The Sakaguchi Laboratory of Developmental Biology Department of Systems Medicine

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Stem cells Chemical Compounds
Transcription Factors Medicine & Life Sciences
Embryonic Stem Cells Medicine & Life Sciences
Pluripotent Stem Cells Medicine & Life Sciences
Induced Pluripotent Stem Cells Medicine & Life Sciences
Genes Medicine & Life Sciences
Blastocyst Medicine & Life Sciences
Cell Differentiation Medicine & Life Sciences

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Research Output 1985 2019

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M., Tada, N., Okano, H. & Akamatsu, W., 2019 Feb 12, In : Stem Cell Reports. 12, 2, p. 305-318 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Pluripotent Stem Cells
Fibroblast Growth Factor 4
Stem Cells
1 Citation (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S., Itoh, H. & Ko, M., 2019 Dec 1, In : Scientific Reports. 9, 1, 913.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Organoids
Nephrons
Transcription Factors
Kidney
3 Citations (Scopus)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. & Ko, M., 2018 Dec 1, In : Scientific Reports. 8, 1, 1189.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Muscle Cells
Skeletal Muscle
RNA
Gene Knockdown Techniques