Medical Education Center

Research Output 1986 2019

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2006
10 Citations (Scopus)

The cyclin-dependent kinase inhibitor p21 limits murine mesangial proliferative glomerulonephritis

Monkawa, T., Pippin, J., Yo, Y., Kopp, J. B., Alpers, C. E. & Shankland, S. J., 2006 Jan, In : Nephron - Experimental Nephrology. 102, 1

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase Inhibitor p21
Mesangial Cells
Glomerulonephritis
Kidney
Apoptosis
17 Citations (Scopus)

The effect of zinc supplementation on ghrelin-immunoreactive cells and lipid parameters in gastrointestinal tissue of streptozotocin-induced female diabetic rats

Bolkent, S., Yanardag, R., Bolkent, S., Mutlu, O., Yildirim, S., Kangawa, K., Minegishi, Y. & Suzuki, H., 2006 Jun, In : Molecular and Cellular Biochemistry. 286, 1-2, p. 77-85 9 p.

Research output: Contribution to journalArticle

Ghrelin
Streptozocin
Zinc
Rats
Tissue
64 Citations (Scopus)

Therapeutic strategies for functional dyspepsia and the introduction of the Rome III classification

Suzuki, H., Nishizawa, T. & Hibi, T., 2006 Jun, In : Journal of Gastroenterology. 41, 6, p. 513-523 11 p.

Research output: Contribution to journalArticle

Dyspepsia
Helicobacter pylori
Randomized Controlled Trials
Placebos
Satiation
2 Citations (Scopus)

Unusual hemangioendothelioma of the liver with epithelioid morphology associated with marked eosinophilia: Autopsy case

Kimura, T., Mukai, M., Kaneko, Y., Hirakata, M., Okamoto, S., Sakamoto, M., Okada, Y. & Ikeda, Y., 2006 Nov, In : Pathology International. 56, 11, p. 694-701 8 p.

Research output: Contribution to journalArticle

Hemangioendothelioma
Eosinophilia
Autopsy
Liver
Neoplasms
2005
5 Citations (Scopus)

Ascorbate stimulates monooxygenase-dependent steroidogenesis in adrenal zona glomerulosa

Mitani, F., Ogishima, T., Mukai, K. & Suematsu, M., 2005 Dec 9, In : Biochemical and Biophysical Research Communications. 338, 1, p. 483-490 8 p.

Research output: Contribution to journalArticle

Zona Glomerulosa
Mixed Function Oxygenases
Ascorbic Acid
Aldosterone
Adrenal Cortex
13 Citations (Scopus)

Association between autoantibodies to the Ku protein and DPB1

Hirakata, M., Suwa, A., Kuwana, M., Sato, S., Mimori, T. & Hardin, J. A., 2005 Feb, In : Arthritis and Rheumatism. 52, 2, p. 668-669 2 p.

Research output: Contribution to journalArticle

HLA-DP Antigens
DNA Helicases
Antinuclear Antibodies
Autoantibodies
Autoimmune Diseases
353 Citations (Scopus)

Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis

Sato, S., Hirakata, M., Kuwana, M., Suwa, A., Inada, S., Mimori, T., Nishikawa, T., Oddis, C. V. & Ikeda, Y., 2005 May, In : Arthritis and Rheumatism. 52, 5, p. 1571-1576 6 p.

Research output: Contribution to journalArticle

Autoantibodies
Peptides
Dermatomyositis
Idiopathic Pulmonary Fibrosis
Connective Tissue Diseases
21 Citations (Scopus)

Autoantibodies to aminoacyl-tRNA synthetases

Hirakata, M., 2005 Jun, In : Internal Medicine. 44, 6, p. 527-528 2 p.

Research output: Contribution to journalArticle

Amino Acyl-tRNA Synthetases
Myositis
Connective Tissue Diseases
Interstitial Lung Diseases
Autoantibodies
42 Citations (Scopus)

Biomarkers in patients with gastric inflammation: A systematic review

Naito, Y., Ito, M., Watanabe, T. & Suzuki, H., 2005, In : Digestion. 72, 2-3, p. 164-180 17 p.

Research output: Contribution to journalArticle

Stomach
Biomarkers
Inflammation
Pepsinogens
Gastrins
2 Citations (Scopus)

Class-specific binding of two aminoacyl-tRNA synthetases to annexin, a Ca2+-and phospholipid-binding protein

Shirakawa, T., Nakamura, A., Kohama, K., Hirakata, M. & Ogihara, S., 2005 Feb, In : Cell Structure and Function. 29, 5-6, p. 159-164 6 p.

Research output: Contribution to journalArticle

Annexins
Amino Acyl-tRNA Synthetases
Phospholipids
Carrier Proteins
Physarum polycephalum
47 Citations (Scopus)

Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies

Sato, S., Hirakata, M., Kuwana, M., Nakamura, K., Suwa, A., Inada, S., Mimori, T. & Ikeda, Y., 2005 Sep, In : Clinical and Experimental Rheumatology. 23, 5, p. 609-615 7 p.

Research output: Contribution to journalArticle

Threonine-tRNA Ligase
Autoantibodies
Interstitial Lung Diseases
Systemic Scleroderma
Arthritis
5 Citations (Scopus)

Does Helicobacter pylori attack ghrelin-producing cells?

Suzuki, H. & Hibi, T., 2005 Apr, In : Journal of Gastroenterology. 40, 4, p. 437-439 3 p.

Research output: Contribution to journalArticle

Ghrelin
Peptide Hormones
Helicobacter Infections
Gastric Mucosa
Helicobacter pylori
63 Citations (Scopus)

Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils

Suzuki, H., Minegishi, Y., Nomoto, Y., Ota, T., Masaoka, T., van den Brink, G. R. & Hibi, T., 2005 Jun, In : Journal of Pathology. 206, 2, p. 186-197 12 p.

Research output: Contribution to journalArticle

Hedgehogs
Gerbillinae
Helicobacter pylori
Stomach
Down-Regulation
40 Citations (Scopus)

Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils

Nomura, S., Suzuki, H., Masaoka, T., Kurabayashi, K., Ishii, H., Kitajima, M., Nomoto, K. & Hibi, T., 2005, In : Helicobacter. 10, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Urease
Gerbillinae
Helicobacter Infections
Helicobacter pylori
Diet
40 Citations (Scopus)

Enhanced ghrelin secretion in rats with cysteamine-induced duodenal ulcers

Fukuhara, S., Suzuki, H., Masaoka, T., Arakawa, M., Hosoda, H., Minegishi, Y., Kangawa, K., Ishii, H., Kitajima, M. & Hibi, T., 2005 Jul, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 1 52-1

Research output: Contribution to journalArticle

Cysteamine
Ghrelin
Duodenal Ulcer
Stomach
Somatostatin
19 Citations (Scopus)

Enhanced plasma ghrelin levels in Helicobacter pylori-colonized, interleukin-1-receptor type 1-homozygous knockout (IL-1R1-1-) mice

Abiko, Y., Suzuki, H., Masaoka, T., Nomura, S., Kurabayashi, K., Hosoda, H., Kangawa, K. & Hibi, T., 2005 Jul 21, In : World Journal of Gastroenterology. 11, 27, p. 4148-4153 6 p.

Research output: Contribution to journalArticle

Interleukin-1 Type I Receptors
Ghrelin
Interleukin-1
Helicobacter pylori
Helicobacter Infections
Dyspepsia
Helicobacter Infections
Helicobacter pylori
Meta-Analysis
Randomized Controlled Trials

Helicobacter pylori-eradication therapy decreases the level of neutrophil-derived oxidants in the ulcerous mucosa of the human stomach: Relationship between ulcer stage and mucosal oxidant level

Suzuki, M., Mihara, H., Suzuki, H., Kitahora, T., Nagahashi, S., Masaoka, T., Tanaka, S., Suzuki, K., Ishii, H. & Hibi, T., 2005 Mar, In : Gastroenterological Endoscopy. 47, 3, p. 366-372 7 p.

Research output: Contribution to journalArticle

Oxidants
Helicobacter pylori
Ulcer
Luminescence
Stomach
1 Citation (Scopus)

Helicobacter pylori infection and gastric cancer

Suzuki, H., Nishizawa, T., Masaoka, T., Mori, M., Iwasaki, E., Tsuchimoto, K. & Hibi, T., 2005 Oct, In : Japan Medical Association Journal. 48, 10, p. 497-504 8 p.

Research output: Contribution to journalArticle

Helicobacter Infections
Helicobacter pylori
Stomach Neoplasms
Stomach
Helicobacter felis
25 Citations (Scopus)

Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis

Okada, T., Noji, S., Goto, Y., Iwata, T., Fujita, T., Okada, T., Matsuzaki, Y., Kuwana, M., Hirakata, M., Horii, A., Matsuno, S., Sunamura, M. & Kawakami, Y., 2005 Oct 10, In : International Journal of Cancer. 116, 6, p. 925-933 9 p.

Research output: Contribution to journalArticle

DNA Repair Enzymes
DNA Mismatch Repair
Dermatomyositis
Pancreatic Neoplasms
Adenocarcinoma
Collagen Diseases
Cyclic Peptides
Immunologic Tests
Antinuclear Antibodies
Serologic Tests
1 Citation (Scopus)
Specimen Handling
Amino Acyl-tRNA Synthetases
Polymyositis
Immunologic Tests
Raynaud Disease

Immunologic tests: Anti-Jo-l antibody (anti-histidyl transfer RNA synthetase antibody)

Katsuki, Y. & Hirakata, M., 2005, In : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 7, p. 505-507 3 p.

Research output: Contribution to journalArticle

Histidine-tRNA Ligase
Specimen Handling
Amino Acyl-tRNA Synthetases
Polymyositis
Immunologic Tests
50 Citations (Scopus)
Dyspepsia
Helicobacter pylori
Quality of Life
Therapeutics
Breath Tests
6 Citations (Scopus)

Investigation of the possibility of human-β defensin 2 (hBD2) as a molecular marker of gastric mucosal inflammation

Ohara, T., Morishita, T., Suzuki, H., Masaoka, T., Nishizawa, T. & Hibi, T., 2005 Sep, In : Hepato-Gastroenterology. 52, 65, p. 1320-1324 5 p.

Research output: Contribution to journalArticle

Defensins
Helicobacter pylori
Helicobacter Infections
Stomach
Inflammation
8 Citations (Scopus)

Lack of circulating autoantibodies to bone morphogenetic protein receptor-II or activin receptor-like kinase 1 in mixed connective tissue disease patients with pulmonary arterial hypertension

Satoh, T., Kimura, K., Okano, Y., Hirakata, M., Kawakami, Y. & Kuwana, M., 2005 Feb, In : Rheumatology. 44, 2, p. 192-196 5 p.

Research output: Contribution to journalArticle

Type II Bone Morphogenetic Protein Receptors
Activin Receptors
Mixed Connective Tissue Disease
Pulmonary Hypertension
Autoantibodies
16 Citations (Scopus)

Long-term strict monitoring of plasma ghrelin and other serological markers of gastric diseases after Helicobacter pylori eradication

Masaoka, T., Suzuki, H., Imaeda, H., Hosoda, H., Ohara, T., Morishita, T., Ishii, H., Kangawa, K. & Hibi, T., 2005 Jan, In : Hepato-Gastroenterology. 52, 61, p. 1-4 4 p.

Research output: Contribution to journalArticle

Stomach Diseases
Ghrelin
Helicobacter pylori
Pepsinogen C
Pepsinogen A
14 Citations (Scopus)

Novel effects other than antisecretory action and off-label use of proton pump inhibitors

Suzuki, H. & Hibi, T., 2005 Jan, In : Expert Opinion on Pharmacotherapy. 6, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

Off-Label Use
Proton Pump Inhibitors
Peptic Ulcer
Acids
Zollinger-Ellison Syndrome
30 Citations (Scopus)

Pristane-induced autoimmunity in germ-free mice

Mizutani, A., Shaheen, V. M., Yoshida, H., Akaogi, J., Kuroda, Y., Nacionales, D. C., Yamasaki, Y., Hirakata, M., Ono, N., Reeves, W. H. & Satoh, M., 2005 Feb, In : Clinical Immunology. 114, 2, p. 110-118 9 p.

Research output: Contribution to journalArticle

Autoimmunity
Hypergammaglobulinemia
Autoantibodies
Granuloma
Specific Pathogen-Free Organisms
19 Citations (Scopus)
Gastric Mucosa
Tretinoin
Vitamin A
Alcohol Dehydrogenase
Protein Isoforms
23 Citations (Scopus)

Role of nociceptin/orphanin FQ (Noc/oFQ) in murine experimental colitis

Kato, S., Tsuzuki, Y., Hokari, R., Okada, Y., Miyazaki, J., Matsuzaki, K., Iwai, A., Kawaguchi, A., Nagao, S., Itoh, K., Suzuki, H., Nabeshima, T. & Miura, S., 2005 Apr, In : Journal of Neuroimmunology. 161, 1-2, p. 21-28 8 p.

Research output: Contribution to journalArticle

Colitis
Dextran Sulfate
Neurogenic Inflammation
Cell Adhesion Molecules
nociceptin

Sensorimotor polyneuropathy as an initial clinical manifestation of sarcoidosis

Sato, S., Nogawa, S., Hirakata, M., Iizuka, H., Suwa, A., Mimori, T. & Ikeda, Y., 2005 Apr, In : Modern Rheumatology. 15, 2, p. 144-147 4 p.

Research output: Contribution to journalArticle

Polyneuropathies
Sarcoidosis
Hypesthesia
Foot
Hand
24 Citations (Scopus)

Successful treatment of recurrent intracardiac thrombus in Behçet's disease with immunosuppressive therapy

Kaneko, Y., Tanaka, K., Yoshizawa, A., Yasuoka, H., Suwa, A., Satoh, T., Iwanaga, S., Ogawa, S., Ikeda, Y. & Hirakata, M., 2005 Nov, In : Clinical and Experimental Rheumatology. 23, 6, p. 885-887 3 p.

Research output: Contribution to journalArticle

Immunosuppressive Agents
Thrombosis
Oral Ulcer
Musculoskeletal System
Uveitis
13 Citations (Scopus)

Synthesis of methyl 1-O-(4-hydroxymethamphetaminyl)-α-D- glucopyranouronate

Nakajima, R., Ono, M., Aiso, S. & Akita, H., 2005 Jun, In : Chemical and Pharmaceutical Bulletin. 53, 6, p. 684-687 4 p.

Research output: Contribution to journalArticle

Methamphetamine
Glucuronic Acid
Metabolites
Urine
4-hydroxyphenylacetate
35 Citations (Scopus)

Therapeutic effects of the combination of methotrexate and bucillamine in early rheumatoid arthritis: A multicenter, double-blind, randomized controlled study

Ichikawa, Y., Saito, T., Yamanaka, H., Akizuki, M., Kondo, H., Kobayashi, S., Oshima, H., Kawai, S., Hama, N., Yamada, H., Mimori, T., Amano, K., Tanaka, Y., Matsuoka, Y., Yamamoto, S., Matsubara, T., Murata, N., Asai, T., Suzuki, Y., Okano, Y. & 15 others, Akaboshi, T., Fujii, T., Hirakata, M., Suzuki, T., Takubo, N., Miyata, Y., Sato, Y., Nishimoto, N., Saito, E., Sawada, S., Rikimaru, A., Yamagata, H., Toma, S., Ito, K. & Yoshida, K., 2005 Oct, In : Modern Rheumatology. 15, 5, p. 323-328 6 p.

Research output: Contribution to journalArticle

Antirheumatic Agents
Therapeutic Uses
Methotrexate
Rheumatoid Arthritis
Drug Therapy

Usefulness of detection of bleeding sites using the system of squirting water

Imaeda, H., Ogata, H., Iwao, Y., Suzuki, H., Hosoe, N., Masaoka, T., Nakashita, M., Aiura, K., Sugino, Y., Nagata, H., Kumai, K., Ishii, H. & Hibi, T., 2005 May, In : Gastroenterological Endoscopy. 47, 5, p. 1121-1125 5 p.

Research output: Contribution to journalArticle

Hemorrhage
Endoscopic Hemostasis
Water
Endoscopes
Hemostatics
2004
6 Citations (Scopus)

13C-ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori infection

Suzuki, M., Maruyama, K., Suzuki, H., Tanaki, S., Suzuki, K. & Ishii, H., 2004 Jul 1, In : Alimentary Pharmacology and Therapeutics. 20, 1, p. 109-115 7 p.

Research output: Contribution to journalArticle

Breath Tests
Helicobacter Infections
Helicobacter pylori
Ethanol
Alcohols
5 Citations (Scopus)

A case of mixed connective tissue disease successfully treated for hemophagocytic syndrome with intermittent intravenous injection of cyclophosphamide

Kato, M., Sato, S., Suzuki, M., Oka, H., Kaneko, Y., Yasuoka, H., Nojima, T., Suwa, A., Hirakata, M. & Ikeda, Y., 2004, In : Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 27, 5, p. 345-349 5 p.

Research output: Contribution to journalArticle

Mixed Connective Tissue Disease
Hemophagocytic Lymphohistiocytosis
Intravenous Injections
Cyclophosphamide
Interstitial Lung Diseases
28 Citations (Scopus)

Antibiotics directly induce apoptosis in B cell lymphoma cells derived from BALB/c mice

Ohara, T., Morishita, T., Suzuki, H., Masaoka, T., Ishii, H. & Hibi, T., 2004 Nov, In : Anticancer Research. 24, 6, p. 3723-3730 8 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Clarithromycin
Apoptosis
Amoxicillin
Anti-Bacterial Agents
23 Citations (Scopus)

Autoantibodies from primary biliary cirrhosis patients with anti-p95c antibodies bind to recombinant p97/VCP and inhibit in vitro nuclear envelope assembly

Miyachi, K., Hirano, Y., Horigome, T., Mimori, T., Miyakawa, H., Onozuka, Y., Shibata, M., Hirakata, M., Suwa, A., Hosaka, H., Matsushima, S., Komatsu, T., Matsushima, H., Hankins, R. W. & Fritzler, M. J., 2004 Jun, In : Clinical and Experimental Immunology. 136, 3, p. 568-573 6 p.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Nuclear Envelope
Autoantibodies
Anti-Idiotypic Antibodies
Serum
48 Citations (Scopus)

Autoimmune pancreatitis with pseudocysts

Nishimura, T., Masaoka, T., Suzuki, H., Aiura, K., Nagata, H. & Ishii, H., 2004 Oct, In : Journal of Gastroenterology. 39, 10, p. 1005-1010 6 p.

Research output: Contribution to journalArticle

Pancreatitis
Pancreas
Immunoglobulin G
Pancreatic Ducts
Back Pain
58 Citations (Scopus)

Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain-related gene A in patients with Behçet's disease

Yasuoka, H., Okazaki, Y., Kawakami, Y., Hirakata, M., Inoko, H., Ikeda, Y. & Kuwana, M., 2004 Nov, In : Arthritis and Rheumatism. 50, 11, p. 3658-3662 5 p.

Research output: Contribution to journalArticle

HLA-B51 Antigen
Cytotoxic T-Lymphocytes
Major Histocompatibility Complex
T-Lymphocytes
Peptides
31 Citations (Scopus)

Comparison of the effects calcitriol and maxacalcitol on secondary hyperparathyroidism in patients on chronic haemodialysis: A randomized propective multicenter trial

Hayashi, M., Tsuchiya, Y., Itaya, Y., Takenaka, T., Kobayashi, K., Yoshizawa, M., Nakamura, R., Monkawa, T. & Ichihara, A., 2004 Aug, In : Nephrology Dialysis Transplantation. 19, 8, p. 2067-2073 7 p.

Research output: Contribution to journalArticle

Secondary Hyperparathyroidism
Calcitriol
Parathyroid Hormone
Multicenter Studies
Renal Dialysis
27 Citations (Scopus)

Down-regulation of matrix-invasive potential of human liver cancer cells by type I interferon and a histone deacetylase inhibitor sodium butyrate.

Kaneko, F., Saito, H., Saito, Y., Wakabayashi, K., Nakamoto, N., Tada, S., Suzuki, H., Tsunematsu, S., Kumagai, N. & Ishii, H., 2004 Apr, In : International Journal of Oncology. 24, 4, p. 837-845 9 p.

Research output: Contribution to journalArticle

Interferon Type I
Histone Deacetylase Inhibitors
Butyric Acid
Liver Neoplasms
Interferon-alpha
42 Citations (Scopus)

Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection

Suzuki, H., Nomura, S., Masaoka, T., Goshima, H., Kamata, N., Kodama, Y., Ishii, H., Kitajima, M., Nomoto, K. & Hibi, T., 2004 Jul 1, In : Alimentary Pharmacology and Therapeutics, Supplement. 20, 1, p. 185-192 8 p.

Research output: Contribution to journalArticle

Urease
Helicobacter Infections
Helicobacter pylori
Egg Yolk
Breath Tests

Effect of dietary anti-Helicobacter pylori-urease immunoglobulin Y on Helicobacter pylori infection

Suzuki, H., Nomura, S., Masaoka, T., Goshima, H., Kamata, N., Kodama, Y., Ishii, H., Kitajima, M., Nomoto, K. & Hibi, T., 2004 Jul, In : Alimentary Pharmacology and Therapeutics, Supplement. 20, 1, p. 185-192 8 p.

Research output: Contribution to journalArticle

Urease
Helicobacter Infections
Helicobacter pylori
Egg Yolk
Breath Tests

Effect of proton pump inhibitors (PPIs) on wound healing of gastric mucosal cell injury

Masaoka, T., Suzuki, H. & Ishii, H., 2004, In : Nippon rinsho. Japanese journal of clinical medicine. 62, 3, p. 556-560 5 p.

Research output: Contribution to journalArticle

Lansoprazole
Proton Pump Inhibitors
Wound Healing
Stomach
Wounds and Injuries
21 Citations (Scopus)

Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats

Kobayashi, K., Monkawa, T., Hayashi, M. & Saruta, T., 2004 Sep, In : Journal of Hypertension. 22, 9, p. 1723-1730 8 p.

Research output: Contribution to journalArticle

Sodium-Hydrogen Antiporter
Inbred SHR Rats
Inbred Dahl Rats
Messenger RNA
Proteins
8 Citations (Scopus)

Helicobacter pylori eradication treatment modulates epithelial cell proliferation and tissue content of hepatocyte growth factor in the gastric mucosa

Suzuki, M., Suzuki, H., Masaoka, T., Tanaka, S., Suzuki, K. & Ishii, H., 2004 Jul, In : Alimentary Pharmacology and Therapeutics, Supplement. 20, 1, p. 158-164 7 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Metaplasia
Gastric Mucosa
Helicobacter pylori
Epithelium
90 Citations (Scopus)

Helicobocter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils

Suzuki, H., Masaoka, T., Hasoda, H., Ota, T., Minegishi, Y., Nomura, S., Kangawa, K. & Ishii, H., 2004 Feb, In : Gut. 53, 2, p. 187-194 8 p.

Research output: Contribution to journalArticle

Ghrelin
Gerbillinae
Pylorus
Stomach
Infection