The Sakaguchi Laboratory

Research Output

1997

Receptor tyrosine kinases involved in hematopoietic progenitor cells

Suda, T., Iwama, A., Hashiyama, M., Sakano, S. & Ohno, M., 1997 Jan 1, In : Leukemia. 11, SUPPL. 3, p. 451-453 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Selective expression of the receptor tyrosine kinase, HTK, on human erythroid progenitor cells

Inada, T., Iwama, A., Sakano, S., Ohno, M., Sawada, K. I. & Suda, T., 1997 Apr 15, In : Blood. 89, 8, p. 2757-2765 9 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets

Hirao, A., Hamaguchi, I., Suda, T. & Yamaguchi, N., 1997 May 1, In : EMBO Journal. 16, 9, p. 2342-2351 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)
1996

Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice

Hamaguchi, I., Yamaguchi, N., Suda, J., Iwama, A., Hirao, A., Hashiyama, M., Aizawa, S. I. & Suda, T., 1996 Jul 5, In : Biochemical and Biophysical Research Communications. 224, 1, p. 172-179 8 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

CD34-deficient mice have reduced eosinophil accumulation after allergen exposure and show a novel crossreactive 90-kD protein

Suzuki, A., Andrew, D. P., Gonzalo, J. A., Fukumoto, M., Spellberg, J., Hashiyama, M., Takimoto, H., Gerwin, N., Webb, L., Molineux, G., Amakawa, R., Tada, Y., Wakeham, A., Brown, J., McNiece, I., Ley, K., Butcher, E. C., Suda, T., Gutierrez-Ramos, J. C. & Mak, T. W., 1996 May 1, In : Blood. 87, 9, p. 3550-3562 13 p.

Research output: Contribution to journalArticle

117 Citations (Scopus)

Characterization of a ligand for receptor protein-tyrosine kinase HTK expressed in immature hematopoietic cells

Sakano, S., Serizawa, R., Inada, T., Iwama, A., Itoh, A., Kato, C., Shimizu, Y., Shinkai, F., Shimizu, R., Kondo, S., Ohno, M. & Suda, T., 1996 Sep 30, In : Oncogene. 13, 4, p. 813-822 10 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Impaired development of CD4+ CD8+ thymocytes by csk-'knock-in' into fyn locus

Kanazawa, S., Ilić, D., Hashiyama, M., Okada, M., Noumura, T., Aizawa, S. & Suda, T., 1996 Aug 10, In : Oncogene. 13, 1, p. 199-204 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Macrophage-stimulating protein activates STK receptor tyrosine kinase on osteoclasts and facilitates bone resorption by osteoclast-like cells

Kurihara, N., Iwama, A., Tatsumi, J., Ikeda, K. & Suda, T., 1996 May 1, In : Blood. 87, 9, p. 3704-3710 7 p.

Research output: Contribution to journalArticle

75 Citations (Scopus)

Macrophage-stimulating protein induces proliferation and migration of murine keratinocytes

Wang, M. H., Dlugosz, A. A., Sun, Y., Suda, T., Skeel, A. & Leonard, E. J., 1996 Jul 10, In : Experimental Cell Research. 226, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor γ chain

Ohbo, K., Suda, T., Hashiyama, M., Mantani, A., Ikebe, M., Miyakawa, K., Moriyama, M., Nakamura, M., Katsuki, M., Takahashi, K., Yamamura, K. I. & Sugamura, K., 1996 Feb 1, In : Blood. 87, 3, p. 956-967 12 p.

Research output: Contribution to journalArticle

194 Citations (Scopus)

Molecular cloning of rat macrophage-stimulating protein and its involvement in the male reproductive system

Ohshiro, K., Iwama, A., Matsuno, K., Ezaki, T., Sakamoto, O., Hamaguchi, I., Takasu, N. & Suda, T., 1996 Oct 3, In : Biochemical and Biophysical Research Communications. 227, 1, p. 273-280 8 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

p59fyn-p125FAK cooperation in Development of CD4+CD8+ Thymocytes

Kanazawa, S., Ilić, D., Hashiyama, M., Noumura, T., Yamamoto, T., Suda, T. & Aizawa, S., 1996 Feb 1, In : Blood. 87, 3, p. 865-870 6 p.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Preferential hematopoiesis by paroxysmal nocturnal hemoglobinuria clone engrafted in SCID mice

Iwamoto, N., Kawaguchi, T., Horikawa, K., Nagakura, S., Kagimoto, T., Suda, T., Takatsuki, K. & Nakakuma, H., 1996 Jun 15, In : Blood. 87, 12, p. 4944-4948 5 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Selkctive expression of a receptor tyrosine kinase, HTK on human erythroid progenitor cells

Inada, T., Iwama, A., Sakano, S., Ohno, M. & Suda, T., 1996 Dec 1, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family

Iwama, A., Yamaguchi, N. & Suda, T., 1996 Nov 1, In : EMBO Journal. 15, 21, p. 5866-5875 10 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

The receptor tyrosine kinase, Cek8, is transiently expressed on subtypes of motoneurons in the spinal cord during development

Ohta, K., Nakamura, M., Hirokawa, K., Tanaka, S., Iwama, A., Suda, T., Ando, M. & Tanaka, H., 1996 Jan, In : Mechanisms of Development. 54, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)
1995

Expression of c-kit receptor (CD 117) and CD34 in leukemic cells

Muroi, K., Nakamurat, M., Amemiya, Y., Suda, T. & Miura, Y., 1995 Jan 1, In : Leukemia and Lymphoma. 16, 3-4, p. 297-305 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Focal adhesion kinase is not essential for in vitro and in vivo differentiation of ES cells

Ilic, D., Furuta, Y., Suda, T., Atsumi, T., Fujimoto, J., Ikawa, Y., Yamamoto, T. & Aizawa, S., 1995 Apr 6, In : Biochemical and Biophysical Research Communications. 209, 1, p. 300-309 10 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Functional molecules expressed in hematopoietic stem cells

Suda, T., 1995 Mar, In : Seikagaku. The Journal of Japanese Biochemical Society. 67, 3, p. 190-203 14 p.

Research output: Contribution to journalReview article

Interleukin-13 selectively suppresses the growth of human macrophage progenitors at the late stage

Sakamoto, O., Hashiyama, M., Minty, A., Ando, M. & Suda, T., 1995, In : Blood. 85, 12, p. 3487-3493 7 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils

Koyanagi, H., Wakasugi, N., Yoshimatsu, K., Takashima, Y., Yodoi, J. J., Momoi, M., Suda, T., Kasahara, T. & Yamaguchi, Y., 1995 Jan 1, In : Biochemical and Biophysical Research Communications. 213, 3, p. 1140-1147 8 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Soluble c‐kit molecule in serum from healthy individuals and patients with haemopoietic disorders

Kawakita, M., Yonemura, Y., Miyake, H., Ohkubo, T., Asou, N., Hayakawa, K., Nakamura, M., Kitoh, T., Osawa, H., Takatsuki, K. & Suda, T., 1995 Sep, In : British Journal of Haematology. 91, 1, p. 23-29 7 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein

Iwama, A., Wang, M. H., Yamaguchi, N., Ohno, N., Okano, K., Sudo, T., Takeya, M., Gervais, F., Morissette, C., Leonard, E. J. & Suda, T., 1995 Jan 1, In : Blood. 86, 9, p. 3394-3403 10 p.

Research output: Contribution to journalArticle

92 Citations (Scopus)

The murine stk gene product, a transmembrane protein tyrosine kinase, is a receptor for macrophage-stimulating protein

Wang, M. H., Iwama, A., Skeel, A., Suda, T. & Leonard, E. J., 1995 Apr 25, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 9, p. 3933-3937 5 p.

Research output: Contribution to journalArticle

Open Access
70 Citations (Scopus)

Transformation into acute basophilic leukaemia in a patient with myelodysplastic syndrome

Yamagata, T., Miwa, A., Eguchi, M., Kitagawa, S., Muroi, K., Hatake, K., Suda, T., Sakamoto, S. & Miura, Y., 1995 Mar, In : British Journal of Haematology. 89, 3, p. 650-652 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
1994

A case of acute promyelocytic leukemia (APL) with myeloblastoma in the oral cavity developing after receiving all-trans retinoic acid (ATRA)

Izumi, T., Hatake, K., Imagawa, S., Yoshikda, M., Ohta, M., Sasaki, R., Miwa, A., Suda, T., Sakamoto, S. & Miura, Y., 1994 Jun, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 35, 6, p. 598-602 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Characterization of mouse non-receptor tyrosine kinase gene, HYL

Hamaguchi, I., Iwama, A., Yamaguchi, N., Sakano, S., Matsuda, Y. & Suda, T., 1994 Nov 1, In : Oncogene. 9, 11, p. 3371-3374 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Expression of sialosyl-Tn in colony-forming unit-erythroid, erythroblasts, B cells, and a subset of CD4+ cells

Muroi, K., Suda, T., Nakamura, M., Okada, S., Nojiri, H., Amemiya, Y., Miura, Y. & Hakomori, S. I., 1994 Jan 1, In : Blood. 83, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase)

Sakano, S., Iwama, A., Inazawa, J., Ariyama, T., Ohno, M. & Suda, T., 1994 Apr 1, In : Oncogene. 9, 4, p. 1155-1161 7 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)
1993

ASYNCHRONOUS EXPRESSION OF c‐kit AND CD34 ON LEUKAEMIC BLASTS

MUROI, K., Nakamura, M., Amemiya, Y., Suda, T. & Miura, Y., 1993 Nov, In : British Journal of Haematology. 85, 3, p. 633-634 2 p.

Research output: Contribution to journalLetter

4 Citations (Scopus)

Expression of c-kit mRNA and protein during the differentiation of human hematopoietic progenitor cells

Yamaguchi, Y., Gunji, Y., Nakamura, M., Hayakawa, K., Maeda, M., Osawa, H., Nagayoshi, K., Kasahara, T. & Suda, T., 1993 Dec 1, In : Experimental Hematology. 21, 9, p. 1233-1238 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Expression of sialyl-Lewis(x) in CD34-positive leukemic blasts [3]

Muroi, K., Suda, T., Nojiri, H., Amemiya, Y., Miura, Y. & Hakomori, S. I., 1993 Jan 1, In : Leukemia. 7, 2, p. 336-337 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Expression of sialyl-lewisx on CD10-positive normal bone marrow cells

Muroi, K., Nakamura, M., Suda, T., Miura, Y. & Hakomori, S. I., 1993 Apr, In : Leukemia Research. 17, 4, p. 389-390 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

Human primitive hematopoietic progenitor cells are more enriched in KIT(low) cells than in KIT(high) cells

Gunji, Y., Nakamura, M., Osawa, H., Nagayoshi, K., Nakauchi, H., Miura, Y., Yanagisawa, M. & Suda, T., 1993 Jan 1, In : Blood. 82, 11, p. 3283-3289 7 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Molecular cloning and characterization of mouse TIE and TEK receptor tyrosine kinase genes and their expression in hematopoietic stem cells

Iwama, A., Hamaguchi, I., Hashiyama, M., Murayama, Y., Yasunaga, K. & Suda, T., 1993 Aug 31, In : Biochemical and Biophysical Research Communications. 195, 1, p. 301-309 9 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)

Rat stem cell factor and IL-6 preferentially support the proliferation of c-kit-positive murine hemopoietic cells rather than their differentiation

Miura, N., Okada, S., Zsebo, K. M., Miura, Y. & Suda, T., 1993 Dec 1, In : Experimental Hematology. 21, 1, p. 143-149 7 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation

Hoshino, Y., Hatake, K., Mimuro, J., Nakamura, Y., Ashizawa, N., Tsunoda, S., Muroi, K., Suda, T., Yoshida, M. & Miwa, A., 1993 Jun, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 34, 6, p. 718-722 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Role of c-kit receptor in the diagnosis of leukemia: A relationship between expression of c-kit receptor and that of CD33 in leukemic blasts

Muroi, K., Amemiya, Y., Miura, Y., Nakamura, M. & Suda, T., 1993 Aug, In : Leukemia Research. 17, 8, p. 725-726 2 p.

Research output: Contribution to journalLetter

2 Citations (Scopus)

Sequential analysis of hematopoietic reconstitution achieved by transplantation of hematopoietic stem cells

Okada, S., Nagayoshi, K., Nakauchi, H., Nishikawa, S. I., Miura, Y. & Suda, T., 1993 Jan 1, In : Blood. 81, 7, p. 1720-1725 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Treatment of 71 adult acute lymphoblastic leukemia

Yoshida, M., Kurata, H., Tsunoda, S., Iwama, A., Suzuki, T., Akutsu, M., Imagawa, S., Tsunoda, J., Furukawa, Y., Komatsu, N., Muroi, K., Ohta, M., Ohsaka, A., Hatake, K., Suda, K., Takagi, S., Sato, Y., Suda, T. & Kitagawa, S., 1993 Jan 1, In : Japanese Journal of Cancer and Chemotherapy. 20, 12, p. 1827-1833 7 p.

Research output: Contribution to journalArticle

1992

Burkitt's lymphoma with granulocytosis and a high level of C-reactive protein

Muroi, K., Izumi, T., Yoshida, M., Suda, T., Miwa, A., Sakamoto, S. & Miura, Y., 1992 Apr, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 33, 4, p. 542-544 3 p.

Research output: Contribution to journalArticle

Expression and function of adhesion molecules on human hematopoietic stem cells: CD34+ LFA-1- cells are more primitive than CD34+ LFA-1+ cells

Gunji, Y., Nakamura, M., Hagiwara, T., Hayakawa, K., Matsushita, H., Osawa, H., Nagayoshi, K., Nakauchi, H., Yanagisawa, M., Miura, Y. & Suda, T., 1992 Jan 1, In : Blood. 80, 2, p. 429-436 8 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)

EXPRESSION OF CD1.1B, CD14 AND CD36 ANTIGENS BY B‐CELL LYMPHOMA

Muroi, K., Toya, K., Suzuki, T., Suda, T., Sakamoto, S. & Miura, Y., 1992 Jan, In : British Journal of Haematology. 80, 1, p. 126-127 2 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Expression of the Tn antigen on erythroid cells from a patient with Tn syndrome

Kamitani, Y., Kajii, E., Suda, T. & Ikemoto, S., 1992 Dec 1, In : The Japanese Journal of Human Genetics. 37, 4, p. 271-283 13 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Function, molecular structure and gene expression of stem cell factor (SCF)

Okada, S. & Suda, T., 1992 Aug, In : Nippon rinsho. Japanese journal of clinical medicine. 50, 8, p. 1872-1878 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7

Hermine, O., Mayeux, P., Titeux, M., Mitjavila, M. T., Casadevall, N., Guichard, J., Komatsu, N., Suda, T., Miura, Y., Vainchenker, W. & Breton-Gorius, J., 1992 Jan 1, In : Blood. 80, 12, p. 3060-3069 10 p.

Research output: Contribution to journalArticle

Open Access
53 Citations (Scopus)

Herbimycin A, an Inhibitor of Tyrosine Kinase, Prolongs Survival of Mice Inoculated with Myeloid Leukemia CI Cells with High Expression of v-abl Tyrosine Kinase

Honma, Y., Okabe-Kado, J., Kasukabe, T., Hozumi, M., Kodama, H., Kajigaya, S., Suda, T. & Miura, Y., 1992 Jul, In : Cancer Research. 52, 14, p. 4017-4020 4 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

In vitro reconstitution of an erythropoietin gene transcription system using its 5′-flanking sequence and a nuclear extract from anemic kidney

Tsuchiya, T., Ochiai, H., Imajoh-Ohmi, S., Ueda, M., Suda, T., Nakamura, M. & Kanegasaki, S., 1992 Jan 15, In : Biochemical and Biophysical Research Communications. 182, 1, p. 137-143 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells

Okada, S., Nakauchi, H., Nagayoshi, K., Nishikawa, S. I., Miura, Y. & Suda, T., 1992 Dec 1, In : Blood. 80, 12, p. 3044-3050 7 p.

Research output: Contribution to journalArticle

392 Citations (Scopus)

Megaloblastic Anemia Associated with Psoriasis: Case Report and Review of the Literature

Iwama, A., Miwa, A., Suzuki, T., Ema, H., Suda, T., Sakamoto, S. & Miura, Y., 1992 Jan 1, In : Internal Medicine. 31, 1, p. 127-130 4 p.

Research output: Contribution to journalArticle

Open Access
3 Citations (Scopus)