The Sakaguchi Laboratory

Research Output

Article

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type i interferon-dependent exhaustion

Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T. & Ohteki, T., 2009 Jun 8, In : Nature medicine. 15, 6, p. 696-700 5 p.

Research output: Contribution to journalArticle

246 Citations (Scopus)

Interleukin-13 and its signaling pathway is associated with obesity-related colorectal tumorigenesis

Matsui, S., Okabayashi, K., Tsuruta, M., Shigeta, K., Seishima, R., Ishida, T., Kondo, T., Suzuki, Y., Hasegawa, H., Shimoda, M., Sugimoto, S., Sato, T. & Kitagawa, Y., 2019 Jul, In : Cancer science. 110, 7, p. 2156-2165 10 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Interleukin-13 selectively suppresses the growth of human macrophage progenitors at the late stage

Sakamoto, O., Hashiyama, M., Minty, A., Ando, M. & Suda, T., 1995, In : Blood. 85, 12, p. 3487-3493 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Interleukin-18 and Crohn's disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T. & Hibi, T., 2001 Feb 6, In : Digestion. 63, SUPPL. 1, p. 37-42 6 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis: A Pilot Study

Sakuraba, A., Sato, T., Morohoshi, Y., Matsuoka, K., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2012 Jun 1, In : Therapeutic Apheresis and Dialysis. 16, 3, p. 213-218 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., Suda, W., Hattori, M., Amagai, M., Ohyama, M. & Kanai, T., 2017 Aug 15, In : Cell Reports. 20, 7, p. 1513-1524 12 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Intramucosal poorly differentiated and signet-ring cell components in patients with ulcerative colitis-associated high-grade dysplasia

Sugimoto, S., Shimoda, M., Iwao, Y., Mutaguchi, M., Nanki, K., Mizuno, S., Kameyama, K., Ogata, H., Naganuma, M. & Kanai, T., 2019 Nov 1, In : Digestive Endoscopy. 31, 6, p. 706-711 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

In vitro differentiation of leukemic cells to eosinophils in the presence of interleukin-5 in two cases of acute myeloid leukemia with the translocation (8;21) (q22;q22)

Ema, H., Kitano, K., Suda, T., Sato, Y., Muroi, K., Ohta, M., Yoshida, M., Sakamoto, S., Eguchi, M. & Miura, Y., 1990, In : Blood. 75, 2, p. 350-356 7 p.

Research output: Contribution to journalArticle

Open Access
41 Citations (Scopus)

In Vitro Differentiation of Leukemic Progenitor Cells in Various Types of Acute Nonlymphocytic Leukemia

Ozawa, K., Miura, Y., Suda, T. & Motoyoshi, K., 1983 May 1, In : Cancer Research. 43, 5, p. 2334-2338 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

In vitro effects of angiopoietins and VEGF on hematopoietic and endothelial cells

Huang, X. L., Takakura, N. & Suda, T., 1999 Oct 14, In : Biochemical and Biophysical Research Communications. 264, 1, p. 133-138 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 Feb 14, In : Nature. 494, 7436, p. 247-250 4 p.

Research output: Contribution to journalArticle

670 Citations (Scopus)

In vitro hematopoietic and endothelial cell development from cells expressing TEK receptor in murine aorta-gonad-mesonephros region

Hamaguchi, I., Huang, X. L., Takakura, N., Tada, J. I., Yamaguchi, Y., Kodama, H. & Suda, T., 1999 Mar 1, In : Blood. 93, 5, p. 1549-1556 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

In vitro modeling of the bipolar disorder and schizophrenia using patient-derived induced pluripotent stem cells with copy number variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019, In : eNeuro. 6, 5, ENEURO.0403-18.2019.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

In vitro reconstitution of an erythropoietin gene transcription system using its 5′-flanking sequence and a nuclear extract from anemic kidney

Tsuchiya, T., Ochiai, H., Imajoh-Ohmi, S., Ueda, M., Suda, T., Nakamura, M. & Kanegasaki, S., 1992 Jan 15, In : Biochemical and Biophysical Research Communications. 182, 1, p. 137-143 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells

Okada, S., Nakauchi, H., Nagayoshi, K., Nishikawa, S. I., Miura, Y. & Suda, T., 1992 Dec 1, In : Blood. 80, 12, p. 3044-3050 7 p.

Research output: Contribution to journalArticle

398 Citations (Scopus)

In vivo changes of hemopoietic progenitors and the expression of the interleukin 5 gene in eosinophilic mice infected with Toxocara canis

Yamaguchi, Y., Matsui, T., Kasahara, T., Etoh, S., Tominaga, A., Takatsu, K., Miura, Y. & Suda, T., 1990 Dec 1, In : Experimental Hematology. 18, 11, p. 1152-1157 6 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Islet Cell Tumor in von Hippel-Lindau Disease

Mizlno, N., Naruse, S., Kitagawa, M., Ishiguro, H., Nakak, Y., Ihda, H., Iizuka, N., Ito, O., Seki, Y., Ko, S. B. H., Yoshikawa, T., Hayakawa, T., Sano, T., Kamiya, J., Nimura, Y. & Nagasaka, T., 1998, In : Internal Medicine. 37, 3, p. 295-299 5 p.

Research output: Contribution to journalArticle

Open Access
4 Citations (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., 2010 Sep 2, In : Blood. 116, 9, p. 1422-1432 11 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero

Kubota, Y., Takubo, K., Hirashima, M., Nagoshi, N., Kishi, K., Okuno, Y., Nakamura-Ishizu, A., Sano, K., Murakami, M., Ema, M., Omatsu, Y., Takahashi, S., Nagasawa, T., Shibuya, M., Okano, H. & Suda, T., 2011 May, In : Journal of Experimental Medicine. 208, 5, p. 949-960 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Isolation and in vitro expansion of human colonic stem cells

Jung, P., Sato, T., Merlos-Suárez, A., Barriga, F. M., Iglesias, M., Rossell, D., Auer, H., Gallardo, M., Blasco, M. A., Sancho, E., Clevers, H. & Batlle, E., 2011 Oct 1, In : Nature medicine. 17, 10, p. 1225-1227 3 p.

Research output: Contribution to journalArticle

375 Citations (Scopus)

Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Kobayashi, I., Kobayashi-Sun, J., Kim, A. D., Pouget, C., Fujita, N., Suda, T. & Traver, D., 2014 Aug 21, In : Nature. 512, 7514, p. 319-323 5 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Karyotype evolution and multilineage involvement of Philadelphia chromosome-positive clones in blastic transformation of two patients with chronic myelocytic leukemia

Sato, Y., Kitano, K., Tsunoda, S., Yoshida, M., Kajii, E., Suda, T., Sakamoto, S., Motoyoshi, K., Saito, M. & Miura, Y., 1988, In : Blood. 71, 6, p. 1561-1567 7 p.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)

Kinetics of drug selection systems in mouse embryonic stem cells

Nakatake, Y., Fujii, S., Masui, S., Sugimoto, T., Torikai-Nishikawa, S., Adachi, K. & Niwa, H., 2013 Aug 7, In : BMC Biotechnology. 13, 64.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells

Nakatake, Y., Fukui, N., Iwamatsu, Y., Masui, S., Takahashi, K., Yagi, R., Yagi, K., Miyazaki, J. I., Matoba, R., Ko, M. S. H. & Niwa, H., 2006 Oct, In : Molecular and cellular biology. 26, 20, p. 7772-7782 11 p.

Research output: Contribution to journalArticle

192 Citations (Scopus)

KLF5 regulates the integrity and oncogenicity of intestinal stem cells

Nakaya, T., Ogawa, S., Manabe, I., Tanaka, M., Sanada, M., Sato, T., Taketo, M. M., Nakao, K., Clevers, H., Fukayama, M., Kuroda, M. & Nagai, R., 2014 May 15, In : Cancer Research. 74, 10, p. 2882-2891 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., 2010 Jul 29, In : Blood. 116, 4, p. 554-563 10 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Lamina Propria c-kit+ Immune Precursors Reside in Human Adult Intestine and Differentiate Into Natural Killer Cells

Chinen, H., Matsuoka, K., Sato, T., Kamada, N., Okamoto, S., Hisamatsu, T., Kobayashi, T., Hasegawa, H., Sugita, A., Kinjo, F., Fujita, J. & Hibi, T., 2007 Aug, In : Gastroenterology. 133, 2, p. 559-573 15 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development

Ko, M. S. H., Kitchen, J. R., Wang, X., Threat, T. A., Wang, X., Hasegawa, A., Sun, T., Grahovac, M. J., Kargul, G. J., Lim, M. K., Cui, Y. S., Sano, Y., Tanaka, T., Liang, Y., Mason, S., Paonessa, P. D., Sauls, A. D., DePalma, G. E., Sharara, R., Rowe, L. B. & 3 others, Eppig, J., Morrell, C. & Doi, H., 2000 Apr, In : Development. 127, 8, p. 1737-1749 13 p.

Research output: Contribution to journalArticle

202 Citations (Scopus)

Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome

Suzuki, M., Oda, M., Ramos, M. P., Pascual, M., Lau, K., Stasiek, E., Agyiri, F., Thompson, R. F., Glass, J. L., Jing, Q., Sandstrom, R., Fazzari, M. J., Hansen, R. S., Stamatoyannopoulos, J. A., McLellan, A. S. & Greally, J. M., 2011 Nov, In : Genome Research. 21, 11, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites

Mito, A., Nakano, Y., Saitoh, T., Gouraud, S. S. S., Yamaguchi, Y., Sato, T., Sasaki, N. & Kojima-Aikawa, K., 2018 Jan 1, In : Glycobiology. 28, 1, p. 21-31 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Leukemia inhibitory factor regulates microvessel density by modulating oxygen-3 dependent VEGF expression in mice

Kubota, Y., Hirashima, M., Kishi, K., Stewart, C. L. & Suda, T., 2008 Jul 1, In : Journal of Clinical Investigation. 118, 7, p. 2393-2403 11 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Localization of recombination activating gene 1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice

Igarashi, H., Kuwata, N., Kiyota, K., Sumita, K., Suda, T., Ono, S., Bauer, S. R. & Sakaguchi, N., 2001 May 1, In : Blood. 97, 9, p. 2680-2687 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Long-term bone marrow failure accompanied by skin pigmentation

Muroi, K., Amemiya, Y., Miwa, A., Suda, T., Sakamoto, S., Noguchi, K. & Miura, Y., 1991 Jan 1, In : International journal of hematology. 54, 4, p. 281-287 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. & 5 others, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 Oct 1, In : Journal of Gastroenterology and Hepatology (Australia). 34, 10, p. 1751-1757 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression

Nakatsukasa, H., Oda, M., Yin, J., Chikuma, S., Ito, M., Koga-Iizuka, M., Someya, K., Kitagawa, Y., Ohkura, N., Sakaguchi, S., Koya, I., Sanosaka, T., Kohyama, J., Tsukada, Y. I., Yamanaka, S., Takamura-Enya, T., Lu, Q. & Yoshimura, A., 2019 Jan 1, In : International immunology. 31, 5, p. 335-347 13 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival

Hamaguchi, I., Morisada, T., Azuma, M., Murakami, K., Kuramitsu, M., Mizukami, T., Ohbo, K., Yamaguchi, K., Oike, Y., Dumont, D. J. & Suda, T., 2006 Feb 1, In : Blood. 107, 3, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice

Ikebe, M., Miyakawa, K., Takahashi, K., Ohbo, K., Nakamura, M., Sugamura, K., Suda, T., Yamamura, K. I. & Tomita, K., 1997, In : International Journal of Experimental Pathology. 78, 3, p. 133-148 16 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease

Kanai, T., Watanabe, M., Okazawa, A., Sato, T., Yamazaki, M., Okamoto, S., Ishii, H., Totsuka, T., Iiyama, R., Okamoto, R., Ikeda, M., Kurimoto, M., Takeda, K., Akira, S. & Hibi, T., 2001 Jan 1, In : Gastroenterology. 121, 4, p. 875-888 14 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)

Macrophages and dendritic cells emerge in the liver during intestinal inflammation and predispose the liver to inflammation

Mikami, Y., Mizuno, S., Nakamoto, N., Hayashi, A., Sujino, T., Sato, T., Kamada, N., Matsuoka, K., Hisamatsu, T., Ebinuma, H., Hibi, T., Yoshimura, A. & Kanai, T., 2014 Jan 2, In : PloS one. 9, 1, e84619.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Macrophage-stimulating protein (MSP) and its receptor, RON, stimulate human osteoclast activity but not proliferation: Effect of MSP distinct from that of hepatocyte growth factor

Kurihara, N., Tatsumi, J., Arai, F., Iwama, A. & Suda, T., 1998 Oct 29, In : Experimental Hematology. 26, 11, p. 1080-1085 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells

Kurihara, N., Iwama, A., Tatsumi, J., Ikeda, K. & Suda, T., 1996 May 1, In : Blood. 87, 9, p. 3704-3710 7 p.

Research output: Contribution to journalArticle

Open Access
75 Citations (Scopus)

Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes

Wang, M. H., Dlugosz, A. A., Sun, Y., Suda, T., Skeel, A. & Leonard, E. J., 1996 Jul 10, In : Experimental Cell Research. 226, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Maintenance of undifferentiated mouse embryonic stem cells in suspension by the serum- and feeder-free defined culture condition

Tsuji, Y., Yoshimura, N., Aoki, H., Sharov, A. A., Ko, M. S. H., Motohashi, T. & Kunisada, T., 2008 Aug, In : Developmental Dynamics. 237, 8, p. 2129-2138 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., 2015 Oct 28, In : Scientific reports. 5, 15876.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner

Miyamoto, K., Ninomiya, K., Sonoda, K. H., Miyauchi, Y., Hoshi, H., Iwasaki, R., Miyamoto, H., Yoshida, S., Sato, Y., Morioka, H., Chiba, K., Egashira, K., Suda, T., Toyama, Y. & Miyamoto, T., 2009 Jun 5, In : Biochemical and Biophysical Research Communications. 383, 3, p. 373-377 5 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

Kubota, Y., Takubo, K., Shimizu, T., Ohno, H., Kishi, K., Shibuya, M., Saya, H. & Suda, T., 2009 May 11, In : Journal of Experimental Medicine. 206, 5, p. 1089-1102 14 p.

Research output: Contribution to journalArticle

246 Citations (Scopus)

Mechanisms of transcription in eosinophils: GATA-1, but not GATA-2, transactivates the promoter of the eosinophil granule major basic protein gene

Yamaguchi, Y., Ackerman, S. J., Minegishi, N., Takiguchi, M., Yamamoto, M. & Suda, T., 1998 May 1, In : Blood. 91, 9, p. 3447-3458 12 p.

Research output: Contribution to journalArticle

Open Access
57 Citations (Scopus)

Megakaryocytopoiesis in vitro of patients with essential thrombocythaemia: effect of plasma and serum on megakaryocyte colony formation

Komatsu, N., Suda, T., Sakata, Y., Eguchi, M., Kaji, K., Saito, M. & Miura, Y., 1986 Oct, In : British Journal of Haematology. 64, 2, p. 241-252 12 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Megaloblastic Anemia Associated with Psoriasis: Case Report and Review of the Literature

Iwama, A., Miwa, A., Suzuki, T., Ema, H., Suda, T., Sakamoto, S. & Miura, Y., 1992 Jan 1, In : Internal Medicine. 31, 1, p. 127-130 4 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)

MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells

Ishiguro, K. I., Matsuura, K., Tani, N., Takeda, N., Usuki, S., Yamane, M., Sugimoto, M., Fujimura, S., Hosokawa, M., Chuma, S., Ko, M. S. H., Araki, K. & Niwa, H., 2020 Feb 24, In : Developmental Cell. 52, 4, p. 429-445.e10

Research output: Contribution to journalArticle

4 Citations (Scopus)