The Sakaguchi Laboratory

Research Output

2000

Elevated levels of macrophage-stimulating protein in induced sputum of patients with bronchiectasis

Takano, Y., Sakamoto, O., Suga, M., Suda, T. & Ando, M., 2000, In : Respiratory Medicine. 94, 8, p. 784-790 7 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Hematopoiesis and angiogenesis

Suda, T., 2000 Dec 1, In : International journal of hematology. 71, 2, p. 99-107 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver

Hsu, H. C., Ema, H., Osawa, M., Nakamura, Y., Suda, T. & Nakauchi, H., 2000 Dec 1, In : Blood. 96, 12, p. 3757-3762 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7

Nicholson, R. H., Pantano, S., Eliason, J. F., Galy, A., Weiler, S., Kaplan, J., Hughes, M. R. & Ko, M. S. H., 2000 Aug 15, In : Genomics. 68, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Serotonin and pancreatic duct function.

Naruse, S., Suzuki, A., Ishiguro, H., Kitagawa, M., Ko, S. B., Yoshikawa, T., Yamamoto, A., Hamada, H. & Hayakawa, T., 2000 Aug, In : Journal of Korean medical science. 15 Suppl, p. S27-28

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

The role of IL-18 on the pathogenesis of Crohn’s disease

Hibi, T., Kana, T., Watanabe, M., Okazawa, S. & Sato, T., 2000 Jan 1, In : Japanese Journal of Clinical Immunology. 23, 6, p. 607-610 4 p.

Research output: Contribution to journalArticle

Vegf-c signaling pathways through vegfr-2 and vegfr-3 in vasculo-angiogenesis and hematopoeesis

Hamada, K., Oike, Y., Takakura, N., Ito, Y., Jussila, L., Dumont, D. J., Alitalo, K. & Suda, T., 2000 Dec 1, In : Blood. 96, 11 PART I, p. 35a

Research output: Contribution to journalArticle

3 Citations (Scopus)

VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis

Hamada, K., Oike, Y., Takakura, N., Ito, Y., Jussila, L., Dumont, D. J., Alitalo, K. & Suda, T., 2000 Dec 1, In : Blood. 96, 12, p. 3793-3800 8 p.

Research output: Contribution to journalArticle

103 Citations (Scopus)
1999

A common signaling pathway via Syk and Lyn tyrosine kinases generated from capping of the sialomucins CD34 and CD43 in immature hematopoietic cells

Tada, J. I., Omine, M., Suda, T. & Yamaguchi, N., 1999 Jun 1, In : Blood. 93, 11, p. 3723-3735 13 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

C/EBPβ and GATA-1 synergistically regulate activity of the eosinophil granule major basic protein promoter: Implication for C/EBPβ activity in eosinophil gene expression

Yamaguchi, Y., Nishio, H., Kishi, K., Ackerman, S. J. & Suda, T., 1999 Aug 15, In : Blood. 94, 4, p. 1429-1439 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo

De Maximy, A. A., Nakatake, Y., Moncada, S., Itoh, N., Thiery, J. P. & Bellusci, S., 1999 Mar 1, In : Mechanisms of Development. 81, 1-2, p. 213-216 4 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)

Endothelial growth factor receptors in human fetal heart

Partanen, T. A., Makinen, T., Arola, J., Suda, T., Weich, H. A. & Alitalo, K., 1999 Aug 10, In : Circulation. 100, 6, p. 583-586 4 p.

Research output: Contribution to journalArticle

Open Access
43 Citations (Scopus)

Green fluorescent protein as a selectable marker of retrovirally transduced hematopoietic progenitors

Kume, A., Hashiyama, M., Suda, T. & Ozawa, K., 1999 Jan 1, In : Stem Cells. 17, 4, p. 226-232 7 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Induction of cell shape changes through activation of the interleukin-3 common β chain receptor by the RON receptor-type tyrosine kinase

Mera, A., Suga, M., Ando, M., Suda, T. & Yamaguchi, N., 1999 May 28, In : Journal of Biological Chemistry. 274, 22, p. 15766-15774 9 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

In vitro effects of angiopoietins and VEGF on hematopoietic and endothelial cells

Huang, X. L., Takakura, N. & Suda, T., 1999 Oct 14, In : Biochemical and Biophysical Research Communications. 264, 1, p. 133-138 6 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

In vitro hematopoietic and endothelial cell development from cells expressing TEK receptor in murine aorta-gonad-mesonephros region

Hamaguchi, I., Huang, X. L., Takakura, N., Tada, J. I., Yamaguchi, Y., Kodama, H. & Suda, T., 1999 Mar 1, In : Blood. 93, 5, p. 1549-1556 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis

Oike, Y., Takakura, N., Hata, A., Kaname, T., Akizuki, M., Yamaguchi, Y., Yasue, H., Araki, K., Yamamura, K. I. & Suda, T., 1999 May 1, In : Blood. 93, 9, p. 2771-2779 9 p.

Research output: Contribution to journalArticle

147 Citations (Scopus)

Novel association of the Src family kinases, Hck and c-Fgr, with CCR3 receptor stimulation: A possible mechanism for eotaxin-induced human eosinophil chemotaxis

El-Shazly, A., Yamaguchi, N., Masuyama, K., Suda, T. & Ishikawa, T., 1999 Oct 14, In : Biochemical and Biophysical Research Communications. 264, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings

Ochi, H., Takeshita, H., Suda, T., Nisitani, S., Honjo, T. & Watanabe, T., 1999 Dec 1, In : Immunology. 98, 4, p. 595-603 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
1998

Analysis of C-KIT, TIE and HTK expression on leukemic cells using flow cytometry: A preliminary report

Muroi, K., Suda, T., Kawano, C., Amemiya, Y., Eguchi, M., Miura, Y. & Ozawa, K., 1998 Sep 1, In : Leukemia Research. 22, 9, p. 827-830 4 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A systematic molecular genetic approach to study mammalian germline development

Abe, K., Ko, M. S. H. & Macgregor, G. R., 1998 Dec 2, In : International Journal of Developmental Biology. 42, 7, p. 1051-1065 15 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells

Sato, A., Iwama, A., Takakura, N., Nishio, H., Yancopoulos, G. D. & Suda, T., 1998 Aug 17, In : International immunology. 10, 8, p. 1217-1227 11 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis

Takakura, N., Huang, X. L., Naruse, T., Hamaguchi, I., Dumont, D. J., Yancopoulos, G. D. & Suda, T., 1998 Nov, In : Immunity. 9, 5, p. 677-686 10 p.

Research output: Contribution to journalArticle

Open Access
252 Citations (Scopus)

Erratum: Tissue-specific expression and mapping of the Cox7ah gene in mouse (Genomics (1998) 49:3 (363-370))

Jaradat, S. A., Ko, M. S. H. & Grossman, L. I., 1998 Dec 15, In : Genomics. 54, 3, p. 583-584 2 p.

Research output: Contribution to journalComment/debate

Evaluation of the role of N-linked oligosaccharides in rat placental lactogen action by site-directed mutagenesis

Hattori, N., Nukada, T., Oda, M., Tanaka, S., Ogawa, T. & Shiota, K., 1998 Oct, In : Endocrine journal. 45, 5, p. 659-674 16 p.

Research output: Contribution to journalArticle

Open Access
6 Citations (Scopus)

Expression and functional analysis of a hemopoietic progenitor antigen, NJ-1 (114/A10), in the megakaryocytic lineage

Duan, Y., Naruse, T., Nakamura, M., Yamaguchi, Y., Kawashima, T., Morikawa, Y., Kitamura, T. & Suda, T., 1998 Dec 18, In : Biochemical and Biophysical Research Communications. 253, 2, p. 401-406 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Fluid secretion in interlobular ducts isolated from guinea-pig pancreas

Ishiguro, H., Naruse, S., Steward, M. C., Kitagawa, M., Ko, S. B. H., Hayakawa, T. & Case, R. M., 1998 Sep 1, In : Journal of Physiology. 511, 2, p. 407-422 16 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Forced GATA-1 expression in the murine myeloid cell line M1: Induction of c-Mpl expression and megakaryocytic/erythroid differentiation

Yamaguehi, Y., Zon, L. I., Ackerman, S. J., Yamamoto, M. & Suda, T., 1998 Jan 15, In : Blood. 91, 2, p. 450-457 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Function of the receptor tyrosine kin ÄSE, HTK/EPHB4 and its ligand, HTKL/EPHRIN-B2 in erythropoiesis

Inada, T., Sakano, S. & Suda, T., 1998 Dec 1, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticle

Generation of a monoclonal antibody that induces apoptosis of hematopoietic cells

Mio, H., Satoh, M., Yokokawa, S., Nishio, H., Suda, T. & Tamaoki, T., 1998 Feb 24, In : Biochemical and Biophysical Research Communications. 243, 3, p. 727-731 5 p.

Research output: Contribution to journalArticle

Hematopoietic activity of tek-ligand, angiopoietins in murine bone marrow cells

Huang, X. L., Takakura, N. & Suda, T., 1998 Dec 1, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticle

Islet Cell Tumor in von Hippel-Lindau Disease

Mizlno, N., Naruse, S., Kitagawa, M., Ishiguro, H., Nakak, Y., Ihda, H., Iizuka, N., Ito, O., Seki, Y., Ko, S. B. H., Yoshikawa, T., Hayakawa, T., Sano, T., Kamiya, J., Nimura, Y. & Nagasaka, T., 1998 Dec 1, In : Internal Medicine. 37, 3, p. 295-299 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Macrophage-stimulating protein (MSP) and its receptor, RON, stimulate human osteoclast activity but not proliferation: Effect of MSP distinct from that of hepatocyte growth factor

Kurihara, N., Tatsumi, J., Arai, F., Iwama, A. & Suda, T., 1998 Oct 29, In : Experimental Hematology. 26, 11, p. 1080-1085 6 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Mechanisms of transcription in eosinophils: GATA-1, but not GATA-2, transactivates the promoter of the eosinophil granule major basic protein gene

Yamaguchi, Y., Ackerman, S. J., Minegishi, N., Takiguchi, M., Yamamoto, M. & Suda, T., 1998 May 1, In : Blood. 91, 9, p. 3447-3458 12 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Models of lineage switching in hematopoietic development: A new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential

Yamaguchi, Y., Nishio, H., Kasahara, T., Ackerman, S. J., Koyanagi, H. & Suda, T., 1998 Jan 1, In : Leukemia. 12, 9, p. 1430-1439 10 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H

Iwatsuki, K., Oda, M., Sun, W., Tanaka, S., Ogawa, T. & Shiota, K., 1998 Jan 1, In : Endocrinology. 139, 12, p. 4976-4983 8 p.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Overexpression of C-terminal Src kinase homologous kinase suppresses activation of Lyn tyrosine kinase required for VLA5-mediated Dami cell spreading

Hirao, A., Huang, X. L., Suda, T. & Yamaguchi, N., 1998 Apr 17, In : Journal of Biological Chemistry. 273, 16, p. 10004-10010 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

The effect of VIP/PACAP family of peptides on pancreatic blood flow and secretion in conscious dogs

Ito, O., Naruse, S., Kitagawa, M., Ishiguro, H., Ko, S., Nakajima, M. & Hayakawa, T., 1998 Nov 30, In : Regulatory Peptides. 78, 1-3, p. 105-112 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
1997

Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase.

Correll, P. H., Iwama, A., Tondat, S., Mayrhofer, G., Suda, T. & Bernstein, A., 1997 Feb, In : Genes and function. 1, 1, p. 69-83 15 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Expression and characterization of endothelial cell receptors in hematopietic cells

Hamaauchi, I., Nisflio, H., Inada, T., Sato, A., Takakura, N., Iwama, A., Suda, J. & Suda, T., 1997 Dec 1, In : Experimental Hematology. 25, 8, 1 p.

Research output: Contribution to journalArticle

Expression and function of murine receptor tyrosine kinases, TIE and TEK, in hematopoietic stem cells

Yano, M., Iwama, A., Nishio, H., Suda, J., Takada, G. & Suda, T., 1997 Jun 15, In : Blood. 89, 12, p. 4317-4326 10 p.

Research output: Contribution to journalArticle

Open Access
79 Citations (Scopus)

Focal adhesion kinase upregulated by granulocyte-macrophage colony- stimulating factor but not by interleukin-3 in differentiating myeloid cells

Kume, A., Nishiura, H., Suda, J. & Suda, T., 1997 May 1, In : Blood. 89, 9, p. 3434-3442 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Functional characterization of the promoter for the gene encoding murine CD34

Yamaguchia, Y., Tenen, D. G. & Suda, T., 1997 Feb 7, In : Biochimica et Biophysica Acta - Gene Structure and Expression. 1350, 2, p. 141-146 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor γ chain-deficient mice

Ikebe, M., Miyakawa, K., Takahashi, K., Ohbo, K., Nakamura, M., Sugamura, K., Suda, T., Yamamura, K. I. & Tomita, K., 1997 Aug 14, In : International Journal of Experimental Pathology. 78, 3, p. 133-148 16 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Receptor tyrosine kinases involved in hematopoietic progenitor cells

Suda, T., Iwama, A., Hashiyama, M., Sakano, S. & Ohno, M., 1997 Jan 1, In : Leukemia. 11, SUPPL. 3, p. 451-453 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility

Sakamoto, O., Iwama, A., Amitani, R., Takehara, T., Yamaguchi, N., Yamamoto, T., Masuyama, K., Yamanaka, T., Ando, M. & Suda, T., 1997 Feb 15, In : Journal of Clinical Investigation. 99, 4, p. 701-709 9 p.

Research output: Contribution to journalArticle

Open Access
67 Citations (Scopus)

Selective expression of the receptor tyrosine kinase, HTK, on human erythroid progenitor cells

Inada, T., Iwama, A., Sakano, S., Ohno, M., Sawada, K. I. & Suda, T., 1997 Apr 15, In : Blood. 89, 8, p. 2757-2765 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets

Hirao, A., Hamaguchi, I., Suda, T. & Yamaguchi, N., 1997 May 1, In : EMBO Journal. 16, 9, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
1996

Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice

Hamaguchi, I., Yamaguchi, N., Suda, J., Iwama, A., Hirao, A., Hashiyama, M., Aizawa, S. I. & Suda, T., 1996 Jul 5, In : Biochemical and Biophysical Research Communications. 224, 1, p. 172-179 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein

Suzuki, A., Andrew, D. P., Gonzalo, J. A., Fukumoto, M., Spellberg, J., Hashiyama, M., Takimoto, H., Gerwin, N., Webb, L., Molineux, G., Amakawa, R., Tada, Y., Wakeham, A., Brown, J., McNiece, I., Ley, K., Butcher, E. C., Suda, T., Gutierrez-Ramos, J. C. & Mak, T. W., 1996 May 1, In : Blood. 87, 9, p. 3550-3562 13 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)