The Sakaguchi Laboratory of Developmental Biology Department of Cell Differentiation

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2019

ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation

Watanuki, S., Kobayashi, H., Sorimachi, Y., Yamamoto, M., Okamoto, S. & Takubo, K., 2019 Jun 18, In : Biochemical and Biophysical Research Communications. 514, 1, p. 287-294 8 p.

Research output: Contribution to journalArticle

2015

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., Garcia, P., Suda, T., Frampton, J. & Ogawa, M., 2015 Feb 1, In : Stem Cells. 33, 2, p. 479-490 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2014

Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function

Nagamachi, A., Nakata, Y., Ueda, T., Yamasaki, N., Ebihara, Y., Tsuji, K., Honda, Z. I., Takubo, K., Suda, T., Oda, H., Inaba, T. & Honda, H., 2014 Jan 31, In : PloS one. 9, 1, e87425.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Kobayashi, I., Kobayashi-Sun, J., Kim, A. D., Pouget, C., Fujita, N., Suda, T. & Traver, D., 2014 Aug 21, In : Nature. 512, 7514, p. 319-323 5 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

Tai-Nagara, I., Matsuoka, S., Ariga, H. & Suda, T., 2014 Jan 2, In : Blood. 123, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

R-spondins/Lgrs expression in tooth development

kawasaki, M., Porntaveetus, T., Kawasaki, K., Oommen, S., Otsuka-Tanaka, Y., Hishinuma, M., Nomoto, T., Maeda, T., Takubo, K., Suda, T., Sharpe, P. T. & Ohazama, A., 2014 Jun, In : Developmental Dynamics. 243, 6, p. 844-851 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Kinoshita, T., Nagamatsu, G., Saito, S., Takubo, K., Horimoto, K. & Suda, T., 2014 May 30, In : Journal of Biological Chemistry. 289, 22, p. 15776-15787 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2013

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity

Shirakawa, T., Yaman-Deveci, R., Tomizawa, S. I., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T. & Ohbo, K., 2013 Sep 1, In : Development (Cambridge). 140, 17, p. 3565-3576 12 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy

Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang, W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O. J. & Koh, G. Y., 2013 Sep 18, In : Science translational medicine. 5, 203, 203ra127.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

Nagamachi, A., Matsui, H., Asou, H., Ozaki, Y., Aki, D., Kanai, A., Takubo, K., Suda, T., Nakamura, T., Wolff, L., Honda, H. & Inaba, T., 2013 Sep 9, In : Cancer Cell. 24, 3, p. 305-317 13 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches

Nakamura-Ishizu, A. & Suda, T., 2013 Feb, In : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2404-2409 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013 Jan 1, In : Blood. 121, 16, p. 3267-3273 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 2013 Nov 8, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

OP9 Bone Marrow Stroma Cells Differentiate into Megakaryocytes and Platelets

Matsubara, Y., Ono, Y., Suzuki, H., Arai, F., Suda, T., Murata, M. & Ikeda, Y., 2013 Mar 1, In : PloS one. 8, 3, e58123.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 2013 Jan 1, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2012

[Regulation of hematopoietic stem cells in niche signaling].

Matsumoto, Y. & Suda, T., 2012 Apr, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., 2012 Sep 1, In : Nature medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

332 Citations (Scopus)

Dynamic regulation of T h17 differentiation by oxygen concentrations

Ikejiri, A., Nagai, S., Goda, N., Kurebayashi, Y., Osada-Oka, M., Takubo, K., Suda, T. & Koyasu, S., 2012 Mar 5, In : International immunology. 24, 3, p. 137-146 10 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 Nov 23, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Neovascular niche for human myeloma cells in immunodeficient mouse bone

Iriuchishima, H., Takubo, K., Miyakawa, Y., Nakamura-Ishizu, A., Miyauchi, Y., Fujita, N., Miyamoto, K., Miyamoto, T., Ikeda, E., Kizaki, M., Nojima, Y. & Suda, T., 2012 Feb 7, In : PloS one. 7, 2, e30557.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 Jul 20, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

170 Citations (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 Nov 1, In : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Optimal ratio of transcription factors for somatic cell reprogramming

Nagamatsu, G., Saito, S., Kosaka, T., Takubo, K., Kinoshita, T., Oya, M., Horimoto, K. & Suda, T., 2012 Oct 19, In : Journal of Biological Chemistry. 287, 43, p. 36273-36282 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 Aug, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 May 1, In : International journal of hematology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

Takaesu, G., Inagaki, M., Takubo, K., Mishina, Y., Hess, P. R., Dean, G. A., Yoshimura, A., Matsumoto, K., Suda, T. & Ninomiya-Tsuji, J., 2012 Nov 30, In : PloS one. 7, 11, e51073.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2011

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., 2011 Feb 24, In : Blood. 117, 8, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., 2011 Sep 29, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M. J., Takubo, K., Arai, F., Nakada, S. & Suda, T., 2011 Apr 21, In : Blood. 117, 16, p. 4169-4180 12 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)
2010

Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells

Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T. & Suda, T., 2010 Jan 14, In : Blood. 115, 2, p. e1-e9

Research output: Contribution to journalArticle

23 Citations (Scopus)

DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4

Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., Masuko, S., Suda, T., Meno, C., Côté, J. F., Nagasawa, T. & Fukui, Y., 2010 Oct 29, In : Circulation research. 107, 9, p. 1102-1105 4 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

Gomei, Y., Nakamura, Y., Yoshihara, H., Hosokawa, K., Iwasaki, H., Suda, T. & Arai, F., 2010 Feb, In : Experimental Hematology. 38, 2, p. 82-89.e1

Research output: Contribution to journalArticle

25 Citations (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., 2010 Sep 2, In : Blood. 116, 9, p. 1422-1432 11 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., 2010 Jul 29, In : Blood. 116, 4, p. 554-563 10 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S. I., Juang, Y. C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A. C., Natsume, T., Suda, T. & Durocher, D., 2010 Aug 19, In : Nature. 466, 7309, p. 941-946 6 p.

Research output: Contribution to journalArticle

225 Citations (Scopus)

Von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina

Kurihara, T., Kubota, Y., Ozawa, Y., Takubo, K., Noda, K., Simon, M. C., Johnson, R. S., Suematsu, M., Tsubota, K., Ishida, S., Goda, N., Suda, T. & Okano, H., 2010 May 1, In : Development. 137, 9, p. 1563-1571 9 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)
2009

Aging and cancer in hematopoietic stem cells

Nitta, E. & Suda, T., 2009 May 1, In : Japanese Journal of Geriatrics. 46, 3, p. 195-199 5 p.

Research output: Contribution to journalArticle

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

Adachi, H., Fujiwara, Y., Kondo, T., Nishikawa, T., Ogawa, R., Matsumura, T., Ishii, N., Nagai, R., Miyata, K., Tabata, M., Motoshima, H., Furukawa, N., Tsuruzoe, K., Kawashima, J., Takeya, M., Yamashita, S., Koh, G. Y., Nagy, A., Suda, T., Oike, Y. & 1 others, Araki, E., 2009 Feb 20, In : Biochemical and Biophysical Research Communications. 379, 4, p. 806-811 6 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: Functional roles of HoxD8 in lymphangiogenesis

Harada, K., Yamazaki, T., Iwata, C., Yoshimatsu, Y., Sase, H., Mishima, K., Morishita, Y., Hirashima, M., Oike, Y., Suda, T., Miura, N., Watabe, T. & Miyazono, K., 2009, In : Journal of Cell Science. 122, 21, p. 3923-3930 8 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin

Tamase, A., Muraguchi, T., Naka, K., Tanaka, S., Kinoshita, M., Hoshii, T., Ohmura, M., Shugo, H., Ooshio, T., Nakada, M., Sawamoto, K., Onodera, M., Matsumoto, K., Oshima, M., Asano, M., Saya, H., Okano, H., Suda, T., Hamada, J. I. & Hirao, A., 2009 Oct 6, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 40, p. 17163-17168 6 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type i interferon-dependent exhaustion

Sato, T., Onai, N., Yoshihara, H., Arai, F., Suda, T. & Ohteki, T., 2009 Jun 8, In : Nature medicine. 15, 6, p. 696-700 5 p.

Research output: Contribution to journalArticle

244 Citations (Scopus)
2008

Brain-specific expression of vascular endothelial growth factor 146 correlates with the blood-brain barrier induction in quail embryos

Ikeda, E., Takubo, K., Kodama, T. & Okada, Y., 2008 Sep 1, In : Developmental Neuroscience. 30, 5, p. 331-339 9 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y. & 4 others, Hata, A., Chiba, S., Nakayama, K. I. & Suda, T., 2008 Apr 15, In : Genes and Development. 22, 8, p. 986-991 6 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity

Ohmura, M., Naka, K., Hoshii, T., Muraguchi, T., Shugo, H., Tamase, A., Uema, N., Ooshio, T., Arai, F., Takubo, K., Nagamatsu, G., Hamaguchi, I., Takagi, M., Ishihara, M., Sakurada, K., Miyaji, H., Suda, T. & Hirao, A., 2008 Dec, In : Stem Cells. 26, 12, p. 3237-3246 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells

Kawasaki, K., Watabe, T., Sase, H., Hirashima, M., Koide, H., Morishita, Y., Yuki, K., Sasaoka, T., Suda, T., Katsuki, M., Miyazono, K. & Miyazawa, K., 2008 Apr 7, In : Journal of Cell Biology. 181, 1, p. 131-141 11 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

VEGFR1 tyrosine kinase signaling promotes lymphangiogenesis as well as angiogenesis indirectly via macrophage recruitment

Murakami, M., Zheng, Y., Hirashima, M., Suda, T., Morita, Y., Ooehara, J., Ema, H., Fong, G. H. & Shibuya, M., 2008 Apr 1, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 4, p. 658-664 7 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)
2007

Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K. I., Harada, M., Motoyama, N., Suda, T. & Hirao, A., 2007 Jun 7, In : Cell stem cell. 1, 1, p. 101-112 12 p.

Research output: Contribution to journalArticle

576 Citations (Scopus)

Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice

Ninomiya, M., Abe, A., Katsumi, A., Xu, J., Ito, M., Arai, F., Suda, T., Ito, M., Kiyoi, H., Kinoshita, T. & Naoe, T., 2007 Jan, In : Leukemia. 21, 1, p. 136-142 7 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification

Morita, K., Miyamoto, T., Fujita, N., Kubota, Y., Ito, K., Takubo, K., Miyamoto, K., Ninomiya, K., Suzuki, T., Iwasaki, R., Yagi, M., Takaishi, H., Toyama, Y. & Suda, T., 2007 Jul 9, In : Journal of Experimental Medicine. 204, 7, p. 1613-1623 11 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes

Ito, K., Takubo, K., Arai, F., Satoh, H., Matsuoka, S., Ohmura, M., Naka, K., Azuma, M., Miyamoto, K., Hosokawa, K., Ikeda, Y., Mak, T. W., Suda, T. & Hirao, A., 2007 Jan 1, In : Journal of Immunology. 178, 1, p. 103-110 8 p.

Research output: Contribution to journalArticle

Open Access
87 Citations (Scopus)