The Sakaguchi Laboratory

Research Output

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Review article
2019

Long-term effect of NUDT15 R139C on hematologic indices in inflammatory bowel disease patients treated with thiopurine

Akiyama, S., Matsuoka, K., Fukuda, K., Hamada, S., Shimizu, M., Nanki, K., Mizuno, S., Kiyohara, H., Arai, M., Sugimoto, S., Iwao, Y., Ogata, H., Hisamatsu, T., Naganuma, M., Motobayashi, M., Suzuki, K., Takenaka, K., Fujii, T., Saito, E., Nagahori, M. & 5 others, Ohtsuka, K., Mochizuki, M., Watanabe, M., Hashiguchi, M. & Kanai, T., 2019 Jan 1, In : Journal of Gastroenterology and Hepatology (Australia).

Research output: Contribution to journalReview article

3 Citations (Scopus)

Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids

Fujii, M., Clevers, H. & Sato, T., 2019 Feb 1, In : Gastroenterology. 156, 3, p. 562-576 15 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)
2018

Advancing Intestinal Organoid Technology Toward Regenerative Medicine

Nakamura, T. & Sato, T., 2018 Jan 1, In : CMGH. 5, 1, p. 51-60 10 p.

Research output: Contribution to journalReview article

30 Citations (Scopus)

Gastroenteropancreatic neuroendocrine neoplasms: genes, therapies and models

Kawasaki, K., Fujii, M. & Sato, T., 2018 Feb 26, In : Disease models & mechanisms. 11, 2

Research output: Contribution to journalReview article

9 Citations (Scopus)
2017

Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells

Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. & Ko, M., 2017, In : Stem Cells International. 2017, 7215010.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2016

Recent trends and future directions for the medical treatment of ulcerative colitis

Naganuma, M., Mizuno, S., Nanki, K., Sugimoto, S. & Kanai, T., 2016 Dec 1, In : Clinical Journal of Gastroenterology. 9, 6, p. 329-336 8 p.

Research output: Contribution to journalReview article

15 Citations (Scopus)
2015

Back to 2D Culture for Ground State of Intestinal Stem Cells

Shimokawa, M. & Sato, T., 2015, In : Cell Stem Cell. 17, 1, p. 5-7 3 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Diagnostic and therapeutic applications of water-immersion colonoscopy

Sugimoto, S. & Mizukami, T., 2015 Jun 7, In : World Journal of Gastroenterology. 21, 21, p. 6451-6459 9 p.

Research output: Contribution to journalReview article

Open Access
14 Citations (Scopus)
2014

Aging of the hematopoietic stem cells niche

Nakamura-Ishizu, A. & Suda, T., 2014 Oct 9, In : International journal of hematology. 100, 4, p. 317-325 9 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Direct reprogramming of fibroblasts and preadipocytes into functional megakaryocytes.

Matsubara, Y., 2014 Apr, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 55, 4, p. 387-395 9 p.

Research output: Contribution to journalReview article

Heterogeneity and hierarchy of hematopoietic stem cells

Ema, H., Morita, Y. & Suda, T., 2014 Feb, In : Experimental Hematology. 42, 2, p. 74-82.e2

Research output: Contribution to journalReview article

70 Citations (Scopus)

Homeostatic regulation of hematopoiesis by the hematopoietic stem cell niche

Takubo, K., 2014 Jan 1, In : Seikagaku. 86, 6, p. 755-765 11 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Metabolic requirements for the maintenance of self-renewing stem cells

Ito, K. & Suda, T., 2014 Apr, In : Nature Reviews Molecular Cell Biology. 15, 4, p. 243-256 14 p.

Research output: Contribution to journalReview article

461 Citations (Scopus)

Opening the door for HIF1α tuning

Takubo, K. & Suda, T., 2014 Jan 9, In : Blood. 123, 2, p. 151-152 2 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

The analysis, roles and regulation of quiescence in hematopoietic stem cells

Nakamura-Ishizu, A., Takizawa, H. & Suda, T., 2014 Dec 15, In : Development (Cambridge). 141, 24, p. 4656-4666 11 p.

Research output: Contribution to journalReview article

79 Citations (Scopus)
2013

[Induction of megakaryocytes and platelet production from mouse and human fibroblasts by p45 NF-E2/Maf].

Ono, Y. & Matsubara, Y., 2013 Nov 1, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 54, 11, p. 2025-2030 6 p.

Research output: Contribution to journalReview article

[Intestinal stem cells].

Sato, T., 2013 Sep, In : Seikagaku. The Journal of Japanese Biochemical Society. 85, 9, p. 743-748 6 p.

Research output: Contribution to journalReview article

Growing self-organizing mini-guts from a single intestinal stem cell: Mechanism and applications

Sato, T. & Clevers, H., 2013 Jan 1, In : Science. 340, 6137, p. 1190-1194 5 p.

Research output: Contribution to journalReview article

512 Citations (Scopus)

No more sugar-coating it: Mucins and platelet biology

Matsubara, Y., 2013 Aug 29, In : Blood. 122, 9, p. 1537-1538 2 p.

Research output: Contribution to journalReview article

2012

Two anatomically distinct niches regulate stem cell activity

Ema, H. & Suda, T., 2012 Sep 13, In : Blood. 120, 11, p. 2174-2181 8 p.

Research output: Contribution to journalReview article

49 Citations (Scopus)
2011

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Suda, T., Takubo, K. & Semenza, G. L., 2011 Oct 4, In : Cell stem cell. 9, 4, p. 298-310 13 p.

Research output: Contribution to journalReview article

417 Citations (Scopus)

Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

Staal, F. J. T., Baum, C., Cowan, C., Dzierzak, E., Hacein-Bey-Abina, S., Karlsson, S., Lapidot, T., Lemischka, I., Mendez-Ferrer, S., Mikkers, H., Moore, K., Moreno, E., Mummery, C. L., Robin, C., Suda, T., Van Pel, M., Vanden Brink, G., Zwaginga, J. J. & Fibbe, W. E., 2011 Jul 1, In : Leukemia. 25, 7, p. 1095-1102 8 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)
2010

Regulation of hematopoietic stem cells by oxygen metabolism

Takubo, K., 2010 Feb 1, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 51, 2, p. 95-103 9 p.

Research output: Contribution to journalReview article

Trophoblast cell lineage in cloned mouse embryos

Oda, M., Shiota, K. & Tanaka, S., 2010 Apr 1, In : Development Growth and Differentiation. 52, 3, p. 285-291 7 p.

Research output: Contribution to journalReview article

12 Citations (Scopus)
2009

Cancer stem cell concepts--lesson from leukemia

Nitta, E. & Suda, T., 2009 Oct, In : Nippon rinsho. Japanese journal of clinical medicine. 67, 10, p. 1863-1867 5 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

Cancer stem cells and their niche

Iwasaki, H. & Suda, T., 2009 Jun 23, In : Cancer science. 100, 7, p. 1166-1172 7 p.

Research output: Contribution to journalReview article

106 Citations (Scopus)
2006

Global gene expression profiling of preimplantation embryos.

Hamatani, T., Ko, M. S., Yamada, M., Kuji, N., Mizusawa, Y., Shoji, M., Hada, T., Asada, H., Maruyama, T. & Yoshimura, Y., 2006 Aug, In : Human cell : official journal of Human Cell Research Society. 19, 3, p. 98-117 20 p.

Research output: Contribution to journalReview article

91 Citations (Scopus)

Hematopoietic stem cell niche in bone marrow

Takubo, K., Hirao, A. & Suda, T., 2006 Apr, In : Seikagaku. The Journal of Japanese Biochemical Society. 78, 4, p. 301-309 9 p.

Research output: Contribution to journalReview article

2005

Hematopoietic stem cells and their niche

Suda, T., Arai, F. & Hirao, A., 2005 Aug 1, In : Trends in Immunology. 26, 8, p. 426-433 8 p.

Research output: Contribution to journalReview article

170 Citations (Scopus)

Regulation of hematopoiesis and its interaction with stem cell niches

Arai, F., Hirao, A. & Suda, T., 2005 Dec 1, In : International journal of hematology. 82, 5, p. 371-376 6 p.

Research output: Contribution to journalReview article

52 Citations (Scopus)

Regulation of self-renewal of hematopoietic stem cells in the niche

Hirao, A., Arai, F., Ito, K. & Suda, T., 2005 Jun, In : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 50, 7, p. 886-891 6 p.

Research output: Contribution to journalReview article

2004

Angiopoietin-related/angiopoietin-like proteins regulate angiogenesis

Oike, Y., Yasunaga, K. & Suda, T., 2004 Jul 1, In : International journal of hematology. 80, 1, p. 21-28 8 p.

Research output: Contribution to journalReview article

95 Citations (Scopus)
2002

Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity

Tanaka, T. S., Kunath, T., Kimber, W. L., Jaradat, S. A., Stagg, C. A., Usuda, M., Yokota, T., Niwa, H., Rossant, J. & Ko, M. S. H., 2002 Dec 1, In : Genome Research. 12, 12, p. 1921-1928 8 p.

Research output: Contribution to journalReview article

192 Citations (Scopus)
2000

Bicarbonate transport in microperfused pancreatic ducts.

Ishiguro, H., Naruse, S., Kitagawa, M., Suzuki, A., Yamamoto, A., Ko, S. B., Hayakawa, T., Case, M. & Steward, M., 2000 Aug, In : Journal of Korean medical science. 15 Suppl, p. S16

Research output: Contribution to journalReview article

Open Access
1995

Functional molecules expressed in hematopoietic stem cells

Suda, T., 1995 Mar, In : Seikagaku. The Journal of Japanese Biochemical Society. 67, 3, p. 190-203 14 p.

Research output: Contribution to journalReview article

1992

Function, molecular structure and gene expression of stem cell factor (SCF)

Okada, S. & Suda, T., 1992 Aug, In : Nippon rinsho. Japanese journal of clinical medicine. 50, 8, p. 1872-1878 7 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)
1991

Cytokines and diseases: hematopoietic factors and hematological diseases

Suda, T., 1991 Sep 10, In : Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine. 80, 9, p. 1383-1387 5 p.

Research output: Contribution to journalReview article

Open Access