The Sakaguchi Laboratory

Research Output

2012

Optimal ratio of transcription factors for somatic cell reprogramming

Nagamatsu, G., Saito, S., Kosaka, T., Takubo, K., Kinoshita, T., Oya, M., Horimoto, K. & Suda, T., 2012 Oct 19, In : Journal of Biological Chemistry. 287, 43, p. 36273-36282 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Passing a baton to the next generation

Suda, T. & Kitamura, S., 2012 Nov 1, In : International journal of hematology. 96, 5, p. 529-530 2 p.

Research output: Contribution to journalEditorial

Pathological neoangiogenesis depends on oxidative stress regulation by ATM

Okuno, Y., Nakamura-Ishizu, A., Otsu, K., Suda, T. & Kubota, Y., 2012 Aug, In : Nature medicine. 18, 8, p. 1208-1216 9 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis

States, J. C., Singh, A. V., Knudsen, T. B., Rouchka, E. C., Ngalame, N. O., Arteel, G. E., Piao, Y. & Ko, M. S. H., 2012 Jun 15, In : PloS one. 7, 6, e38713.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I. & Suda, T., 2012 Jan 1, In : Journal of Cellular Physiology. 227, 2, p. 421-430 10 p.

Research output: Contribution to journalShort survey

157 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 Aug, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 May 1, In : International journal of hematology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration

Xie, H., Sun, X., Piao, Y., Jegga, A. G., Handwerger, S., Ko, M. S. H. & Dey, S. K., 2012 Sep 14, In : Journal of Biological Chemistry. 287, 38, p. 32288-32297 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Stochastic modeling for the expression of a gene regulated by competing transcription factors

Yang, H. T. & Ko, M. S. H., 2012 Mar 14, In : PloS one. 7, 3, e32376.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Structure and function of the pancreas in the polycystic kidney rat

Yi, L., Naruse, S., Furuya, S., Yamamoto, A., Nakakuki, M., Nagao, S., Yoshihara, D., Ko, S. B. H., Wei, M., Kondo, T. & Ishiguro, H., 2012 Nov, In : Pancreas. 41, 8, p. 1292-1298 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

Takaesu, G., Inagaki, M., Takubo, K., Mishina, Y., Hess, P. R., Dean, G. A., Yoshimura, A., Matsumoto, K., Suda, T. & Ninomiya-Tsuji, J., 2012 Nov 30, In : PloS one. 7, 11, e51073.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Three cases of bronchial asthma preceding IgG4-related autoimmune pancreatitis

Ito, S., Ko, S. B. H., Morioka, M., Imaizumi, K., Kondo, M., Mizuno, N. & Hasegawa, Y., 2012, In : Allergology International. 61, 1, p. 171-174 4 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency

Hammachi, F., Morrison, G. M., Sharov, A. A., Livigni, A., Narayan, S., Papapetrou, E. P., O'Malley, J., Kaji, K., Ko, M. S. H., Ptashne, M. & Brickman, J. M., 2012 Feb 23, In : Cell Reports. 1, 2, p. 99-109 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Two anatomically distinct niches regulate stem cell activity

Ema, H. & Suda, T., 2012 Sep 13, In : Blood. 120, 11, p. 2174-2181 8 p.

Research output: Contribution to journalReview article

49 Citations (Scopus)

Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis

Mayumi, T., Inui, K., Maetani, I., Yokoe, M., Sakamoto, T., Yoshida, M., Ko, S., Hirata, K. & Takada, T., 2012 Aug, In : Pancreas. 41, 6, p. 869-875 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells

Hirata, T., Amano, T., Nakatake, Y., Amano, M., Piao, Y., Hoang, H. G. & Ko, M. S. H., 2012, In : Scientific reports. 2, 208.

Research output: Contribution to journalArticle

59 Citations (Scopus)
2013

[Induction of megakaryocytes and platelet production from mouse and human fibroblasts by p45 NF-E2/Maf].

Ono, Y. & Matsubara, Y., 2013 Nov 1, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 54, 11, p. 2025-2030 6 p.

Research output: Contribution to journalReview article

[Intestinal stem cells].

Sato, T., 2013 Sep, In : Seikagaku. The Journal of Japanese Biochemical Society. 85, 9, p. 743-748 6 p.

Research output: Contribution to journalReview article

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance

Livigni, A., Peradziryi, H., Sharov, A. A., Chia, G., Hammachi, F., Migueles, R. P., Sukparangsi, W., Pernagallo, S., Bradley, M., Nichols, J., Ko, M. S. H. & Brickman, J. M., 2013 Nov 18, In : Current Biology. 23, 22, p. 2233-2244 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity

Shirakawa, T., Yaman-Deveci, R., Tomizawa, S. I., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T. & Ohbo, K., 2013 Sep 1, In : Development (Cambridge). 140, 17, p. 3565-3576 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy

Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang, W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O. J. & Koh, G. Y., 2013 Sep 18, In : Science translational medicine. 5, 203, 203ra127.

Research output: Contribution to journalArticle

73 Citations (Scopus)

A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice

Hayashi, A., Sato, T., Kamada, N., Mikami, Y., Matsuoka, K., Hisamatsu, T., Hibi, T., Roers, A., Yagita, H., Ohteki, T., Yoshimura, A. & Kanai, T., 2013 Jun 12, In : Cell Host and Microbe. 13, 6, p. 711-722 12 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Conversion of primordial germ cells to pluripotent stem cells: Methods for cell tracking and culture conditions

Nagamatsu, G. & Suda, T., 2013 Sep 4, Imaging and Tracking Stem Cells: Methods and Protocols. p. 49-56 8 p. (Methods in Molecular Biology; vol. 1052).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma

Mizuno, N., Yatabe, Y., Hara, K., Hijioka, S., Imaoka, H., Shimizu, Y., Ko, S. B. H. & Yamao, K., 2013 Oct 16, In : Frontiers in Physiology. 4 SEP, Article 269.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice

Handa, T., Kanai, T., Sato, T., Mikami, Y., Sujino, T., Hayashi, A., Mizuno, S., Matsumoto, A., Hisamatsu, T. & Hibi, T., 2013 Feb 1, In : Immunology Letters. 150, 1-2, p. 123-129 7 p.

Research output: Contribution to journalArticle

Developmental arrest and mouse antral not-surrounded nucleolus oocytes

Monti, M., Zanoni, M., Calligaro, A., Ko, M. S. H., Mauri, P. & Redi, C. A., 2013 Jan, In : Biology of reproduction. 88, 1, 2.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Endoscopic detorsion for sigmoid volvulus using unsedated water-immersion colonoscopy

Sugimoto, S., Mizukami, T., Ito, T., Tsunoda, Y., Imamura, S., Tamura, T., Nagakubo, S., Morohoshi, Y., Koike, Y., Fujita, Y. & Komatsu, H., 2013, In : Endoscopy. 45, SUPPL2, p. E263-E264

Research output: Contribution to journalComment/debate

Open Access
3 Citations (Scopus)

Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells

Ikushima, Y. M., Arai, F., Nakamura, Y., Hosokawa, K., Kubota, Y., Hirashima, M., Toyama, H. & Suda, T., 2013 Jan 4, In : Biochemical and Biophysical Research Communications. 430, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Establishment of novel prediction system of intestinal absorption in humans using human intestinal tissues

Miyake, M., Toguchi, H., Nishibayashi, T., Higaki, K., Sugita, A., Koganei, K., Kamada, N., Kitazume, M. T., Hisamatsu, T., Sato, T., Okamoto, S., Kanai, T. & Hibi, T., 2013 Aug, In : Journal of Pharmaceutical Sciences. 102, 8, p. 2564-2571 8 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications

Sato, T. & Clevers, H., 2013, In : Science. 340, 6137, p. 1190-1194 5 p.

Research output: Contribution to journalReview article

542 Citations (Scopus)

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

Nagamachi, A., Matsui, H., Asou, H., Ozaki, Y., Aki, D., Kanai, A., Takubo, K., Suda, T., Nakamura, T., Wolff, L., Honda, H. & Inaba, T., 2013 Sep 9, In : Cancer Cell. 24, 3, p. 305-317 13 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches

Nakamura-Ishizu, A. & Suda, T., 2013 Feb, In : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2404-2409 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Identification of transcription factors for lineage-specific ESC differentiation

Yamamizu, K., Piao, Y., Sharov, A. A., Zsiros, V., Yu, H., Nakazawa, K., Schlessinger, D. & Ko, M. S. H., 2013 Dec 17, In : Stem cell reports. 1, 6, p. 545-559 15 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

IL-22-Producing RORγt-Dependent Innate Lymphoid Cells Play a Novel Protective Role in Murine Acute Hepatitis

Matsumoto, A., Kanai, T., Mikami, Y., Chu, P. S., Nakamoto, N., Ebinuma, H., Saito, H., Sato, T., Yagita, H. & Hibi, T., 2013 Apr 23, In : PloS one. 8, 4, e62853.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Induction of pluripotent stem cells from primordial germ cells by single reprogramming factors

Nagamatsu, G., Kosaka, T., Saito, S., Honda, H., Takubo, K., Kinoshita, T., Akiyama, H., Sudo, T., Horimoto, K., Oya, M. & Suda, T., 2013 Mar, In : Stem Cells. 31, 3, p. 479-487 9 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

Ko, S. B. H., Azuma, S., Yokoyama, Y., Yamamoto, A., Kyokane, K., Niida, S., Ishiguro, H. & Ko, M. S. H., 2013 Jun 16, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 12, p. G1103-G1116

Research output: Contribution to journalArticle

8 Citations (Scopus)

In vitro expansion of single Lgr5 + liver stem cells induced by Wnt-driven regeneration

Huch, M., Dorrell, C., Boj, S. F., Van Es, J. H., Li, V. S. W., Van De Wetering, M., Sato, T., Hamer, K., Sasaki, N., Finegold, M. J., Haft, A., Vries, R. G., Grompe, M. & Clevers, H., 2013 Feb 14, In : Nature. 494, 7436, p. 247-250 4 p.

Research output: Contribution to journalArticle

681 Citations (Scopus)

Kinetics of drug selection systems in mouse embryonic stem cells

Nakatake, Y., Fujii, S., Masui, S., Sugimoto, T., Torikai-Nishikawa, S., Adachi, K. & Niwa, H., 2013 Aug 7, In : BMC Biotechnology. 13, 64.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Mucosal healing with oral tacrolimus is associated with favorable medium- and long-term prognosis in steroid-refractory/dependent ulcerative colitis patients

Miyoshi, J., Matsuoka, K., Inoue, N., Hisamatsu, T., Ichikawa, R., Yajima, T., Okamoto, S., Naganuma, M., Sato, T., Kanai, T., Ogata, H., Iwao, Y. & Hibi, T., 2013 Dec 15, In : Journal of Crohn's and Colitis. 7, 12, p. e609-e614

Research output: Contribution to journalArticle

37 Citations (Scopus)

No more sugar-coating it: Mucins and platelet biology

Matsubara, Y., 2013 Aug 29, In : Blood. 122, 9, p. 1537-1538 2 p.

Research output: Contribution to journalReview article

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013, In : Blood. 121, 16, p. 3267-3273 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 2013 Nov 8, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

Matsubara, Y., Ono, Y., Suzuki, H., Arai, F., Suda, T., Murata, M. & Ikeda, Y., 2013 Mar 1, In : PloS one. 8, 3, e58123.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Primary mouse small intestinal epithelial cell cultures

Sato, T. & Clevers, H., 2013, Epithelial Cell Culture Protocols: Second Edition. Randell, S. & Fulcher, L. (eds.). p. 319-328 10 p. (Methods in Molecular Biology; vol. 945).

Research output: Chapter in Book/Report/Conference proceedingChapter

134 Citations (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 2013, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

Takubo, K., Nagamatsu, G., Kobayashi, C. I., Nakamura-Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Rahimi, Y., Johnson, R. S., Soga, T., Hirao, A., Suematsu, M. & Suda, T., 2013 Jan 3, In : Cell stem cell. 12, 1, p. 49-61 13 p.

Research output: Contribution to journalArticle

332 Citations (Scopus)

Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells

Hung, S. S. C., Wong, R. C. B., Sharov, A. A., Nakatake, Y., Yu, H. & Ko, M. S. H., 2013 Aug, In : DNA Research. 20, 4, p. 391-401 11 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Role of iPSC-Producing Factors in Pre-Implantation Embryos

Amano, T. & Ko, M. S. H., 2013 Oct 1, Principles of Cloning: Second Edition. Elsevier Inc., p. 473-484 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Spur cell anemia associated with alcoholic cirrhosis

Sugimoto, S., Yamagishi, Y., Ebinuma, H. & Kanai, T., 2013 Dec 23, In : Internal Medicine. 52, 24, 1 p.

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Nishiyama, A., Sharov, A. A., Piao, Y., Amano, M., Amano, T., Hoang, H. G., Binder, B. Y., Tapnio, R., Bassey, U., Malinou, J. N., Correa-Cerro, L. S., Yu, H., Xin, L., Meyers, E., Zalzman, M., Nakatake, Y., Stagg, C., Sharova, L., Qian, Y., Dudekula, D. & 9 others, Sheer, S., Cadet, J. S., Hirata, T., Yang, H. T., Goldberg, I., Evans, M. K., Longo, D. L., Schlessinger, D. & Ko, M. S. H., 2013 Mar 25, In : Scientific reports. 3, 1390.

Research output: Contribution to journalArticle

38 Citations (Scopus)