The Sakaguchi Laboratory

Research Output

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Suda, T., Takubo, K. & Semenza, G. L., 2011 Oct 4, In : Cell stem cell. 9, 4, p. 298-310 13 p.

Research output: Contribution to journalReview article

420 Citations (Scopus)

Metabolic requirements for the maintenance of self-renewing stem cells

Ito, K. & Suda, T., 2014 Apr, In : Nature Reviews Molecular Cell Biology. 15, 4, p. 243-256 14 p.

Research output: Contribution to journalReview article

481 Citations (Scopus)

Mini-Gut Organoids: Reconstitution of the Stem Cell Niche

Date, S. & Sato, T., 2015 Nov 13, In : Annual Review of Cell and Developmental Biology. 31, p. 269-289 21 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

Matano, M., Date, S., Shimokawa, M., Takano, A., Fujii, M., Ohta, Y., Watanabe, T., Kanai, T. & Sato, T., 2015 Mar, In : Nature medicine. 21, 3, p. 256-262 7 p.

Research output: Contribution to journalArticle

399 Citations (Scopus)

Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids

Fujii, M., Clevers, H. & Sato, T., 2019 Feb 1, In : Gastroenterology. 156, 3, p. 562-576 15 p.

Research output: Contribution to journalReview article

14 Citations (Scopus)

Models of lineage switching in hematopoietic development: A new myeloid-committed eosinophil cell line (YJ) demonstrates trilineage potential

Yamaguchi, Y., Nishio, H., Kasahara, T., Ackerman, S. J., Koyanagi, H. & Suda, T., 1998 Jan 1, In : Leukemia. 12, 9, p. 1430-1439 10 p.

Research output: Contribution to journalArticle

Open Access
13 Citations (Scopus)

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain

Ohbo, K., Suda, T., Hashiyama, M., Mantani, A., Ikebe, M., Miyakawa, K., Moriyama, M., Nakamura, M., Katsuki, M., Takahashi, K., Yamamura, K. I. & Sugamura, K., 1996 Feb 1, In : Blood. 87, 3, p. 956-967 12 p.

Research output: Contribution to journalArticle

Open Access
196 Citations (Scopus)

Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H

Iwatsuki, K., Oda, M., Sun, W., Tanaka, S., Ogawa, T. & Shiota, K., 1998 Jan 1, In : Endocrinology. 139, 12, p. 4976-4983 8 p.

Research output: Contribution to journalArticle

Open Access
25 Citations (Scopus)

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells

Iwama, A., Hamaguchi, I., Hashiyama, M., Murayama, Y., Yasunaga, K. & Suda, T., 1993 Aug 31, In : Biochemical and Biophysical Research Communications. 195, 1, p. 301-309 9 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)

Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase)

Sakano, S., Iwama, A., Inazawa, J., Ariyama, T., Ohno, M. & Suda, T., 1994 Apr 1, In : Oncogene. 9, 4, p. 1155-1161 7 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system

Ohshiro, K., Iwama, A., Matsuno, K., Ezaki, T., Sakamoto, O., Hamaguchi, I., Takasu, N. & Suda, T., 1996 Oct 3, In : Biochemical and Biophysical Research Communications. 227, 1, p. 273-280 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Molecular mechanisms of pancreatic stone formation in chronic pancreatitis

Ko, S. B. H., Azuma, S., Yoshikawa, T., Yamamoto, A., Kyokane, K., Ko, M. S. H. & Ishiguro, H., 2012, In : Frontiers in Physiology. 3 NOV, Article 415.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Morphological examinations of murine granulocyte/macrophage colonies grown in serum-free cultures

Kubota, K., Motoyoshi, K., Kajigaya, S., Suda, T., Saito, M. & Miura, Y., 1983 Jul 29, In : Experimental Hematology. 11, 5, p. 364-370 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

Tai-Nagara, I., Matsuoka, S., Ariga, H. & Suda, T., 2014 Jan 2, In : Blood. 123, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T. & Nakayama, K. I., 2004 Mar 5, In : Journal of Biological Chemistry. 279, 10, p. 9417-9423 7 p.

Research output: Contribution to journalArticle

196 Citations (Scopus)

Mucosal concentrations of N-acetyl-5-aminosalicylic acid related to endoscopic activity in ulcerative colitis patients with mesalamine

Fukuda, T., Naganuma, M., Takabayashi, K., Hagihara, Y., Tanemoto, S., Nomura, E., Yoshimatsu, Y., Sugimoto, S., Nanki, K., Mizuno, S., Mikami, Y., Fukuhara, K., Sujino, T., Mutaguchi, M., Inoue, N., Ogata, H., Iwao, Y., Abe, T. & Kanai, T., 2020, (Accepted/In press) In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalArticle

Open Access

Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients

Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 Dec 15, In : Journal of Crohn's and Colitis. 7, 12, p. e609-e614

Research output: Contribution to journalArticle

36 Citations (Scopus)

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

Dominguez-Brauer, C., Hao, Z., Elia, A. J., Fortin, J. M., Nechanitzky, R., Brauer, P. M., Sheng, Y., Mana, M. D., Chio, I. I. C., Haight, J., Pollett, A., Cairns, R., Tworzyanski, L., Inoue, S., Reardon, C., Marques, A., Silvester, J., Cox, M. A., Wakeham, A., Yilmaz, O. H. & 5 others, Sabatini, D. M., van Es, J. H., Clevers, H., Sato, T. & Mak, T. W., 2016 Aug 4, In : Cell stem cell. 19, 2, p. 205-216 12 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Multiple myeloma with hemolytic anemia and thrombocytopenia

Muroi, K., Imagawa, S., Suda, T., Kajii, E., Otuka, Y., Sakurabayashi, I., Amemiya, Y., Sakamoto, S. & Miura, Y., 1991 Aug, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 32, 8, p. 909-911 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Multipotent and Committed CD34+ Cells in Bone Marrow Transplantation

Ema, H., Suda, T., Nakauchi, H., Nakamura, Y., Iwama, A., Imagawa, S., Akutsu, M., Kano, Y., Kato, S., Yabe, M., Yoshida, M., Sakamoto, S., Amemiya, Y. & Miura, Y., 1991 May, In : Japanese Journal of Cancer Research. 82, 5, p. 547-552 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Myeloid and erythroid lineage expression of haemopoietic progenitors derived from an abnormal clone in erythroleukaemia

Suda, T., Sato, Y., Furukawa, Y., Suda, J., Eguchi, M., Saito, M. & Miura, Y., 1986 Dec, In : British Journal of Haematology. 64, 4, p. 647-656 10 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 Nov 23, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neovascular niche for human myeloma cells in immunodeficient mouse bone

Iriuchishima, H., Takubo, K., Miyakawa, Y., Nakamura-Ishizu, A., Miyauchi, Y., Fujita, N., Miyamoto, K., Miyamoto, T., Ikeda, E., Kizaki, M., Nojima, Y. & Suda, T., 2012 Feb 7, In : PloS one. 7, 2, e30557.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors

Matsushita, M., Nakatake, Y., Arai, I., Ibata, K., Kouda, K., Goparaju, S. K., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S., Kanai, T., Yuzaki, M. & Ko, M. S. H., 2017 May 31, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Neurogenin3 delineates the earliest stages of spermatogenesis in the mouse testis

Yoshida, S., Takakura, A., Ohbo, K., Abe, K., Wakabayashi, J., Yamamoto, M., Suda, T. & Nabeshima, Y. I., 2004 May 15, In : Developmental Biology. 269, 2, p. 447-458 12 p.

Research output: Contribution to journalArticle

199 Citations (Scopus)

Neuropilin-1 on hematopoietic cells as a source of vascular development

Yamada, Y., Oike, Y., Ogawa, H., Ito, Y., Fujisawa, H., Suda, T. & Takakura, N., 2003 Mar 1, In : Blood. 101, 5, p. 1801-1809 9 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

New IJH guidelines highlight greater transparency

Sipp, D. & Suda, T., 2011 Apr 1, In : International journal of hematology. 93, 4, p. 411-412 2 p.

Research output: Contribution to journalEditorial

Niche regulation of hematopoietic stem cells in the endosteum: The role of thrombopoietinmpl signaling in the maintenance of quiescent Hematopoietic Stem Cells

Arai, F., Yoshihara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H. & Suda, T., 2009 Jan 1, Hematopoietic Stem Cells VII. Blackwell Publishing Inc., p. 36-46 11 p. (Annals of the New York Academy of Sciences; vol. 1176).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

49 Citations (Scopus)

No more sugar-coating it: Mucins and platelet biology

Matsubara, Y., 2013 Aug 29, In : Blood. 122, 9, p. 1537-1538 2 p.

Research output: Contribution to journalReview article

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S. I., Juang, Y. C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A. C., Natsume, T., Suda, T. & Durocher, D., 2010 Aug 19, In : Nature. 466, 7309, p. 941-946 6 p.

Research output: Contribution to journalArticle

225 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 Jul 20, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Nonpathogenic Escherichia coli strain Nissle 1917 prevents murine acute and chronic colitis

Kamada, N., Inoue, N., Hisamatsu, T., Okamoto, S., Matsuoka, K., Sato, T., Chinen, H., Hong, K. S., Yamada, T., Suzuki, Y., Suzuki, T., Watanabe, N., Tsuchimoto, K. & Hibi, T., 2005 May 1, In : Inflammatory bowel diseases. 11, 5, p. 455-463 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta

Hamada, Y., Hiroe, T., Suzuki, Y., Oda, M., Tsujimoto, Y., Coleman, J. R. & Tanaka, S., 2007 Mar, In : Differentiation. 75, 3, p. 268-278 11 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Not merely quiescent: Telomeres in quiescent HSCs

Nakamura-Ishizu, A. & Suda, T., 2014 Nov 20, In : Blood. 124, 22, p. 3179-3180 2 p.

Research output: Contribution to journalComment/debate

Novel association of the Src family kinases, Hck and c-Fgr, with CCR3 receptor stimulation: A possible mechanism for eotaxin-induced human eosinophil chemotaxis

El-Shazly, A., Yamaguchi, N., Masuyama, K., Suda, T. & Ishikawa, T., 1999 Oct 14, In : Biochemical and Biophysical Research Communications. 264, 1, p. 163-170 8 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013 Jan 1, In : Blood. 121, 16, p. 3267-3273 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 Nov 1, In : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 2013 Nov 8, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Nude Mice Bearing Human CSF-Producing Tumor: Analysis of Hemopoietic Factor(s) Acting on Primitive Stem Cells

Takeda, K., Miura, Y., Suda, T. & Sudo, T., 1987 Jan 1, In : Cell structure and function. 12, 3, p. 273-280 8 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Observation of deworming process in intestinal Diphyllobothrium latum parasitism by Gastrografin injection into jejunum through double-balloon enteroscope

Ko, S. B. H., Ohmiya, N., Nakamura, M., Honda, W., Shirai, O., Takenaka, H., Niwa, Y. & Goto, H., 2008 Aug 1, In : American Journal of Gastroenterology. 103, 8, p. 2149-2150 2 p.

Research output: Contribution to journalLetter

3 Citations (Scopus)

Of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics

Matsuoka, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Nagauma, M., Kanai, T., Mochizuki, M. & Hashiguchi, M., 2020, In : International journal of clinical pharmacology and therapeutics. 58, 2, p. 89-102 14 p.

Research output: Contribution to journalArticle

Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

Yuasa, H., Oike, Y., Iwama, A., Nishikata, I., Sugiyama, D., Perkins, A., Mucenski, M. L., Suda, T. & Morishita, K., 2005 Jun 1, In : EMBO Journal. 24, 11, p. 1976-1987 12 p.

Research output: Contribution to journalArticle

139 Citations (Scopus)

Online First publication

Suda, T., Akashi, K., Lu, D. P., Kim, C. C., Issaragrisil, S. & Hoelzer, D. F., 2008 Jan 1, In : International journal of hematology. 87, 1, 1 p.

Research output: Contribution to journalEditorial

On the biomechanics of stem cell niche formation in the gut - Modelling growing organoids

Buske, P., Przybilla, J., Loeffler, M., Sachs, N., Sato, T., Clevers, H. & Galle, J., 2012 Sep 1, In : FEBS Journal. 279, 18, p. 3475-3487 13 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

Matsubara, Y., Ono, Y., Suzuki, H., Arai, F., Suda, T., Murata, M. & Ikeda, Y., 2013 Mar 1, In : PloS one. 8, 3, e58123.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Opening the door for HIF1α tuning

Takubo, K. & Suda, T., 2014 Jan 9, In : Blood. 123, 2, p. 151-152 2 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Organization of the chemokine genes in the human and mouse major clusters of CC and CXC chemokines: Diversification between the two species

Nomiyama, H., Mera, A., Ohneda, O., Miura, R., Suda, T. & Yoshie, O., 2001 Apr, In : Genes and Immunity. 2, 2, p. 110-113 4 p.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response

Sato, T., Nakai, T., Tamura, N., Okamoto, S., Matsuoka, K., Sakuraba, A., Fukushima, T., Uede, T. & Hibi, T., 2005 Sep 1, In : Gut. 54, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Osteoprotegerin regulates pancreatic β-cell homeostasis upon microbial invasion

Kuroda, Y., Maruyama, K., Fujii, H., Sugawara, I., Ko, S., Yasuda, H., Matsui, H. & Matsuo, K., 2016 Jan 11, In : PLoS One. 11, 1, e0146544.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Overexpression of C-terminal Src kinase homologous kinase suppresses activation of Lyn tyrosine kinase required for VLA5-mediated Dami cell spreading

Hirao, A., Huang, X. L., Suda, T. & Yamaguchi, N., 1998 Apr 17, In : Journal of Biological Chemistry. 273, 16, p. 10004-10010 7 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)