The Sakaguchi Laboratory of Developmental Biology Department of Systems Medicine

Research Output 1985 2019

2019
1 Citation (Scopus)

Induced Pluripotent Stem Cells Reprogrammed with Three Inhibitors Show Accelerated Differentiation Potentials with High Levels of 2-Cell Stage Marker Expression

Nishihara, K., Shiga, T., Nakamura, E., Akiyama, T., Sasaki, T., Suzuki, S., Ko, M., Tada, N., Okano, H. & Akamatsu, W., 2019 Feb 12, In : Stem Cell Reports. 12, 2, p. 305-318 14 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Pluripotent Stem Cells
Fibroblast Growth Factor 4
Stem Cells
2 Citations (Scopus)

Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors

Hiratsuka, K., Monkawa, T., Akiyama, T., Nakatake, Y., Oda, M., Goparaju, S. K., Kimura, H., Chikazawa-Nohtomi, N., Sato, S., Ishiguro, K., Yamaguchi, S., Suzuki, S., Morizane, R., Ko, S., Itoh, H. & Ko, M., 2019 Dec 1, In : Scientific Reports. 9, 1, 913.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Organoids
Nephrons
Transcription Factors
Kidney

In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of PCDH15 and RELN

Ishii, T., Ishikawa, M., Fujimori, K., Maeda, T., Kushima, I., Arioka, Y., Mori, D., Nakatake, Y., Yamagata, B., Nio, S., Kato, T. A., Yang, N., Wernig, M., Kanba, S., Mimura, M., Ozaki, N. & Okano, H., 2019 Sep 1, In : eNeuro. 6, 5

Research output: Contribution to journalArticle

Open Access
Induced Pluripotent Stem Cells
Bipolar Disorder
Schizophrenia
Neurons
Psychiatry
2018
3 Citations (Scopus)

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Akiyama, T., Sato, S., Chikazawa-Nohtomi, N., Soma, A., Kimura, H., Wakabayashi, S., Ko, S. & Ko, M., 2018 Dec 1, In : Scientific Reports. 8, 1, 1189.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Muscle Cells
Skeletal Muscle
RNA
Gene Knockdown Techniques
3 Citations (Scopus)

Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors 10 Technology 1004 Medical Biotechnology

Ida, H., Akiyama, T., Ishiguro, K., Goparaju, S. K., Nakatake, Y., Chikazawa-Nohtomi, N., Sato, S., Kimura, H., Yokoyama, Y., Nagino, M., Ko, M. & Ko, S., 2018 Oct 25, In : Stem Cell Research and Therapy. 9, 1, 277.

Research output: Contribution to journalArticle

Endocrine Cells
Biotechnology
Stem cells
Transcription Factors
Cells

Selective modulation of local linkages between active transcription and oxidative demethylation activity shapes cardiomyocyte-specific gene-body epigenetic status in mice

Oda, M., Wakabayashi, S., Ari Wijetunga, N., Yuasa, S., Enomoto, H., Kaneda, R., Yoon, S. H., Mittal, N., Jing, Q., Suzuki, M., Greally, J. M., Fukuda, K. & Makino, S., 2018 May 10, In : BMC Genomics. 19, 1, 349.

Research output: Contribution to journalArticle

Cardiac Myocytes
Epigenomics
Genes
Body Regions
Histone Code
7 Citations (Scopus)

Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification

Sadahiro, T., Isomi, M., Muraoka, N., Kojima, H., Haginiwa, S., Kurotsu, S., Tamura, F., Tani, H., Tohyama, S., Fujita, J., Miyoshi, H., Kawamura, Y., Goshima, N., Iwasaki, Y., Murano, K., Saito, K., Oda, M., Andersen, P., Kwon, C., Uosaki, H. & 3 others, Nishizono, H., Fukuda, K. & Ieda, M., 2018 Sep 6, In : Cell Stem Cell. 23, 3, p. 382-395 14 p.

Research output: Contribution to journalArticle

Somites
Pluripotent Stem Cells
Mesoderm
Clustered Regularly Interspaced Short Palindromic Repeats
Germ Layers
5 Citations (Scopus)

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy

Nakamoto, F. K., Okamoto, S., Mitsui, J., Sone, T., Ishikawa, M., Yamamoto, Y., Kanegae, Y., Nakatake, Y., Imaizumi, K., Ishiura, H., Tsuji, S. & Okano, H., 2018 Dec 1, In : Scientific Reports. 8, 1, 14215.

Research output: Contribution to journalArticle

coenzyme Q10
Multiple System Atrophy
Induced Pluripotent Stem Cells
Neurons
Clustered Regularly Interspaced Short Palindromic Repeats
2017
6 Citations (Scopus)

Bicarbonate-rich fluid secretion predicted by a computational model of guinea-pig pancreatic duct epithelium

Yamaguchi, M., Steward, M. C., Smallbone, K., Sohma, Y., Yamamoto, A., Ko, S., Kondo, T. & Ishiguro, H., 2017, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Fluids and Secretions
Pancreatic Ducts
Chloride-Bicarbonate Antiporters
Bicarbonates
Cystic Fibrosis Transmembrane Conductance Regulator

Epigenetic barrier against the propagation of fluctuating gene expression in embryonic stem cells

Saito, Y., Kunitomi, A., Seki, T., Tohyama, S., Kusumoto, D., Takei, M., Kashimura, S., Hashimoto, H., Yozu, G., Motoda, C., Shimojima, M., Egashira, T., Oda, M., Fukuda, K. & Yuasa, S., 2017 Sep 1, In : FEBS Letters. 591, 18, p. 2879-2889 11 p.

Research output: Contribution to journalLetter

Embryonic Stem Cells
Stem cells
Epigenomics
Gene expression
Gene Expression
1 Citation (Scopus)

Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells

Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. & Ko, M., 2017, In : Stem Cells International. 2017, 7215010.

Research output: Contribution to journalReview article

Pluripotent Stem Cells
Epigenomics
Muscle Cells
Skeletal Muscle
Transcription Factors
6 Citations (Scopus)

Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells

Hirayama, M., Ko, S., Kawakita, T., Akiyama, T., Goparaju, S. K., Soma, A., Nakatake, Y., Sakota, M., Chikazawa-Nohtomi, N., Shimmura, S., Tsubota, K. & Ko, M., 2017 Dec 1, In : npj Aging and Mechanisms of Disease. 3, 1, 1.

Research output: Contribution to journalArticle

Lacrimal Apparatus
Pluripotent Stem Cells
Transcription Factors
Epithelium
Microarray Analysis
8 Citations (Scopus)

Neural differentiation of human embryonic stem cells induced by the transgene-mediated overexpression of single transcription factors

Matsushita, M., Nakatake, Y., Arai, I., Ibata, K., Kohda, K., Goparaju, S. K., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S., Kanai, T., Yuzaki, M. & Ko, M., 2017 May 31, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Stem cells
Transgenes
Transcription Factors
Neurons
Doxycycline
19 Citations (Scopus)

Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors

Goparaju, S. K., Kohda, K., Ibata, K., Soma, A., Nakatake, Y., Akiyama, T., Wakabayashi, S., Matsushita, M., Sakota, M., Kimura, H., Yuzaki, M., Ko, S. & Ko, M., 2017 Feb 13, In : Scientific Reports. 7, 42367.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Transcription Factors
Neurons
Messenger RNA
Preclinical Drug Evaluations

Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells

Arai, Y., Takahashi, D., Asano, K., Tanaka, M., Oda, M., Ko, S., Ko, M., Mandai, S., Nomura, N., Rai, T., Uchida, S. & Sohara, E., 2017 Jan 1, In : Scientific Reports. 7, 46580.

Research output: Contribution to journalArticle

Janus Kinase 1
C Chemokines
STAT1 Transcription Factor
Interferon-gamma
Salts
23 Citations (Scopus)

SCODE: An efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation

Matsumoto, H., Kiryu, H., Furusawa, C., Ko, M., Ko, S., Gouda, N., Hayashi, T. & Nikaido, I., 2017 Aug 1, In : Bioinformatics. 33, 15, p. 2314-2321 8 p.

Research output: Contribution to journalArticle

Regulatory Networks
RNA
Cell
Genes
Ordinary differential equations
35 Citations (Scopus)

Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression

Torii, H., Kurihara, T., Seko, Y., Negishi, K., Ohnuma, K., Inaba, T., Kawashima, M., Jiang, X., Kondo, S., Miyauchi, M., Miwa, Y., Katada, Y., Mori, K., Kato, K., Tsubota, K., Goto, H., Oda, M., Hatori, M. & Tsubota, K., 2017 Feb 1, In : EBioMedicine. 15, p. 210-219 10 p.

Research output: Contribution to journalArticle

Contact lenses
Myopia
Elongation
Eyeglasses
Light
2016
4 Citations (Scopus)

Emergence of undifferentiated colonies from mouse embryonic stem cells undergoing differentiation by retinoic acid treatment

Sharova, L. V., Sharov, A. A., Piao, Y., Stagg, C. A., Amano, T., Qian, Y., Dudekula, D., Schlessinger, D. & Ko, M., 2016 Apr 29, (Accepted/In press) In : In Vitro Cellular and Developmental Biology - Animal. p. 1-9 9 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Tretinoin
Stem cells
Cell Differentiation
Leukemia Inhibitory Factor
1 Citation (Scopus)

Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos

Ishiguro, K. I., Nakatake, Y., Chikazawa-Nohtomi, N., Kimura, H., Akiyama, T., Oda, M., Ko, S. & Ko, M., 2016 Oct 3, (Accepted/In press) In : In Vitro Cellular and Developmental Biology - Animal. p. 1-12 12 p.

Research output: Contribution to journalArticle

Zinc Fingers
Blastocyst
Stem cells
Zinc
Proteins
3 Citations (Scopus)

Gene array analysis of neural crest cells identifies transcription factors necessary for direct conversion of embryonic fibroblasts into neural crest cells

Motohashi, T., Watanabe, N., Nishioka, M., Nakatake, Y., Yulan, P., Mochizuki, H., Kawamura, Y., Ko, M., Goshima, N. & Kunisada, T., 2016 Mar 15, In : Biology Open. 5, 3, p. 311-322 12 p.

Research output: Contribution to journalArticle

neural crest
Neural Crest
Fibroblasts
fibroblasts
Transcription Factors
8 Citations (Scopus)

Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines

Yamamizu, K., Sharov, A. A., Piao, Y., Amano, M., Yu, H., Nishiyama, A., Dudekula, D. B., Schlessinger, D. & Ko, M., 2016 May 6, In : Scientific Reports. 6, 25667.

Research output: Contribution to journalArticle

Gene Expression Profiling
Transcription Factors
Cell Line
Embryonic Stem Cells
Transcriptome
2 Citations (Scopus)

Induction of specific neuron types by overexpression of single transcription factors

Teratani-Ota, Y., Yamamizu, K., Piao, Y., Sharova, L., Amano, M., Yu, H., Schlessinger, D., Ko, M. & Sharov, A. A., 2016 Jun 1, (Accepted/In press) In : In Vitro Cellular and Developmental Biology - Animal. p. 1-13 13 p.

Research output: Contribution to journalArticle

Neurons
Embryonic Stem Cells
Transcription Factors
Stem cells
GABAergic Neurons
4 Citations (Scopus)

Osteoprotegerin regulates pancreatic β-cell homeostasis upon microbial invasion

Kuroda, Y., Maruyama, K., Fujii, H., Sugawara, I., Ko, S., Yasuda, H., Matsui, H. & Matsuo, K., 2016 Jan 11, In : PLoS One. 11, 1, e0146544.

Research output: Contribution to journalArticle

Osteoprotegerin
lipopolysaccharides
homeostasis
Homeostasis
insulin secretion
18 Citations (Scopus)

Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells

Akiyama, T., Wakabayashi, S., Soma, A., Sato, S., Nakatake, Y., Oda, M., Murakami, M., Sakota, M., Chikazawa-Nohtomi, N., Ko, S. & Ko, M., 2016 Oct 15, In : Development (Cambridge). 143, 20, p. 3674-3685 12 p.

Research output: Contribution to journalArticle

Histone Demethylases
Pluripotent Stem Cells
Developmental Genes
Preclinical Drug Evaluations
Cell Transplantation
4 Citations (Scopus)

Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis

Ishiguro, K. I., Monti, M., Akiyama, T., Kimura, H., Chikazawa-Nohtomi, N., Sakota, M., Sato, S., Redi, C. A., Ko, S. & Ko, M., 2016 Oct 3, (Accepted/In press) In : In Vitro Cellular and Developmental Biology - Animal. p. 1-12 12 p.

Research output: Contribution to journalArticle

Prophase
Oogenesis
Zinc Fingers
Spermatogenesis
Zinc
15 Citations (Scopus)
Zinc Fingers
Transcriptional Activation
Genome
Blastocyst
Heterochromatin
2015
8 Citations (Scopus)

Correction of Down syndrome and Edwards syndrome aneuploidies in human cell cultures

Amano, T., Jeffries, E., Amano, M., Ko, A. C., Yu, H. & Ko, M., 2015 May 6, In : DNA Research. 22, 5, p. 331-342 12 p.

Research output: Contribution to journalArticle

Aneuploidy
Down Syndrome
Cell Culture Techniques
Chromosomes, Human, Pair 21
Biological Products
18 Citations (Scopus)

ExAtlas: An interactive online tool for meta-analysis of gene expression data

Sharov, A. A., Schlessinger, D. & Ko, M., 2015 Dec 1, In : Journal of Bioinformatics and Computational Biology. 13, 6, 1550019.

Research output: Contribution to journalArticle

Gene expression
Meta-Analysis
Gene Ontology
Genes
Transcriptome
3 Citations (Scopus)

Functional characteristics of L1156F-CFTR associated with alcoholic chronic pancreatitis in Japanese

Kondo, S., Fujiki, K., Ko, S., Yamamoto, A., Nakakuki, M., Ito, Y., Shcheynikov, N., Kitagawa, M., Naruse, S. & Ishiguro, H., 2015 Aug 18, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G260-G269

Research output: Contribution to journalArticle

Alcoholic Pancreatitis
Cystic Fibrosis Transmembrane Conductance Regulator
Chronic Pancreatitis
Regulator Genes
Cystic Fibrosis
15 Citations (Scopus)

H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells

Kunitomi, A., Yuasa, S., Sugiyama, F., Saito, Y., Seki, T., Kusumoto, D., Kashimura, S., Takei, M., Tohyama, S., Hashimoto, H., Egashira, T., Tanimoto, Y., Mizuno, S., Tanaka, S., Okuno, H., Yamazawa, K., Watanabe, H., Oda, M., Kaneda, R., Matsuzaki, Y. & 5 others, Nagai, T., Okano, H., Yagami, K. I., Tanaka, M. & Fukuda, K., 2015 Apr 28, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Stem cells
Embryonic Stem Cells
Oocytes
Histones
18 Citations (Scopus)

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., 2015 Oct 28, In : Scientific reports. 5, 15876.

Research output: Contribution to journalArticle

Open Access
5-Methylcytosine
Zygote
Embryonic Development
Mothers
DNA Methylation
27 Citations (Scopus)

Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells

Akiyama, T., Xin, L., Oda, M., Sharov, A. A., Amano, M., Piao, Y., Cadet, J. S., Dudekula, D. B., Qian, Y., Wang, W., Ko, S. & Ko, M., 2015 May 6, In : DNA Research. 22, 5, p. 307-318 12 p.

Research output: Contribution to journalArticle

Heterochromatin
Genomic Instability
Telomere Homeostasis
Chromatin Assembly and Disassembly
Karyotype
2014
52 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 I. Concept and diagnosis of autoimmune pancreatitis

Okazaki, K., Kawa, S., Kamisawa, T., Ito, T., Inui, K., Irie, H., Nishino, T., Notohara, K., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T., Kubo, K., Ohara, H., Irisawa, A., Fujinaga, Y., Hasebe, O. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014, In : Journal of Gastroenterology. 49, 4, p. 567-588 22 p.

Research output: Contribution to journalArticle

Pancreatitis
Guidelines
Differential Diagnosis
Databases
25 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 II. Extrapancreatic lesions, differential diagnosis

Kawa, S., Okazaki, K., Kamisawa, T., Kubo, K., Ohara, H., Hasebe, O., Fujinaga, Y., Irisawa, A., Notohara, K., Ito, T., Inui, K., Irie, H., Nishino, T., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014, In : Journal of Gastroenterology. 49, 5, p. 765-784 20 p.

Research output: Contribution to journalArticle

Pancreatitis
Autoimmune Diseases
Japan
Differential Diagnosis
Guidelines
109 Citations (Scopus)

Amendment of the Japanese Consensus Guidelines for Autoimmune Pancreatitis, 2013 III. Treatment and prognosis of autoimmune pancreatitis

Kamisawa, T., Okazaki, K., Kawa, S., Ito, T., Inui, K., Irie, H., Nishino, T., Notohara, K., Nishimori, I., Tanaka, S., Nishiyama, T., Suda, K., Shiratori, K., Tanaka, M., Shimosegawa, T., Kubo, K., Ohara, H., Irisawa, A., Fujinaga, Y., Hasebe, O. & 19 others, Yamamoto, H., Uchida, K., Kanno, A., Kubota, K., Ko, S., Sakagami, J., Shimizu, K., Sugiyama, M., Tada, M., Nakazawa, T., Nishino, H., Hamano, H., Hirooka, Y., Hirano, K., Masamune, A., Masuda, A., Mizuno, N., Yamaguchi, K. & Yoshida, H., 2014, In : Journal of Gastroenterology. 49, 6, p. 961-970 10 p.

Research output: Contribution to journalArticle

Pancreatitis
Guidelines
Steroids
Obstructive Jaundice
Therapeutics
2 Citations (Scopus)

Chromatin properties of regulatory DNA probed by manipulation of transcription factors

Sharov, A. A., Nishiyama, A., Qian, Y., Dudekula, D. B., Longo, D. L., Schlessinger, D. & Ko, M., 2014 Aug 1, In : Journal of Computational Biology. 21, 8, p. 569-577 9 p.

Research output: Contribution to journalArticle

Transcription factors
Chromatin
Transcription Factor
Manipulation
DNA
30 Citations (Scopus)

Efficient generation of integration-free human induced pluripotent stem cells from keratinocytes by simple transfection of episomal vectors

Piao, Y., Hung, S. S. C., Lim, S. Y., Wong, R. C. B. & Ko, M., 2014, In : Stem cells translational medicine. 3, 7, p. 787-791 5 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Keratinocytes
Transfection
Hip
Embryoid Bodies
8 Citations (Scopus)

SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1)

Yamamizu, K., Schlessinger, D. & Ko, M., 2014 Nov 1, In : Development (Cambridge). 141, 22, p. 4254-4266 13 p.

Research output: Contribution to journalArticle

Germ Layers
Embryonic Stem Cells
Cell Differentiation
Transcription Factors
Doxycycline
2 Citations (Scopus)

Unprecedented cell-selection using ultra-quick freezing combined with aquaporin expression

Kato, Y., Miyauchi, T., Abe, Y., Kojić, D., Tanaka, M., Chikazawa, N., Nakatake, Y., Ko, S., Kobayashi, D., Hazama, A., Fujiwara, S., Uchida, T. & Yasui, M., 2014 Feb 18, In : PLoS One. 9, 2, e87644.

Research output: Contribution to journalArticle

Aquaporins
aquaporins
Freezing
freezing
CHO Cells
2013
21 Citations (Scopus)

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance

Livigni, A., Peradziryi, H., Sharov, A. A., Chia, G., Hammachi, F., Migueles, R. P., Sukparangsi, W., Pernagallo, S., Bradley, M., Nichols, J., Ko, M. & Brickman, J. M., 2013 Nov 18, In : Current Biology. 23, 22, p. 2233-2244 12 p.

Research output: Contribution to journalArticle

Xenopus
Stem cells
adhesion
stem cells
embryo (animal)
11 Citations (Scopus)

Cytoplasmic expression of LGR5 in pancreatic adenocarcinoma

Mizuno, N., Yatabe, Y., Hara, K., Hijioka, S., Imaoka, H., Shimizu, Y., Ko, S. & Yamao, K., 2013, In : Frontiers in Physiology. 4 SEP, Article 269.

Research output: Contribution to journalArticle

Adenocarcinoma
Pancreatic Neoplasms
Endocrine Cells
Cytoplasm
Stem Cells
37 Citations (Scopus)

Identification of transcription factors for lineage-specific ESC differentiation

Yamamizu, K., Piao, Y., Sharov, A. A., Zsiros, V., Yu, H., Nakazawa, K., Schlessinger, D. & Ko, M., 2013 Dec 17, In : Stem Cell Reports. 1, 6, p. 545-559 15 p.

Research output: Contribution to journalArticle

Transcription Factors
Cell Differentiation
Transcriptome
Gene expression
Muscle Cells
8 Citations (Scopus)

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

Ko, S., Azuma, S., Yokoyama, Y., Yamamoto, A., Kyokane, K., Niida, S., Ishiguro, H. & Ko, M., 2013 Jun 16, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 12

Research output: Contribution to journalArticle

Pancreas
Stem Cells
Inflammation
Pancreatitis
Adrenal Cortex Hormones
13 Citations (Scopus)

Kinetics of drug selection systems in mouse embryonic stem cells

Nakatake, Y., Fujii, S., Masui, S., Sugimoto, T., Torikai-Nishikawa, S., Adachi, K. & Niwa, H., 2013 Aug 7, In : BMC Biotechnology. 13, 64.

Research output: Contribution to journalArticle

Pharmacokinetics
Transgenes
Genes
Drug Resistance
Pharmaceutical Preparations
16 Citations (Scopus)

Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells

Hung, S. S. C., Wong, R. C. B., Sharov, A. A., Nakatake, Y., Yu, H. & Ko, M., 2013 Aug, In : DNA Research. 20, 4, p. 391-401 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factors
Embryonic Stem Cells
Embryonic Structures
Genes
Proteins

Role of iPSC-Producing Factors in Pre-Implantation Embryos

Amano, T. & Ko, M., 2013 Oct, Principles of Cloning: Second Edition. Elsevier Inc., p. 473-484 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Induced Pluripotent Stem Cells
Stem Cell Factor
Stem cells
Embryonic Stem Cells
Pluripotent Stem Cells
32 Citations (Scopus)

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Nishiyama, A., Sharov, A. A., Piao, Y., Amano, M., Amano, T., Hoang, H. G., Binder, B. Y., Tapnio, R., Bassey, U., Malinou, J. N., Correa-Cerro, L. S., Yu, H., Xin, L., Meyers, E., Zalzman, M., Nakatake, Y., Stagg, C., Sharova, L., Qian, Y., Dudekula, D. & 9 others, Sheer, S., Cadet, J. S., Hirata, T., Yang, H. T., Goldberg, I., Evans, M. K., Longo, D. L., Schlessinger, D. & Ko, M., 2013, In : Scientific Reports. 3, 1390.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Transcription Factors
Gene Expression
Gene Regulatory Networks
Transcriptome
116 Citations (Scopus)

Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Morgani, S. M., Canham, M. A., Nichols, J., Sharov, A. A., Migueles, R., Ko, M. & Brickman, J. M., 2013 Mar 27, In : Cell Reports. 3, 6, p. 1945-1957 13 p.

Research output: Contribution to journalArticle

Totipotent Stem Cells
Embryonic Stem Cells
Stem cells
Cell culture
Ground state
54 Citations (Scopus)

Zscan4 restores the developmental potency of embryonic stem cells.

Amano, T., Hirata, T., Falco, G., Monti, M., Sharova, L. V., Amano, M., Sheer, S., Hoang, H. G., Piao, Y., Stagg, C. A., Yamamizu, K., Akiyama, T. & Ko, M. S. H., 2013, In : Nature Communications. 4, 1966.

Research output: Contribution to journalArticle

stem cells
Embryonic Stem Cells
Stem cells
embryos
Embryonic Structures
2012
11 Citations (Scopus)

Deletion of Slc26a6 alters the stoichiometry of apical Cl-/HCO3 - exchange in mouse pancreatic duct

Ishiguro, H., Song, Y., Yamamoto, A., Steward, M. C., Ko, S., Stewart, A. K., Soleimani, M., Liu, B. C., Kondo, T. & Jin, C. X., 2012 Oct 15, In : American Journal of Physiology - Cell Physiology. 303, 8

Research output: Contribution to journalArticle

Chloride-Bicarbonate Antiporters
Pancreatic Ducts
Membranes
Cystic Fibrosis Transmembrane Conductance Regulator
Alkalies