Center for Integrated Medical Research

Research Output 2001 2019

  • 26 Article
  • 1 Conference contribution
2019
1 Citation (Scopus)

Innervation of the tibial epiphysis through the intercondylar foramen

Matsuo, K., Ji, S., Miya, A., Yoda, M., Hamada, Y., Tanaka, T., Takao-Kawabata, R., Kawaai, K., Kuroda, Y. & Shibata, S., 2019 Mar 1, In : Bone. 120, p. 297-304 8 p.

Research output: Contribution to journalArticle

Venus
Epiphyses
Schwann Cells
Sensory Receptor Cells
Knee Joint

Trans-pairing between osteoclasts and osteoblasts shapes the cranial base during development

Edamoto, M., Kuroda, Y., Yoda, M., Kawaai, K. & Matsuo, K., 2019 Dec 1, In : Scientific Reports. 9, 1, 1956.

Research output: Contribution to journalArticle

Open Access
Skull Base
Osteoclasts
Osteoblasts
Posterior Cranial Fossa
Bone and Bones
2018

Granulocyte-colony stimulating factor enhances load-induced muscle hypertrophy in mice

Ohashi, M., Okubo, K., Mizuno, S., Yoda, M., Shirasawa, H., Chiba, K., Horiuchi, K., Matsumoto, M. & Nakamura, M., 2018 Jan 1, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Granulocyte Colony-Stimulating Factor
Hypertrophy
Muscle
Muscles
Granulocyte Colony-Stimulating Factor Receptors

Inhibition of ADAM10 in satellite cells accelerates muscle regeneration following muscle injury

Mizuno, S., Yoda, M., Shimoda, M., Chiba, K., Nakamura, M. & Horiuchi, K., 2018 Jan 1, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

Muscle Cells
Regeneration
Muscles
Wounds and Injuries
Cell Differentiation
1 Citation (Scopus)

Targeted ablation of p38α MAPK suppresses denervation-induced muscle atrophy

Yuasa, K., Okubo, K., Yoda, M., Otsu, K., Ishii, Y., Nakamura, M., Itoh, Y. & Horiuchi, K., 2018 Dec 1, In : Scientific Reports. 8, 1, 9037.

Research output: Contribution to journalArticle

Muscular Atrophy
Denervation
p38 Mitogen-Activated Protein Kinases
Cell Aging
Cell Differentiation
2017
10 Citations (Scopus)

Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

Shirasawa, H., Matsumura, N., Shimoda, M., Oki, S., Yoda, M., Tohmonda, T., Kanai, Y., Matsumoto, M., Nakamura, M. & Horiuchi, K., 2017 Jan 31, In : Scientific Reports. 7, 41552.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor Receptors
Mesenchymal Stromal Cells
Humeral Head
Muscles
Rotator Cuff
2016
1 Citation (Scopus)

Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass

Hirozane, T., Tohmonda, T., Yoda, M., Shimoda, M., Kanai, Y., Matsumoto, M., Morioka, H., Nakamura, M. & Horiuchi, K., 2016 Sep 28, In : Scientific Reports. 6, 34426.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Osteoclasts
Bone and Bones
DNA Damage
Bone Resorption
2015
14 Citations (Scopus)

ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface

Uchikawa, S., Yoda, M., Tohmonda, T., Kanaji, A., Matsumoto, M., Toyama, Y. & Horiuchi, K., 2015 Feb 1, In : Cytokine. 71, 2, p. 238-245 8 p.

Research output: Contribution to journalArticle

Interleukin-1 Type II Receptors
Interleukins
Interleukin-1
Interleukin Receptors
Interleukin-1 Receptors
7 Citations (Scopus)

A disintegrin and metalloprotease 10 (ADAM10) is indispensable for maintenance of the muscle satellite cell pool

Mizuno, S., Yoda, M., Shimoda, M., Tohmonda, T., Okada, Y., Toyama, Y., Takeda, SI., Nakamura, M., Matsumoto, M. & Horiuchi, K., 2015 Nov 20, In : Journal of Biological Chemistry. 290, 47, p. 28456-28464 9 p.

Research output: Contribution to journalArticle

Disintegrins
Metalloproteases
Muscle Cells
Muscle
Maintenance
1 Citation (Scopus)

Generation and characterization of a novel shoulder contracture mouse model

Oki, S., Shirasawa, H., Yoda, M., Matsumura, N., Tohmonda, T., Yuasa, K., Nakamura, M., Matsumoto, M. & Horiuchi, K., 2015 Nov 1, In : Journal of Orthopaedic Research. 33, 11, p. 1732-1738 7 p.

Research output: Contribution to journalArticle

Bursitis
Contracture
Shoulder Joint
Gene Expression
Animal Models
16 Citations (Scopus)

IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis

Tohmonda, T., Yoda, M., Iwawaki, T., Matsumoto, M., Nakamura, M., Mikoshiba, K., Toyama, Y. & Horiuchi, K., 2015 Aug 3, In : Journal of Clinical Investigation. 125, 8, p. 3269-3279 11 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Osteoclasts
Osteogenesis
Endoplasmic Reticulum
NFATC Transcription Factors
2013
13 Citations (Scopus)

Conditional Inactivation of TNFα-Converting Enzyme in Chondrocytes Results in an Elongated Growth Plate and Shorter Long Bones

Saito, K., Horiuchi, K., Kimura, T., Mizuno, S., Yoda, M., Morioka, H., Akiyama, H., Threadgill, D., Okada, Y., Toyama, Y. & Satou, K., 2013 Jan 18, In : PLoS One. 8, 1, e54853.

Research output: Contribution to journalArticle

growth plate
Growth Plate
chondrocytes
Chondrocytes
Epidermal Growth Factor Receptor
26 Citations (Scopus)

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

Yoda, M., Kimura, T., Tohmonda, T., Morioka, H., Matsumoto, M., Okada, Y., Toyama, Y. & Horiuchi, K., 2013 Jan 14, In : PLoS One. 8, 1, e54412.

Research output: Contribution to journalArticle

Transgenic Mice
Genes
genetically modified organisms
Defects
mice
11 Citations (Scopus)

The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in PTH-induced osteoclastogenesis

Tohmonda, T., Yoda, M., Mizuochi, H., Morioka, H., Matsumoto, M., Urano, F., Toyama, Y. & Horiuchi, K., 2013 Jan 18, In : Journal of Biological Chemistry. 288, 3, p. 1691-1695 5 p.

Research output: Contribution to journalArticle

Parathyroid Hormone Receptor Type 1
Parathyroid Hormone
Osteogenesis
Osteoblasts
Transcription
2012
22 Citations (Scopus)

A novel multi-kinase inhibitor pazopanib suppresses growth of synovial sarcoma cells through inhibition of the PI3K-AKT pathway

Hosaka, S., Horiuchi, K., Yoda, M., Nakayama, T. R., Tohmonda, T., Susa, M., Nakamura, M., Chiba, K., Toyama, Y. & Morioka, H., 2012 Sep, In : Journal of Orthopaedic Research. 30, 9, p. 1493-1498 6 p.

Research output: Contribution to journalArticle

Synovial Sarcoma
Phosphatidylinositol 3-Kinases
Phosphotransferases
Growth
Cytotoxins
22 Citations (Scopus)

The transient appearance of zipper-like actin superstructures during the fusion of osteoclasts

Takito, J., Nakamura, M., Yoda, M., Tohmonda, T., Uchikawa, S., Horiuchi, K., Toyama, Y. & Chiba, K., 2012 Feb 1, In : Journal of Cell Science. 125, 3, p. 662-672 11 p.

Research output: Contribution to journalArticle

Osteoclasts
Actins
Bone Diseases
Giant Cells
Cherubism
2011
29 Citations (Scopus)

Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis

Yoda, M., Kimura, T., Tohmonda, T., Uchikawa, S., Koba, T., Takito, J., Morioka, H., Matsumoto, M., Link, D. C., Chiba, K., Okada, Y., Toyama, Y. & Horiuchi, K., 2011 Dec 22, In : Blood. 118, 26, p. 6939-6942 4 p.

Research output: Contribution to journalArticle

Myeloproliferative Disorders
Cells
Hematopoiesis
Granulocyte Colony-Stimulating Factor
Stem cells
67 Citations (Scopus)

The IRE1α-XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix

Tohmonda, T., Miyauchi, Y., Ghosh, R., Yoda, M., Uchikawa, S., Takito, J., Morioka, H., Nakamura, M., Iwawaki, T., Chiba, K., Toyama, Y., Urano, F. & Horiuchi, K., 2011 May 1, In : EMBO Reports. 12, 5, p. 451-457 7 p.

Research output: Contribution to journalArticle

Osteoblasts
Inositol
Transcription
Carrier Proteins
Unfolded Protein Response
19 Citations (Scopus)

VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage raw 264.7 cells

Shirakabe, K., Hattori, S., Seiki, M., Koyasu, S. & Okada, Y., 2011 Dec 16, In : Journal of Biological Chemistry. 286, 50, p. 43154-43163 10 p.

Research output: Contribution to journalArticle

Macrophages
Metalloproteases
Phagocytosis
Membrane Proteins
Disintegrins
2010
11 Citations (Scopus)

GRIP1 enhances estrogen receptor α-dependent extracellular matrix gene expression in chondrogenic cells

Kato, M., Takaishi, H., Yoda, M., Tohmonda, T., Takito, J., Fujita, N., Hosogane, N., Horiuchi, K., Kimura, T., Okada, Y., Saito, T., Kawaguchi, H., Kikuchi, T., Matsumoto, M., Toyama, Y. & Chiba, K., 2010 Jul, In : Osteoarthritis and Cartilage. 18, 7, p. 934-941 8 p.

Research output: Contribution to journalArticle

Nuclear Receptor Coactivator 2
Gene expression
Estrogen Receptors
Extracellular Matrix
Proteins
29 Citations (Scopus)

Inhibition of STAT1 accelerates bone fracture healing

Tajima, K., Takaishi, H., Takito, J., Tohmonda, T., Yoda, M., Ota, N., Kosaki, N., Matsumoto, M., Ikegami, H., Nakamura, T., Kimura, T., Okada, Y., Horiuchi, K., Chiba, K. & Toyama, Y., 2010 Jul, In : Journal of Orthopaedic Research. 28, 7, p. 937-941 5 p.

Research output: Contribution to journalArticle

STAT1 Transcription Factor
Fracture Healing
Bone Fractures
Osteogenesis
Osteoblasts
13 Citations (Scopus)

Receptor activator of NF-κB (RANK) ligand induces ectodomain shedding of RANK in murine RAW264.7 macrophages

Hakozaki, A., Yoda, M., Tohmonda, T., Furukawa, M., Hikata, T., Uchikawa, S., Takaishi, H., Matsumoto, M., Chiba, K., Horiuchi, K. & Toyama, Y., 2010 Mar 1, In : Journal of Immunology. 184, 5, p. 2442-2448 7 p.

Research output: Contribution to journalArticle

RANK Ligand
Osteogenesis
Macrophages
Membrane Proteins
Osteoclasts
2009
27 Citations (Scopus)

Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice

Ota, N., Takaishi, H., Kosaki, N., Takito, J., Yoda, M., Tohmonda, T., Kimura, T., Okada, Y., Yasuda, H., Kawaguchi, H., Matsumoto, M., Chiba, K., Ikegami, H. & Toyama, Y., 2009 Nov, In : Endocrinology. 150, 11, p. 4823-4834 12 p.

Research output: Contribution to journalArticle

Osteoprotegerin
Fracture Healing
Bone Fractures
Chondrocytes
Cartilage
41 Citations (Scopus)

IL-27 abrogates receptor activator of NF-κB ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos

Furukawa, M., Takaishi, H., Takito, J., Yoda, M., Sakai, S., Hikata, T., Hakozaki, A., Uchikawa, S., Matsumoto, M., Chiba, K., Kimura, T., Okada, Y., Matsuo, K., Yoshida, H. & Toyama, Y., 2009 Aug 15, In : Journal of Immunology. 183, 4, p. 2397-2406 10 p.

Research output: Contribution to journalArticle

Interleukin-27
Granulocyte-Macrophage Progenitor Cells
Osteogenesis
Ligands
Osteoclasts
2008
30 Citations (Scopus)

Transmission of force sensation by micro-macro bilateral control with scaling of control gains

Susa, S., Shimono, T., Takei, T., Atsuta, K., Shimojima, N., Ozawa, S., Morikawa, Y. & Ohnishi, K., 2008, International Workshop on Advanced Motion Control, AMC. Vol. 1. p. 532-537 6 p. 4516123

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gain control
Macros
Scaling Factor
Reproducibility
Scaling
2002

Detection of stimulants from charred bodies killed by a traffic accident: Distribution in the bodies

Nakajima, R., Shinozuka, T., Takei, S., Ohue, O., Baba, M., Ro, A., Yanagida, J. & Murai, T., 2002, In : Japanese Journal of Forensic Toxicology. 20, 1, p. 49-55 7 p.

Research output: Contribution to journalArticle

Methamphetamine
Highway accidents
Traffic Accidents
Urine
Gas chromatography
2001
33 Citations (Scopus)

Sudden death due to cardiovascular disorders: A review of the studies on the medico-legal cases in Tokyo

Murai, T., Baba, M., Ro, A., Murai, N., Matsuo, Y., Takada, A. & Saito, K., 2001 Sep, In : Keio Journal of Medicine. 50, 3, p. 175-181 7 p.

Research output: Contribution to journalArticle

Coroners and Medical Examiners
Tokyo
Sudden Death
Myocardial Ischemia
Cause of Death