The Sakaguchi Laboratory of Developmental Biology Department of Cell Differentiation

Research Output

2019

ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation

Watanuki, S., Kobayashi, H., Sorimachi, Y., Yamamoto, M., Okamoto, S. & Takubo, K., 2019 Jun 18, In : Biochemical and Biophysical Research Communications. 514, 1, p. 287-294 8 p.

Research output: Contribution to journalArticle

2015

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., Garcia, P., Suda, T., Frampton, J. & Ogawa, M., 2015 Feb 1, In : Stem Cells. 33, 2, p. 479-490 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function

Nagamachi, A., Nakata, Y., Ueda, T., Yamasaki, N., Ebihara, Y., Tsuji, K., Honda, Z. I., Takubo, K., Suda, T., Oda, H., Inaba, T. & Honda, H., 2014 Jan 31, In : PloS one. 9, 1, e87425.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Aging of the hematopoietic stem cells niche

Nakamura-Ishizu, A. & Suda, T., 2014 Oct 9, In : International journal of hematology. 100, 4, p. 317-325 9 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)

Direct reprogramming of fibroblasts and preadipocytes into functional megakaryocytes.

Matsubara, Y., 2014 Apr, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 55, 4, p. 387-395 9 p.

Research output: Contribution to journalReview article

Heterogeneity and hierarchy of hematopoietic stem cells

Ema, H., Morita, Y. & Suda, T., 2014 Feb, In : Experimental Hematology. 42, 2, p. 74-82.e2

Research output: Contribution to journalReview article

72 Citations (Scopus)

Homeostatic regulation of hematopoiesis by the hematopoietic stem cell niche

Takubo, K., 2014 Jan 1, In : Seikagaku. 86, 6, p. 755-765 11 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Kobayashi, I., Kobayashi-Sun, J., Kim, A. D., Pouget, C., Fujita, N., Suda, T. & Traver, D., 2014 Aug 21, In : Nature. 512, 7514, p. 319-323 5 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Metabolic requirements for the maintenance of self-renewing stem cells

Ito, K. & Suda, T., 2014 Apr, In : Nature Reviews Molecular Cell Biology. 15, 4, p. 243-256 14 p.

Research output: Contribution to journalReview article

481 Citations (Scopus)

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

Tai-Nagara, I., Matsuoka, S., Ariga, H. & Suda, T., 2014 Jan 2, In : Blood. 123, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Not merely quiescent: Telomeres in quiescent HSCs

Nakamura-Ishizu, A. & Suda, T., 2014 Nov 20, In : Blood. 124, 22, p. 3179-3180 2 p.

Research output: Contribution to journalComment/debate

Opening the door for HIF1α tuning

Takubo, K. & Suda, T., 2014 Jan 9, In : Blood. 123, 2, p. 151-152 2 p.

Research output: Contribution to journalReview article

1 Citation (Scopus)

R-spondins/Lgrs expression in tooth development

kawasaki, M., Porntaveetus, T., Kawasaki, K., Oommen, S., Otsuka-Tanaka, Y., Hishinuma, M., Nomoto, T., Maeda, T., Takubo, K., Suda, T., Sharpe, P. T. & Ohazama, A., 2014 Jun, In : Developmental Dynamics. 243, 6, p. 844-851 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Kinoshita, T., Nagamatsu, G., Saito, S., Takubo, K., Horimoto, K. & Suda, T., 2014 May 30, In : Journal of Biological Chemistry. 289, 22, p. 15776-15787 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

[Induction of megakaryocytes and platelet production from mouse and human fibroblasts by p45 NF-E2/Maf].

Ono, Y. & Matsubara, Y., 2013 Nov 1, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 54, 11, p. 2025-2030 6 p.

Research output: Contribution to journalReview article

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity

Shirakawa, T., Yaman-Deveci, R., Tomizawa, S. I., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T. & Ohbo, K., 2013 Sep 1, In : Development (Cambridge). 140, 17, p. 3565-3576 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy

Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang, W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O. J. & Koh, G. Y., 2013 Sep 18, In : Science translational medicine. 5, 203, 203ra127.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Conversion of primordial germ cells to pluripotent stem cells: Methods for cell tracking and culture conditions

Nagamatsu, G. & Suda, T., 2013 Sep 4, Imaging and Tracking Stem Cells: Methods and Protocols. p. 49-56 8 p. (Methods in Molecular Biology; vol. 1052).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

Nagamachi, A., Matsui, H., Asou, H., Ozaki, Y., Aki, D., Kanai, A., Takubo, K., Suda, T., Nakamura, T., Wolff, L., Honda, H. & Inaba, T., 2013 Sep 9, In : Cancer Cell. 24, 3, p. 305-317 13 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches

Nakamura-Ishizu, A. & Suda, T., 2013 Feb, In : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2404-2409 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

No more sugar-coating it: Mucins and platelet biology

Matsubara, Y., 2013 Aug 29, In : Blood. 122, 9, p. 1537-1538 2 p.

Research output: Contribution to journalReview article

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013 Jan 1, In : Blood. 121, 16, p. 3267-3273 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 2013 Nov 8, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

Matsubara, Y., Ono, Y., Suzuki, H., Arai, F., Suda, T., Murata, M. & Ikeda, Y., 2013 Mar 1, In : PloS one. 8, 3, e58123.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 2013 Jan 1, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012

[Regulation of hematopoietic stem cells in niche signaling].

Matsumoto, Y. & Suda, T., 2012 Apr, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A Meg by any other name

Matsubara, Y., 2012 Sep 6, In : Blood. 120, 10, p. 1970-1971 2 p.

Research output: Contribution to journalComment/debate

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., 2012 Sep 1, In : Nature medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

332 Citations (Scopus)

Dynamic regulation of T h17 differentiation by oxygen concentrations

Ikejiri, A., Nagai, S., Goda, N., Kurebayashi, Y., Osada-Oka, M., Takubo, K., Suda, T. & Koyasu, S., 2012 Mar 5, In : International immunology. 24, 3, p. 137-146 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Gene expression profiling and regulatory networks in single cells

Arai, F., Hosokawa, K., Matsumoto, Y., Toyama, H. & Suda, T., 2012 Feb 1, New Frontiers of Network Analysis in Systems Biology. Springer Netherlands, p. 1-13 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 Nov 23, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neovascular niche for human myeloma cells in immunodeficient mouse bone

Iriuchishima, H., Takubo, K., Miyakawa, Y., Nakamura-Ishizu, A., Miyauchi, Y., Fujita, N., Miyamoto, K., Miyamoto, T., Ikeda, E., Kizaki, M., Nojima, Y. & Suda, T., 2012 Feb 7, In : PloS one. 7, 2, e30557.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 Jul 20, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 Nov 1, In : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Optimal ratio of transcription factors for somatic cell reprogramming

Nagamatsu, G., Saito, S., Kosaka, T., Takubo, K., Kinoshita, T., Oya, M., Horimoto, K. & Suda, T., 2012 Oct 19, In : Journal of Biological Chemistry. 287, 43, p. 36273-36282 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Passing a baton to the next generation

Suda, T. & Kitamura, S., 2012 Nov 1, In : International journal of hematology. 96, 5, p. 529-530 2 p.

Research output: Contribution to journalEditorial

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I. & Suda, T., 2012 Jan 1, In : Journal of Cellular Physiology. 227, 2, p. 421-430 10 p.

Research output: Contribution to journalShort survey

152 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 Aug, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 May 1, In : International journal of hematology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

Takaesu, G., Inagaki, M., Takubo, K., Mishina, Y., Hess, P. R., Dean, G. A., Yoshimura, A., Matsumoto, K., Suda, T. & Ninomiya-Tsuji, J., 2012 Nov 30, In : PloS one. 7, 11, e51073.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Two anatomically distinct niches regulate stem cell activity

Ema, H. & Suda, T., 2012 Sep 13, In : Blood. 120, 11, p. 2174-2181 8 p.

Research output: Contribution to journalReview article

49 Citations (Scopus)
2011

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., 2011 Feb 24, In : Blood. 117, 8, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Hematopoiesis and bone remodeling

Suda, T., 2011 May 26, In : Blood. 117, 21, p. 5556-5557 2 p.

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., 2011 Sep 29, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Suda, T., Takubo, K. & Semenza, G. L., 2011 Oct 4, In : Cell stem cell. 9, 4, p. 298-310 13 p.

Research output: Contribution to journalReview article

420 Citations (Scopus)

New IJH guidelines highlight greater transparency

Sipp, D. & Suda, T., 2011 Apr 1, In : International journal of hematology. 93, 4, p. 411-412 2 p.

Research output: Contribution to journalEditorial

Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

Staal, F. J. T., Baum, C., Cowan, C., Dzierzak, E., Hacein-Bey-Abina, S., Karlsson, S., Lapidot, T., Lemischka, I., Mendez-Ferrer, S., Mikkers, H., Moore, K., Moreno, E., Mummery, C. L., Robin, C., Suda, T., Van Pel, M., Vanden Brink, G., Zwaginga, J. J. & Fibbe, W. E., 2011 Jul 1, In : Leukemia. 25, 7, p. 1095-1102 8 p.

Research output: Contribution to journalReview article

17 Citations (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M. J., Takubo, K., Arai, F., Nakada, S. & Suda, T., 2011 Apr 21, In : Blood. 117, 16, p. 4169-4180 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2010

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., 2010 Mar 5, In : Cell stem cell. 6, 3, p. 194-198 5 p.

Research output: Contribution to journalLetter

71 Citations (Scopus)

Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells

Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T. & Suda, T., 2010 Jan 14, In : Blood. 115, 2, p. e1-e9

Research output: Contribution to journalArticle

23 Citations (Scopus)