The Sakaguchi Laboratory

Research Output

2010

Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro

Barker, N., Huch, M., Kujala, P., van de Wetering, M., Snippert, H. J., van Es, J. H., Sato, T., Stange, D. E., Begthel, H., van den Born, M., Danenberg, E., van den Brink, S., Korving, J., Abo, A., Peters, P. J., Wright, N., Poulsom, R. & Clevers, H., 2010 Jan 8, In : Cell stem cell. 6, 1, p. 25-36 12 p.

Research output: Contribution to journalArticle

805 Citations (Scopus)

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S. I., Juang, Y. C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A. C., Natsume, T., Suda, T. & Durocher, D., 2010 Aug 19, In : Nature. 466, 7309, p. 941-946 6 p.

Research output: Contribution to journalArticle

215 Citations (Scopus)

Regulation of hematopoietic stem cells by oxygen metabolism

Takubo, K., 2010 Feb 1, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 51, 2, p. 95-103 9 p.

Research output: Contribution to journalReview article

Trophoblast cell lineage in cloned mouse embryos

Oda, M., Shiota, K. & Tanaka, S., 2010 Apr 1, In : Development Growth and Differentiation. 52, 3, p. 285-291 7 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Zscan4 regulates telomere elongation and genomic stability in ES cells

Zalzman, M., Falco, G., Sharova, L. V., Nishiyama, A., Thomas, M., Lee, S. L., Stagg, C. A., Hoang, H. G., Yang, H. T., Indig, F. E., Wersto, R. P. & Ko, M. S. H., 2010 Apr 8, In : Nature. 464, 7290, p. 858-863 6 p.

Research output: Contribution to journalArticle

208 Citations (Scopus)
2009

Aging and cancer in hematopoietic stem cells

Nitta, E. & Suda, T., 2009 May 1, In : Japanese Journal of Geriatrics. 46, 3, p. 195-199 5 p.

Research output: Contribution to journalArticle

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

Adachi, H., Fujiwara, Y., Kondo, T., Nishikawa, T., Ogawa, R., Matsumura, T., Ishii, N., Nagai, R., Miyata, K., Tabata, M., Motoshima, H., Furukawa, N., Tsuruzoe, K., Kawashima, J., Takeya, M., Yamashita, S., Koh, G. Y., Nagy, A., Suda, T., Oike, Y. & 1 others, Araki, E., 2009 Feb 20, In : Biochemical and Biophysical Research Communications. 379, 4, p. 806-811 6 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis

Ko, S. B. H., Mizuno, N., Yatabe, Y., Yoshikawa, T., Ishiguro, H., Yamamoto, A., Azuma, S., Naruse, S., Yamao, K., Muallem, S. & Goto, H., 2009 Dec 1, In : Journal of Medical Investigation. 56, SUPPL. 1, p. 318-321 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Cancer stem cell concepts--lesson from leukemia

Nitta, E. & Suda, T., 2009 Oct, In : Nippon rinsho. Japanese journal of clinical medicine. 67, 10, p. 1863-1867 5 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Cancer stem cells and their niche

Iwasaki, H. & Suda, T., 2009 Jun 23, In : Cancer science. 100, 7, p. 1166-1172 7 p.

Research output: Contribution to journalReview article

106 Citations (Scopus)

CFTR Functions as a bicarbonate channel in pancreatic duct cells

Ishiguro, H., Steward, M. C., Naruse, S., Shigeru, B. H. K., Goto, H., Case, R. M., Kondo, T. & Yamamoto, A., 2009 Mar 1, In : Journal of General Physiology. 133, 3, p. 315-326 12 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Database for mRNA half-life of 19 977 genes obtained by DNA microarray analysis of pluripotent and differentiating mouse embryonic stem cells

Sharova, L. V., Sharov, A. A., Nedorezov, T., Piao, Y., Shaik, N. & Ko, M. S. H., 2009 Feb 1, In : DNA Research. 16, 1, p. 45-58 14 p.

Research output: Contribution to journalArticle

285 Citations (Scopus)

Dax1 binds to Oct3/4 and inhibits its transcriptional activity in embryonic stem cells

Sun, C., Nakatake, Y., Akagi, T., Ura, H., Matsuda, T., Nishiyama, A., Koide, H., Ko, M. S. H., Niwa, H. & Yokota, T., 2009 Aug 1, In : Molecular and Cellular Biology. 29, 16, p. 4574-4583 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Defining developmental potency and cell lineage trajectories by expression profiling of differentiating mouse embryonic stem cells

Aiba, K., Nedorezov, T., Piao, Y., Nishiyama, A., Matoba, R., Sharova, L. V., Sharov, A. A., Yamanaka, S., Niwa, H. & Ko, M. S. H., 2009 Feb 1, In : DNA Research. 16, 1, p. 73-80 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos

Oda, M., Tanaka, S., Yamazaki, Y., Ohta, H., Iwatani, M., Suzuki, M., Ohgane, J., Hattori, N., Yanagimachi, R., Wakayama, T. & Shiota, K., 2009 Sep 22, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 38, p. 16293-16297 5 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Exhaustive search for over-represented DNA sequence motifs with cisfinder

Sharov, A. A. & Ko, M. S. H., 2009 Oct 1, In : DNA Research. 16, 5, p. 261-273 13 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Glucose transport in interlobular ducts isolated from rat pancreas

Futakuchi, S., Ishiguro, H., Naruse, S., Ko, S. B. H., Fujiki, K., Yamamoto, A., Nakakuki, M., Song, Y., Steward, M. C., Kondo, T. & Goto, H., 2009 Dec 1, In : Journal of Medical Investigation. 56, SUPPL. 1, p. 308-311 4 p.

Research output: Contribution to journalArticle

Granulocyte and monocyte adsorption apheresis therapy modulates monocyte-derived dendritic cell function in patients with ulcerative colitis

Iwakami, Y., Sakuraba, A., Sato, T., Takada, Y., Izumiya, M., Ichikawa, H. & Hibi, T., 2009 Apr 1, In : Therapeutic Apheresis and Dialysis. 13, 2, p. 138-146 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

High glucose inhibits HCO3 and fluid secretion in rat pancreatic ducts

Futakuchi, S., Ishiguro, H., Naruse, S., Ko, S. B. H., Fujiki, K., Yamamoto, A., Nakakuki, M., Song, Y., Steward, M. C., Kondo, T. & Goto, H., 2009 Nov 1, In : Pflugers Archiv European Journal of Physiology. 459, 1, p. 215-226 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers

Oda, M., Glass, J. L., Thompson, R. F., Mo, Y., Olivier, E. N., Figueroa, M. E., Selzer, R. R., Richmond, T. A., Zhang, X., Dannenberg, L., Green, R. D., Melnick, A., Hatchwell, E., Bouhassira, E. E., Verma, A., Suzuki, M. & Greally, J. M., 2009 Jul 30, In : Nucleic acids research. 37, 12, p. 3829-3839 11 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

Histological diagnosis of autoimmune pancreatitis using EUS-guided trucut biopsy: A comparison study with EUS-FNA

Mizuno, N., Bhatia, V., Hosoda, W., Sawaki, A., Hoki, N., Hara, K., Takagi, T., Ko, S. B. H., Yatabe, Y., Goto, H. & Yamao, K., 2009 May 12, In : Journal of gastroenterology. 44, 7, p. 742-750 9 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: Functional roles of HoxD8 in lymphangiogenesis

Harada, K., Yamazaki, T., Iwata, C., Yoshimatsu, Y., Sase, H., Mishima, K., Morishita, Y., Hirashima, M., Oike, Y., Suda, T., Miura, N., Watabe, T. & Miyazono, K., 2009 Nov 30, In : Journal of Cell Science. 122, 21, p. 3923-3930 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type i interferon-dependent exhaustion

Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T. & Ohteki, T., 2009 Jun 8, In : Nature medicine. 15, 6, p. 696-700 5 p.

Research output: Contribution to journalArticle

239 Citations (Scopus)

Lactoferrin in gastrointestinal disease

Hayakawa, T., Jin, C. X., Ko, S. B. H., Kitagawa, M. & Ishiguro, H., 2009 Oct 5, In : Internal Medicine. 48, 15, p. 1251-1254 4 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

Maintenance of undifferentiated mouse embryonic stem cells in suspension by the serum- and feeder-free defined culture condition (Developmental Dynamics 237, (2129-2138))

Tsuji, Y., Yoshimura, N., Aoki, H., Sharov, A. A., Ko, M. S. H., Motohashi, T. & Kunisada, T., 2009 Feb 1, In : Developmental Dynamics. 238, 2, 1 p.

Research output: Contribution to journalComment/debate

Niche regulation of hematopoietic stem cells in the endosteum: The role of thrombopoietinmpl signaling in the maintenance of quiescent Hematopoietic Stem Cells

Arai, F., Yoshihara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H. & Suda, T., 2009 Jan 1, Hematopoietic Stem Cells VII. Blackwell Publishing Inc., p. 36-46 11 p. (Annals of the New York Academy of Sciences; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

48 Citations (Scopus)

Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis

Ohta, E., Itoh, T., Nemoto, T., Kumagai, J., Ko, S. B. H., Ishibashi, K., Ohno, M., Uchida, K., Ohta, A., Sohara, E., Uchida, S., Sasaki, S. & Rai, T., 2009 Dec 1, In : American Journal of Physiology - Cell Physiology. 297, 6, p. C1368-C1378

Research output: Contribution to journalArticle

32 Citations (Scopus)

Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation

Shibayama, M., Ohno, S., Osaka, T., Sakamoto, R., Tokunaga, A., Nakatake, Y., Sato, M. & Yoshida, N., 2009 Nov 1, In : FEBS Journal. 276, 22, p. 6658-6668 11 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Requirement for Shh and Fox family genes at different stages in sweat gland development

Kunisada, M., Cui, C. Y., Piao, Y., Ko, M. S. H. & Schlessinger, D., 2009 May 7, In : Human molecular genetics. 18, 10, p. 1769-1778 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Sato, T., Vries, R. G., Snippert, H. J., Van De Wetering, M., Barker, N., Stange, D. E., Van Es, J. H., Abo, A., Kujala, P., Peters, P. J. & Clevers, H., 2009 May 14, In : Nature. 459, 7244, p. 262-265 4 p.

Research output: Contribution to journalArticle

2417 Citations (Scopus)

Standard steroid treatment for autoimmune pancreatitis

Kamisawa, T., Shimosegawa, T., Okazaki, K., Nishino, T., Watanabe, H., Kanno, A., Okumura, F., Nishikawa, T., Kobayashi, K., Ichiya, T., Takatori, H., Yamakita, K., Kubota, K., Hamano, H., Okamura, K., Hirano, K., Ito, T., Ko, S. B. H. & Omata, M., 2009 Nov 1, In : Gut. 58, 11, p. 1504-1507 4 p.

Research output: Contribution to journalArticle

433 Citations (Scopus)

Th1/Th17 Immune Response Is Induced by Mesenteric Lymph Node Dendritic Cells in Crohn's Disease

Sakuraba, A., Sato, T., Kamada, N., Kitazume, M., Sugita, A. & Hibi, T., 2009 Nov, In : Gastroenterology. 137, 5, p. 1736-1745 10 p.

Research output: Contribution to journalArticle

146 Citations (Scopus)

The HELP assay.

Oda, M. & Greally, J. M., 2009, In : Methods in molecular biology (Clifton, N.J.). 507, p. 77-87 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos

Stanghellini, I., Falco, G., Lee, S. L., Monti, M. & Ko, M. S. H., 2009 Dec 1, In : Gene Expression Patterns. 9, 8, p. 595-602 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors

Nishiyama, A., Xin, L., Sharov, A. A., Thomas, M., Mowrer, G., Meyers, E., Piao, Y., Mehta, S., Yee, S., Nakatake, Y., Stagg, C., Sharova, L., Correa-Cerro, L. S., Bassey, U., Hoang, H., Kim, E., Tapnio, R., Qian, Y., Dudekula, D., Zalzman, M. & 13 others, Li, M., Falco, G., Yang, H. T., Lee, S. L., Monti, M., Stanghellini, I., Islam, M. N., Nagaraja, R., Goldberg, I., Wang, W., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2009 Oct 2, In : Cell stem cell. 5, 4, p. 420-433 14 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)
2008

A new beginning for the International Journal of Hematology: A message from the Editor-in-Chief

Suda, T., 2008 Jan 1, In : International journal of hematology. 87, 1, 1 p.

Research output: Contribution to journalEditorial

An in situ hybridization-based screen for heterogeneously expressed genes in mouse ES cells

Carter, M. G., Stagg, C. A., Falco, G., Yoshikawa, T., Bassey, U. C., Aiba, K., Sharova, L. V., Shaik, N. & Ko, M. S. H., 2008 Feb 1, In : Gene Expression Patterns. 8, 3, p. 181-198 18 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)
26 Citations (Scopus)

Asian diagnostic criteria for autoimmune pancreatitis: Consensus of the Japan-Korea Symposium on Autoimmune Pancreatitis

Otsuki, M., Chung, J. B., Okazaki, K., Kim, M. H., Kamisawa, T., Kawa, S., Park, S. W., Shimosegawa, T., Lee, K., Ito, T., Nishimori, I., Notohara, K., Naruse, S., Ko, S. B. H. & Kihara, Y., 2008 Jun 1, In : Journal of gastroenterology. 43, 6, p. 403-408 6 p.

Research output: Contribution to journalArticle

360 Citations (Scopus)

BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells

Yan, Z., Wang, Z., Sharova, L., Sharov, A. A., Ling, C., Piao, Y., Aiba, K., Matoba, R., Wang, W. & Ko, M. S. H., 2008 May 1, In : Stem Cells. 26, 5, p. 1155-1165 11 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Brain-specific expression of vascular endothelial growth factor 146 correlates with the blood-brain barrier induction in quail embryos

Ikeda, E., Takubo, K., Kodama, T. & Okada, Y., 2008 Sep 1, In : Developmental Neuroscience. 30, 5, p. 331-339 9 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Changes in H3K79 methylation during preimplantation development in mice

Ooga, M., Inoue, A., Kageyama, S. I., Akiyama, T., Nagata, M. & Aoki, F., 2008 Mar 1, In : Biology of reproduction. 78, 3, p. 413-424 12 p.

Research output: Contribution to journalArticle

Open Access
62 Citations (Scopus)

Comparative analysis of oocyte transcript profiles reveals a high degree of conservation among species

Vallée, M., Aiba, K., Piao, Y., Palin, M. F., Ko, M. S. H. & Sirard, M. A., 2008 Apr 1, In : Reproduction. 135, 4, p. 439-448 10 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Current View: Intestinal Stem Cells and Signaling

Scoville, D. H., Sato, T., He, X. C. & Li, L., 2008 Mar, In : Gastroenterology. 134, 3, p. 849-864 16 p.

Research output: Contribution to journalArticle

287 Citations (Scopus)

Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary

Sharov, A. A., Falco, G., Piao, Y., Poosala, S., Becker, K. G., Zonderman, A. B., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2008 Jun 3, In : BMC Biology. 6, 24.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Essential role of chromatin remodeling protein bptf in early mouse embryos and embryonic stem cells

Landry, J., Sharov, A. A., Piao, Y., Sharova, L. V., Xiao, H., Southon, E., Matta, J., Tessarollo, L., Zhang, Y. E., Ko, M. S. H., Kuehn, M. R., Yamaguchi, T. P. & Wu, C., 2008 Oct 1, In : PLoS Genetics. 4, 10, e1000241.

Research output: Contribution to journalArticle

87 Citations (Scopus)

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y. & 4 others, Hata, A., Chiba, S., Nakayama, K. I. & Suda, T., 2008 Apr 15, In : Genes and Development. 22, 8, p. 986-991 6 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

Gene structure and functional characterization of growth hormone in Dogfish, squalus acanthias

Moriyama, S., Oda, M., Yamazaki, T., Yamaguchi, K., Amiya, N., Takahashi, A., Amano, M., Goto, T., Nozaki, M., Meguro, H. & Kawauchi, H., 2008 Jun 1, In : Zoological Science. 25, 6, p. 604-613 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data

Sharov, A. A., Masui, S., Sharova, L. V., Piao, Y., Aiba, K., Matoba, R., Xin, L., Niwa, H. & Ko, M. S. H., 2008 Jun 3, In : BMC Genomics. 9, 269.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity

Ohmura, M., Naka, K., Hoshii, T., Muraguchi, T., Shugo, H., Tamase, A., Uema, N., Ooshio, T., Arai, F., Takubo, K., Nagamatsu, G., Hamaguchi, I., Takagi, M., Ishihara, M., Sakurada, K., Miyaji, H., Suda, T. & Hirao, A., 2008 Dec 1, In : Stem Cells. 26, 12, p. 3237-3246 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)