The Sakaguchi Laboratory

Research Output

Article

Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis

Ohta, E., Itoh, T., Nemoto, T., Kumagai, J., Ko, S. B. H., Ishibashi, K., Ohno, M., Uchida, K., Ohta, A., Sohara, E., Uchida, S., Sasaki, S. & Rai, T., 2009 Dec 1, In : American Journal of Physiology - Cell Physiology. 297, 6, p. C1368-C1378

Research output: Contribution to journalArticle

33 Citations (Scopus)

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Higashikuse, Y., Mittal, N., Arimura, T., Yoon, S. H., Oda, M., Enomoto, H., Kaneda, R., Hattori, F., Suzuki, T., Kawakami, A., Gasch, A., Furukawa, T., Labeit, S., Fukuda, K., Kimura, A. & Makino, S., 2019 Jan 1, In : DMM Disease Models and Mechanisms. 12, 11, dmm.041103.

Research output: Contribution to journalArticle

Open Access

Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer

Tanaka, S., Oda, M., Toyoshima, Y., Wakayama, T., Tanaka, M., Hattori, N., Yoshida, N., Ohgane, J., Yanagimachi, R. & Shiota, K., 2001 Jan 1, In : Biology of reproduction. 65, 6, p. 1813-1821 9 p.

Research output: Contribution to journalArticle

Open Access
170 Citations (Scopus)

Platelet peroxidase-positive blast cells in transient myeloproliferative disorder with Down's syndrome

Suda, J., Eguchi, M., Ozawa, T., Furukawa, T., Hayashi, Y., Kojima, S., Maeda, H., Tadokoro, K., Sato, Y., Miura, Y., Ohara, A. & Suda, T., 1988, In : British Journal of Haematology. 68, 2, p. 181-187 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Predominance of macrophage-colony formation in human cord blood

Ijima, H., Suda, T. & Miura, Y., 1982 Jan 1, In : Experimental Hematology. 10, 2, p. 234-240 7 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice

Iwamoto, N., Kawaguchi, T., Horikawa, K., Nagakura, S., Kagimoto, T., Suda, T., Takatsuki, K. & Nakakuma, H., 1996 Jun 15, In : Blood. 87, 12, p. 4944-4948 5 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis

Takubo, K., Hirao, A., Ohmura, M., Azuma, M., Arai, F., Nagamatsu, G. & Suda, T., 2006 Dec 29, In : Biochemical and Biophysical Research Communications. 351, 4, p. 993-998 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Proliferation and differentiation of murine mast cells in vitro

Suda, T., 1985 Dec 1, In : Acta Haematologica Japonica. 48, 8, p. 1937-1945 9 p.

Research output: Contribution to journalArticle

Proliferative Effect of Human Granulocyte Colony‐stimulating Factor on Blast Cells of Acute Promyelocytic Leukemia

Kitano, K., Suda, T., Sato, Y. & Miura, Y., 1988 Jul, In : Japanese Journal of Cancer Research. 79, 7, p. 843-849 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 2013 Jan 1, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Purified interleukin-3 and erythropoietin support the terminal differentiation of hemopoietic progenitors in serum-free culture

Suda, J., Suda, T., Kubota, K., Ihle, J. N., Saito, M. & Miura, Y., 1986 Jul 30, In : Blood. 67, 4, p. 1002-1006 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors

Yamaguchi, Y., Suda, T., Suda, J., Eguchi, M., Miura, Y., Harada, N., Tominaga, A. & Takatsu, K., 1988 Jan 1, In : Journal of Experimental Medicine. 167, 1, p. 43-56 14 p.

Research output: Contribution to journalArticle

Open Access
447 Citations (Scopus)

Radiation sensitivity of leukemic progenitor cells in acute nonlymphocytic leukemia

Ozawa, K., Miura, Y., Suda, T. & Motoyoshi, K., 1983 May 1, In : Cancer Research. 43, 5, p. 2339-2341 3 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors

Goparaju, S. K., Kouda, K., Ibata, K., Soma, A., Nakatake, Y., Akiyama, T., Wakabayashi, S., Matsushita, M., Sakota, M., Kimura, H., Yuzaki, M., Ko, S. B. H. & Ko, M. S. H., 2017 Feb 13, In : Scientific reports. 7, 42367.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells

Kawasaki, K., Watabe, T., Sase, H., Hirashima, M., Koide, H., Morishita, Y., Yuki, K., Sasaoka, T., Suda, T., Katsuki, M., Miyazono, K. & Miyazawa, K., 2008 Apr 7, In : Journal of Cell Biology. 181, 1, p. 131-141 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Rat stem cell factor and IL-6 preferentially support the proliferation of c-kit-positive murine hemopoietic cells rather than their differentiation

Miura, N., Okada, S., Zsebo, K. M., Miura, Y. & Suda, T., 1993 Dec 1, In : Experimental Hematology. 21, 1, p. 143-149 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., 2006 Apr 1, In : Nature medicine. 12, 4, p. 446-451 6 p.

Research output: Contribution to journalArticle

905 Citations (Scopus)

Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification

Morita, K., Miyamoto, T., Fujita, N., Kubota, Y., Ito, K., Takubo, K., Miyamoto, K., Ninomiya, K., Suzuki, T., Iwasaki, R., Yagi, M., Takaishi, H., Toyama, Y. & Suda, T., 2007 Jul 9, In : Journal of Experimental Medicine. 204, 7, p. 1613-1623 11 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Reactivity profiles of leukemic myeloblasts with monoclonal antibodies directed to sialosyl-Le(x) and other lacto-series type 2 chain antigens: Absence of reactivity with normal hematopoietic progenitor cells

Muroi, K., Suda, T., Nojiri, H., Ema, H., Amemiya, Y., Miura, Y., Nakauchi, H., Singhal, A. & Hakomori, S. I., 1992, In : Blood. 79, 3, p. 713-719 7 p.

Research output: Contribution to journalArticle

Open Access
34 Citations (Scopus)

Receptor tyrosine kinases involved in hematopoietic progenitor cells

Suda, T., Iwama, A., Hashiyama, M., Sakano, S. & Ohno, M., 1997 Jan 1, In : Leukemia. 11, SUPPL. 3, p. 451-453 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Reconstruction of the Human Colon Epithelium In Vivo

Sugimoto, S., Ohta, Y., Fujii, M., Matano, M., Shimokawa, M., Nanki, K., Date, S., Nishikori, S., Nakazato, Y., Nakamura, T., Kanai, T. & Sato, T., 2018 Feb 1, In : Cell Stem Cell. 22, 2, p. 171-176.e5

Research output: Contribution to journalArticle

34 Citations (Scopus)

Redistribution of ERK/MAP kinase to uropod-like structures in interleukin-3-induced cell shape changes

Mera, A., Suga, M., Nakayama, Y., Ando, M., Suda, T. & Yamaguchi, N., 2002 Nov 1, In : Immunology Letters. 84, 2, p. 117-124 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation

Hoshino, Y., Hatake, K., Mimuro, J., Nakamura, Y., Ashizawa, N., Tsunoda, S., Muroi, K., Suda, T., Yoshida, M. & Miwa, A., 1993 Jun, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 34, 6, p. 718-722 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages

Sato, T., Ishikawa, S., Asano, J., Yamamoto, H., Fujii, M., Sato, T., Yamamoto, K., Kitagaki, K., Akashi, T., Okamoto, R. & Ohteki, T., 2020 Aug 1, In : Nature Cell Biology. 22, 8, p. 919-926 8 p.

Research output: Contribution to journalArticle

Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings

Ochi, H., Takeshita, H., Suda, T., Nisitani, S., Honjo, T. & Watanabe, T., 1999 Dec 1, In : Immunology. 98, 4, p. 595-603 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Regulation of hematopoietic stem cells by the niche

Arai, F., Hirao, A. & Suda, T., 2005 Feb, In : Trends in Cardiovascular Medicine. 15, 2, p. 75-79 5 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., Ikeda, Y., Mak, T. W. & Suda, T., 2004 Oct 21, In : Nature. 431, 7011, p. 997-1002 6 p.

Research output: Contribution to journalArticle

847 Citations (Scopus)

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes

Ito, K., Takubo, K., Arai, F., Satoh, H., Matsuoka, S., Ohmura, M., Naka, K., Azuma, M., Miyamoto, K., Hosokawa, K., Ikeda, Y., Mak, T. W., Suda, T. & Hirao, A., 2007 Jan 1, In : Journal of Immunology. 178, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

Open Access
87 Citations (Scopus)

Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells

Oike, Y., Ito, Y., Hamada, K., Zhang, X. Q., Miyata, K., Arai, F., Inada, T., Araki, K., Nakagata, N., Takeya, M., Kisanuki, Y. Y., Yanagisawa, M., Gale, N. W. & Suda, T., 2002 Aug 15, In : Blood. 100, 4, p. 1326-1333 8 p.

Research output: Contribution to journalArticle

Open Access
103 Citations (Scopus)

Regulatory mechanism of granulopoiesis in the bone marrow of CSF-producing tumor-bearing nude mice

Motoyoshi, K., Suda, T., Takaku, F. & Miura, Y., 1983, In : Blood. 62, 5, p. 980-987 8 p.

Research output: Contribution to journalArticle

Open Access
7 Citations (Scopus)

Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells

Hung, S. S. C., Wong, R. C. B., Sharov, A. A., Nakatake, Y., Yu, H. & Ko, M. S. H., 2013 Aug 1, In : DNA Research. 20, 4, p. 391-401 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Response of newly established mouse myeloid leukemic cell lines to MC3T3-G2/PA6 preadipocytes and hematopoietic factors

Kodama, H., Iizuka, M., Tomiyama, T., Yoshida, K., Seki, M., Suda, T. & Nishikawa, S. I., 1991, In : Blood. 77, 1, p. 49-54 6 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Restricted VH gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis

Inoue, N., Watanabe, M., Sato, T., Okazawa, A., Yamazaki, M., Kanai, T., Ogata, H., Iwao, Y., Ishii, H. & Hibi, T., 2001 Jan 1, In : Gastroenterology. 121, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Retinoic acid promotes differentiation of trophoblast stem cells to a giant cell fate

Yan, J., Tanaka, S., Oda, M., Makino, T., Ohgane, J. & Shiota, K., 2001 Jul 15, In : Developmental Biology. 235, 2, p. 422-432 11 p.

Research output: Contribution to journalArticle

71 Citations (Scopus)

Retropharyngeal neuroblastoma causing airway obstruction in a newborn-Survival with surgical treatment alone

Yokoya, S., Suda, T., Koyama, M., Yanagisawa, M., Kamoshita, S., Miyakawa, K. & Moriyama, S., 1982 Apr, In : Journal of Pediatric Surgery. 17, 2, p. 180-181 2 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils

Koyanagi, H., Wakasugi, N., Yoshimatsu, K., Takashima, Y., Yodoi, J. J., Momoi, M., Suda, T., Kasahara, T. & Yamaguchi, Y., 1995 Jan 1, In : Biochemical and Biophysical Research Communications. 213, 3, p. 1140-1147 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

RoLe of Hematopoietic Stem Cells in Angiogenesis

Suda, T. & Takakura, N., 2001 Jan 1, In : International journal of hematology. 74, 3, p. 266-271 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Role of IL-5 in IL-2-induced eosinophilia. In vivo and in vitro expression of IL-5 mRNA by IL-2

Yamaguchi, Y., Suda, T., Shiozaki, H., Miura, Y., Hitoshi, Y., Tominaga, A., Takatsu, K. & Kasahara, T., 1990 Jan 1, In : Journal of Immunology. 145, 3, p. 873-877 5 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 Aug, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 May 1, In : International journal of hematology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

R-spondins/Lgrs expression in tooth development

kawasaki, M., Porntaveetus, T., Kawasaki, K., Oommen, S., Otsuka-Tanaka, Y., Hishinuma, M., Nomoto, T., Maeda, T., Takubo, K., Suda, T., Sharpe, P. T. & Ohazama, A., 2014 Jun, In : Developmental Dynamics. 243, 6, p. 844-851 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells

Arai, Y., Takahashi, D., Asano, K., Tanaka, M., Oda, M., Ko, S., Ko, M., Mandai, S., Nomura, N., Rai, T., Uchida, S. & Sohara, E., 2017 Jan 1, In : Scientific Reports. 7, 46580.

Research output: Contribution to journalArticle

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

Noda, M., Ko, M., Ogura, A., Liu, D. G., Amano, T., Takano, T. & Ikawa, Y., 1985 Dec 1, In : Nature. 318, 6041, p. 73-75 3 p.

Research output: Contribution to journalArticle

338 Citations (Scopus)

SCODE: An efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation

Matsumoto, H., Kiryu, H., Furusawa, C., Ko, M., Ko, S., Gouda, N., Hayashi, T. & Nikaido, I., 2017 Aug 1, In : Bioinformatics. 33, 15, p. 2314-2321 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice

Oda, M., Wakabayashi, S., Ari Wijetunga, N., Yuasa, S., Enomoto, H., Kaneda, R., Yoon, S. H., Mittal, N., Jing, Q., Suzuki, M., Greally, J. M., Fukuda, K. & Makino, S., 2018 May 10, In : BMC Genomics. 19, 1, 349.

Research output: Contribution to journalArticle

Selkctive expression of a receptor tyrosine kinase, HTK on human erythroid progenitor cells

Inada, T., Iwama, A., Sakano, S., Ohno, M. & Suda, T., 1996 Dec 1, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

Sequential analysis of hematopoietic reconstitution achieved by transplantation of hematopoietic stem cells

Okada, S., Nagayoshi, K., Nakauchi, H., Nishikawa, S. I., Miura, Y. & Suda, T., 1993, In : Blood. 81, 7, p. 1720-1725 6 p.

Research output: Contribution to journalArticle

Open Access
32 Citations (Scopus)

Serotonin and pancreatic duct function.

Naruse, S., Suzuki, A., Ishiguro, H., Kitagawa, M., Ko, S. B., Yoshikawa, T., Yamamoto, A., Hamada, H. & Hayakawa, T., 2000 Aug, In : Journal of Korean medical science. 15 Suppl, p. S27-28

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/β-Catenin and Hippo/YAP Signaling

Oudhoff, M. J., Braam, M. J. S., Freeman, S. A., Wong, D., Rattray, D. G., Wang, J., Antignano, F., Snyder, K., Refaeli, I., Hughes, M. R., McNagny, K. M., Gold, M. R., Arrowsmith, C. H., Sato, T., Rossi, F. M. V., Tatlock, J. H., Owen, D. R., Brown, P. J. & Zaph, C., 2016 Apr 4, In : Developmental Cell. 37, 1, p. 47-57 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Significance of Conducting 2 Types of Fecal Tests in Patients With Ulcerative Colitis

Naganuma, M., Kobayashi, T., Nasuno, M., Motoya, S., Kato, S., Matsuoka, K., Hokari, R., Watanabe, C., Sakamoto, H., Yamamoto, H., Sasaki, M., Watanabe, K., Iijima, H., Endo, Y., Ichikawa, H., Ozeki, K., Tanida, S., Ueno, N., Fujiya, M., Sako, M. & 6 others, Takeuchi, K., Sugimoto, S., Abe, T., Hibi, T., Suzuki, Y. & Kanai, T., 2020 May, In : Clinical Gastroenterology and Hepatology. 18, 5, p. 1102-1111.e5

Research output: Contribution to journalArticle

Open Access