The Sakaguchi Laboratory

Research Output

2012

Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis

Mayumi, T., Inui, K., Maetani, I., Yokoe, M., Sakamoto, T., Yoshida, M., Ko, S., Hirata, K. & Takada, T., 2012 Aug 1, In : Pancreas. 41, 6, p. 869-875 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos

Akiyama, T., Suzuki, O., Matsuda, J. & Aoki, F., 2011 Oct, In : PLoS Genetics. 7, 10, e1002279.

Research output: Contribution to journalArticle

Open Access
89 Citations (Scopus)

Effects of CFTR gene silencing by siRNA or the luminal application of a CFTR activator on fluid secretion from guinea-pig pancreatic duct cells

Ko, S. B. H., Yamamoto, A., Azuma, S., Song, H., Kamimura, K., Nakakuki, M., Gray, M. A., Becq, F., Ishiguro, H. & Goto, H., 2011 Jul 15, In : Biochemical and Biophysical Research Communications. 410, 4, p. 904-909 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., 2011 Feb 24, In : Blood. 117, 8, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Hematopoiesis and bone remodeling

Suda, T., 2011 May 26, In : Blood. 117, 21, p. 5556-5557 2 p.

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., 2011 Sep 29, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Intravenous fluid therapy successfully prevents renal injury by gemcitabine in patients with pancreatic cancer

Ko, S. B. H., Azuma, S., Kamimura, K., Goto, H., Anzai, N., Yamamoto, A., Ishiguro, H. & Mizuno, N., 2011 Jul 1, In : Pancreas. 40, 5, p. 784-787 4 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., Clevers, H. & Batlle, E., 2011 Oct 1, In : Nature medicine. 17, 10, p. 1225-1227 3 p.

Research output: Contribution to journalArticle

372 Citations (Scopus)

Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome

Suzuki, M., Oda, M., Ramos, M. P., Pascual, M., Lau, K., Stasiek, E., Agyiri, F., Thompson, R. F., Glass, J. L., Jing, Q., Sandstrom, R., Fazzari, M. J., Hansen, R. S., Stamatoyannopoulos, J. A., McLellan, A. S. & Greally, J. M., 2011 Nov 1, In : Genome Research. 21, 11, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Suda, T., Takubo, K. & Semenza, G. L., 2011 Oct 4, In : Cell stem cell. 9, 4, p. 298-310 13 p.

Research output: Contribution to journalReview article

420 Citations (Scopus)

New IJH guidelines highlight greater transparency

Sipp, D. & Suda, T., 2011 Apr 1, In : International journal of hematology. 93, 4, p. 411-412 2 p.

Research output: Contribution to journalEditorial

Pancreatic stone protein/regenerating protein family in pancreatic and gastrointestinal diseases

Jin, C. X., Hayakawa, T., Ko, S. B. H., Ishiguro, H. & Kitagawa, M., 2011 Aug 11, In : Internal Medicine. 50, 15, p. 1507-1516 10 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

SLC26 anion exchangers of guinea pig pancreatic duct: Molecular cloning and functional characterization

Stewart, A. K., Shmukler, B. E., Vandorpe, D. H., Reimold, F., Heneghan, J. F., Nakakuki, M., Akhavein, A., Ko, S., Ishiguro, H. & Alper, S. L., 2011 Aug 1, In : American Journal of Physiology - Cell Physiology. 301, 2, p. C289-C303

Research output: Contribution to journalArticle

30 Citations (Scopus)

Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

Staal, F. J. T., Baum, C., Cowan, C., Dzierzak, E., Hacein-Bey-Abina, S., Karlsson, S., Lapidot, T., Lemischka, I., Mendez-Ferrer, S., Mikkers, H., Moore, K., Moreno, E., Mummery, C. L., Robin, C., Suda, T., Van Pel, M., Vanden Brink, G., Zwaginga, J. J. & Fibbe, W. E., 2011 Jul 1, In : Leukemia. 25, 7, p. 1095-1102 8 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M. J., Takubo, K., Arai, F., Nakada, S. & Suda, T., 2011 Apr 21, In : Blood. 117, 16, p. 4169-4180 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2010

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., 2010 Mar 5, In : Cell stem cell. 6, 3, p. 194-198 5 p.

Research output: Contribution to journalLetter

71 Citations (Scopus)

Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells

Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T. & Suda, T., 2010 Jan 14, In : Blood. 115, 2, p. e1-e9

Research output: Contribution to journalArticle

23 Citations (Scopus)

Corticosteroids Correct Aberrant CFTR Localization in the Duct and Regenerate Acinar Cells in Autoimmune Pancreatitis

Ko, S. B. H., Mizuno, N., Yatabe, Y., Yoshikawa, T., Ishiguro, H., Yamamoto, A., Azuma, S., Naruse, S., Yamao, K., Muallem, S. & Goto, H., 2010 May, In : Gastroenterology. 138, 5, p. 1988-1996.e3

Research output: Contribution to journalArticle

79 Citations (Scopus)

Dkk4 and eda regulate distinctive developmental mechanisms for subtypes of mouse hair

Cui, C. Y., Kunisada, M., Piao, Y., Childress, V., Ko, M. S. H. & Schlessinger, D., 2010, In : PloS one. 5, 4, e10009.

Research output: Contribution to journalArticle

22 Citations (Scopus)

DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4

Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., Masuko, S., Suda, T., Meno, C., Côté, J. F., Nagasawa, T. & Fukui, Y., 2010 Oct 29, In : Circulation research. 107, 9, p. 1102-1105 4 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Erratum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (Nature Medicine (2006)12 (446-451))

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., 2010 Jan 1, In : Nature medicine. 16, 1, 1 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

Gomei, Y., Nakamura, Y., Yoshihara, H., Hosokawa, K., Iwasaki, H., Suda, T. & Arai, F., 2010 Feb, In : Experimental Hematology. 38, 2, p. 82-89.e1

Research output: Contribution to journalArticle

25 Citations (Scopus)

Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript

Canham, M. A., Sharov, A. A., Ko, M. S. H. & Brickman, J. M., 2010 May, In : PLoS biology. 8, 5

Research output: Contribution to journalArticle

172 Citations (Scopus)

Generation of induced pluripotent stem cells from human terminally differentiated circulating t cells

Seki, T., Yuasa, S., Oda, M., Egashira, T., Yae, K., Kusumoto, D., Nakata, H., Tohyama, S., Hashimoto, H., Kodaira, M., Okada, Y., Seimiya, H., Fusaki, N., Hasegawa, M. & Fukuda, K., 2010 Jul, In : Cell stem cell. 7, 1, p. 11-14 4 p.

Research output: Contribution to journalLetter

368 Citations (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., 2010 Sep 2, In : Blood. 116, 9, p. 1422-1432 11 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., 2010 Jul 29, In : Blood. 116, 4, p. 554-563 10 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S. I., Juang, Y. C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A. C., Natsume, T., Suda, T. & Durocher, D., 2010 Aug 19, In : Nature. 466, 7309, p. 941-946 6 p.

Research output: Contribution to journalArticle

225 Citations (Scopus)

Regulation of hematopoietic stem cells by oxygen metabolism

Takubo, K., 2010 Feb 1, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 51, 2, p. 95-103 9 p.

Research output: Contribution to journalReview article

Trophoblast cell lineage in cloned mouse embryos

Oda, M., Shiota, K. & Tanaka, S., 2010 Apr 1, In : Development Growth and Differentiation. 52, 3, p. 285-291 7 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina

Kurihara, T., Kubota, Y., Ozawa, Y., Takubo, K., Noda, K., Simon, M. C., Johnson, R. S., Suematsu, M., Tsubota, K., Ishida, S., Goda, N., Suda, T. & Okano, H., 2010 May 1, In : Development. 137, 9, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2009

Aging and cancer in hematopoietic stem cells

Nitta, E. & Suda, T., 2009 May 1, In : Japanese Journal of Geriatrics. 46, 3, p. 195-199 5 p.

Research output: Contribution to journalArticle

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

Adachi, H., Fujiwara, Y., Kondo, T., Nishikawa, T., Ogawa, R., Matsumura, T., Ishii, N., Nagai, R., Miyata, K., Tabata, M., Motoshima, H., Furukawa, N., Tsuruzoe, K., Kawashima, J., Takeya, M., Yamashita, S., Koh, G. Y., Nagy, A., Suda, T., Oike, Y. & 1 others, Araki, E., 2009 Feb 20, In : Biochemical and Biophysical Research Communications. 379, 4, p. 806-811 6 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis

Ko, S. B. H., Mizuno, N., Yatabe, Y., Yoshikawa, T., Ishiguro, H., Yamamoto, A., Azuma, S., Naruse, S., Yamao, K., Muallem, S. & Goto, H., 2009 Dec 1, In : Journal of Medical Investigation. 56, SUPPL. 1, p. 318-321 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Cancer stem cell concepts--lesson from leukemia

Nitta, E. & Suda, T., 2009 Oct, In : Nippon rinsho. Japanese journal of clinical medicine. 67, 10, p. 1863-1867 5 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Cancer stem cells and their niche

Iwasaki, H. & Suda, T., 2009 Jun 23, In : Cancer science. 100, 7, p. 1166-1172 7 p.

Research output: Contribution to journalReview article

106 Citations (Scopus)

CFTR Functions as a bicarbonate channel in pancreatic duct cells

Ishiguro, H., Steward, M. C., Naruse, S., Shigeru, B. H. K., Goto, H., Case, R. M., Kondo, T. & Yamamoto, A., 2009 Mar 1, In : Journal of General Physiology. 133, 3, p. 315-326 12 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells

Sun, C., Nakatake, Y., Akagi, T., Ura, H., Matsuda, T., Nishiyama, A., Koide, H., Ko, M. S. H., Niwa, H. & Yokota, T., 2009 Aug, In : Molecular and cellular biology. 29, 16, p. 4574-4583 10 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos

Oda, M., Tanaka, S., Yamazaki, Y., Ohta, H., Iwatani, M., Suzuki, M., Ohgane, J., Hattori, N., Yanagimachi, R., Wakayama, T. & Shiota, K., 2009 Sep 22, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16293-16297 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Glucose transport in interlobular ducts isolated from rat pancreas

Futakuchi, S., Ishiguro, H., Naruse, S., Ko, S. B. H., Fujiki, K., Yamamoto, A., Nakakuki, M., Song, Y., Steward, M. C., Kondo, T. & Goto, H., 2009 Dec 1, In : Journal of Medical Investigation. 56, SUPPL. 1, p. 308-311 4 p.

Research output: Contribution to journalArticle

Granulocyte and monocyte adsorption apheresis therapy modulates monocyte-derived dendritic cell function in patients with ulcerative colitis

Iwakami, Y., Sakuraba, A., Sato, T., Takada, Y., Izumiya, M., Ichikawa, H. & Hibi, T., 2009 Apr 1, In : Therapeutic Apheresis and Dialysis. 13, 2, p. 138-146 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

High glucose inhibits HCO3 and fluid secretion in rat pancreatic ducts

Futakuchi, S., Ishiguro, H., Naruse, S., Ko, S. B. H., Fujiki, K., Yamamoto, A., Nakakuki, M., Song, Y., Steward, M. C., Kondo, T. & Goto, H., 2009 Nov 1, In : Pflugers Archiv European Journal of Physiology. 459, 1, p. 215-226 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers

Oda, M., Glass, J. L., Thompson, R. F., Mo, Y., Olivier, E. N., Figueroa, M. E., Selzer, R. R., Richmond, T. A., Zhang, X., Dannenberg, L., Green, R. D., Melnick, A., Hatchwell, E., Bouhassira, E. E., Verma, A., Suzuki, M. & Greally, J. M., 2009, In : Nucleic acids research. 37, 12, p. 3829-3839 11 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Histological diagnosis of autoimmune pancreatitis using EUS-guided trucut biopsy: A comparison study with EUS-FNA

Mizuno, N., Bhatia, V., Hosoda, W., Sawaki, A., Hoki, N., Hara, K., Takagi, T., Ko, S. B. H., Yatabe, Y., Goto, H. & Yamao, K., 2009 May 12, In : Journal of gastroenterology. 44, 7, p. 742-750 9 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: Functional roles of HoxD8 in lymphangiogenesis

Harada, K., Yamazaki, T., Iwata, C., Yoshimatsu, Y., Sase, H., Mishima, K., Morishita, Y., Hirashima, M., Oike, Y., Suda, T., Miura, N., Watabe, T. & Miyazono, K., 2009, In : Journal of Cell Science. 122, 21, p. 3923-3930 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin

Tamase, A., Muraguchi, T., Naka, K., Tanaka, S., Kinoshita, M., Hoshii, T., Ohmura, M., Shugo, H., Ooshio, T., Nakada, M., Sawamoto, K., Onodera, M., Matsumoto, K., Oshima, M., Asano, M., Saya, H., Okano, H., Suda, T., Hamada, J. I. & Hirao, A., 2009 Oct 6, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 40, p. 17163-17168 6 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type i interferon-dependent exhaustion

Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T. & Ohteki, T., 2009 Jun 8, In : Nature medicine. 15, 6, p. 696-700 5 p.

Research output: Contribution to journalArticle

244 Citations (Scopus)

Lactoferrin in gastrointestinal disease

Hayakawa, T., Jin, C. X., Ko, S. B. H., Kitagawa, M. & Ishiguro, H., 2009 Oct 5, In : Internal Medicine. 48, 15, p. 1251-1254 4 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

Niche regulation of hematopoietic stem cells in the endosteum: The role of thrombopoietinmpl signaling in the maintenance of quiescent Hematopoietic Stem Cells

Arai, F., Yoshihara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H. & Suda, T., 2009 Jan 1, Hematopoietic Stem Cells VII. Blackwell Publishing Inc., p. 36-46 11 p. (Annals of the New York Academy of Sciences; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

49 Citations (Scopus)

Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis

Ohta, E., Itoh, T., Nemoto, T., Kumagai, J., Ko, S. B. H., Ishibashi, K., Ohno, M., Uchida, K., Ohta, A., Sohara, E., Uchida, S., Sasaki, S. & Rai, T., 2009 Dec 1, In : American Journal of Physiology - Cell Physiology. 297, 6, p. C1368-C1378

Research output: Contribution to journalArticle

33 Citations (Scopus)