The Sakaguchi Laboratory

Research Output

2012

Cdx2 determines the fate of postnatal intestinal endoderm

Stringer, E. J., Duluc, I., Saandi, T., Davidson, I., Bialecka, M., Sato, T., Barker, N., Clevers, H., Pritchard, C. A., Winton, D. J., Wright, N. A., Freund, J. N., Deschamps, J. & Beck, F., 2012 Feb 1, In : Development. 139, 3, p. 465-474 10 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Clinical diagnostic criteria of IgG4-related sclerosing cholangitis 2012

Ohara, H., Okazaki, K., Tsubouchi, H., Inui, K., Kawa, S., Kamisawa, T., Tazuma, S., Uchida, K., Hirano, K., Yoshida, H., Nishino, T., Ko, S. B. H., Mizuno, N., Hamano, H., Kanno, A., Notohara, K., Hasebe, O., Nakazawa, T., Nakanuma, Y. & Takikawa, H., 2012 Sep, In : Journal of Hepato-Biliary-Pancreatic Sciences. 19, 5, p. 536-542 7 p.

Research output: Contribution to journalReview article

220 Citations (Scopus)

Controlled gene expression in primary Lgr5 organoid cultures

Koo, B. K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., Van Es, J. H. & Clevers, H., 2012 Jan 1, In : Nature Methods. 9, 1, p. 81-83 3 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO3- exchange in mouse pancreatic duct

Ishiguro, H., Song, Y., Yamamoto, A., Steward, M. C., Ko, S. B. H., Stewart, A. K., Soleimani, M., Liu, B. C., Kondo, T. & Jin, C. X., 2012 Oct 15, In : American Journal of Physiology - Cell Physiology. 303, 8, p. C815-C824

Research output: Contribution to journalArticle

12 Citations (Scopus)

Detection of a large heterozygous deletion and a splicing defect in the CFTR transcripts from nasal swab of a Japanese case of cystic fibrosis

Nakakuki, M., Fujiki, K., Yamamoto, A., Ko, S. B., Yi, L., Ishiguro, M., Yamaguchi, M., Kondo, S., Maruyama, S., Yanagimoto, K., Naruse, S. & Ishiguro, H., 2012 Jul 1, In : Journal of Human Genetics. 57, 7, p. 427-433 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Dynamic regulation of T h17 differentiation by oxygen concentrations

Ikejiri, A., Nagai, S., Goda, N., Kurebayashi, Y., Osada-Oka, M., Takubo, K., Suda, T. & Koyasu, S., 2012 Mar 5, In : International immunology. 24, 3, p. 137-146 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5 + stem cell

Yui, S., Nakamura, T., Sato, T., Nemoto, Y., Mizutani, T., Zheng, X., Ichinose, S., Nagaishi, T., Okamoto, R., Tsuchiya, K., Clevers, H. & Watanabe, M., 2012 Apr 1, In : Nature medicine. 18, 4, p. 618-623 6 p.

Research output: Contribution to journalArticle

422 Citations (Scopus)

Gene expression profiling and regulatory networks in single cells

Arai, F., Hosokawa, K., Matsumoto, Y., Toyama, H. & Suda, T., 2012 Feb 1, New Frontiers of Network Analysis in Systems Biology. Springer Netherlands, p. 1-13 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetic analysis of essential cardiac transcription factors in 256 patients with non-syndromic congenital heart defects

Kodo, K., Nishizawa, T., Furutani, M., Arai, S., Ishihara, K., Oda, M., Makino, S., Fukuda, K., Takahashi, T., Matsuoka, R., Nakanishi, T. & Yamagishi, H., 2012 Jul 5, In : Circulation Journal. 76, 7, p. 1703-1711 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Intermittent Granulocyte and Monocyte Apheresis Versus Mercaptopurine for Maintaining Remission of Ulcerative Colitis: A Pilot Study

Sakuraba, A., Sato, T., Morohoshi, Y., Matsuoka, K., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2012 Jun 1, In : Therapeutic Apheresis and Dialysis. 16, 3, p. 213-218 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Molecular mechanisms of pancreatic stone formation in chronic pancreatitis

Ko, S. B. H., Azuma, S., Yoshikawa, T., Yamamoto, A., Kyokane, K., Ko, M. S. H. & Ishiguro, H., 2012, In : Frontiers in Physiology. 3 NOV, Article 415.

Research output: Contribution to journalArticle

10 Citations (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 Nov 23, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neovascular niche for human myeloma cells in immunodeficient mouse bone

Iriuchishima, H., Takubo, K., Miyakawa, Y., Nakamura-Ishizu, A., Miyauchi, Y., Fujita, N., Miyamoto, K., Miyamoto, T., Ikeda, E., Kizaki, M., Nojima, Y. & Suda, T., 2012 Feb 7, In : PloS one. 7, 2, e30557.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 Jul 20, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 Nov 1, In : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

On the biomechanics of stem cell niche formation in the gut - Modelling growing organoids

Buske, P., Przybilla, J., Loeffler, M., Sachs, N., Sato, T., Clevers, H. & Galle, J., 2012 Sep 1, In : FEBS Journal. 279, 18, p. 3475-3487 13 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Optimal ratio of transcription factors for somatic cell reprogramming

Nagamatsu, G., Saito, S., Kosaka, T., Takubo, K., Kinoshita, T., Oya, M., Horimoto, K. & Suda, T., 2012 Oct 19, In : Journal of Biological Chemistry. 287, 43, p. 36273-36282 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Passing a baton to the next generation

Suda, T. & Kitamura, S., 2012 Nov 1, In : International journal of hematology. 96, 5, p. 529-530 2 p.

Research output: Contribution to journalEditorial

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I. & Suda, T., 2012 Jan 1, In : Journal of Cellular Physiology. 227, 2, p. 421-430 10 p.

Research output: Contribution to journalShort survey

152 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 Aug, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 May 1, In : International journal of hematology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration

Xie, H., Sun, X., Piao, Y., Jegga, A. G., Handwerger, S., Ko, M. S. H. & Dey, S. K., 2012 Sep 14, In : Journal of Biological Chemistry. 287, 38, p. 32288-32297 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Structure and function of the pancreas in the polycystic kidney rat

Yi, L., Naruse, S., Furuya, S., Yamamoto, A., Nakakuki, M., Nagao, S., Yoshihara, D., Ko, S. B. H., Wei, M., Kondo, T. & Ishiguro, H., 2012 Nov 1, In : Pancreas. 41, 8, p. 1292-1298 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

Takaesu, G., Inagaki, M., Takubo, K., Mishina, Y., Hess, P. R., Dean, G. A., Yoshimura, A., Matsumoto, K., Suda, T. & Ninomiya-Tsuji, J., 2012 Nov 30, In : PloS one. 7, 11, e51073.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Three cases of bronchial asthma preceding IgG4-related autoimmune pancreatitis

Ito, S., Ko, S. B. H., Morioka, M., Imaizumi, K., Kondo, M., Mizuno, N. & Hasegawa, Y., 2012 Jan 1, In : Allergology International. 61, 1, p. 171-174 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Two anatomically distinct niches regulate stem cell activity

Ema, H. & Suda, T., 2012 Sep 13, In : Blood. 120, 11, p. 2174-2181 8 p.

Research output: Contribution to journalReview article

49 Citations (Scopus)

Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis

Mayumi, T., Inui, K., Maetani, I., Yokoe, M., Sakamoto, T., Yoshida, M., Ko, S., Hirata, K. & Takada, T., 2012 Aug 1, In : Pancreas. 41, 6, p. 869-875 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

[Induction of megakaryocytes and platelet production from mouse and human fibroblasts by p45 NF-E2/Maf].

Ono, Y. & Matsubara, Y., 2013 Nov 1, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 54, 11, p. 2025-2030 6 p.

Research output: Contribution to journalReview article

[Intestinal stem cells].

Sato, T., 2013 Sep, In : Seikagaku. The Journal of Japanese Biochemical Society. 85, 9, p. 743-748 6 p.

Research output: Contribution to journalReview article

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance

Livigni, A., Peradziryi, H., Sharov, A. A., Chia, G., Hammachi, F., Migueles, R. P., Sukparangsi, W., Pernagallo, S., Bradley, M., Nichols, J., Ko, M. S. H. & Brickman, J. M., 2013 Nov 18, In : Current Biology. 23, 22, p. 2233-2244 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity

Shirakawa, T., Yaman-Deveci, R., Tomizawa, S. I., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T. & Ohbo, K., 2013 Sep 1, In : Development (Cambridge). 140, 17, p. 3565-3576 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy

Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang, W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O. J. & Koh, G. Y., 2013 Sep 18, In : Science translational medicine. 5, 203, 203ra127.

Research output: Contribution to journalArticle

69 Citations (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 Jun 12, In : Cell Host and Microbe. 13, 6, p. 711-722 12 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Conversion of primordial germ cells to pluripotent stem cells: Methods for cell tracking and culture conditions

Nagamatsu, G. & Suda, T., 2013 Sep 4, Imaging and Tracking Stem Cells: Methods and Protocols. p. 49-56 8 p. (Methods in Molecular Biology; vol. 1052).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma

Mizuno, N., Yatabe, Y., Hara, K., Hijioka, S., Imaoka, H., Shimizu, Y., Ko, S. B. H. & Yamao, K., 2013 Oct 16, In : Frontiers in Physiology. 4 SEP, Article 269.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice

Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 Feb 1, In : Immunology Letters. 150, 1-2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Endoscopic detorsion for sigmoid volvulus using unsedated water-immersion colonoscopy

Sugimoto, S., Mizukami, T., Ito, T., Tsunoda, Y., Imamura, S., Tamura, T., Nagakubo, S., Morohoshi, Y., Koike, Y., Fujita, Y. & Komatsu, H., 2013, In : Endoscopy. 45, SUPPL2, p. E263-E264

Research output: Contribution to journalComment/debate

Open Access
3 Citations (Scopus)

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

Miyake, M., Toguchi, H., Nishibayashi, T., Higaki, K., Sugita, A., Koganei, K., Kamada, N., Kitazume, M. T., Hisamatsu, T., Sato, T., Okamoto, S., Kanai, T. & Hibi, T., 2013 Aug, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2564-2571 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications

Sato, T. & Clevers, H., 2013, In : Science. 340, 6137, p. 1190-1194 5 p.

Research output: Contribution to journalReview article

522 Citations (Scopus)

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

Nagamachi, A., Matsui, H., Asou, H., Ozaki, Y., Aki, D., Kanai, A., Takubo, K., Suda, T., Nakamura, T., Wolff, L., Honda, H. & Inaba, T., 2013 Sep 9, In : Cancer Cell. 24, 3, p. 305-317 13 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches

Nakamura-Ishizu, A. & Suda, T., 2013 Feb, In : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2404-2409 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Identification of transcription factors for lineage-specific ESC differentiation

Yamamizu, K., Piao, Y., Sharov, A. A., Zsiros, V., Yu, H., Nakazawa, K., Schlessinger, D. & Ko, M. S. H., 2013 Dec 17, In : Stem cell reports. 1, 6, p. 545-559 15 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Chu, P. S., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PloS one. 8, 4, e62853.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

Ko, S. B. H., Azuma, S., Yokoyama, Y., Yamamoto, A., Kyokane, K., Niida, S., Ishiguro, H. & Ko, M. S. H., 2013 Jun 16, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 12, p. G1103-G1116

Research output: Contribution to journalArticle

8 Citations (Scopus)

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 Feb 14, In : Nature. 494, 7436, p. 247-250 4 p.

Research output: Contribution to journalArticle

662 Citations (Scopus)

Kinetics of drug selection systems in mouse embryonic stem cells

Nakatake, Y., Fujii, S., Masui, S., Sugimoto, T., Torikai-Nishikawa, S., Adachi, K. & Niwa, H., 2013 Aug 7, In : BMC Biotechnology. 13, 64.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients

Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 Dec 15, In : Journal of Crohn's and Colitis. 7, 12, p. e609-e614

Research output: Contribution to journalArticle

36 Citations (Scopus)

No more sugar-coating it: Mucins and platelet biology

Matsubara, Y., 2013 Aug 29, In : Blood. 122, 9, p. 1537-1538 2 p.

Research output: Contribution to journalReview article

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013 Jan 1, In : Blood. 121, 16, p. 3267-3273 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 2013 Nov 8, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)