The Sakaguchi Laboratory

Research Output

2004

Derivation and morphological characterization of mouse spermatogonial stem cell lines

Ogawa, T., Ohmura, M., Tamura, Y., Kita, K., Ohbo, K., Suda, T. & Kubota, Y., 2004 Nov 1, In : Archives of Histology and Cytology. 67, 4, p. 297-306 10 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Dynamic control of cystic fibrosis transmembrane conductance regulator Cl-/HCO3- selectivity by external Cl -

Shcheynikov, N., Kim, K. H., Kim, K. M., Dorwart, M. R., Ko, S. B. H., Goto, H., Naruse, S., Thomas, P. J. & Muallem, S., 2004 May 21, In : Journal of Biological Chemistry. 279, 21, p. 21857-21865 9 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Gating of CFTR by the STAS domain of SLC26 transporters

Ko, S. B. H., Zeng, W., Dorwart, M. R., Luo, X., Kim, K. H., Millen, L., Goto, H., Naruse, S., Soyombo, A., Thomas, P. J. & Muallem, S., 2004 Apr 1, In : Nature Cell Biology. 6, 4, p. 343-350 8 p.

Research output: Contribution to journalArticle

321 Citations (Scopus)

Genetic evidence for CFTR dysfunction in Japanese: background for chronic pancreatitis.

Fujiki, K., Ishiguro, H., Ko, S. B., Mizuno, N., Suzuki, Y., Takemura, T., Yamamoto, A., Yoshikawa, T., Kitagawa, M., Hayakawa, T., Sakai, Y., Takayama, T., Saito, M., Kondo, T. & Naruse, S., 2004 May, In : Journal of medical genetics. 41, 5, p. e55

Research output: Contribution to journalLetter

Open Access
37 Citations (Scopus)

Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes

Okazawa, A., Kanai, T., Nakamaru, K., Sato, T., Inoue, N., Ogata, H., Iwao, Y., Ikeda, M., Kawamura, T., Makita, S., Uraushihara, K., Okamoto, R., Yamazaki, M., Kurimoto, M., Ishii, H., Watanabe, M. & Hibi, T., 2004 May 1, In : Clinical and Experimental Immunology. 136, 2, p. 269-276 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Hyperexpression of Inducible Costimulator and Its Contribution on Lamina Propria T Cells in Inflammatory Bowel Disease

Sato, T., Kanai, T., Watanabe, M., Sakuraba, A., Okamoto, S., Nakai, T., Okazawa, A., Inoue, N., Totsuka, T., Yamazaki, M., Kroczek, R. A., Fukushima, T., Ishii, H. & Hibi, T., 2004 Mar, In : Gastroenterology. 126, 3, p. 829-839 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T. & Nakayama, K. I., 2004 Mar 5, In : Journal of Biological Chemistry. 279, 10, p. 9417-9423 7 p.

Research output: Contribution to journalArticle

194 Citations (Scopus)

Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis

Yoshida, S., Takakura, A., Ohbo, K., Abe, K., Wakabayashi, J., Yamamoto, M., Suda, T. & Nabeshima, Y. I., 2004 May 15, In : Developmental Biology. 269, 2, p. 447-458 12 p.

Research output: Contribution to journalArticle

197 Citations (Scopus)

Regulation of cell cycle in hematopoietic stem cells by the niche

Hirao, A., Arai, F. & Suda, T., 2004 Dec, In : Cell Cycle. 3, 12, p. 1481-1483 3 p.

Research output: Contribution to journalShort survey

Open Access
30 Citations (Scopus)

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., Ikeda, Y., Mak, T. W. & Suda, T., 2004 Oct 21, In : Nature. 431, 7011, p. 997-1002 6 p.

Research output: Contribution to journalArticle

845 Citations (Scopus)

Spatial analysis of germ stem cell development in Oct-4/EGFP transgenic mice

Ohmura, M., Yoshida, S., Ide, Y., Nagamatsu, G., Suda, T. & Ohbo, K., 2004 Nov 1, In : Archives of Histology and Cytology. 67, 4, p. 285-296 12 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction or Th1 mediated immunopathology in Crohn's disease

Matsuoka, K., Inoue, N., Sato, T., Okamoto, S., Hisamatsu, T., Kishi, Y., Sakuraba, A., Hitotsumatsu, O., Ogata, H., Koganei, K., Fukushima, T., Kanai, T., Watanabe, M., Ishii, H. & Hibi, T., 2004 Sep, In : Gut. 53, 9, p. 1303-1308 6 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S., Takubo, K., Ito, K., Koh, G. Y. & Suda, T., 2004 Jul 23, In : Cell. 118, 2, p. 149-161 13 p.

Research output: Contribution to journalArticle

1382 Citations (Scopus)
2003

Defective smooth muscle development in qkl-deficient mice

Li, Z., Takakura, N., Oike, Y., Imanaka, T., Araki, K., Suda, T., Kaname, T., Kondo, T., Abe, K. & Yamamura, K. I., 2003 Oct 1, In : Development Growth and Differentiation. 45, 5-6, p. 449-462 14 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Distinct roles of ephrin-B2 forward and EphB4 reverse signaling in endothelial cells

Hamada, K., Oike, Y., Ito, Y., Maekawa, H., Miyata, K., Shimomura, T. & Suda, T., 2003 Feb 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 23, 2, p. 190-197 8 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Ephrin-B2 Induces Migration of Endothelial Cells Through the Phosphatidylinositol-3 Kinase Pathway and Promotes Angiogenesis in Adult Vasculature

Maekawa, H., Oike, Y., Kanda, S., Ito, Y., Yamada, Y., Kurihara, H., Nagai, R. & Suda, T., 2003 Nov 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 23, 11, p. 2008-2014 7 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Ethanol induces fluid hypersecretion from guinea-pig pancreatic duct cells

Yamamoto, A., Ishiguro, H., Ko, S. B. H., Suzuki, A., Wang, Y., Hamada, H., Mizuno, N., Kitagawa, M., Hayakawa, T. & Naruse, S., 2003 Sep 15, In : Journal of Physiology. 551, 3, p. 917-926 10 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Identification and characterization of stem cells in prepubertal spermatogenesis in mice

Ohbo, K., Yoshida, S., Ohmura, M., Ohneda, O., Ogawa, T., Tsuchiya, H., Kuwana, T., Kehler, J., Abe, K., Schöler, H. R. & Suda, T., 2003 Jun 1, In : Developmental Biology. 258, 1, p. 209-225 17 p.

Research output: Contribution to journalArticle

174 Citations (Scopus)

Inhibition of Angiogenesis and Vascular Leakiness by Angiopoietin-Related Protein 4

Ito, Y., Oike, Y., Yasunaga, K., Hamada, K., Miyata, K., Matsumoto, S. I., Sugano, S., Tanihara, H., Masuho, Y. & Suda, T., 2003 Oct 15, In : Cancer Research. 63, 20, p. 6651-6657 7 p.

Research output: Contribution to journalArticle

132 Citations (Scopus)

Neuropilin-1 on hematopoietic cells as a source of vascular development

Yamada, Y., Oike, Y., Ogawa, H., Ito, Y., Fujisawa, H., Suda, T. & Takakura, N., 2003 Mar 1, In : Blood. 101, 5, p. 1801-1809 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The expression of platelet endothelial cell adhesion molecule-1 in mouse primordial germ cells during their migration and early gonadal formation

Wakayama, T., Hamada, K., Yamamoto, M., Suda, T. & Iseki, S., 2003 May 1, In : Histochemistry and Cell Biology. 119, 5, p. 355-362 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Transcriptome analysis of mouse stem cells and early embryos

Sharov, A. A., Piao, Y., Matoba, R., Dudekula, D. B., Qian, Y., VanBuren, V., Falco, G., Martin, P. R., Stagg, C. A., Bassey, U. C., Wang, Y., Carter, M. G., Hamatani, T., Aiba, K., Akutsu, H., Sharova, L., Tanaka, T. S., Kimber, W. L., Yoshikawa, T., Jaradat, S. A. & 20 others, Pantano, S., Nagaraja, R., Boheler, K. R., Taub, D., Hodes, R. J., Longo, D. L., Schlessinger, D., Keller, J., Klotz, E., Kelsoe, G., Umezawa, A., Vescovi, A. L., Rossant, J., Kunath, T., Hogan, B. L. M., Curci, A., D'Urso, M., Kelso, J., Hide, W. & Ko, M. S. H., 2003 Dec 1, In : PLoS biology. 1, 3

Research output: Contribution to journalArticle

145 Citations (Scopus)
2002

AE4 is a DIDS-sensitive Cl-/HCO3- exchanger in the basolateral membrane of the renal CCD and the SMG duct

Ko, S. B. H., Luo, X., Hager, H., Rojek, A., Choi, J. Y., Licht, C., Suzuki, M., Muallem, S., Nielsen, S. & Ishibashi, K., 2002 Oct, In : American Journal of Physiology - Cell Physiology. 283, 4 52-4, p. C1206-C1218

Research output: Contribution to journalArticle

88 Citations (Scopus)

Analysis of human TIE2 function on hematopoietic stem cells in umbilical cord blood

Yuasa, H., Takakura, N., Shimomura, T., Suenobu, S., Yamada, T., Nagayama, H., Oike, Y. & Suda, T., 2002 Nov 30, In : Biochemical and Biophysical Research Communications. 298, 5, p. 731-737 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Aquaporins in rat pancreatic interlobular ducts

Ko, S. B. H., Naruse, S., Kitagawa, M., Ishiguro, H., Furuya, S., Mizuno, N., Wang, Y., Yoshikawa, T., Suzuki, A., Shimano, S. & Hayakawa, T., 2002 Jun 27, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 282, 2 45-2, p. G324-G331

Research output: Contribution to journalArticle

42 Citations (Scopus)

A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis

Suenobu, S., Takakura, N., Inada, T., Yamada, Y., Yuasa, H., Zhang, X. Q., Sakano, S., Oike, Y. & Suda, T., 2002 Jan 1, In : Biochemical and Biophysical Research Communications. 293, 3, p. 1124-1131 8 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

Hirao, A., Cheung, A., Duncan, G., Girard, P. M., Elia, A. J., Wakeham, A., Okada, H., Sarkissian, T., Wong, J. A., Sakai, T., De Stanchina, E., Bristow, R. G., Suda, T., Lowe, S. W., Jeggo, P. A., Elledge, S. J. & Mak, T. W., 2002 Sep 1, In : Molecular and cellular biology. 22, 18, p. 6521-6532 12 p.

Research output: Contribution to journalArticle

294 Citations (Scopus)

Differentiation of trophoblast lineage is associated with DNA methylation and demethylation

Ohgane, J., Hattori, N., Oda, M., Tanaka, S. & Shiota, K., 2002 Jan 18, In : Biochemical and Biophysical Research Communications. 290, 2, p. 701-706 6 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Effect of direct angiogenesis inhibition in rheumatoid arthritis using a soluble vascular endothelial growth factor receptor 1 chimeric protein

Sekimoto, T., Hamada, K., Oike, Y., Matsuoka, T., Matsumoto, M., Chosa, E., Suda, T., Tajima, N. & Yamamura, K. I., 2002 Feb 12, In : Journal of Rheumatology. 29, 2, p. 240-245 6 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Expression and function of NJ-1 surface antigen in megakaryopoiesis

Tang, H., Zhang, X. Q., Naruse, T., Ohbo, K. & Suda, T., 2002 Jan 1, In : Biochemical and Biophysical Research Communications. 292, 3, p. 667-674 8 p.

Research output: Contribution to journalArticle

Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cells

Burger, P. E., Coetzee, S., McKeehan, W. L., Kan, M., Cook, P., Fan, Y., Suda, T., Hebbel, R. P., Novitzky, N., Muller, W. A. & Lynette Wilson, E., 2002 Nov 15, In : Blood. 100, 10, p. 3527-3535 9 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Redistribution of ERK/MAP kinase to uropod-like structures in interleukin-3-induced cell shape changes

Mera, A., Suga, M., Nakayama, Y., Ando, M., Suda, T. & Yamaguchi, N., 2002 Nov 1, In : Immunology Letters. 84, 2, p. 117-124 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells

Oike, Y., Ito, Y., Hamada, K., Zhang, X. Q., Miyata, K., Arai, F., Inada, T., Araki, K., Nakagata, N., Takeya, M., Kisanuki, Y. Y., Yanagisawa, M., Gale, N. W. & Suda, T., 2002 Aug 15, In : Blood. 100, 4, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

Open Access
102 Citations (Scopus)
2001

5-Hydroxytryptamine strongly inhibits fluid secretion in guinea pig pancreatic duct cells

Suzuki, A., Naruse, S., Kitagawa, M., Ishiguro, H., Yoshikawa, T., Ko, S. B. H., Yamamoto, A., Hamada, H. & Hayakawa, T., 2001 Jan 1, In : Journal of Clinical Investigation. 108, 5, p. 749-756 8 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)

Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion

Ueno, M., Igarashi, K., Kimura, N., Okita, K., Takizawa, M., Nobuhisa, I., Kojima, T., Kitamura, T., Samulowitz, U., Vestweber, D., Shimomura, T., Suda, T., Nakashima, K. & Taga, T., 2001 Sep 21, In : Biochemical and Biophysical Research Communications. 287, 2, p. 501-506 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis

Yamada, Y., Takakura, N., Yasue, H., Ogawa, H., Fujisawa, H. & Suda, T., 2001 Mar 15, In : Blood. 97, 6, p. 1671-1678 8 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Expression of angiopoietin-2 in human glioma cells and its role for angiogenesis

Koga, K., Todaka, T., Morioka, M., Hamada, J. I., Kai, Y., Yano, S., Okamura, A., Ushio, Y., Takakura, N. & Suda, T., 2001 Aug 15, In : Cancer Research. 61, 16, p. 6248-6254 7 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Expression of discoidin domain receptor 1 tyrosine kinase on the human bronchial epithelium

Sakamoto, O., Suga, M., Suda, T. & Ando, M., 2001, In : European Respiratory Journal. 17, 5, p. 969-974 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Increased renal angiopoietin-1 expression in folic acid-induced nephrotoxicity in mice

Long, D. A., Woolf, A. S., Suda, T. & Yuan, H. T., 2001 Dec 17, In : Journal of the American Society of Nephrology. 12, 12, p. 2721-2731 11 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

In early development of the rat mRNA for the major myelin protein P0 is expressed in nonsensory areas of the embryonic inner ear, notochord, enteric nervous system, and olfactory ensheathing cells

Kolatsi-Joannou, M., Li, X. Z., Suda, T., Yuan, H. T. & Woolf, A. S., 2001 Sep 4, In : Developmental Dynamics. 222, 1, p. 40-51 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Insulinoma with Subsequent Association of Zollinger-Ellison Syndrome

Mizuno, N., Naruse, S., Kitagawa, M., Ishiguro, H., Ito, O., Ko, S. B. H., Yoshikawa, T., Tanahashi, C., Ito, M. & Hayakawa, T., 2001 May, In : Internal Medicine. 40, 5, p. 386-390 5 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Interleukin-18 and Crohn's disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T. & Hibi, T., 2001 Feb 6, In : Digestion. 63, SUPPL. 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Localization of recombination activating gene 1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice

Igarashi, H., Kuwata, N., Kiyota, K., Sumita, K., Suda, T., Ono, S., Bauer, S. R. & Sakaguchi, N., 2001 May 1, In : Blood. 97, 9, p. 2680-2687 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T., Yamazaki, M., Okamoto, S., Ishii, H., Totsuka, T., Iiyama, R., Okamoto, R., Ikeda, M., Kurimoto, M., Takeda, K., Akira, S. & Hibi, T., 2001 Jan 1, In : Gastroenterology. 121, 4, p. 875-888 14 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)

Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: Diversification between the two species

Nomiyama, H., Mera, A., Ohneda, O., Miura, R., Suda, T. & Yoshie, O., 2001 Apr, In : Genes and Immunity. 2, 2, p. 110-113 4 p.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Overexpression of the Csk homologous kinase (Chk tyrosine kinase) induces multinucleation: A possible role for chromosome-associated Chk in chromosome dynamics

Yamaguchi, N., Nakayama, Y., Urakami, T., Suzuki, S., Nakamura, T., Suda, T. & Oku, N., 2001 May 30, In : Journal of Cell Science. 114, 9, p. 1631-1641 11 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

PAL31 expression in rat trophoblast giant cells

Oda, M., Sun, W., Hattori, N., Tanaka, S. & Shiota, K., 2001 Sep 28, In : Biochemical and Biophysical Research Communications. 287, 3, p. 721-726 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer

Tanaka, S., Oda, M., Toyoshima, Y., Wakayama, T., Tanaka, M., Hattori, N., Yoshida, N., Ohgane, J., Yanagimachi, R. & Shiota, K., 2001 Jan 1, In : Biology of reproduction. 65, 6, p. 1813-1821 9 p.

Research output: Contribution to journalArticle

Open Access
170 Citations (Scopus)

Restricted VH gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis

Inoue, N., Watanabe, M., Sato, T., Okazawa, A., Yamazaki, M., Kanai, T., Ogata, H., Iwao, Y., Ishii, H. & Hibi, T., 2001 Jan 1, In : Gastroenterology. 121, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Retinoic acid promotes differentiation of trophoblast stem cells to a giant cell fate

Yan, J., Tanaka, S., Oda, M., Makino, T., Ohgane, J. & Shiota, K., 2001 Jul 15, In : Developmental Biology. 235, 2, p. 422-432 11 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)