The Sakaguchi Laboratory

Research Output

2007

Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells

Masui, S., Nakatake, Y., Toyooka, Y., Shimosato, D., Yagi, R., Takahashi, K., Okochi, H., Okuda, A., Matoba, R., Sharov, A. A., Ko, M. S. H. & Niwa, H., 2007 Jun, In : Nature Cell Biology. 9, 6, p. 625-635 11 p.

Research output: Contribution to journalArticle

797 Citations (Scopus)

Prox1 induces lymphatic endothelial differentiation via integrin α9 and other signaling cascades

Mishima, K., Watabe, T., Saito, A., Yoshimatsu, Y., Imaizumi, N., Masui, S., Hirashima, M., Morisada, T., Oike, Y., Araie, M., Niwa, H., Kubo, H., Suda, T. & Miyazono, K., 2007 Apr, In : Molecular biology of the cell. 18, 4, p. 1421-1429 9 p.

Research output: Contribution to journalArticle

109 Citations (Scopus)

PTEN-deficient intestinal stem cells initiate intestinal polyposis

He, X. C., Yin, T., Grindley, J. C., Tian, Q., Sato, T., Tao, W. A., Dirisina, R., Porter-Westpfahl, K. S., Hembree, M., Johnson, T., Wiedemann, L. M., Barrett, T. A., Hood, L., Wu, H. & Li, L., 2007 Feb, In : Nature genetics. 39, 2, p. 189-198 10 p.

Research output: Contribution to journalArticle

336 Citations (Scopus)

Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification

Morita, K., Miyamoto, T., Fujita, N., Kubota, Y., Ito, K., Takubo, K., Miyamoto, K., Ninomiya, K., Suzuki, T., Iwasaki, R., Yagi, M., Takaishi, H., Toyama, Y. & Suda, T., 2007 Jul 9, In : Journal of Experimental Medicine. 204, 7, p. 1613-1623 11 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Regulation of hematopoietic stem cells in the osteoblastic niche

Aria, F. & Suda, T., 2007 Dec 1, Osteoimmunology. p. 61-67 7 p. (Advances in Experimental Medicine and Biology; vol. 602).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Citations (Scopus)

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes

Ito, K., Takubo, K., Arai, F., Satoh, H., Matsuoka, S., Ohmura, M., Naka, K., Azuma, M., Miyamoto, K., Hosokawa, K., Ikeda, Y., Mak, T. W., Suda, T. & Hirao, A., 2007 Jan 1, In : Journal of Immunology. 178, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

Open Access
88 Citations (Scopus)

Zscan4: A novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells

Falco, G., Lee, S. L., Stanghellini, I., Bassey, U. C., Hamatani, T. & Ko, M. S. H., 2007 Jul 15, In : Developmental Biology. 307, 2, p. 539-550 12 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)
2006

A CTX family cell adhesion molecule, JAM4, is expressed in stem cell and progenitor cell populations of both male germ cell and hematopoietic cell lineages

Nagamatsu, G., Ohmura, M., Mizukami, T., Hamaguchi, I., Hirabayashi, S., Yoshida, S., Hata, Y., Suda, T. & Ohbo, K., 2006 Nov, In : Molecular and cellular biology. 26, 22, p. 8498-8506 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

CisView: A browser and database of cis-regulatory modules predicted in the mouse genome

Sharov, A. A., Dudekula, D. B. & Ko, M. S. H., 2006, In : DNA Research. 13, 3, p. 123-134 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6

Shcheynikov, N., Wang, Y., Park, M., Ko, S. B. H., Dorwart, M., Naruse, S., Thomas, P. J. & Muallem, S., 2006 May, In : Journal of General Physiology. 127, 5, p. 511-524 14 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Differentiation of arterial and venous endothelial cells and vascular morphogenesis

Hirashima, M. & Suda, T., 2006 Mar 1, In : Endothelium: Journal of Endothelial Cell Research. 13, 2, p. 137-145 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Dissecting Oct3/4-regulated gene networks in embryonic stem cells by expression profiling

Matoba, R., Niwa, H., Masui, S., Ohtsuka, S., Carter, M. G., Sharov, A. A. & Ko, M. S. H., 2006 Dec 20, In : PloS one. 1, 1, e26.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Enhancement of antibacterial activity of β-lactam antibiotics by [P2W18O62]6-, [SiMo12O40]4-, and [PTi2W10O40]7- against methicillin-resistant and vancomycin-resistant Staphylococcus aureus

Inoue, M., Suzuki, T., Fujita, Y., Oda, M., Matsumoto, N. & Yamase, T., 2006 Jul 1, In : Journal of Inorganic Biochemistry. 100, 7, p. 1225-1233 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Fecal pancreatic elastase: A reproducible marker for severe exocrine pancreatic insufficiency

Naruse, S., Ishiguro, H., Ko, S. B. H., Yoshikawa, T., Yamamoto, T., Yamamoto, A., Futakuchi, S., Goto, H., Saito, Y. & Takahashi, S., 2006 Sep 1, In : Journal of gastroenterology. 41, 9, p. 901-908 8 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

For the further development of the International Journal of Hematology

Uchiyama, T. & Suda, T., 2006 Feb 1, In : International journal of hematology. 83, 2, 1 p.

Research output: Contribution to journalEditorial

Genomic structure of the sea lamprey growth hormone-encoding gene

Moriyama, S., Oda, M., Takahashi, A., Sower, S. A. & Kawauchi, H., 2006 Aug, In : General and Comparative Endocrinology. 148, 1, p. 33-40 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Global gene expression profiling of preimplantation embryos.

Hamatani, T., Ko, M. S., Yamada, M., Kuji, N., Mizusawa, Y., Shoji, M., Hada, T., Asada, H., Maruyama, T. & Yoshimura, Y., 2006 Aug, In : Human cell : official journal of Human Cell Research Society. 19, 3, p. 98-117 20 p.

Research output: Contribution to journalReview article

91 Citations (Scopus)

Hematopoietic stem cell niche in bone marrow

Takubo, K., Hirao, A. & Suda, T., 2006 Apr, In : Seikagaku. The Journal of Japanese Biochemical Society. 78, 4, p. 301-309 9 p.

Research output: Contribution to journalReview article

Open Access
123 Citations (Scopus)

Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis

Morohoshi, Y., Matsuoka, K., Chinen, H., Kamada, N., Sato, T., Hisamatsu, T., Okamoto, S., Inoue, N., Takaishi, H., Ogata, H., Iwao, Y. & Hibi, T., 2006 Apr 1, In : Journal of gastroenterology. 41, 4, p. 318-324 7 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells

Nakatake, Y., Fukui, N., Iwamatsu, Y., Masui, S., Takahashi, K., Yagi, R., Yagi, K., Miyazaki, J. I., Matoba, R., Ko, M. S. H. & Niwa, H., 2006 Oct, In : Molecular and cellular biology. 26, 20, p. 7772-7782 11 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)

Loss of Tie2 receptor compromises embryonic stem cell-derived endothelial but not hematopoietic cell survival

Hamaguchi, I., Morisada, T., Azuma, M., Murakami, K., Kuramitsu, M., Mizukami, T., Ohbo, K., Yamaguchi, K., Oike, Y., Dumont, D. J. & Suda, T., 2006 Feb 1, In : Blood. 107, 3, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis

Takubo, K., Hirao, A., Ohmura, M., Azuma, M., Arai, F., Nagamatsu, G. & Suda, T., 2006 Dec 29, In : Biochemical and Biophysical Research Communications. 351, 4, p. 993-998 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., 2006 Apr, In : Nature medicine. 12, 4, p. 446-451 6 p.

Research output: Contribution to journalArticle

914 Citations (Scopus)

Regulatory interaction between CFTR and the SLC26 transporters

Shcheynikov, N., Ko, S. B. H., Zeng, W., Joo, Y. C., Dorwart, M. R., Thomas, P. J. & Muallem, S., 2006 Dec 1, Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. p. 177-186 10 p. (Novartis Foundation Symposium; vol. 273).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

48 Citations (Scopus)

Synergistic effect of polyoxometalates in combination with oxacillin against methicillin-resistant and vancomycin-resistant Staphylococcus aureus: a high initial inoculum of 1 × 108 cfu/ml for in vivo test

Inoue, M., Suzuki, T., Fujita, Y., Oda, M., Matsumoto, N., Iijima, J. & Yamase, T., 2006 Jun 1, In : Biomedicine and Pharmacotherapy. 60, 5, p. 220-226 7 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The first round of mouse spermatogenesis is a distinctive program that lacks the self-renewing spermatogonia stage

Yoshida, S., Sukeno, M., Nakagawa, T., Ohbo, K., Nagamatsu, G., Suda, T. & Nabeshima, Y. I., 2006 Apr, In : Development. 133, 8, p. 1495-1505 11 p.

Research output: Contribution to journalArticle

236 Citations (Scopus)

The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells

Park, J. M., Kohn, M. J., Bruinsma, M. W., Vech, C., Intine, R. V., Fuhrmann, S., Grinberg, A., Mukherjee, I., Love, P. E., Ko, M. S., DePamphilis, M. L. & Maraia, R. J., 2006 Feb, In : Molecular and cellular biology. 26, 4, p. 1445-1451 7 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Trophoblast Stem Cells

Oda, M., Shiota, K. & Tanaka, S., 2006 Jan 1, Adult Stem Cells. Academic Press Inc., p. 387-400 14 p. (Methods in Enzymology; vol. 419).

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Citations (Scopus)
2005

Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria

Kamada, N., Hisamatsu, T., Okamoto, S., Sato, T., Matsuoka, K., Arai, K., Nakai, T., Hasegawa, A., Inoue, N., Watanabe, N., Akagawa, K. S. & Hibi, T., 2005 Nov 15, In : Journal of Immunology. 175, 10, p. 6900-6908 9 p.

Research output: Contribution to journalArticle

Open Access
169 Citations (Scopus)

Antibacterial activity of highly negative charged polyoxotungstates, K 27[KAs4W40O140] and K 18[KSb9W21O86], and Keggin-structural polyoxotungstates against Helicobacter pylori

Inoue, M., Segawa, K., Matsunaga, S., Matsumoto, N., Oda, M. & Yamase, T., 2005 May, In : Journal of Inorganic Biochemistry. 99, 5, p. 1023-1031 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

A quantitative matrigel assay for assessing repopulating capacity of prostate stem cells

Azuma, M., Hirao, A., Takubo, K., Hamaguchi, I., Kitamura, T. & Suda, T., 2005 Dec 16, In : Biochemical and Biophysical Research Communications. 338, 2, p. 1164-1170 7 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

CD24 is expressed specifically in the nucleus pulposus of intervertebral discs

Fujita, N., Miyamoto, T., Imai, J. I., Hosogane, N., Suzuki, T., Yagi, M., Morita, K., Ninomiya, K., Miyamoto, K., Takaishi, H., Matsumoto, M., Morioka, H., Yabe, H., Chiba, K., Watanabe, S., Toyama, Y. & Suda, T., 2005 Dec 30, In : Biochemical and Biophysical Research Communications. 338, 4, p. 1890-1896 7 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Cooperative interaction of Angiopoietin-like proteins 1 and 2 in vascular development

Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., Nagai, N., Koh, G. Y., Watanabe, S. & Suda, T., 2005 Sep 20, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 38, p. 13502-13507 6 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells

Yagi, M., Miyamoto, T., Sawatani, Y., Iwamoto, K., Hosogane, N., Fujita, N., Morita, K., Ninomiya, K., Suzuki, T., Miyamoto, K., Oike, Y., Takeya, M., Toyama, Y. & Suda, T., 2005 Aug 1, In : Journal of Experimental Medicine. 202, 3, p. 345-351 7 p.

Research output: Contribution to journalArticle

551 Citations (Scopus)

Dual effects of n-alcohols on fluid secretion from guinea pig pancreatic ducts

Hamada, H., Ishiguro, H., Yamamoto, A., Shimano-Futakuchi, S., Ko, S. B. H., Yoshikawa, T., Goto, H., Kitagawa, M., Hayakawa, T., Seo, Y. & Naruse, S., 2005 Jun 1, In : American Journal of Physiology - Cell Physiology. 288, 6 57-6, p. C1431-C1439

Research output: Contribution to journalArticle

6 Citations (Scopus)

Genome-wide assembly and analysis of alternative transcripts in mouse

Sharov, A. A., Dudekula, D. B. & Ko, M. S. H., 2005 May, In : Genome Research. 15, 5, p. 748-754 7 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Hematopoietic cells regulate the angiogenic switch during tumorigenesis

Okamoto, R., Ueno, M., Yamada, Y., Takahashi, N., Sano, H., Suda, T. & Takakura, N., 2005 Apr 1, In : Blood. 105, 7, p. 2757-2763 7 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Hematopoietic stem cells and their niche

Suda, T., Arai, F. & Hirao, A., 2005 Aug 1, In : Trends in Immunology. 26, 8, p. 426-433 8 p.

Research output: Contribution to journalReview article

171 Citations (Scopus)

Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells

Itoh, T., Rai, T., Kuwahara, M., Ko, S. B. H., Uchida, S., Sasaki, S. & Ishibashi, K., 2005 May 13, In : Biochemical and Biophysical Research Communications. 330, 3, p. 832-838 7 p.

Research output: Contribution to journalArticle

139 Citations (Scopus)

Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages

Tamura, T., Thotakura, P., Tanaka, T. S., Ko, M. S. H. & Ozato, K., 2005 Sep 15, In : Blood. 106, 6, p. 1938-1947 10 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells

Akagi, T., Usuda, M., Matsuda, T., Ko, M. S. H., Niwa, H., Asano, M., Koide, H. & Yokota, T., 2005 May 27, In : Biochemical and Biophysical Research Communications. 331, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the α/β hydrolase domain containing 2 gene

Miyata, K., Oike, Y., Hoshii, T., Maekawa, H., Ogawa, H., Suda, T., Araki, K. & Yamamura, K. I., 2005 Apr 1, In : Biochemical and Biophysical Research Communications. 329, 1, p. 296-304 9 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Nonpathogenic Escherichia coli strain Nissle 1917 prevents murine acute and chronic colitis

Kamada, N., Inoue, N., Hisamatsu, T., Okamoto, S., Matsuoka, K., Sato, T., Chinen, H., Hong, K. S., Yamada, T., Suzuki, Y., Suzuki, T., Watanabe, N., Tsuchimoto, K. & Hibi, T., 2005 May 1, In : Inflammatory bowel diseases. 11, 5, p. 455-463 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

Yuasa, H., Oike, Y., Iwama, A., Nishikata, I., Sugiyama, D., Perkins, A., Mucenski, M. L., Suda, T. & Morishita, K., 2005 Jun 1, In : EMBO Journal. 24, 11, p. 1976-1987 12 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response

Sato, T., Nakai, T., Tamura, N., Okamoto, S., Matsuoka, K., Sakuraba, A., Fukushima, T., Uede, T. & Hibi, T., 2005 Sep, In : Gut. 54, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Regulation of hematopoiesis and its interaction with stem cell niches

Arai, F., Hirao, A. & Suda, T., 2005 Dec 1, In : International journal of hematology. 82, 5, p. 371-376 6 p.

Research output: Contribution to journalReview article

52 Citations (Scopus)

Regulation of hematopoietic stem cells by the niche

Arai, F., Hirao, A. & Suda, T., 2005 Feb, In : Trends in Cardiovascular Medicine. 15, 2, p. 75-79 5 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Regulation of self-renewal of hematopoietic stem cells in the niche

Hirao, A., Arai, F., Ito, K. & Suda, T., 2005 Jun, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 50, 7, p. 886-891 6 p.

Research output: Contribution to journalReview article

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

Hamada, K., Sasaki, T., Koni, P. A., Natsui, M., Kishimoto, H., Sasaki, J., Yajima, N., Horie, Y., Hasegawa, G., Naito, M., Miyazaki, J. I., Suda, T., Itoh, H., Nakao, K., Tak, W. M., Nakano, T. & Suzuki, A., 2005 Sep 1, In : Genes and Development. 19, 17, p. 2054-2065 12 p.

Research output: Contribution to journalArticle

216 Citations (Scopus)