The Sakaguchi Laboratory of Developmental Biology Department of Cell Differentiation

Research Output 1979 2015

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2015
5 Citations (Scopus)

Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes

Sakamoto, H., Takeda, N., Arai, F., Hosokawa, K., Garcia, P., Suda, T., Frampton, J. & Ogawa, M., 2015 Feb 1, In : Stem Cells. 33, 2, p. 479-490 12 p.

Research output: Contribution to journalArticle

Proto-Oncogene Proteins c-myb
Hematopoietic Stem Cells
Oncogene Proteins
Hematopoiesis
Bromodeoxyuridine
2014
2 Citations (Scopus)

[Homeostatic regulation of hematopoiesis by the hematopoietic stem cell niche]

Takubo, K., 2014 Dec 1, In : Seikagaku. The Journal of Japanese Biochemical Society. 86, 6, p. 755-765 11 p.

Research output: Contribution to journalArticle

Alpha Subunit Hypoxia-Inducible Factor 1
Intracellular Signaling Peptides and Proteins
Endothelial cells
Granulocyte Colony-Stimulating Factor
Cadherins
16 Citations (Scopus)

Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function

Nagamachi, A., Nakata, Y., Ueda, T., Yamasaki, N., Ebihara, Y., Tsuji, K., Honda, Z. I., Takubo, K., Suda, T., Oda, H., Inaba, T. & Honda, H., 2014 Jan 31, In : PLoS One. 9, 1, e87425.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
apoptosis
inflammation
Cells

Direct reprogramming of fibroblasts and preadipocytes into functional megakaryocytes.

Matsubara, Y., 2014, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 55, 4, p. 387-395 9 p.

Research output: Contribution to journalArticle

p45 Subunit NF-E2 Transcription Factor
Genetic Transduction
Nuclear Transfer Techniques
Thrombopoietin
Induced Pluripotent Stem Cells
68 Citations (Scopus)

Heterogeneity and hierarchy of hematopoietic stem cells

Ema, H., Morita, Y. & Suda, T., 2014 Feb, In : Experimental Hematology. 42, 2, p. 74-82 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Terminology
Cell Differentiation
Stem Cells
Transplantation
55 Citations (Scopus)

Jam1a-Jam2a interactions regulate haematopoietic stem cell fate through Notch signalling

Kobayashi, I., Kobayashi-Sun, J., Kim, A. D., Pouget, C., Fujita, N., Suda, T. & Traver, D., 2014 Aug 21, In : Nature. 512, 7514, p. 319-323 5 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Somites
Ligands
Blood Vessels
Aorta
413 Citations (Scopus)

Metabolic requirements for the maintenance of self-renewing stem cells

Ito, K. & Suda, T., 2014, In : Nature Reviews Molecular Cell Biology. 15, 4, p. 243-256 14 p.

Research output: Contribution to journalArticle

Stem Cells
Metabolomics
Glycolysis
Hematopoietic Stem Cells
Metabolic Networks and Pathways
27 Citations (Scopus)

Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress

Tai-Nagara, I., Matsuoka, S., Ariga, H. & Suda, T., 2014 Jan 2, In : Blood. 123, 1, p. 41-50 10 p.

Research output: Contribution to journalArticle

Oxidative stress
Hematopoietic Stem Cells
Stem cells
Oxidative Stress
Reactive Oxygen Species

Not merely quiescent: Telomeres in quiescent HSCs

Nakamura-Ishizu, A. & Suda, T., 2014 Nov 20, In : Blood. 124, 22, p. 3179-3180 2 p.

Research output: Contribution to journalArticle

Animals
Apoptosis
9 Citations (Scopus)

R-spondins/Lgrs expression in tooth development

kawasaki, M., Porntaveetus, T., Kawasaki, K., Oommen, S., Otsuka-Tanaka, Y., Hishinuma, M., Nomoto, T., Maeda, T., Takubo, K., Suda, T., Sharpe, P. T. & Ohazama, A., 2014, In : Developmental Dynamics. 243, 6, p. 844-851 8 p.

Research output: Contribution to journalArticle

Tooth
Diastema
Odontogenesis
Supernumerary Tooth
Tooth Germ
9 Citations (Scopus)

Telomerase reverse transcriptase has an extratelomeric function in somatic cell reprogramming

Kinoshita, T., Nagamatsu, G., Saito, S., Takubo, K., Horimoto, K. & Suda, T., 2014 May 30, In : Journal of Biological Chemistry. 289, 22, p. 15776-15787 12 p.

Research output: Contribution to journalArticle

Telomerase
Chromosomes
Stem cells
Induced Pluripotent Stem Cells
Chromosome Aberrations
68 Citations (Scopus)

The analysis, roles and regulation of quiescence in hematopoietic stem cells

Nakamura-Ishizu, A., Takizawa, H. & Suda, T., 2014 Dec 15, In : Development (Cambridge). 141, 24, p. 4656-4666 11 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Single-Cell Analysis
Multipotent Stem Cells
Intrinsic Factor
Adult Stem Cells
34 Citations (Scopus)

The IL-2/CD25 axis maintains distinct subsets of chronic myeloid leukemia-initiating cells

Kobayashi, C. I., Takubo, K., Kobayashi, H., Nakamura-Ishizu, A., Honda, H., Kataoka, K., Kumano, K., Akiyama, H., Sudo, T., Kurokawa, M. & Suda, T., 2014 Apr 17, In : Blood. 123, 16, p. 2540-2549 10 p.

Research output: Contribution to journalArticle

Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Protein-Tyrosine Kinases
Interleukin-2
Stem cells
Leukemia
2013

[Induction of megakaryocytes and platelet production from mouse and human fibroblasts by p45 NF-E2/Maf].

Ono, Y. & Matsubara, Y., 2013 Nov, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 54, 11, p. 2025-2030 6 p.

Research output: Contribution to journalArticle

p45 Subunit NF-E2 Transcription Factor
Proto-Oncogene Proteins c-maf
Megakaryocytes
Transcription Factors
Blood Platelets
28 Citations (Scopus)

An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity

Shirakawa, T., Yaman-Deveci, R., Tomizawa, S. I., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y., Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T. & Ohbo, K., 2013 Sep 1, In : Development (Cambridge). 140, 17, p. 3565-3576 12 p.

Research output: Contribution to journalArticle

Spermatogonia
Epigenomics
DNA Methylation
Histone Code
Pluripotent Stem Cells
63 Citations (Scopus)

Angiopoietin-1 guides directional angiogenesis through integrin αvβ5 signaling for recovery of ischemic retinopathy

Lee, J., Kim, K. E., Choi, D. K., Jang, J. Y., Jung, J. J., Kiyonari, H., Shioi, G., Chang, W., Suda, T., Mochizuki, N., Nakaoka, Y., Komuro, I., Yoo, O. J. & Koh, G. Y., 2013 Sep 18, In : Science Translational Medicine. 5, 203, 203ra127.

Research output: Contribution to journalArticle

Angiopoietin-1
Integrins
Blood Vessels
Retinal Vessels
Retinopathy of Prematurity
57 Citations (Scopus)

Haploinsufficiency of SAMD9L, an Endosome Fusion Facilitator, Causes Myeloid Malignancies in Mice Mimicking Human Diseases with Monosomy 7

Nagamachi, A., Matsui, H., Asou, H., Ozaki, Y., Aki, D., Kanai, A., Takubo, K., Suda, T., Nakamura, T., Wolff, L., Honda, H. & Inaba, T., 2013 Sep 9, In : Cancer Cell. 24, 3, p. 305-317 13 p.

Research output: Contribution to journalArticle

Haploinsufficiency
Endosomes
Neoplasms
Cytokine Receptors
Myeloid Leukemia
28 Citations (Scopus)

Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches

Nakamura-Ishizu, A. & Suda, T., 2013 Feb, In : Biochimica et Biophysica Acta - General Subjects. 1830, 2, p. 2404-2409 6 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Hematopoietic Stem Cells
Stem cells
Stem Cells
Neoplastic Stem Cells
3 Citations (Scopus)

Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder.

Sato, T., Ikeda, M., Yotsumoto, S., Shimada, Y., Higuchi, T., Kobayashi, H., Fukuda, T., Ohashi, T., Suda, T. & Ohteki, T., 2013 Apr 18, In : Blood. 121, 16, p. 3267-3273 7 p.

Research output: Contribution to journalArticle

Transplantation Conditioning
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Interferon Type I
Stem cells
Interferons
16 Citations (Scopus)

Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells

Yamashita, M., Nitta, E., Nagamatsu, G., Ikushima, Y. M., Hosokawa, K., Arai, F. & Suda, T., 2013 Nov 8, In : Biochemical and Biophysical Research Communications. 441, 1, p. 196-201 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Maintenance
DNA Damage
Apoptosis
24 Citations (Scopus)

Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.

Ikushima, Y. M., Arai, F., Hosokawa, K., Toyama, H., Takubo, K., Furuyashiki, T., Narumiya, S. & Suda, T., 2013 Mar 14, In : Blood. 121, 11, p. 1995-2007 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Prostaglandins E
Stem cells
Mesenchymal Stromal Cells
Receptors, Prostaglandin E, EP2 Subtype
2012
1 Citation (Scopus)

[Regulation of hematopoietic stem cells in niche signaling].

Matsumoto, Y. & Suda, T., 2012 Apr, In : Nihon rinsho. Japanese journal of clinical medicine. 70 Suppl 2, p. 133-138 6 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Neoplastic Stem Cells
Hematopoietic Stem Cells
Bone Marrow Cells
288 Citations (Scopus)

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Ito, K., Carracedo, A., Weiss, D., Arai, F., Ala, U., Avigan, D. E., Schafer, Z. T., Evans, R. M., Suda, T., Lee, C. H. & Pandolfi, P. P., 2012 Sep, In : Nature Medicine. 18, 9, p. 1350-1358 9 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Hematopoietic Stem Cells
Stem cells
Leukemia
Fatty Acids
38 Citations (Scopus)

Dynamic regulation of T h17 differentiation by oxygen concentrations

Ikejiri, A., Nagai, S., Goda, N., Kurebayashi, Y., Osada-Oka, M., Takubo, K., Suda, T. & Koyasu, S., 2012, In : International Immunology. 24, 3, p. 137-146 10 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Oxygen
Cell Differentiation
Von Hippel-Lindau Tumor Suppressor Protein
Spleen
57 Citations (Scopus)

Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells

Krohne, T. U., Westenskow, P. D., Kurihara, T., Friedlander, D. F., Lehmann, M., Dorsey, A. L., Li, W., Zhu, S., Schultz, A., Wang, J., Siuzdak, G., Ding, S. & Friedlander, M., 2012, In : Stem cells translational medicine. 1, 2, p. 96-109 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Retinal Pigments
Retinal Pigment Epithelium
Epithelial Cells
Transplants
3 Citations (Scopus)

N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs

Toyama, H., Arai, F., Hosokawa, K., Ikushima, Y. M. & Suda, T., 2012 Nov 23, In : Biochemical and Biophysical Research Communications. 428, 3, p. 354-359 6 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Liver
Bone
161 Citations (Scopus)

Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche

Sugimura, R., He, X. C., Venkatraman, A., Arai, F., Box, A., Semerad, C., Haug, J. S., Peng, L., Zhong, X. B., Suda, T. & Li, L., 2012 Jul 20, In : Cell. 150, 2, p. 351-365 15 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Hematopoietic Stem Cells
Stem cells
Cadherins
Osteoblasts
8 Citations (Scopus)

Nucleostemin in injury-induced liver regeneration

Shugo, H., Ooshio, T., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Muraguchi, T., Tamase, A., Uema, N., Yamashita, T., Nakamoto, Y., Suda, T., Kaneko, S. & Hirao, A., 2012 Nov 1, In : Stem Cells and Development. 21, 16, p. 3044-3054 11 p.

Research output: Contribution to journalArticle

Liver Regeneration
Hepatocytes
Wounds and Injuries
Liver
Hepatectomy
142 Citations (Scopus)

Regulation of reactive oxygen species in stem cells and cancer stem cells

Kobayashi, C. I. & Suda, T., 2012 Jan, In : Journal of Cellular Physiology. 227, 2, p. 421-430 10 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Stem cells
Reactive Oxygen Species
Stem Cells
Oxidation-Reduction
30 Citations (Scopus)

Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche

Arai, F., Hosokawa, K., Toyama, H., Matsumoto, Y. & Suda, T., 2012 Aug, In : Annals of the New York Academy of Sciences. 1266, 1, p. 72-77 6 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Bone
Bone Marrow
22 Citations (Scopus)

Roles of the hypoxia response system in hematopoietic and leukemic stem cells

Takubo, K. & Suda, T., 2012 May, In : International Journal of Hematology. 95, 5, p. 478-483 6 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem Cells
Neoplastic Stem Cells
Drug Resistance
Cell Aging
167 Citations (Scopus)

Targeted deletion of Vegfa in adult mice induces vision loss

Kurihara, T., Westenskow, P. D., Bravo, S., Aguilar, E. & Friedlander, M., 2012 Nov 1, In : Journal of Clinical Investigation. 122, 11, p. 4213-4217 5 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Eye Neoplasms
Retinal Cone Photoreceptor Cells
Color Vision
Photoreceptor Cells
49 Citations (Scopus)

Two anatomically distinct niches regulate stem cell activity

Ema, H. & Suda, T., 2012 Sep 13, In : Blood. 120, 11, p. 2174-2181 8 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Stem cells
Stem Cells
Cell Count
Adult Stem Cells
24 Citations (Scopus)

Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells

Westenskow, P. D., Moreno, S. K., Krohne, T. U., Kurihara, T., Zhu, S., Zhang, Z. N., Zhao, T., Xu, Y., Ding, S. & Friedlander, M., 2012 Sep, In : Investigative Ophthalmology and Visual Science. 53, 10, p. 6282-6290 9 p.

Research output: Contribution to journalArticle

Retinal Pigment Epithelium
Phagocytosis
Flow Cytometry
Fluorescein-5-isothiocyanate
Transplants
2011
16 Citations (Scopus)

Astrocyte pvhl and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye

Kurihara, T., Westenskow, P. D., Krohne, T. U., Aguilar, E., Johnson, R. S. & Friedlander, M., 2011 Nov 14, In : Journal of Cell Biology. 195, 4, p. 689-701 13 p.

Research output: Contribution to journalArticle

Astrocytes
Vascular Endothelial Growth Factor A
Blood Vessels
Protein Isoforms
Gene Deletion
25 Citations (Scopus)

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., 2011 Feb 24, In : Blood. 117, 8, p. 2373-2377 5 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Stem cells
Maintenance
Cell Cycle
Cells
21 Citations (Scopus)

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation

Kharazi, S., Mead, A. J., Mansour, A., Hultquist, A., Böiers, C., Luc, S., Buza-Vidas, N., Ma, Z., Ferry, H., Atkinson, D., Reckzeh, K., Masson, K., Cammenga, J., Rönnstrand, L., Arai, F., Suda, T., Nerlov, C., Sitnicka, E. & Jacobsen, S. E. W., 2011 Sep 29, In : Blood. 118, 13, p. 3613-3621 9 p.

Research output: Contribution to journalArticle

Gene Dosage
Genes
Alleles
Ligands
Phenotype
394 Citations (Scopus)

Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Suda, T., Takubo, K. & Semenza, G. L., 2011 Oct 4, In : Cell Stem Cell. 9, 4, p. 298-310 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Homeostasis
Maintenance
Multipotent Stem Cells
Anaerobiosis
160 Citations (Scopus)

P57 Kip2 and p27 Kip1 cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I. & Suda, T., 2011 Sep 2, In : Cell Stem Cell. 9, 3, p. 247-261 15 p.

Research output: Contribution to journalArticle

HSC70 Heat-Shock Proteins
Hematopoietic Stem Cells
Cell Cycle
Cyclin D1
Cyclin-Dependent Kinase Inhibitor p57
17 Citations (Scopus)

Stem cell self-renewal: Lessons from bone marrow, gut and iPS toward clinical applications

Staal, F. J. T., Baum, C., Cowan, C., Dzierzak, E., Hacein-Bey-Abina, S., Karlsson, S., Lapidot, T., Lemischka, I., Mendez-Ferrer, S., Mikkers, H., Moore, K., Moreno, E., Mummery, C. L., Robin, C., Suda, T., Van Pel, M., Vanden Brink, G., Zwaginga, J. J. & Fibbe, W. E., 2011 Jul, In : Leukemia. 25, 7, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

Stem Cells
Bone Marrow
Cell- and Tissue-Based Therapy
Hematopoietic Stem Cells
Cell Self Renewal
41 Citations (Scopus)

Telomerase reverse transcriptase protectsATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

Nitta, E., Yamashita, M., Hosokawa, K., Xian, M., Takubo, K., Arai, F., Nakada, S. & Suda, T., 2011 Apr 21, In : Blood. 117, 16, p. 4169-4180 12 p.

Research output: Contribution to journalArticle

Telomerase
Telomere
Hematopoietic Stem Cells
Stem cells
Reactive Oxygen Species
2010
70 Citations (Scopus)

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Hembree, M., Yin, T., Nakamura, Y., Gomei, Y., Takubo, K., Shiama, H., Matsuoka, S., Li, L. & Suda, T., 2010 Mar 5, In : Cell Stem Cell. 6, 3, p. 194-198 5 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Gene Expression Regulation
Cadherins
Hematopoietic Stem Cells
Cell Adhesion
23 Citations (Scopus)

Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells

Kobayashi, I., Ono, H., Moritomo, T., Kano, K., Nakanishi, T. & Suda, T., 2010 Jan 14, In : Blood. 115, 2

Research output: Contribution to journalArticle

Mammals
Zebrafish
Hematopoietic Stem Cells
Stem cells
Gene expression
31 Citations (Scopus)

DOCK180 is a rac activator that regulates cardiovascular development by acting downstream of CXCR4

Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., Masuko, S., Suda, T., Meno, C., Côté, J. F., Nagasawa, T. & Fukui, Y., 2010 Oct 29, In : Circulation Research. 107, 9, p. 1102-1105 4 p.

Research output: Contribution to journalArticle

Cell Movement
src Homology Domains
Endothelial Cells
Cardiovascular Abnormalities
CXCR4 Receptors
2 Citations (Scopus)

Erratum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells (Nature Medicine (2006)12 (446-451))

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y. & Suda, T., 2010 Jan, In : Nature Medicine. 16, 1, p. 129 1 p.

Research output: Contribution to journalArticle

p38 Mitogen-Activated Protein Kinases
Hematopoietic Stem Cells
Reactive Oxygen Species
Medicine
25 Citations (Scopus)

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

Gomei, Y., Nakamura, Y., Yoshihara, H., Hosokawa, K., Iwasaki, H., Suda, T. & Arai, F., 2010 Feb, In : Experimental Hematology. 38, 2

Research output: Contribution to journalArticle

Angiopoietin-2
Angiopoietin-1
Hematopoietic Stem Cells
Bone Marrow
Ligands
133 Citations (Scopus)

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

Nakamura, Y., Arai, F., Iwasaki, H., Hosokawa, K., Kobayashi, I., Gomei, Y., Matsumoto, Y., Yoshihara, H. & Suda, T., 2010 Sep 2, In : Blood. 116, 9, p. 1422-1432 11 p.

Research output: Contribution to journalArticle

Activated-Leukocyte Cell Adhesion Molecule
Hematopoietic Stem Cells
Stem cells
Cells
Population
83 Citations (Scopus)

Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells

Hosokawa, K., Arai, F., Yoshihara, H., Iwasaki, H., Nakamura, Y., Gomei, Y. & Suda, T., 2010 Jul 29, In : Blood. 116, 4, p. 554-563 10 p.

Research output: Contribution to journalArticle

Cadherins
Hematopoietic Stem Cells
Stem cells
Small Interfering RNA
Bone
206 Citations (Scopus)

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S. I., Juang, Y. C., O'Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., Gingras, A. C., Natsume, T., Suda, T. & Durocher, D., 2010 Aug 19, In : Nature. 466, 7309, p. 941-946 6 p.

Research output: Contribution to journalArticle

Ubiquitination
DNA Damage
Chromatin
Double-Stranded DNA Breaks
Enzyme Inhibitors

Regulation of hematopoietic stem cells by oxygen metabolism

Takubo, K., 2010 Feb, In : [Rinshō ketsueki] The Japanese journal of clinical hematology. 51, 2, p. 95-103 9 p.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Hematopoietic Stem Cells
Bone Marrow Cells
Cell Division
Cell Differentiation