 Citations (Scopus)

Molecular mechanisms of pancreatic stone formation in chronic pancreatitis

Ko, S., Azuma, S., Yoshikawa, T., Yamamoto, A., Kyokane, K., Ko, M. & Ishiguro, H., 2012, In : Frontiers in Physiology. 3 NOV, Article 415.

Research output: Contribution to journalArticle

Chronic Pancreatitis
Cystic Fibrosis Transmembrane Conductance Regulator
Pancreatic Ducts
Adrenal Cortex Hormones
Chloride Channels
3 Citations (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 Nov 23, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Liver
Bone
167 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 Jul 20, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Hematopoietic Stem Cells
Stem cells
Cadherins
Osteoblasts
9 Citations (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 Nov 1, In : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

Liver Regeneration
Hepatocytes
Wounds and Injuries
Liver
Hepatectomy
49 Citations (Scopus)

On the biomechanics of stem cell niche formation in the gut - Modelling growing organoids

Buske, P., Przybilla, J., Loeffler, M., Sachs, N., Sato, T., Clevers, H. & Galle, J., 2012 Sep, In : FEBS Journal. 279, 18, p. 3475-3487 13 p.

Research output: Contribution to journalArticle

Organoids
Stem Cell Niche
Biomechanics
Stem cells
Biomechanical Phenomena
145 Citations (Scopus)

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I. & Suda, T., 2012 Jan, In : Journal of Cellular Physiology. 227, 2, p. 421-430 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Stem cells
Reactive Oxygen Species
Stem Cells
Oxidation-Reduction
31 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 Aug, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Bone
Bone Marrow
24 Citations (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 May, In : International Journal of Hematology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem Cells
Neoplastic Stem Cells
Drug Resistance
Cell Aging
29 Citations (Scopus)

Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration

Xie, H., Sun, X., Piao, Y., Jegga, A. G., Handwerger, S., Ko, M. & Dey, S. K., 2012 Sep 14, In : Journal of Biological Chemistry. 287, 38, p. 32288-32297 10 p.

Research output: Contribution to journalArticle

Endocannabinoids
Trophoblasts
Blastocyst
Cell Movement
Amplification
171 Citations (Scopus)

Targeted deletion of Vegfa in adult mice induces vision loss

Kurihara, T., Westenskow, P. D., Bravo, S., Aguilar, E. & Friedlander, M., 2012 Nov 1, In : Journal of Clinical Investigation. 122, 11, p. 4213-4217 5 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Eye Neoplasms
Retinal Cone Photoreceptor Cells
Color Vision
Photoreceptor Cells
49 Citations (Scopus)

Two anatomically distinct niches regulate stem cell activity

Ema, H. & Suda, T., 2012 Sep 13, In : Blood. 120, 11, p. 2174-2181 8 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Stem cells
Stem Cells
Cell Count
Adult Stem Cells
24 Citations (Scopus)

Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells

Westenskow, P. D., Moreno, S. K., Krohne, T. U., Kurihara, T., Zhu, S., Zhang, Z. N., Zhao, T., Xu, Y., Ding, S. & Friedlander, M., 2012 Sep, In : Investigative Ophthalmology and Visual Science. 53, 10, p. 6282-6290 9 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Phagocytosis
Flow Cytometry
Fluorescein-5-isothiocyanate
Transplants
2011
17 Citations (Scopus)

Astrocyte pvhl and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye

Kurihara, T., Westenskow, P. D., Krohne, T. U., Aguilar, E., Johnson, R. S. & Friedlander, M., 2011 Nov 14, In : Journal of Cell Biology. 195, 4, p. 689-701 13 p.

Research output: Contribution to journalArticle

Astrocytes
Vascular Endothelial Growth Factor A
Blood Vessels
Protein Isoforms
Gene Deletion
26 Citations (Scopus)

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., 2011 Feb 24, In : Blood. 117, 8, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Maintenance
Cell Cycle
Cells
21 Citations (Scopus)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., 2011 Sep 29, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

Gene Dosage
Genes
Alleles
Ligands
Phenotype
352 Citations (Scopus)

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., Clevers, H. & Batlle, E., 2011 Oct, In : Nature Medicine. 17, 10, p. 1225-1227 3 p.

Research output: Contribution to journalArticle

Eph Family Receptors
Stem cells
Stem Cells
Stem Cell Niche
Biopsy
23 Citations (Scopus)

Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome

Suzuki, M., Oda, M., Ramos, M. P., Pascual, M., Lau, K., Stasiek, E., Agyiri, F., Thompson, R. F., Glass, J. L., Jing, Q., Sandstrom, R., Fazzari, M. J., Hansen, R. S., Stamatoyannopoulos, J. A., McLellan, A. S. & Greally, J. M., 2011 Nov, In : Genome Research. 21, 11, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

Heterochromatin
Cytosine
Human Genome
Methylation
Genome
409 Citations (Scopus)

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Suda, T., Takubo, K. & Semenza, G. L., 2011 Oct 4, In : Cell Stem Cell. 9, 4, p. 298-310 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Homeostasis
Maintenance
Multipotent Stem Cells
Anaerobiosis
164 Citations (Scopus)

P57 Kip2 and p27 Kip1 cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I. & Suda, T., 2011 Sep 2, In : Cell Stem Cell. 9, 3, p. 247-261 15 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
Hematopoietic Stem Cells
Cell Cycle
Cyclin D1
Cyclin-Dependent Kinase Inhibitor p57
17 Citations (Scopus)

Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

Staal, F. J. T., Baum, C., Cowan, C., Dzierzak, E., Hacein-Bey-Abina, S., Karlsson, S., Lapidot, T., Lemischka, I., Mendez-Ferrer, S., Mikkers, H., Moore, K., Moreno, E., Mummery, C. L., Robin, C., Suda, T., Van Pel, M., Vanden Brink, G., Zwaginga, J. J. & Fibbe, W. E., 2011 Jul, In : Leukemia. 25, 7, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

Stem Cells
Bone Marrow
Cell- and Tissue-Based Therapy
Hematopoietic Stem Cells
Cell Self Renewal
42 Citations (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M., Takubo, K., Arai, F., Nakada, S. & Suda, T., 2011 Apr 21, In : Blood. 117, 16, p. 4169-4180 12 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Hematopoietic Stem Cells
Stem cells
Reactive Oxygen Species
2010
70 Citations (Scopus)

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., 2010 Mar 5, In : Cell Stem Cell. 6, 3, p. 194-198 5 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Gene Expression Regulation
Cadherins
Hematopoietic Stem Cells
Cell Adhesion
23 Citations (Scopus)

Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells

Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T. & Suda, T., 2010 Jan 14, In : Blood. 115, 2

Research output: Contribution to journalArticle

Mammals
Zebrafish
Hematopoietic Stem Cells
Stem cells
Gene expression
31 Citations (Scopus)

DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4

Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., Masuko, S., Suda, T., Meno, C., Côté, J. F., Nagasawa, T. & Fukui, Y., 2010 Oct 29, In : Circulation Research. 107, 9, p. 1102-1105 4 p.

Research output: Contribution to journalArticle

Cell Movement
src Homology Domains
Endothelial Cells
Cardiovascular Abnormalities
CXCR4 Receptors
2 Citations (Scopus)

Erratum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (Nature Medicine (2006)12 (446-451))

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., 2010 Jan, In : Nature Medicine. 16, 1, p. 129 1 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Hematopoietic Stem Cells
Reactive Oxygen Species
Medicine
25 Citations (Scopus)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

Gomei, Y., Nakamura, Y., Yoshihara, H., Hosokawa, K., Iwasaki, H., Suda, T. & Arai, F., 2010 Feb, In : Experimental Hematology. 38, 2

Research output: Contribution to journalArticle

Angiopoietin-2
Angiopoietin-1
Hematopoietic Stem Cells
Bone Marrow
Ligands
364 Citations (Scopus)

Generation of induced pluripotent stem cells from human terminally differentiated circulating t cells

Seki, T., Yuasa, S., Oda, M., Egashira, T., Yae, K., Kusumoto, D., Nakata, H., Tohyama, S., Hashimoto, H., Kodaira, M., Okada, Y., Seimiya, H., Fusaki, N., Hasegawa, M. & Fukuda, K., 2010 Jul, In : Cell Stem Cell. 7, 1, p. 11-13 3 p.

Research output: Contribution to journalArticle

Organic Cation Transport Proteins
SOXB1 Transcription Factors
Octamer Transcription Factor-3
Kruppel-Like Transcription Factors
Proto-Oncogene Proteins c-myc
135 Citations (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., 2010 Sep 2, In : Blood. 116, 9, p. 1422-1432 11 p.

Research output: Contribution to journalArticle

Activated-Leukocyte Cell Adhesion Molecule
Hematopoietic Stem Cells
Stem cells
Cells
Population
83 Citations (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., 2010 Jul 29, In : Blood. 116, 4, p. 554-563 10 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Small Interfering RNA
Bone
210 Citations (Scopus)

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S. I., Juang, Y. C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A. C., Natsume, T., Suda, T. & Durocher, D., 2010 Aug 19, In : Nature. 466, 7309, p. 941-946 6 p.

Research output: Contribution to journalArticle

Ubiquitination
DNA Damage
Chromatin
Double-Stranded DNA Breaks
Enzyme Inhibitors

Regulation of hematopoietic stem cells by oxygen metabolism

Takubo, K., 2010 Feb, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 51, 2, p. 95-103 9 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Hematopoietic Stem Cells
Bone Marrow Cells
Cell Division
Cell Differentiation